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Eric C. Beyer

InstitutionUniversity of Chicago
DepartmentPediatrics-Hematology and Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Professor of Pediatrics
    Section of Hematology/Oncology and Stem Cell Transplantation

    Vice Chairman for Academic Affairs
    Department of Pediatrics

    Dr. Beyer is a physician scientist who practices pediatric hematology/oncology and has a broad background in basic laboratory and translational research. His laboratory has spent more nearly 30 years investigating intercellular communication (as mediated by the channels contained within gap junctions) and how its disruptions contribute to disease. These studies encompass basic investigations including identification and cloning of the subunit proteins, characterization of structure-function physiological relationships, determination of pathways of biosynthesis and degradation.
    Dr. Beyer's laboratory has also been pursuing translational examinations of the roles of these proteins in diseases including cataracts, deafness, arrhythmias, cancer, and premature labor. The group has spent many years studying the connexins expressed in the eye lens. They are elucidating the process of cataract development by studying mouse and cell culture models that mimic the pathologies seen in human families with connexin mutants and inherited cataracts. Dr. Beyer has investigated the roles of cardiac connexins in normal cardiac conduction and in the pathogenesis of arrhythmias. He is studying the roles of circulating extracellular vesicles in the vascular pathologies that underlie the crises of patients with sickle cell disease. He has mentored many students and post-doctoral fellows within his laboratory.

    Collapse Biography 
    Collapse education and training
    University of ChicagoABBiological Sciences
    UCSDPHDPhysiology and Pharmacology
    Children's Hospital, BostonInternship and ResidencyPediatrics
    Children's Hospital and Dana Farber Cancer Center, BostonFellowshipPediatric Hematology/Oncology
    Collapse awards and honors
    American Society for Clinical Investigation
    Society for Pediatric Research
    Fellow, American Heart Association
    Fellow, Association for Research in Vision and Ophthalmology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Minogue PJ, Rodriguez SH, Berthoud VM, Beyer EC. Pediatric cataracts of different etiologies contain insoluble, calcified particles. Front Ophthalmol (Lausanne). 2023; 3. PMID: 37441058; PMCID: PMC10338002.
    2. Williams JC, Bledsoe SB, Sommer AJ, Minogue PJ, Gao J, Mathias RT, Beyer EC, Berthoud VM. A crystallin mutant cataract with mineral deposits. J Biol Chem. 2023 08; 299(8):104935. PMID: 37331601; PMCID: PMC10407958.
      Citations: 1     Fields:    Translation:Animals
    3. Beyer EC, Berthoud VM, Lim JC, Donaldson PJ. Editorial: Ion channels, pumps, and transporters in lens physiology and disease. Front Physiol. 2022; 13:1071215. PMID: 36406990; PMCID: PMC9670118.
    4. Beyer EC, Mathias RT, Berthoud VM. Loss of fiber cell communication may contribute to the development of cataracts of many different etiologies. Front Physiol. 2022; 13:989524. PMID: 36171977; PMCID: PMC9511111.
      Citations: 2     
    5. Jara O, Minogue PJ, Berthoud VM, Beyer EC. Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice. Cells. 2022 09 07; 11(18). PMID: 36139360; PMCID: PMC9496683.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Minogue PJ, Sommer AJ, Williams JC, Bledsoe SB, Beyer EC, Berthoud VM. Connexin Mutants Cause Cataracts Through Deposition of Apatite. Front Cell Dev Biol. 2022; 10:951231. PMID: 35938173; PMCID: PMC9355134.
      Citations: 2     
    7. Gemel J, Zhang J, Mao Y, Lapping-Carr G, Beyer EC. Circulating Small Extracellular Vesicles May Contribute to Vaso-Occlusive Crises in Sickle Cell Disease. J Clin Med. 2022 Feb 03; 11(3). PMID: 35160266; PMCID: PMC8836895.
      Citations: 1     
    8. Minogue PJ, Tong JJ, Wichmann K, Mysliwiec H, Ebihara L, Beyer EC, Berthoud VM. Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation. J Biol Chem. 2022 03; 298(3):101673. PMID: 35120923; PMCID: PMC8927986.
      Citations: 2     Fields:    Translation:HumansCells
    9. Tong JJ, Khan U, Haddad BG, Minogue PJ, Beyer EC, Berthoud VM, Reichow SL, Ebihara L. Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant. Biophys J. 2021 12 21; 120(24):5644-5656. PMID: 34762867; PMCID: PMC8715219.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    10. Lapping-Carr G, Gemel J, Mao Y, Sparks G, Harrington M, Peddinti R, Beyer EC. Insights image for "Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells". Pediatr Res. 2021 03; 89(4):1036. PMID: 33790407.
      Citations: 1     Fields:    Translation:HumansCells
    11. Gemel J, Mao Y, Lapping-Carr G, Beyer EC. Gap Junctions between Endothelial Cells Are Disrupted by Circulating Extracellular Vesicles from Sickle Cell Patients with Acute Chest Syndrome. Int J Mol Sci. 2020 Nov 24; 21(23). PMID: 33255173; PMCID: PMC7727676.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    12. Jara O, Minogue PJ, Berthoud VM, Beyer EC. Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens? Biomolecules. 2020 10 07; 10(10). PMID: 33036381; PMCID: PMC7600092.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Lapping-Carr G, Gemel J, Mao Y, Beyer EC. Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease. Front Physiol. 2020; 11:1063. PMID: 33013455; PMCID: PMC7495019.
