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Anne I. Sperling

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
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    Dr. Sperling is Professor of Medicine, Associate Vice Chair for Research of the Dept of Medicine, Director of the Respiratory Biology Training Grant, and Director of the Cytometry and Antibody Technology Core Facility. She has served as a regular member of the NIH Hypersensitivity, Autoimmunity, and Immune-mediated Diseases (HAI) Study Section, and the Lung Cellular and Molecular Immunology (LCMI) Study Section. Dr. Sperling's research program focuses on the role of the immune system in lung diseases in humans and mouse models. She has made significant contributions to understanding how T cell costimulatory molecules influence inflammation and disease, and the regulation of inflammation resolution in allergic asthma. Recently, her group has been expanding its focus to address translational and basic questions in human lung diseases such as asthma, idiopathic pulmonary fibrosis, and sarcoidosis.

    Research Statement: The focus of my laboratory is to elucidate on the immune response characteristic of lung diseases such as atopic asthma and idiopathic pulmonary fibrosis. While in the past we focused highly on the resolution of airway inflammation (Tong et al JEM 2006 and Tong et al AJRCMB 2010), the current research is focused on the initial steps in the development of Th2 inflammation. Our goal is to determine how specific allergic stimuli signals the immune response to drive type 2 inflammation and Th2 differentiation.

    We have recently made three important discoveries that elucidate mechanisms involved in sensitization to allergens in the lungs. Our first finding is that allergen specific IgG in immune complexes with allergen, can directly induce dendritic cells to produce the Th2 promoting cytokine, IL-33 (Tjota et al JCI 2013). Through recent GWAS studies, IL-33 and its receptor have recently been found to be in the top five genes involved in asthma. We have found that a major source of IL-33 in various Th2 inflammatory models is the respiratory DC. Further, we have now found that this IL-33 production is essential for Th2 mediated inflammation in our models.

    Second, we have made the exciting discovery that the transcription factor, Interferon Regulatory Factor 4 (IRF4) directs dendritic cells to promote TH2 responses (Williams et al Nature Comm 2013). Respiratory dendritic cells (DC) are the primary initiator of T cells during lung allergic responses. DCs process inhaled allergen, traffic to draining lymph nodes, present antigen-peptides to T cells, and guide the type of T-helper response initiated. However, the mechanisms involved in priming a DC to direct Th2 helper cell differentiation have not yet been elucidated. We now believe that we have identified a key transcription factor that when expressed in DCs, confers the ability of the DC to drive Th2 immunity in the lungs. Using microarray analsysis, we identified this transcription factor as being expressed in the Th2 driving DCs, but not in other DC populations. Additionally, mice with a conditional deletion of IRF4 in DCs produce a much reduced Th2 responses after allergic challenge, while DCs with overexpression of IRF4 drive naïve CD4 T lymphocytes toward a Th2 phenotype. Thus, these data identify IRF4 as a key transcriptional regulator in DCs necessary for the development of Th2 responses.

    Third, we have discovered that two distinct Th2 stimuli, Immune Complexes and HDM, both utilize FcR-gamma associated receptors, Fc-gammaRIII and Dectin-2 respectively, to promote Th2-mediated lung inflammation (Tjota et al. JACI 2014). We have demonstrated that both ICs and HDM induce expression of IL-33, a critical mediator in asthma pathogenesis and the differentiation of Th2 cells, in DCs. Upregulation of IL-33 in DCs is dependent on FcR-gamma, toll-like receptor 4 (TLR4), and phosphoinositide 3 (PI3)-kinase. Exogenous IL-33 is sufficient to restore development of Th2 responses in FcR-gamma-deficient mice. Finally, adoptive transfer of allergen-pulsed FcR-gamma+/- BMDCs restores development of Th2-type inflammation in FcR-gamma-deficient mice, demonstrating the necessity of this signaling pathway in DCs for allergen-induced inflammation.

    Together, these data identify a mechanism whereby Th2 stimuli signal through FcR-gamma-associated receptors on DCs to induce IRF4 expression and upregulation of IL-33 production. These DCs cells are central to the induction of Th2-differentiation and type 2 allergic airway inflammation.


    Dr. Sperling's NIH Commons ID is ASPERLING
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    University of Chicago, Chicago, ILPostdoctoral Fellowship1994
    Tufts University, Boston, MAPhD1990Immunology
    Smith College, Northampton,MAA.B.1984Biology

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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      PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
      1. Cox BP, Hannan RT, Batrash N, Raichura P, Sperling AI, Shim YM, Sturek JM. Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin. Am J Respir Cell Mol Biol. 2024 Apr 09. PMID: 38593005.
        Citations:    
      2. Kalinina O, Minter LM, Sperling AI, Le P, Osborne BA, Zhang S, Stiff P, Knight KL, Hollinger MK. Exopolysaccharide-Treated Dendritic Cells Effectively Ameliorate Acute Graft-versus-Host Disease. Transplant Cell Ther. 2024 Jan; 30(1):79.e1-79.e10. PMID: 37924979.
        Citations:    Fields:    Translation:HumansAnimalsCells
      3. Si Y, Wang Y, Tian Q, Wang Q, Pollard JM, Srivastava PK, Esser-Kahn AP, Collier JH, Sperling AI, Chong AS. Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes. Cell Rep. 2023 10 31; 42(10):113299. PMID: 37864794; PMCID: PMC10676754.
        Citations: 1     Fields:    Translation:AnimalsCells
      4. Zamora-Pineda J, Kalinina O, Sperling AI, Knight KL. Mechanism of TLR4-Mediated Anti-Inflammatory Response Induced by Exopolysaccharide from the Probiotic Bacillus subtilis. J Immunol. 2023 10 15; 211(8):1232-1239. PMID: 37672039.
        Citations:    Fields:    Translation:HumansAnimalsCells
      5. Zhao AY, Unterman A, Abu Hussein N, Sharma P, Flint J, Yan X, Adams TS, Justet A, Sumida TS, Zhao J, Schupp JC, Raredon MSB, Ahangari F, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling AI, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung Diseases. bioRxiv. 2023 Sep 22. PMID: 37786685; PMCID: PMC10541583.