      Citations: 10     
    14. Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC. Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization. Int J Mol Sci. 2020 Aug 13; 21(16). PMID: 32823750; PMCID: PMC7461132.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Lapping-Carr G, Gemel J, Mao Y, Sparks G, Harrington M, Peddinti R, Beyer EC. Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells. Pediatr Res. 2021 03; 89(4):776-784. PMID: 32454519; PMCID: PMC8261277.
      Citations: 5     Fields:    Translation:HumansCells
    16. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164; PMCID: PMC7334106.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    17. Jara O, Mysliwiec H, Minogue PJ, Berthoud VM, Beyer EC. p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency. Mol Vis. 2020; 26:204-215. PMID: 32214786; PMCID: PMC7090271.
      Citations: 3     Fields:    Translation:AnimalsCells
    18. Minogue PJ, Beyer EC, Berthoud VM. CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice. Mol Vis. 2019; 25:535-545. PMID: 31908399; PMCID: PMC6925666.
      Citations: 3     Fields:    Translation:AnimalsCells
    19. Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC. The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation. Invest Ophthalmol Vis Sci. 2019 05 01; 60(6):2336-2346. PMID: 31117126; PMCID: PMC6534014.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Gemel J, Kilkus J, Dawson G, Beyer EC. Connecting Exosomes and Connexins. Cancers (Basel). 2019 Apr 04; 11(4). PMID: 30987321; PMCID: PMC6520873.
      Citations: 13     
    21. Jara O, Minogue PJ, Berthoud VM, Beyer EC. Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses. Exp Eye Res. 2018 10; 175:192-198. PMID: 29913165; PMCID: PMC6167189.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    22. Gao J, Minogue PJ, Beyer EC, Mathias RT, Berthoud VM. Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice. Am J Physiol Cell Physiol. 2018 04 01; 314(4):C492-C503. PMID: 29351411; PMCID: PMC5966789.
      Citations: 21     Fields:    Translation:AnimalsCells
    23. Leybaert L, Lampe PD, Dhein S, Kwak BR, Ferdinandy P, Beyer EC, Laird DW, Naus CC, Green CR, Schulz R. Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev. 2017 10; 69(4):396-478. PMID: 28931622; PMCID: PMC5612248.
      Citations: 109     Fields:    Translation:HumansAnimals
    24. Kuo DS, Sokol JT, Minogue PJ, Berthoud VM, Slavotinek AM, Beyer EC, Gould DB. Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract. PLoS One. 2017; 12(8):e0183438. PMID: 28827829; PMCID: PMC5565107.
      Citations: 5     Fields:    Translation:HumansCells
    25. Minogue PJ, Gao J, Zoltoski RK, Novak LA, Mathias RT, Beyer EC, Berthoud VM. Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4366–4374. PMID: 28810266; PMCID: PMC5558631.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Zhong G, Akoum N, Appadurai DA, Hayrapetyan V, Ahmed O, Beyer EC, Moreno AP, Martinez AD. Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry. Front Physiol. 2017; 8:346. PMID: 28611680; PMCID: PMC5447054.
      Citations: 4     
    27. Beyer EC, Berthoud VM. Gap junction gene and protein families: Connexins, innexins, and pannexins. Biochim Biophys Acta Biomembr. 2018 Jan; 1860(1):5-8. PMID: 28559187; PMCID: PMC5704981.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    28. Lapping-Carr G, Khalyfa A, Rangel S, Darlington W, Beyer EC, Peddinti R, Cunningham JM, Gozal D. Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings. Pediatr Pulmonol. 2017 Nov; 52(11):1478-1485. PMID: 28486752; PMCID: PMC5653417.
      Citations: 12     Fields:    Translation:HumansCells
    29. Beyer EC, Berthoud VM. Gap junction structure: unraveled, but not fully revealed. F1000Res. 2017; 6:568. PMID: 28529713; PMCID: PMC5414816.
      Citations: 17     Fields:    
    30. Gemel J, Su Z, Gileles-Hillel A, Khalyfa A, Gozal D, Beyer EC. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol. 2017 01 17; 18(Suppl 1):7. PMID: 28124622; PMCID: PMC5267331.
      Citations: 13     Fields:    Translation:Animals
    31. Senthil Kumar G, Dinesh Kumar K, Minogue PJ, Berthoud VM, Kannan R, Beyer EC, Santhiya ST. The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family. Open Access J Ophthalmol. 2016; 1(1). PMID: 28530003; PMCID: PMC5438206.
      Citations: 1     
    32. Berthoud VM, Minogue PJ, Lambert PA, Snabb JI, Beyer EC. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem. 2016 08 19; 291(34):17569-78. PMID: 27317663; PMCID: PMC5016154.
      Citations: 22     Fields:    Translation:Animals
    33. Berthoud VM, Minogue PJ, Snabb JI, Dzhashiashvili Y, Novak LA, Zoltoski RK, Popko B, Beyer EC. Connexin23 deletion does not affect lens transparency. Exp Eye Res. 2016 05; 146:283-288. PMID: 27038752; PMCID: PMC4920263.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Beyer EC. Are these connexins compatible and does it matter? Channels (Austin). 2015; 9(2):63-4. PMID: 25891180; PMCID: PMC4594495.
      Citations: 1     Fields:    Translation:AnimalsCells
    35. Tong JJ, Minogue PJ, Kobeszko M, Beyer EC, Berthoud VM, Ebihara L. The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating. J Membr Biol. 2015 Feb; 248(1):145-55. PMID: 25404239; PMCID: PMC4300453.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    36. Gemel J, Levy AE, Simon AR, Bennett KB, Ai X, Akhter S, Beyer EC. Connexin40 abnormalities and atrial fibrillation in the human heart. J Mol Cell Cardiol. 2014 Nov; 76:159-68. PMID: 25200600; PMCID: PMC4250516.
      Citations: 36     Fields:    Translation:HumansCells
    37. Berthoud VM, Minogue PJ, Yu H, Snabb JI, Beyer EC. Connexin46fs380 causes progressive cataracts. Invest Ophthalmol Vis Sci. 2014 Aug 07; 55(10):6639-48. PMID: 25103261; PMCID: PMC4207115.
      Citations: 15     Fields:    Translation:Animals
    38. O'Donnell JJ, Birukova AA, Beyer EC, Birukov KG. Gap junction protein connexin43 exacerbates lung vascular permeability. PLoS One. 2014; 9(6):e100931. PMID: 24967639; PMCID: PMC4072707.
      Citations: 37     Fields:    Translation:HumansCells
    39. Gemel J, Simon AR, Patel D, Xu Q, Matiukas A, Veenstra RD, Beyer EC. Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated. J Mol Cell Cardiol. 2014 Sep; 74:330-9. PMID: 24973497; PMCID: PMC4135452.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    40. Beyer EC, Berthoud VM. Connexin hemichannels in the lens. Front Physiol. 2014; 5:20. PMID: 24575044; PMCID: PMC3920103.
      Citations: 51     
    41. Patel D, Gemel J, Xu Q, Simon AR, Lin X, Matiukas A, Beyer EC, Veenstra RD. Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties. FEBS Lett. 2014 Apr 17; 588(8):1458-64. PMID: 24457199; PMCID: PMC3989446.
      Citations: 10     Fields:    Translation:HumansCells
    42. Berthoud VM, Minogue PJ, Osmolak P, Snabb JI, Beyer EC. Roles and regulation of lens epithelial cell connexins. FEBS Lett. 2014 Apr 17; 588(8):1297-303. PMID: 24434541; PMCID: PMC3992928.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    43. Rutledge CA, Ng FS, Sulkin MS, Greener ID, Sergeyenko AM, Liu H, Gemel J, Beyer EC, Sovari AA, Efimov IR, Dudley SC. c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction. J Am Coll Cardiol. 2014 Mar 11; 63(9):928-34. PMID: 24361364; PMCID: PMC3963804.
      Citations: 29     Fields:    Translation:AnimalsCells
    44. Berthoud VM, Minogue PJ, Yu H, Schroeder R, Snabb JI, Beyer EC. Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation. Invest Ophthalmol Vis Sci. 2013 Nov 19; 54(12):7614-22. PMID: 24204043; PMCID: PMC3835270.
      Citations: 27     Fields:    Translation:AnimalsCells
    45. Beyer EC, Lin X, Veenstra RD. Interfering amino terminal peptides and functional implications for heteromeric gap junction formation. Front Pharmacol. 2013; 4:67. PMID: 23734129; PMCID: PMC3659311.
      Citations: 8     
    46. Minogue PJ, Beyer EC, Berthoud VM. A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor. J Biol Chem. 2013 Jul 12; 288(28):20427-34. PMID: 23720739; PMCID: PMC3711308.
      Citations: 17     Fields:    Translation:HumansCells
    47. Beyer EC, Ebihara L, Berthoud VM. Connexin mutants and cataracts. Front Pharmacol. 2013; 4:43. PMID: 23596416; PMCID: PMC3625720.
      Citations: 62     
    48. Yan J, Kong W, Zhang Q, Beyer EC, Walcott G, Fast VG, Ai X. c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias. Cardiovasc Res. 2013 Mar 01; 97(3):589-97. PMID: 23241357; PMCID: PMC3567788.
      Citations: 36     Fields:    Translation:AnimalsCells
    49. Senthil Kumar G, Kyle JW, Minogue PJ, Dinesh Kumar K, Vasantha K, Berthoud VM, Beyer EC, Santhiya ST. An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract. Exp Eye Res. 2013 May; 110:136-41. PMID: 23116563; PMCID: PMC3570674.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    50. Figueroa V, Lagos CF, Berthoud VM, Beyer EC, Jara O, Acuña R, García IE, Maripillán J, Sáez JC, Araya-Secchi R, Pérez-Acle T, Martínez AD. Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Mol Biol Cell. 2012 Sep; 23(17):3299-311. PMID: 22787277; PMCID: PMC3431943.
      Citations: 23     Fields:    Translation:HumansCells
    51. Gemel J, Nelson TK, Burt JM, Beyer EC. Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer. J Membr Biol. 2012 Jun; 245(5-6):231-41. PMID: 22729648; PMCID: PMC3501935.
      Citations: 7     Fields:    Translation:HumansCells
    52. Smith TD, Mohankumar A, Minogue PJ, Beyer EC, Berthoud VM, Koval M. Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization. J Membr Biol. 2012 Jun; 245(5-6):221-30. PMID: 22722762; PMCID: PMC3501836.
      Citations: 22     Fields:    Translation:HumansCells
    53. Beyer EC, Lipkind GM, Kyle JW, Berthoud VM. Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure. Biochim Biophys Acta. 2012 Aug; 1818(8):1823-30. PMID: 22037495; PMCID: PMC3298602.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    54. Minogue PJ, Berthoud VM, Beyer EC, Martínez AD, Maripillán J, Acuña R. Different domains are critical for oligomerization compatibility of different connexins. Biochem J. 2011 May 15; 436(1):35-43. PMID: 21348854; PMCID: PMC3252639.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    55. Allen MJ, Gemel J, Beyer EC, Lal R. Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces. J Biol Chem. 2011 Jun 24; 286(25):22139-46. PMID: 21543330; PMCID: PMC3121358.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    56. Lichtenstein A, Minogue PJ, Beyer EC, Berthoud VM. Autophagy: a pathway that contributes to connexin degradation. J Cell Sci. 2011 Mar 15; 124(Pt 6):910-20. PMID: 21378309; PMCID: PMC3048889.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    57. Tong JJ, Minogue PJ, Guo W, Chen TL, Beyer EC, Berthoud VM, Ebihara L. Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. Am J Physiol Cell Physiol. 2011 May; 300(5):C1055-64. PMID: 21228318; PMCID: PMC3093948.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    58. Graw J, Schmidt W, Minogue PJ, Rodriguez J, Tong JJ, Klopp N, Illig T, Ebihara L, Berthoud VM, Beyer EC. The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation. Mol Vis. 2009 Sep 14; 15:1881-5. PMID: 19756179; PMCID: PMC2743802.