        Citations:    
      6. Zhao JO, Patel BK, Krishack P, Stutz MR, Pearson SD, Lin J, Lecompte-Osorio PA, Dugan KC, Kim S, Gras N, Pohlman A, Kress JP, Hall JB, Sperling AI, Adegunsoye A, Verhoef PA, Wolfe KS. Identification of Clinically Significant Cytokine Signature Clusters in Patients With Septic Shock. Crit Care Med. 2023 12 01; 51(12):e253-e263. PMID: 37678209; PMCID: PMC10840934.
        Citations:    Fields:    Translation:Humans
      7. Moore BB, Ballinger MN, Bauer NN, Blackwell TS, Borok Z, Budinger GRS, Camoretti-Mercado B, Erzurum SC, Himes BE, Keshamouni VG, Kulkarni HS, Mallampalli RK, Mariani TJ, Martinez FJ, McCombs JE, Newcomb DC, Johnston RA, O'Reilly MA, Prakash YS, Ridge KM, Sime PJ, Sperling AI, Violette S, Wilkes DS, Königshoff M. Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 08; 20(8):1077-1087. PMID: 37526479; PMCID: PMC10405615.
        Citations:    Fields:    Translation:Humans
      8. Yoon YM, Velez TE, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DC, Clark MR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Anderson M, DeRisi JL, Shum AK, Sperling AI. Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies. medRxiv. 2023 May 11. PMID: 37214861; PMCID: PMC10197719.
        Citations:    
      9. Upadhyay V, Yoon YM, Vazquez SE, Velez TE, Jones KD, Lee CT, Law CS, Wolters PJ, Lee S, Yang MM, Farrand E, Noth I, Strek ME, Anderson M, DeRisi J, Sperling AI, Shum AK. PhIP-Seq uncovers novel autoantibodies and unique endotypes in interstitial lung disease. bioRxiv. 2023 Apr 24. PMID: 37163026; PMCID: PMC10168232.
        Citations:    
      10. Adegunsoye A, Newton CA, Oldham JM, Ley B, Lee CT, Linderholm AL, Chung JH, Garcia N, Zhang D, Vij R, Guzy R, Jablonski R, Bag R, Voogt RS, Ma SF, Sperling AI, Raghu G, Martinez FJ, Strek ME, Wolters PJ, Garcia CK, Pierce BL, Noth I. Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts. Nat Commun. 2023 03 17; 14(1):1489. PMID: 36932145; PMCID: PMC10023792.
        Citations: 5     Fields:    Translation:HumansCells
      11. Huang Y, Guzy R, Ma SF, Bonham CA, Jou J, Schulte JJ, Kim JS, Barros AJ, Espindola MS, Husain AN, Hogaboam CM, Sperling AI, Noth I. Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis. BMJ Open Respir Res. 2023 02; 10(1). PMID: 36725082; PMCID: PMC9896241.
        Citations:    Translation:HumansCells
      12. MacDonald ME, Weathered RK, Stewart EC, Magold AI, Mukherjee A, Gurbuxani S, Smith H, McMullen P, Mueller J, Husain AN, Salles CM, Briquez PS, Rouhani SJ, Yu J, Trujillo J, Pyzer AR, Gajewski TF, Sperling AI, Kilarski WW, Swartz MA. Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents. Blood Adv. 2022 12 27; 6(24):6249-6262. PMID: 35977099; PMCID: PMC9394105.
        Citations: 3     Fields:    Translation:AnimalsCells
      13. Yoon YM, Hrusch CL, Fei N, Mills KAM, Hollinger MK, Velez TE, Leone VA, Chang EB, Sperling AI, Barrón GM. Gut microbiota modulates bleomycin-induced acute lung injury response in mice. Respir Res. 2022 Dec 10; 23(1):337. PMID: 36496380; PMCID: PMC9741526.
        Citations: 3     Fields:    Translation:Animals
      14. Camacho DF, Velez TE, Hollinger MK, Wang E, Howard CL, Darnell EP, Kennedy DE, Krishack PA, Hrusch CL, Clark MR, Moon JJ, Sperling AI. IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses. JCI Insight. 2022 11 08; 7(21). PMID: 36194494; PMCID: PMC9675458.
        Citations: 2     Fields:    Translation:AnimalsCells
      15. Jia G, Zhong X, Im HK, Schoettler N, Pividori M, Hogarth DK, Sperling AI, White SR, Naureckas ET, Lyttle CS, Terao C, Kamatani Y, Akiyama M, Matsuda K, Kubo M, Cox NJ, Ober C, Rzhetsky A, Solway J. Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712. PMID: 36344522; PMCID: PMC9640644.
        Citations: 3     Fields:    Translation:Humans
      16. Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA. Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity. Sci Adv. 2022 10 07; 8(40):eabn3777. PMID: 36206332; PMCID: PMC9544317.
        Citations: 16     Fields:    Translation:HumansCells
      17. Rahimi RA, Cho JL, Jakubzick CV, Khader SA, Lambrecht BN, Lloyd CM, Molofsky AB, Talbot S, Bonham CA, Drake WP, Sperling AI, Singer BD. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 07; 67(1):e1-18. PMID: 35776495; PMCID: PMC9273224.
        Citations: 2     Fields:    Translation:HumansAnimals
      18. Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA. SARS-CoV-2 infection induces cross-reactive autoantibodies against angiotensin II. medRxiv. 2021 Nov 02. PMID: 34751272; PMCID: PMC8575143.
        Citations:    
      19. Aneas I, Decker DC, Howard CL, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Schoetler N, Ober C, Sperling AI, Sobreira DR, Tena J, Gomez-Skarmeta JL, Nóbrega MA. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115. PMID: 34675193; PMCID: PMC8531453.
        Citations: 15     Fields:    Translation:HumansAnimalsCells
      20. Kasal DN, Liang Z, Hollinger MK, O'Leary CY, Lisicka W, Sperling AI, Bendelac A. A Gata3 enhancer necessary for ILC2 development and function. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). PMID: 34353913; PMCID: PMC8364216.
        Citations: 10     Fields:    Translation:AnimalsCells
      21. Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Fang Y, Mutlu GM. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226. PMID: 33971111; PMCID: PMC8399572.