      Citations: 11     Fields:    Translation:HumansCells
    59. Minogue PJ, Tong JJ, Arora A, Russell-Eggitt I, Hunt DM, Moore AT, Ebihara L, Beyer EC, Berthoud VM. A mutant connexin50 with enhanced hemichannel function leads to cell death. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5837-45. PMID: 19684000; PMCID: PMC2788668.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    60. Lin X, Gemel J, Glass A, Zemlin CW, Beyer EC, Veenstra RD. Connexin40 and connexin43 determine gating properties of atrial gap junction channels. J Mol Cell Cardiol. 2010 Jan; 48(1):238-45. PMID: 19486903; PMCID: PMC2813328.
      Citations: 30     Fields:    Translation:AnimalsCells
    61. Kyle JW, Berthoud VM, Kurutz J, Minogue PJ, Greenspan M, Hanck DA, Beyer EC. The N terminus of connexin37 contains an alpha-helix that is required for channel function. J Biol Chem. 2009 Jul 24; 284(30):20418-27. PMID: 19478091; PMCID: PMC2740466.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    62. Berthoud VM, Beyer EC. Oxidative stress, lens gap junctions, and cataracts. Antioxid Redox Signal. 2009 Feb; 11(2):339-53. PMID: 18831679; PMCID: PMC2763361.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    63. Lichtenstein A, Gaietta GM, Deerinck TJ, Crum J, Sosinsky GE, Beyer EC, Berthoud VM. The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum. Exp Eye Res. 2009 Mar; 88(3):600-9. PMID: 19073179; PMCID: PMC2695785.
      Citations: 15     Fields:    Translation:HumansCells
    64. Kyle JW, Minogue PJ, Thomas BC, Domowicz DA, Berthoud VM, Hanck DA, Beyer EC. An intact connexin N-terminus is required for function but not gap junction formation. J Cell Sci. 2008 Aug 15; 121(Pt 16):2744-50. PMID: 18664489; PMCID: PMC2752142.
      Citations: 29     Fields:    Translation:HumansCells
    65. Thomas BC, Minogue PJ, Valiunas V, Kanaporis G, Brink PR, Berthoud VM, Beyer EC. Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2549-56. PMID: 18326694; PMCID: PMC2694449.
      Citations: 23     Fields:    Translation:HumansCells
    66. Gemel J, Lin X, Collins R, Veenstra RD, Beyer EC. Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. Biochem Biophys Res Commun. 2008 May 02; 369(2):388-94. PMID: 18291099; PMCID: PMC2323682.
      Citations: 15     Fields:    Translation:HumansCells
    67. Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I, Webster AR, Hunt DM, Ebihara L, Beyer EC, Berthoud VM, Moore AT. A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J Med Genet. 2008 Mar; 45(3):155-60. PMID: 18006672; PMCID: PMC2756454.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    68. Chung J, Berthoud VM, Novak L, Zoltoski R, Heilbrunn B, Minogue PJ, Liu X, Ebihara L, Kuszak J, Beyer EC. Transgenic overexpression of connexin50 induces cataracts. Exp Eye Res. 2007 Mar; 84(3):513-28. PMID: 17217947; PMCID: PMC1857337.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    69. Wang M, Berthoud VM, Beyer EC. Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis. J Cell Sci. 2007 Jan 15; 120(Pt 2):320-9. PMID: 17200141; PMCID: PMC2754384.
      Citations: 20     Fields:    Translation:HumansCells
    70. Brunk I, Grosse J, Beyer E, Veh RW, Bergmann M, Grosse G, Ahnert-Hilger G, Höltje M. Differential distribution of voltage-gated potassium channels Kv 1.1-Kv1.6 in the rat retina during development. J Neurosci Res. 2007 Jan; 85(1):19-33. PMID: 17075900.
      Citations: 9     Fields:    Translation:Animals
    71. Gemel J, Lin X, Veenstra RD, Beyer EC. N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci. 2006 Jun 01; 119(Pt 11):2258-68. PMID: 16723732; PMCID: PMC3237058.
      Citations: 24     Fields:    Translation:HumansCells
    72. Arora A, Minogue PJ, Liu X, Reddy MA, Ainsworth JR, Bhattacharya SS, Webster AR, Hunt DM, Ebihara L, Moore AT, Beyer EC, Berthoud VM. A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. J Med Genet. 2006 Jan; 43(1):e2. PMID: 16397066; PMCID: PMC2564510.
      Citations: 52     Fields:    Translation:HumansCells
    73. Minogue PJ, Liu X, Ebihara L, Beyer EC, Berthoud VM. An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem. 2005 Dec 09; 280(49):40788-95. PMID: 16204255; PMCID: PMC2720622.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    74. Wang M, Berthoud VM, Seul KH, Gemel J, Valiunas V, Kumari S, Brink PR, Beyer EC, Martínez AD. Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1185-93. PMID: 15979566; PMCID: PMC2751629.
      Citations: 9     Fields:    Translation:HumansCells
    75. Almeida NA, Menezes DC, Elliott DA, Lai D, Beyer EC, Campos de Carvalho AC, Costa MW, Linhares VL. Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5. Cardiovasc Res. 2004 Dec 01; 64(3):402-11. PMID: 15537493; PMCID: PMC3252638.
      Citations: 36     Fields:    Translation:AnimalsCells
    76. Berthoud VM, Singh R, Minogue PJ, Ragsdale CW, Beyer EC. Highly restricted pattern of connexin36 expression in chick somite development. Anat Embryol (Berl). 2004 Nov; 209(1):11-8. PMID: 15455226; PMCID: PMC2754387.
      Citations: 10     Fields:    Translation:AnimalsCells
    77. Puljung MC, Berthoud VM, Beyer EC, Hanck DA. Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels. J Gen Physiol. 2004 Nov; 124(5):587-603. PMID: 15504903; PMCID: PMC2234009.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    78. Lin X, Gemel J, Beyer EC, Veenstra RD. Dynamic model for ventricular junctional conductance during the cardiac action potential. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1113-23. PMID: 15513960; PMCID: PMC2752676.
      Citations: 21     Fields:    Translation:AnimalsCells
    79. Seul KH, Kang KY, Lee KS, Kim SH, Beyer EC. Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. Biochem Biophys Res Commun. 2004 Jul 09; 319(4):1144-51. PMID: 15194487.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    80. Gemel J, Valiunas V, Brink PR, Beyer EC. Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci. 2004 May 15; 117(Pt 12):2469-80. PMID: 15128867.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    81. Berthoud VM, Minogue PJ, Laing JG, Beyer EC. Pathways for degradation of connexins and gap junctions. Cardiovasc Res. 2004 May 01; 62(2):256-67. PMID: 15094346.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    82. Musa H, Fenn E, Crye M, Gemel J, Beyer EC, Veenstra RD. Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions. J Physiol. 2004 Jun 15; 557(Pt 3):863-78. PMID: 15107469; PMCID: PMC1665163.
      Citations: 49     Fields:    Translation:AnimalsCells
    83. Berthoud VM, Branes MC, Martinez AD, Beyer EC, Saez JC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev. 2003 Oct; 83(4):1359-400. PMID: 14506308.
      Citations: 438     Fields:    Translation:HumansAnimalsCells
    84. Hayrapetyan V, Moreno AP, Beyer EC, Martínez AD. A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization. Cell Commun Adhes. 2003 Jul-Dec; 10(4-6):323-8. PMID: 14681036; PMCID: PMC2752146.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    85. Berthoud VM, Minogue PJ, Guo J, Williamson EK, Xu X, Ebihara L, Beyer EC. Loss of function and impaired degradation of a cataract-associated mutant connexin50. Eur J Cell Biol. 2003 May; 82(5):209-21. PMID: 12800976; PMCID: PMC2763359.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    86. Lampe P, Beyer E. New developments in the gap junction field: report from the 2002 ASCB meeting. Cell Commun Adhes. 2003 Jan-Feb; 10(1):55-8. PMID: 12881041.
      Citations:    Fields:    Translation:HumansAnimalsCells
    87. Beyer EC, Berthoud VM, Beyer EC, Berthoud VM. Gap junction synthesis and degradation as therapeutic targets. Curr Drug Targets. 2002 Dec; 3(6):409-16. PMID: 12448693.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    88. Valiunas V, Beyer EC, Brink PR. Cardiac gap junction channels show quantitative differences in selectivity. Circ Res. 2002 Jul 26; 91(2):104-11. PMID: 12142342.
      Citations: 61     Fields:    Translation:HumansCells
    89. Martinez AD, Hayrapetyan V, Moreno AP, Beyer EC. Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation. Circ Res. 2002 May 31; 90(10):1100-7. PMID: 12039800.
      Citations: 65     Fields:    Translation:HumansCells
    90. Xu X, Berthoud VM, Beyer EC, Ebihara L. Functional role of the carboxyl terminal domain of human connexin 50 in gap junctional channels. J Membr Biol. 2002 Mar 15; 186(2):101-12. PMID: 11944087; PMCID: PMC2744361.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    91. Johnson CM, Kanter EM, Green KG, Laing JG, Betsuyaku T, Beyer EC, Steinberg TH, Saffitz JE, Yamada KA. Redistribution of connexin45 in gap junctions of connexin43-deficient hearts. Cardiovasc Res. 2002 Mar; 53(4):921-35. PMID: 11922902.
      Citations: 12     Fields:    Translation:AnimalsCells
    92. Valiunas V, Gemel J, Brink PR, Beyer EC. Gap junction channels formed by coexpressed connexin40 and connexin43. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1675-89. PMID: 11557558.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    93. Elenes S, Martinez AD, Delmar M, Beyer EC, Moreno AP, Elenes S, Martinez AD, Delmar M, Beyer EC, Moreno AP. Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43. Biophys J. 2001 Sep; 81(3):1406-18. PMID: 11509355; PMCID: PMC1301620.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    94. Berthoud VM, Montegna EA, Atal N, Aithal NH, Brink PR, Beyer EC, Berthoud VM, Montegna EA, Atal N, Aithal NH, Brink PR, Beyer EC. Heteromeric connexons formed by the lens connexins, connexin43 and connexin56. Eur J Cell Biol. 2001 Jan; 80(1):11-9. PMID: 11211930.
      Citations: 15     Fields:    Translation:AnimalsCells
    95. Larson DM, Christensen TG, Sagar GD, Beyer EC, Larson DM, Christensen TG, Sagar GD, Beyer EC. TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in endothelial cells. Endothelium. 2001; 8(4):255-60. PMID: 11824477.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    96. Jacob A, Beyer EC. Mouse connexin 45: genomic cloning and exon usage. DNA Cell Biol. 2001 Jan; 20(1):11-9. PMID: 11242539.