        Citations: 3     Fields:    Translation:HumansCells
      22. Barnes H, Troy L, Lee CT, Sperling A, Strek M, Glaspole I. Hypersensitivity pneumonitis: Current concepts in pathogenesis, diagnosis, and treatment. Allergy. 2022 02; 77(2):442-453. PMID: 34293188.
        Citations: 11     Fields:    Translation:Humans
      23. McMullen P, Pytel P, Snyder A, Smith H, Vickery J, Brainer J, Guzy R, Wu D, Schoettler N, Adegunsoye A, Sperling A, Hart J, Alpert L, Chang A, Gurbuxani S, Krausz T, Husain AN, Mueller J. A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza. J Pathol Clin Res. 2021 09; 7(5):459-470. PMID: 33960723; PMCID: PMC8239851.
        Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
      24. Krishack PA, Hollinger MK, Kuzel TG, Decker TS, Louviere TJ, Hrusch CL, Sperling AI, Verhoef PA. IL-33-mediated Eosinophilia Protects against Acute Lung Injury. Am J Respir Cell Mol Biol. 2021 05; 64(5):569-578. PMID: 33571420; PMCID: PMC8086044.
        Citations: 12     Fields:    Translation:HumansAnimalsCells
      25. Lee TH, Wu D, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy. bioRxiv. 2021 Jan 18. PMID: 33469586; PMCID: PMC7814823.
        Citations:    
      26. Wagar LE, Salahudeen A, Constantz CM, Wendel BS, Lyons MM, Mallajosyula V, Jatt LP, Adamska JZ, Blum LK, Gupta N, Jackson KJL, Yang F, Roskin KM, Blaine KM, Meister KD, Ahmad IN, Cortese M, Dora EG, Tucker SN, Sperling AI, Jain A, Davies DH, Felgner PL, Hammer GB, Kim PS, Robinson WH, Boyd SD, Kuo CJ, Davis MM, Röltgen K. Modeling human adaptive immune responses with tonsil organoids. Nat Med. 2021 01; 27(1):125-135. PMID: 33432170; PMCID: PMC7891554.
        Citations: 75     Fields:    Translation:HumansCells
      27. Bhavani SV, Wolfe KS, Hrusch CL, Greenberg JA, Krishack PA, Lin J, Lecompte-Osorio P, Carey KA, Kress JP, Coopersmith CM, Sperling AI, Verhoef PA, Churpek MM, Patel BK. Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis. Crit Care Med. 2020 11; 48(11):1645-1653. PMID: 32947475; PMCID: PMC7837282.
        Citations: 19     Fields:    Translation:Humans
      28. Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFß signaling through TGFBR1 stabilization. Nat Commun. 2020 08 26; 11(1):4254. PMID: 32848143; PMCID: PMC7449970.
        Citations: 35     Fields:    Translation:HumansAnimalsCells
      29. Si Y, Tian Q, Zhao F, Kelly SH, Shores LS, Camacho DF, Sperling AI, Andrade MS, Collier JH, Chong AS. Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses. Sci Adv. 2020 08; 6(32):eaba0995. PMID: 32821819; PMCID: PMC7413739.
        Citations: 18     Fields:    Translation:Cells
      30. Maisel K, Hrusch CL, Medellin JEG, Potin L, Chapel DB, Nurmi H, Camacho DF, Gleyzer R, Alitalo K, Sperling AI, Swartz MA. Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation. Mucosal Immunol. 2021 01; 14(1):144-151. PMID: 32518367; PMCID: PMC7725864.
        Citations: 3     Fields:    Translation:AnimalsCells
      31. Adegunsoye A, Alqalyoobi S, Linderholm A, Bowman WS, Lee CT, Pugashetti JV, Sarma N, Ma SF, Haczku A, Sperling A, Strek ME, Noth I, Oldham JM. Circulating Plasma Biomarkers of Survival in Antifibrotic-Treated Patients With Idiopathic Pulmonary Fibrosis. Chest. 2020 10; 158(4):1526-1534. PMID: 32450241; PMCID: PMC7545483.
        Citations: 21     Fields:    Translation:Humans
      32. Alqalyoobi S, Adegunsoye A, Linderholm A, Hrusch C, Cutting C, Ma SF, Sperling A, Noth I, Strek ME, Oldham JM. Circulating Plasma Biomarkers of Progressive Interstitial Lung Disease. Am J Respir Crit Care Med. 2020 01 15; 201(2):250-253. PMID: 31524503; PMCID: PMC6961741.
        Citations: 13     Fields:    Translation:Humans
      33. Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C. Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells. Commun Biol. 2019; 2:411. PMID: 31754641; PMCID: PMC6853923.
        Citations: 8     Translation:HumansCells
      34. Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C. Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells. Commun Biol. 2019 Nov 13; 2(1):411. PMID: 31925217.
        Citations:    
      35. Hrusch CL, Stein MM, Gozdz J, Holbreich M, Vercelli D, Ober C, Sperling AI, von Mutius E. T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children. J Allergy Clin Immunol. 2019 11; 144(5):1391-1401.e10. PMID: 31401285; PMCID: PMC6842432.
        Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
      36. Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, Misharin AV. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 08; 61(2):150-161. PMID: 31368812; PMCID: PMC6670040.
        Citations: 28     Fields:    Translation:HumansAnimalsCells
      37. Sharma A, Laxman B, Naureckas ET, Hogarth DK, Sperling AI, Solway J, Ober C, Gilbert JA, White SR. Associations between fungal and bacterial microbiota of airways and asthma endotypes. J Allergy Clin Immunol. 2019 11; 144(5):1214-1227.e7. PMID: 31279011; PMCID: PMC6842419.
        Citations: 58     Fields:    Translation:HumansAnimalsCells
      38. Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV, Mutlu GM. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 06 15; 199(12):1517-1536. PMID: 30554520; PMCID: PMC6580683.
        Citations: 509     Fields:    Translation:HumansAnimalsCells
      39. White SR, Laxman B, Naureckas ET, Hogarth DK, Solway J, Sperling AI, Ober C. Evidence for an IL-6-high asthma phenotype in asthmatic patients of African ancestry. J Allergy Clin Immunol. 2019 07; 144(1):304-306.e4. PMID: 31029772; PMCID: PMC6612296.