      Citations: 2     Fields:    Translation:AnimalsCells
    97. Beyer EC, Gemel J, Berthoud VM, Valiunas V, Moreno AP, Brink PR, Beyer EC, Gemel J, Berthoud VM, Valiunas V, Moreno AP, Brink PR. Heteromeric mixing of connexins: compatibility of partners and functional consequences. Cell Commun Adhes. 2001; 8(4-6):199-204. PMID: 12064588.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    98. Beardslee MA, Lerner DL, Tadros PN, Laing JG, Beyer EC, Yamada KA, Schuessler RB, Saffitz JE, Kléber AG. Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res. 2000 Oct 13; 87(8):656-62. PMID: 11029400.
      Citations: 187     Fields:    Translation:AnimalsCells
    99. Berthoud VM, Beyer EC, Seul KH. Peptide inhibitors of intercellular communication. Am J Physiol Lung Cell Mol Physiol. 2000 Oct; 279(4):L619-22. PMID: 11000120.
      Citations: 9     Fields:    Translation:AnimalsCells
    100. Pal JD, Liu X, Mackay D, Shiels A, Berthoud VM, Beyer EC, Ebihara L. Connexin46 mutations linked to congenital cataract show loss of gap junction channel function. Am J Physiol Cell Physiol. 2000 Sep; 279(3):C596-602. PMID: 10942709.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    101. Seul KH, Beyer EC. Mouse connexin37: gene structure and promoter analysis. Biochim Biophys Acta. 2000 Jul 24; 1492(2-3):499-504. PMID: 11004519.
      Citations: 4     Fields:    Translation:AnimalsCells
    102. Kumari SS, Varadaraj K, Valiunas V, Ramanan SV, Christensen EA, Beyer EC, Brink PR. Functional expression and biophysical properties of polymorphic variants of the human gap junction protein connexin37. Biochem Biophys Res Commun. 2000 Jul 21; 274(1):216-24. PMID: 10903921.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    103. Berthoud VM, Hall DH, Strahsburger E, Beyer EC, Sáez JC. Gap junctions in the chicken pineal gland. Brain Res. 2000 Apr 10; 861(2):257-70. PMID: 10760487.
      Citations: 4     Fields:    Translation:AnimalsCells
    104. Beyer EC, Gemel J, Seul KH, Larson DM, Banach K, Brink PR. Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins. Braz J Med Biol Res. 2000 Apr; 33(4):391-7. PMID: 10775303.
      Citations: 7     Fields:    Translation:AnimalsCells
    105. Berthoud VM, Westphale EM, Grigoryeva A, Beyer EC. PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):850-8. PMID: 10711703.
      Citations: 15     Fields:    Translation:AnimalsCells
    106. Berthoud VM, Tadros PN, Beyer EC. Connexin and gap junction degradation. Methods. 2000 Feb; 20(2):180-7. PMID: 10671311.
      Citations: 10     Fields:    Translation:AnimalsCells
    107. Larson DM, Seul KH, Berthoud VM, Lau AF, Sagar GD, Beyer EC. Functional expression and biochemical characterization of an epitope-tagged connexin37. Mol Cell Biol Res Commun. 2000 Feb; 3(2):115-21. PMID: 10775509.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    108. Hwan Seul K, Beyer EC. Heterogeneous localization of connexin40 in the renal vasculature. Microvasc Res. 2000 Jan; 59(1):140-8. PMID: 10625581.
      Citations: 28     Fields:    Translation:AnimalsCells
    109. Pal JD, Berthoud VM, Beyer EC, Mackay D, Shiels A, Ebihara L. Molecular mechanism underlying a Cx50-linked congenital cataract. Am J Physiol. 1999 06; 276(6):C1443-6. PMID: 10362609.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    110. Berthoud VM, Bassnett S, Beyer EC. Cultured chicken embryo lens cells resemble differentiating fiber cells in vivo and contain two kinetic pools of connexin56. Exp Eye Res. 1999 Apr; 68(4):475-84. PMID: 10192805.
      Citations: 10     Fields:    Translation:AnimalsCells
    111. Ebihara L, Xu X, Oberti C, Beyer EC, Berthoud VM. Co-expression of lens fiber connexins modifies hemi-gap-junctional channel behavior. Biophys J. 1999 Jan; 76(1 Pt 1):198-206. PMID: 9876134; PMCID: PMC1302511.
      Citations: 24     Fields:    Translation:AnimalsCells
    112. Alexi-Meskishvili V, Beyer E, Hetzer R, Dähnert I. Successful total correction of complete atrioventricular canal, total anomalous pulmonary venous drainage and unroofed coronary sinus in an infant. Eur J Cardiothorac Surg. 1999 Jan; 15(1):95-6. PMID: 10077381.
      Citations:    Fields:    Translation:Humans
    113. Wagner TL, Beyer EC, McMahon DG. Cloning and functional expression of a novel gap junction channel from the retina of Danio aquipinnatus. Vis Neurosci. 1998 Nov-Dec; 15(6):1137-44. PMID: 9839978.
      Citations: 4     Fields:    Translation:AnimalsCells
    114. Beardslee MA, Laing JG, Beyer EC, Saffitz JE. Rapid turnover of connexin43 in the adult rat heart. Circ Res. 1998 Sep 21; 83(6):629-35. PMID: 9742058.
      Citations: 173     Fields:    Translation:Animals
    115. Dodge SM, Beardslee MA, Darrow BJ, Green KG, Beyer EC, Saffitz JE. Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol. 1998 Sep; 32(3):800-7. PMID: 9741530.
      Citations: 26     Fields:    Translation:AnimalsCells
    116. Laing JG, Tadros PN, Green K, Saffitz JE, Beyer EC. Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes. Cardiovasc Res. 1998 Jun; 38(3):711-8. PMID: 9747439.
      Citations: 33     Fields:    Translation:AnimalsCells
    117. Kwong KF, Schuessler RB, Green KG, Laing JG, Beyer EC, Boineau JP, Saffitz JE. Differential expression of gap junction proteins in the canine sinus node. Circ Res. 1998 Mar 23; 82(5):604-12. PMID: 9529165.
      Citations: 31     Fields:    Translation:AnimalsCells
    118. Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation. 1998 Feb 24; 97(7):686-91. PMID: 9495305.
      Citations: 71     Fields:    Translation:AnimalsCells
    119. Civitelli R, Ziambaras K, Warlow PM, Lecanda F, Nelson T, Harley J, Atal N, Beyer EC, Steinberg TH. Regulation of connexin43 expression and function by prostaglandin E2 (PGE2) and parathyroid hormone (PTH) in osteoblastic cells. J Cell Biochem. 1998 Jan 01; 68(1):8-21. PMID: 9407310.
      Citations: 29     Fields:    Translation:AnimalsCells
    120. Seul KH, Tadros PN, Beyer EC. Mouse connexin40: gene structure and promoter analysis. Genomics. 1997 Nov 15; 46(1):120-6. PMID: 9403066.
      Citations: 8     Fields:    Translation:AnimalsCells
    121. Laing JG, Tadros PN, Westphale EM, Beyer EC. Degradation of connexin43 gap junctions involves both the proteasome and the lysosome. Exp Cell Res. 1997 Nov 01; 236(2):482-92. PMID: 9367633.
      Citations: 72     Fields:    Translation:AnimalsCells
    122. Brink PR, Cronin K, Banach K, Peterson E, Westphale EM, Seul KH, Ramanan SV, Beyer EC. Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37. Am J Physiol. 1997 10; 273(4):C1386-96. PMID: 9357785.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    123. Guerrero PA, Schuessler RB, Davis LM, Beyer EC, Johnson CM, Yamada KA, Saffitz JE. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J Clin Invest. 1997 Apr 15; 99(8):1991-8. PMID: 9109444; PMCID: PMC508024.
      Citations: 88     Fields:    Translation:Animals
    124. Berthoud VM, Beyer EC, Kurata WE, Lau AF, Lampe PD. The gap-junction protein connexin 56 is phosphorylated in the intracellular loop and the carboxy-terminal region. Eur J Biochem. 1997 Feb 15; 244(1):89-97. PMID: 9063450.
      Citations: 22     Fields:    Translation:AnimalsCells
    125. Larson DM, Wrobleski MJ, Sagar GD, Westphale EM, Beyer EC. Differential regulation of connexin43 and connexin37 in endothelial cells by cell density, growth, and TGF-beta1. Am J Physiol. 1997 Feb; 272(2 Pt 1):C405-15. PMID: 9124282.
      Citations: 16     Fields:    Translation:AnimalsCells
    126. Cao D, Lin G, Westphale EM, Beyer EC, Steinberg TH. Mechanisms for the coordination of intercellular calcium signaling in insulin-secreting cells. J Cell Sci. 1997 Feb; 110 ( Pt 4):497-504. PMID: 9067601.
      Citations: 18     Fields:    Translation:AnimalsCells
    127. Albrecht JL, Atal NS, Tadros PN, Orsino A, Lye SJ, Sadovsky Y, Beyer EC. Rat uterine myometrium contains the gap junction protein connexin45, which has a differing temporal expression pattern from connexin43. Am J Obstet Gynecol. 1996 Oct; 175(4 Pt 1):853-8. PMID: 8885735.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    128. Darrow BJ, Fast VG, Beyer EC, Saffitz JE, Kléber AG. Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996 Aug; 79(2):174-83. PMID: 8755993.
      Citations: 43     Fields:    Translation:AnimalsCells
    129. Essner JJ, Laing JG, Beyer EC, Johnson RG, Hackett PB. Expression of zebrafish connexin43.4 in the notochord and tail bud of wild-type and mutant no tail embryos. Dev Biol. 1996 Aug 01; 177(2):449-62. PMID: 8806823.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    130. Veenstra RD, Wang HZ, Beblo DA, Chilton MG, Harris AL, Beyer EC, Brink PR. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res. 1995 Dec; 77(6):1156-65. PMID: 7586229.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    131. Fick J, Barker FG, Dazin P, Westphale EM, Beyer EC, Israel MA. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11071-5. PMID: 7479939; PMCID: PMC40573.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    132. Van Camp G, Coucke P, Speleman F, Van Roy N, Beyer EC, Oostra BA, Willems PJ. The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195. Genomics. 1995 Nov 20; 30(2):402-3. PMID: 8586454.
      Citations: 2     Fields:    Translation:HumansCells
    133. Laing JG, Beyer EC. The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway. J Biol Chem. 1995 Nov 03; 270(44):26399-403. PMID: 7592854.
      Citations: 81     Fields:    Translation:AnimalsCells
    134. Beblo DA, Wang HZ, Beyer EC, Westphale EM, Veenstra RD. Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40. Circ Res. 1995 Oct; 77(4):813-22. PMID: 7554128.
      Citations: 34     Fields:    Translation:AnimalsCells
    135. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE. Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol. 1995 Oct; 6(10 Pt 1):813-22. PMID: 8542077.