        Citations: 10     Fields:    Translation:Humans
      40. Adegunsoye A, Oldham JM, Sperling AI, Noth I, Strek ME, Chung JH. Reply to Lescoat et al. and to Khamis et al. Am J Respir Crit Care Med. 2019 04 15; 199(8):1041-1042. PMID: 30653922; PMCID: PMC6467307.
        Citations:    Fields:    Translation:Humans
      41. Krishack PA, Louviere TJ, Decker TS, Kuzel TG, Greenberg JA, Camacho DF, Hrusch CL, Sperling AI, Verhoef PA. Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils. JCI Insight. 2019 03 21; 4(6). PMID: 30721149; PMCID: PMC6482999.
        Citations: 29     Fields:    Translation:HumansAnimalsCells
      42. Adegunsoye A, Oldham JM, Bonham C, Hrusch C, Nolan P, Klejch W, Bellam S, Mehta U, Thakrar K, Pugashetti JV, Husain AN, Montner SM, Straus CM, Vij R, Sperling AI, Noth I, Strek ME, Chung JH. Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment. An Observational Cohort Study with Independent Validation. Am J Respir Crit Care Med. 2019 03 15; 199(6):747-759. PMID: 30216085; PMCID: PMC6423102.
        Citations: 20     Fields:    Translation:Humans
      43. Bonham CA, Hrusch CL, Blaine KM, Manns ST, Vij R, Oldham JM, Churpek MM, Strek ME, Noth I, Sperling AI. T cell Co-Stimulatory molecules ICOS and CD28 stratify idiopathic pulmonary fibrosis survival. Respir Med X. 2019; 1. PMID: 32455343; PMCID: PMC7243672.
        Citations: 4     
      44. Williams JW, Ferreira CM, Blaine KM, Rayon C, Tong J, Peter ME, Sperling AI, Velázquez F. Non-apoptotic Fas (CD95) Signaling on T Cells Regulates the Resolution of Th2-Mediated Inflammation. Front Immunol. 2018; 9:2521. PMID: 30443253; PMCID: PMC6221963.
        Citations: 9     Fields:    Translation:AnimalsCells
      45. Ferreira CM, Williams JW, Tong J, Rayon C, Blaine KM, Sperling AI. Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation. Front Immunol. 2018; 9:2395. PMID: 30425708; PMCID: PMC6219400.
        Citations: 1     Fields:    Translation:AnimalsCells
      46. Stein MM, Hrusch CL, Sperling AI, Ober C. Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies. Genes Immun. 2019 07; 20(6):462-472. PMID: 29977032; PMCID: PMC8026236.
        Citations: 4     Fields:    Translation:HumansCells
      47. Greenberg JA, Hrusch CL, Jaffery MR, David MZ, Daum RS, Hall JB, Kress JP, Sperling AI, Verhoef PA. Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality. Crit Care. 2018 Apr 25; 22(1):107. PMID: 29695270; PMCID: PMC5916828.
        Citations: 17     Fields:    Translation:HumansCells
      48. Krishack PA, Wang K, Rzhetsky A, Solway J, Sperling AI, Verhoef PA. Preexisting Type 2 Immune Activation Protects against the Development of Sepsis. Am J Respir Cell Mol Biol. 2017 11; 57(5):628-630. PMID: 29090959; PMCID: PMC5705910.
        Citations: 9     Fields:    Translation:HumansAnimalsCells
      49. Ober C, Sperling AI, von Mutius E, Vercelli D. Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol. 2017 Oct; 48:51-60. PMID: 28843541; PMCID: PMC5682224.
        Citations: 30     Fields:    Translation:Humans
      50. Tjota MY, Camacho DF, Turnquist HR, Sperling AI. IL-33 Drives Monocyte Recruitment to Lung Interstitium through Chemokine Upregulation. Immunohorizons. 2017 Aug 01; 1(6):101-108. PMID: 29629429; PMCID: PMC5889047.
        Citations: 5     Fields:    
      51. Hrusch CL, Manns ST, Bryazka D, Casaos J, Bonham CA, Jaffery MR, Blaine KM, Mills KAM, Verhoef PA, Adegunsoye AO, Williams JW, Tjota MY, Moore TV, Strek ME, Noth I, Sperling AI. ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol. 2018 01; 11(1):61-70. PMID: 28488693; PMCID: PMC5681437.
        Citations: 15     Fields:    Translation:HumansAnimalsCells
      52. White SR, Nicodemus-Johnson J, Laxman B, Denner DR, Naureckas ET, Hogarth DK, Stern R, Minc A, Solway J, Sperling A, Ober C. Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma. J Allergy Clin Immunol. 2017 09; 140(3):857-860. PMID: 28363527; PMCID: PMC5591772.
        Citations: 9     Fields:    Translation:HumansCells
      53. Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. DNA methylation in lung cells is associated with asthma endotypes and genetic risk. JCI Insight. 2016 12 08; 1(20):e90151. PMID: 27942592; PMCID: PMC5139904.
        Citations: 73     Fields:    Translation:HumansCells
      54. Adegunsoye A, Hrusch CL, Bonham CA, Jaffery MR, Blaine KM, Sullivan M, Churpek MM, Strek ME, Noth I, Sperling AI. Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function. Front Immunol. 2016; 7:516. PMID: 27933058; PMCID: PMC5120085.
        Citations: 14     Fields:    
      55. Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med. 2016 Aug 04; 375(5):411-421. PMID: 27518660; PMCID: PMC5137793.
        Citations: 346     Fields:    Translation:HumansAnimalsCellsPHPublic Health
      56. Kariuki SN, Maranville JC, Baxter SS, Jeong C, Nakagome S, Hrusch CL, Witonsky DB, Sperling AI, Di Rienzo A. Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells. PLoS One. 2016; 11(7):e0159779. PMID: 27454520; PMCID: PMC4959717.
        Citations: 8     Fields:    Translation:HumansCells
      57. Gozdz J, Holbreich M, Metwali N, Thorne PS, Sperling AI, Martinez FD, Ober C, von Mutius E, Vercelli D. Amish and Hutterite Environmental Farm Products Have Opposite Effects on Experimental Models of Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S99. PMID: 27027969; PMCID: PMC5015741.
        Citations: 4     Fields:    
      58. Nicodemus-Johnson J, Naughton KA, Sudi J, Hogarth K, Naurekas ET, Nicolae DL, Sperling AI, Solway J, White SR, Ober C. Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):376-85. PMID: 26474238; PMCID: PMC4803084.
        Citations: 55     Fields:    Translation:HumansCells
      59. Denner DR, Sangwan N, Becker JB, Hogarth DK, Oldham J, Castillo J, Sperling AI, Solway J, Naureckas ET, Gilbert JA, White SR. Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways. J Allergy Clin Immunol. 2016 05; 137(5):1398-1405.e3. PMID: 26627545; PMCID: PMC4860110.
        Citations: 85     Fields:    Translation:HumansCells
      60. Verhoef PA, Constantinides MG, McDonald BD, Urban JF, Sperling AI, Bendelac A. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol. 2016 Feb; 137(2):591-600.e1. PMID: 26602165; PMCID: PMC4747811.
        Citations: 18     Fields:    Translation:AnimalsCells
      61. Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR. ?d Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice. Gastroenterology. 2015 Jun; 148(7):1417-26. PMID: 25747597; PMCID: PMC4685713.
        Citations: 62     Fields:    Translation:AnimalsCells
      62. Hrusch CL, Tjota MY, Sperling AI. The role of dendritic cells and monocytes in the maintenance and loss of respiratory tolerance. Curr Allergy Asthma Rep. 2015 Jan; 15(1):494. PMID: 25430955; PMCID: PMC4737703.
        Citations: 5     Fields:    Translation:HumansAnimalsCells
      63. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Dec 08; 26(6):938. PMID: 28898680.
        Citations: 80     Fields:    
      64. Sperling AI, Ansel KM. Editorial overview: Allergy and hypersensitivity. Curr Opin Immunol. 2014 Dec; 31:ix-xi. PMID: 25456768.
        Citations:    Fields:    Translation:HumansAnimals
      65. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52. PMID: 25446897; PMCID: PMC4254577.
        Citations: 497     Fields:    Translation:HumansAnimalsCells
      66. Tjota MY, Sperling AI. Distinct dendritic cell subsets actively induce Th2 polarization. Curr Opin Immunol. 2014 Dec; 31:44-50. PMID: 25290173; PMCID: PMC4737705.
        Citations: 18     Fields:    Translation:HumansAnimalsCells
      67. Tjota MY, Hrusch CL, Blaine KM, Williams JW, Barrett NA, Sperling AI. Signaling through FcR?-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. J Allergy Clin Immunol. 2014 Sep; 134(3):706-713.e8. PMID: 25088053; PMCID: PMC4149927.
        Citations: 30     Fields:    Translation:HumansAnimalsCells
      68. Chen B, Moore TV, Li Z, Sperling AI, Zhang C, Andrade J, Rodriguez A, Bahroos N, Huang Y, Morrisey EE, Gruber PJ, Solway J. Gata5 deficiency causes airway constrictor hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):787-95. PMID: 24199649; PMCID: PMC4068924.
        Citations: 8     Fields:    Translation:AnimalsCells
      69. Flor AC, Williams JH, Blaine KM, Duggan RC, Sperling AI, Schwartz DA, Kron SJ. DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry. Chembiochem. 2014 Jan 24; 15(2):267-75. PMID: 24375983; PMCID: PMC3925401.
        Citations: 2     Fields:    
      70. Cannon JL, Asperti-Boursin F, Letendre KA, Brown IK, Korzekwa KE, Blaine KM, Oruganti SR, Sperling AI, Moses ME. PKC? regulates T cell motility via ezrin-radixin-moesin localization to the uropod. PLoS One. 2013; 8(11):e78940. PMID: 24250818; PMCID: PMC3826749.
        Citations: 7     Fields:    Translation:HumansCells
      71. Williams JW, Yau D, Sethakorn N, Kach J, Reed EB, Moore TV, Cannon J, Jin X, Xing H, Muslin AJ, Sperling AI, Dulin NO. RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L693-701. PMID: 24077945; PMCID: PMC3840273.
        Citations: 10     Fields:    Translation:AnimalsCells
      72. Wu Q, Gardiner GJ, Berry E, Wagner SR, Lu T, Clay BS, Moore TV, Ferreira CM, Williams JW, Luster AD, Medoff BD, Cannon JL, Sperling AI, Shilling RA. ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. PLoS One. 2013; 8(8):e72955. PMID: 23967339; PMCID: PMC3742557.
        Citations: 5     Fields:    Translation:AnimalsCells
      73. Tjota MY, Williams JW, Lu T, Clay BS, Byrd T, Hrusch CL, Decker DC, de Araujo CA, Bryce PJ, Sperling AI. IL-33-dependent induction of allergic lung inflammation by Fc?RIII signaling. J Clin Invest. 2013 May; 123(5):2287-97. PMID: 23585480; PMCID: PMC3635716.
        Citations: 49     Fields:    Translation:AnimalsCells
      74. Kach J, Sandbo N, Sethakorn N, Williams J, Reed EB, La J, Tian X, Brain SD, Rajendran K, Krishnan R, Sperling AI, Birukov K, Dulin NO. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L757-64. PMID: 23585227; PMCID: PMC3680759.
        Citations: 15     Fields:    Translation:HumansAnimalsCells
      75. Shilling RA, Williams JW, Perera J, Berry E, Wu Q, Cummings OW, Sperling AI, Huang H. Autoreactive T and B cells induce the development of bronchus-associated lymphoid tissue in the lung. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):406-14. PMID: 23371062; PMCID: PMC3653607.
        Citations: 13     Fields:    Translation:AnimalsCells
      76. Nicodemus-Johnson J, Laxman B, Stern RK, Sudi J, Tierney CN, Norwick L, Hogarth DK, McConville JF, Naureckas ET, Sperling AI, Solway J, Krishnan JA, Nicolae DL, White SR, Ober C. Maternal asthma and microRNA regulation of soluble HLA-G in the airway. J Allergy Clin Immunol. 2013 Jun; 131(6):1496-503. PMID: 23534973; PMCID: PMC3779062.
        Citations: 25     Fields:    Translation:HumansPHPublic Health
      77. Patterson KC, Franek BS, Sperling AI, Sweiss NJ, Niewold TB, Müller-Quernheim J. Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease. Cytokine. 2013 Mar; 61(3):906-11. PMID: 23384655; PMCID: PMC3615886.
        Citations: 19     Fields:    Translation:Humans
      78. Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, Decker DC, Blaine KM, Fixsen BR, Singh H, Sciammas R, Sperling AI. Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun. 2013; 4:2990. PMID: 24356538; PMCID: PMC4003872.
        Citations: 190     Fields:    Translation:AnimalsCells
      79. Williams JW, Tjota MY, Sperling AI. The contribution of allergen-specific IgG to the development of th2-mediated airway inflammation. J Allergy (Cairo). 2012; 2012:236075. PMID: 23150737; PMCID: PMC3485540.
        Citations: 23     
      80. Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102. PMID: 22511722; PMCID: PMC3345021.
        Citations: 92     Fields:    Translation:AnimalsCells
      81. Patterson KC, Hogarth K, Husain AN, Sperling AI, Niewold TB. The clinical and immunologic features of pulmonary fibrosis in sarcoidosis. Transl Res. 2012 Nov; 160(5):321-31. PMID: 22683422; PMCID: PMC3910531.
        Citations: 21     Fields:    Translation:Humans
      82. Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polic B, Al-Harthi L, Sperling AI, Guevara-Patiño JA. NKG2D signaling on CD8? T cells represses T-bet and rescues CD4-unhelped CD8? T cell memory recall but not effector responses. Nat Med. 2012 Feb 26; 18(3):422-8. PMID: 22366950; PMCID: PMC3436127.
        Citations: 37     Fields:    Translation:HumansAnimalsCells
      83. Moore TV, Clay BS, Cannon JL, Histed A, Shilling RA, Sperling AI. Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):843-50. PMID: 21421907; PMCID: PMC3208611.
        Citations: 11     Fields:    Translation:AnimalsCells
      84. Moore TV, Clay BS, Ferreira CM, Williams JW, Rogozinska M, Cannon JL, Shilling RA, Marzo AL, Sperling AI. Protective effector memory CD4 T cells depend on ICOS for survival. PLoS One. 2011 Feb 18; 6(2):e16529. PMID: 21364749; PMCID: PMC3041765.
        Citations: 17     Fields:    Translation:AnimalsCells
      85. Cannon JL, Mody PD, Blaine KM, Chen EJ, Nelson AD, Sayles LJ, Moore TV, Clay BS, Dulin NO, Shilling RA, Burkhardt JK, Sperling AI. CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011 Apr; 22(7):954-63. PMID: 21289089; PMCID: PMC3069020.
        Citations: 18     Fields:    Translation:AnimalsCells
      86. Bhorade SM, Chen H, Molinero L, Liao C, Garrity ER, Vigneswaran WT, Shilling R, Sperling A, Chong A, Alegre ML. Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Transplantation. 2010 Sep 15; 90(5):540-6. PMID: 20628341; PMCID: PMC4737704.
        Citations: 28     Fields:    Translation:HumansCells
      87. Shaffer MH, Huang Y, Corbo E, Wu GF, Velez M, Choi JK, Saotome I, Cannon JL, McClatchey AI, Sperling AI, Maltzman JS, Oliver PM, Bhandoola A, Laufer TM, Burkhardt JK. Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS One. 2010 Aug 27; 5(8):e12404. PMID: 20806059; PMCID: PMC2929185.
        Citations: 4     Fields:    Translation:AnimalsCells
      88. Zhao Y, Tong J, He D, Pendyala S, Evgeny B, Chun J, Sperling AI, Natarajan V. Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. Respir Res. 2009 Nov 20; 10:114. PMID: 19930563; PMCID: PMC2788521.
        Citations: 33     Fields:    Translation:AnimalsCells
      89. Clay BS, Shilling RA, Bandukwala HS, Moore TV, Cannon JL, Welcher AA, Weinstock JV, Sperling AI. Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. PLoS One. 2009 Nov 04; 4(11):e7525. PMID: 19888475; PMCID: PMC2768787.
        Citations: 12     Fields:    Translation:AnimalsCells
      90. Tong J, Clay BS, Ferreira CM, Bandukwala HS, Moore TV, Blaine KM, Williams JW, Hoffman LM, Hamann KJ, Shilling RA, Weinstock JV, Sperling AI. Fas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma. Am J Respir Cell Mol Biol. 2010 Sep; 43(3):342-8. PMID: 19855087; PMCID: PMC2933550.
        Citations: 7     Fields:    Translation:AnimalsCells
      91. Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. Cell Immunol. 2009; 259(2):177-84. PMID: 19646680; PMCID: PMC2748173.
        Citations: 7     Fields:    Translation:AnimalsCells
      92. Tesciuba AG, Shilling RA, Agarwal MD, Bandukwala HS, Clay BS, Moore TV, Weinstock JV, Welcher AA, Sperling AI. ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes. J Immunol. 2008 Jul 15; 181(2):1019-24. PMID: 18606653; PMCID: PMC2560985.
        Citations: 10     Fields:    Translation:AnimalsCells
      93. Cannon JL, Mody PD, Balachandran D, Henriksen KJ, Smith CE, Tong J, Clay BS, Miller SD, Sperling AI, Collins A. CD43 regulates Th2 differentiation and inflammation. J Immunol. 2008 Jun 01; 180(11):7385-93. PMID: 18490738; PMCID: PMC2669414.
        Citations: 14     Fields:    Translation:AnimalsCells
      94. Yau DM, Sethakorn N, Taurin S, Kregel S, Sandbo N, Camoretti-Mercado B, Sperling AI, Dulin NO. Regulation of Smad-mediated gene transcription by RGS3. Mol Pharmacol. 2008 May; 73(5):1356-61. PMID: 18287247; PMCID: PMC3329871.
        Citations: 9     Fields:    Translation:HumansAnimalsCells
      95. Pinto LH, Eaton E, Chen B, Fleisher J, Shuster D, McCauley J, Kedainis D, Siepka SM, Shimomura K, Song EJ, Husain A, Lakser OJ, Mitchell RW, Dowell ML, Brown M, Camoretti-Mercado B, Naclerio R, Sperling AI, Levin SI, Turek FW, Solway J. Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness. Mamm Genome. 2008 Jan; 19(1):2-14. PMID: 18167028.
        Citations: 2     Fields:    Translation:Animals
      96. Bandukwala HS, Clay BS, Tong J, Mody PD, Cannon JL, Shilling RA, Verbeek JS, Weinstock JV, Solway J, Sperling AI. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med. 2007 Aug 06; 204(8):1875-89. PMID: 17664287; PMCID: PMC2118666.
        Citations: 36     Fields:    Translation:AnimalsCells
      97. Mody PD, Cannon JL, Bandukwala HS, Blaine KM, Schilling AB, Swier K, Sperling AI. Signaling through CD43 regulates CD4 T-cell trafficking. Blood. 2007 Oct 15; 110(8):2974-82. PMID: 17638845; PMCID: PMC2018673.
        Citations: 15     Fields:    Translation:HumansAnimalsCells
      98. Clay BS, Sperling AI. T-cell costimulation blockade in immunologic diseases: role of CD28 family members. Expert Rev Clin Immunol. 2007 May; 3(3):383-93. PMID: 20477681.
        Citations:    Fields:    
      99. Shilling RA, Bandukwala HS, Sperling AI. Regulation of T:B cell interactions by the inducible costimulator molecule: does ICOS "induce" disease? Clin Immunol. 2006 Oct; 121(1):13-8. PMID: 16790364.
        Citations: 11     Fields:    Translation:HumansAnimalsCells
      100. Tong J, Bandulwala HS, Clay BS, Anders RA, Shilling RA, Balachandran DD, Chen B, Weinstock JV, Solway J, Hamann KJ, Sperling AI. Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma. J Exp Med. 2006 May 15; 203(5):1173-84. PMID: 16618792; PMCID: PMC2121201.
        Citations: 32     Fields:    Translation:HumansAnimalsCells
      101. Blair C, Naclerio RM, Yu X, Thompson K, Sperling A. Role of type 1 T helper cells in the resolution of acute Streptococcus pneumoniae sinusitis: a mouse model. J Infect Dis. 2005 Oct 01; 192(7):1237-44. PMID: 16136467.
        Citations: 6     Fields:    Translation:AnimalsCells
      102. Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI. Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production. J Immunol. 2005 Aug 15; 175(4):2061-5. PMID: 16081771.
        Citations: 14     Fields:    Translation:HumansCells
      103. Yu X, Sperling A, Blair C, Thompson K, Naclerio R. Antigen stimulation of TH2 cells augments acute bacterial sinusitis in mice. J Allergy Clin Immunol. 2004 Aug; 114(2):328-34. PMID: 15316511.
        Citations: 3     Fields:    Translation:AnimalsCells
      104. Tong J, Allenspach EJ, Takahashi SM, Mody PD, Park C, Burkhardt JK, Sperling AI. CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism. J Exp Med. 2004 May 03; 199(9):1277-83. PMID: 15117976; PMCID: PMC2211903.
        Citations: 19     Fields:    Translation:AnimalsCells
      105. Ford ML, Onami TM, Sperling AI, Ahmed R, Evavold BD. CD43 modulates severity and onset of experimental autoimmune encephalomyelitis. J Immunol. 2003 Dec 15; 171(12):6527-33. PMID: 14662853.
        Citations: 16     Fields:    Translation:AnimalsCells
      106. Kang HS, Blink SE, Chin RK, Lee Y, Kim O, Weinstock J, Waldschmidt T, Conrad D, Chen B, Solway J, Sperling AI, Fu YX. Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation. J Exp Med. 2003 Dec 01; 198(11):1643-52. PMID: 14638845; PMCID: PMC2194142.
        Citations: 13     Fields:    Translation:AnimalsCells
      107. Dorscheid DR, Low E, Conforti A, Shifrin S, Sperling AI, White SR. Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation. J Allergy Clin Immunol. 2003 Feb; 111(2):360-6. PMID: 12589357.
        Citations: 13     Fields:    Translation:HumansAnimalsCells
      108. Cullinan P, Sperling AI, Burkhardt JK, Cullinan P, Sperling AI, Burkhardt JK. The distal pole complex: a novel membrane domain distal to the immunological synapse. Immunol Rev. 2002 Nov; 189:111-22. PMID: 12445269.
        Citations: 38     Fields:    Translation:HumansAnimalsCells
      109. Boetticher E, Sperling AI, Kim KP, Meliton AY, Zhu X, Lambertino A, Cho W, Leff AR, Muñoz NM. Quantitation of secretory group V phospholipase A(2) in human tissues by sandwich enzyme-linked immunosorbent assay. J Immunol Methods. 2002 Apr 01; 262(1-2):41-51. PMID: 11983218.
        Citations: 1     Fields:    Translation:HumansCells
      110. Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001 Nov; 15(5):739-50. PMID: 11728336.
        Citations: 82     Fields:    Translation:AnimalsCells
      111. Sperling AI, Sperling AI. ICOS costimulation: is it the key to selective immunotherapy? Clin Immunol. 2001 Sep; 100(3):261-2. PMID: 11513538.
        Citations: 3     Fields:    Translation:Humans
      112. Tesciuba AG, Subudhi S, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AI, Tesciuba AG, Subudhi S, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AI. Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease. J Immunol. 2001 Aug 15; 167(4):1996-2003. PMID: 11489981.
        Citations: 34     Fields:    Translation:AnimalsCells
      113. Sperling AI, Bluestone JA. ICOS costimulation: It's not just for TH2 cells anymore. Nat Immunol. 2001 Jul; 2(7):573-4. PMID: 11429535.
        Citations: 13     Fields:    Translation:AnimalsCells
      114. Shiels H, Li X, Schumacker PT, Maltepe E, Padrid PA, Sperling A, Thompson CB, Lindsten T. TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. Am J Pathol. 2000 Aug; 157(2):679-88. PMID: 10934170; PMCID: PMC1850138.
        Citations: 31     Fields:    Translation:HumansAnimals
      115. Kim KP, Han SK, Boetticher E, Sperling AI, Sano H, Zhu X, Cho W, Leff AR, Muñoz NM. Characterization of monoclonal antibodies specific for 14-kDa human group V secretory phospholipase A2 (hVPLA2). Hybridoma. 2000 Apr; 19(2):171-6. PMID: 10868798.
        Citations: 2     Fields:    Translation:HumansAnimalsCells
      116. Douglas IS, Leff AR, Sperling AI. CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. J Immunol. 2000 Mar 15; 164(6):3385-91. PMID: 10706734.
        Citations: 4     Fields:    Translation:HumansCells
      117. Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 1999 Dec 06; 190(11):1657-68. PMID: 10587356; PMCID: PMC2195727.
        Citations: 28     Fields:    Translation:HumansAnimalsCells
      118. Sperling AI, Sedy JR, Manjunath N, Kupfer A, Ardman B, Burkhardt JK. TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. J Immunol. 1998 Dec 15; 161(12):6459-62. PMID: 9862667.
        Citations: 31     Fields:    Translation:HumansCells
      119. Hamann KJ, Dorscheid DR, Ko FD, Conforti AE, Sperling AI, Rabe KF, White SR. Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium. Am J Respir Cell Mol Biol. 1998 Oct; 19(4):537-42. PMID: 9761749.
        Citations: 37     Fields:    Translation:HumansCells
      120. Padrid PA, Mathur M, Li X, Herrmann K, Qin Y, Cattamanchi A, Weinstock J, Elliott D, Sperling AI, Bluestone JA. CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):453-62. PMID: 9533932.
        Citations: 25     Fields:    Translation:HumansAnimalsCells
      121. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. J Immunol. 1997 Jul 01; 159(1):86-91. PMID: 9200442.
        Citations: 2     Fields:    Translation:AnimalsCells
      122. Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. CD28 costimulation promotes the production of Th2 cytokines. J Immunol. 1997 Jan 15; 158(2):658-65. PMID: 8992981.
        Citations: 64     Fields:    Translation:AnimalsCells
      123. Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J Immunol. 1996 Nov 01; 157(9):3909-17. PMID: 8892622.
        Citations: 44     Fields:    Translation:AnimalsCells
      124. Sperling AI, Bluestone JA. The complexities of T-cell co-stimulation: CD28 and beyond. Immunol Rev. 1996 Oct; 153:155-82. PMID: 9010723.
        Citations: 18     Fields:    Translation:AnimalsCells
      125. Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA. TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen. J Immunol. 1996 Sep 15; 157(6):2320-7. PMID: 8805629.
        Citations: 1     Fields:    Translation:AnimalsCells
      126. Walunas TL, Sperling AI, Khattri R, Thompson CB, Bluestone JA. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol. 1996 Feb 01; 156(3):1006-13. PMID: 8557973.
        Citations: 27     Fields:    Translation:AnimalsCells
      127. Sandor M, Sperling AI, Cook GA, Weinstock JV, Lynch RG, Bluestone JA. Two waves of gamma delta T cells expressing different V delta genes are recruited into schistosome-induced liver granulomas. J Immunol. 1995 Jul 01; 155(1):275-84. PMID: 7602105.
        Citations: 20     Fields:    Translation:AnimalsCells
      128. Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995 Jul 01; 182(1):139-46. PMID: 7790813; PMCID: PMC2192086.
        Citations: 31     Fields:    Translation:AnimalsCells
      129. Green JM, Noel PJ, Sperling AI, Walunas TL, Lenschow DJ, Stack R, Gray GS, Bluestone JA, Thompson CB. T cell costimulation through the CD28 receptor. Proc Assoc Am Physicians. 1995 Apr; 107(1):41-6. PMID: 8630743.
        Citations: 5     Fields:    Translation:HumansAnimalsCells
      130. Bluestone JA, Khattri R, Sciammas R, Sperling AI. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol. 1995; 11:307-53. PMID: 8689560.
        Citations: 17     Fields:    Translation:HumansAnimalsCells
      131. Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, Thompson CB. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1994 Sep; 1(6):501-8. PMID: 7534617.
        Citations: 92     Fields:    Translation:AnimalsCells
      132. Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol. 1994 Sep 01; 153(5):1990-7. PMID: 7519638.
        Citations: 68     Fields:    Translation:AnimalsCells
      133. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol. 1994 Jun 01; 152(11):5392-7. PMID: 8189058.
        Citations: 45     Fields:    Translation:HumansCells
      134. Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA. TCR gamma delta cells: mysterious cells of the immune system. Immunol Res. 1994; 13(4):268-79. PMID: 7616054.
        Citations: 7     Fields:    Translation:HumansAnimalsCells
      135. Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, Fitch FW. The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11875-9. PMID: 8265641; PMCID: PMC48087.
        Citations: 15     Fields:    Translation:AnimalsCells
      136. Sperling AI, Linsley PS, Barrett TA, Bluestone JA. CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes. J Immunol. 1993 Dec 01; 151(11):6043-50. PMID: 8245449.
        Citations: 9     Fields:    Translation:AnimalsCells
      137. Peterman GM, Spencer C, Sperling AI, Bluestone JA. Role of gamma delta T cells in murine collagen-induced arthritis. J Immunol. 1993 Dec 01; 151(11):6546-58. PMID: 8245484.
        Citations: 38     Fields:    Translation:AnimalsCells
      138. Sperling AI, Bluestone JA. Non-classical MHC molecules: the first line of defence? Curr Biol. 1993 May 01; 3(5):294-6. PMID: 15335753.
        Citations:    Fields:    
      139. Sperling AI, Cron RQ, Decker DC, Stern DA, Bluestone JA. Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection. J Immunol. 1992 Nov 15; 149(10):3200-7. PMID: 1431099.
        Citations: 12     Fields:    Translation:Animals
      140. Johnson RM, Lancki DW, Sperling AI, Dick RF, Spear PG, Fitch FW, Bluestone JA. A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I. J Immunol. 1992 Feb 15; 148(4):983-8. PMID: 1310711.
        Citations: 29     Fields:    Translation:AnimalsCells
      141. Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, Hedrick S, Rellahan B, Matis LA. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunol Rev. 1991 Apr; 120:5-33. PMID: 1650760.
        Citations: 13     Fields:    Translation:AnimalsCells
      142. Sperling AI, Wortis HH. CD4-, CD8- gamma/delta cells from normal mice respond to a syngeneic B cell lymphoma and can induce its differentiation. Int Immunol. 1989; 1(4):434-42. PMID: 2577376.
        Citations: 10     Fields:    Translation:AnimalsCells
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