      Citations: 56     Fields:    Translation:HumansCells
    136. Kanter HL, Beyer EC, Saffitz JE. Structural and molecular determinants of intercellular coupling in cardiac myocytes. Microsc Res Tech. 1995 Aug 01; 31(5):357-63. PMID: 8534897.
      Citations: 1     Fields:    Translation:AnimalsCells
    137. Koval M, Geist ST, Westphale EM, Kemendy AE, Civitelli R, Beyer EC, Steinberg TH. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43. J Cell Biol. 1995 Aug; 130(4):987-95. PMID: 7642714; PMCID: PMC2199959.
      Citations: 37     Fields:    Translation:AnimalsCells
    138. Saffitz JE, Davis LM, Darrow BJ, Kanter HL, Laing JG, Beyer EC. The molecular basis of anisotropy: role of gap junctions. J Cardiovasc Electrophysiol. 1995 Jun; 6(6):498-510. PMID: 7551319.
      Citations: 28     Fields:    Translation:HumansCells
    139. Ebihara L, Berthoud VM, Beyer EC. Distinct behavior of connexin56 and connexin46 gap junctional channels can be predicted from the behavior of their hemi-gap-junctional channels. Biophys J. 1995 May; 68(5):1796-803. PMID: 7612821; PMCID: PMC1282082.
      Citations: 48     Fields:    Translation:AnimalsCells
    140. Beyer EC, Davis LM, Saffitz JE, Veenstra RD. Cardiac intercellular communication: consequences of connexin distribution and diversity. Braz J Med Biol Res. 1995 Apr; 28(4):415-25. PMID: 8520538.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    141. Darrow BJ, Laing JG, Lampe PD, Saffitz JE, Beyer EC. Expression of multiple connexins in cultured neonatal rat ventricular myocytes. Circ Res. 1995 Mar; 76(3):381-7. PMID: 7859384.
      Citations: 47     Fields:    Translation:AnimalsCells
    142. Little TL, Beyer EC, Duling BR. Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo. Am J Physiol. 1995 Feb; 268(2 Pt 2):H729-39. PMID: 7864199.
      Citations: 73     Fields:    Translation:AnimalsCells
    143. Davis LM, Saffitz JE, Beyer EC. Modulation of connexin43 expression: effects on cellular coupling. J Cardiovasc Electrophysiol. 1995 Feb; 6(2):103-14. PMID: 7780626.
      Citations: 2     Fields:    Translation:AnimalsCells
    144. Moreno AP, Laing JG, Beyer EC, Spray DC. Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells. Am J Physiol. 1995 Feb; 268(2 Pt 1):C356-65. PMID: 7532358.
      Citations: 36     Fields:    Translation:HumansCells
    145. Beyer E, Ivleva T, Artykova G, Wiederschain G. Change of isoforms' spectra of alpha-L-fucosidase from human skin fibroblasts in intracellular storage of nonhydrolyzable substances. Biochim Biophys Acta. 1995 Jan 25; 1270(1):7-11. PMID: 7827138.
      Citations: 1     Fields:    Translation:HumansCells
    146. Berthoud VM, Cook AJ, Beyer EC. Characterization of the gap junction protein connexin56 in the chicken lens by immunofluorescence and immunoblotting. Invest Ophthalmol Vis Sci. 1994 Nov; 35(12):4109-17. PMID: 7960593.
      Citations: 11     Fields:    Translation:AnimalsCells
    147. Luque EA, Veenstra RD, Beyer EC, Lemanski LF. Localization and distribution of gap junctions in normal and cardiomyopathic hamster heart. J Morphol. 1994 Nov; 222(2):203-13. PMID: 7799439.
      Citations: 4     Fields:    Translation:AnimalsCells
    148. Chen SC, Davis LM, Westphale EM, Beyer EC, Saffitz JE. Expression of multiple gap junction proteins in human fetal and infant hearts. Pediatr Res. 1994 Nov; 36(5):561-6. PMID: 7877871.
      Citations: 8     Fields:    Translation:Humans
    149. Davis LM, Kanter HL, Beyer EC, Saffitz JE. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J Am Coll Cardiol. 1994 Oct; 24(4):1124-32. PMID: 7930207.
      Citations: 46     Fields:    Translation:AnimalsCells
    150. Minkoff R, Rundus VR, Parker SB, Hertzberg EL, Laing JG, Beyer EC. Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible. Anat Embryol (Berl). 1994 Sep; 190(3):231-41. PMID: 7818094.
      Citations: 13     Fields:    Translation:AnimalsCells
    151. Gupta VK, Berthoud VM, Atal N, Jarillo JA, Barrio LC, Beyer EC. Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression. Invest Ophthalmol Vis Sci. 1994 Sep; 35(10):3747-58. PMID: 8088962.
      Citations: 28     Fields:    Translation:AnimalsCells
    152. Veenstra RD, Wang HZ, Beyer EC, Brink PR. Selective dye and ionic permeability of gap junction channels formed by connexin45. Circ Res. 1994 Sep; 75(3):483-90. PMID: 7520372.
      Citations: 47     Fields:    Translation:AnimalsCells
    153. Donaldson PJ, Roos M, Evans C, Beyer E, Kistler J. Electrical properties of mammalian lens epithelial gap junction channels. Invest Ophthalmol Vis Sci. 1994 Aug; 35(9):3422-8. PMID: 8056517.
      Citations: 6     Fields:    Translation:AnimalsCells
    154. Kanter HL, Saffitz JE, Beyer EC. Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. J Mol Cell Cardiol. 1994 Jul; 26(7):861-8. PMID: 7966354.
      Citations: 15     Fields:    Translation:HumansCells
    155. Dong Y, Roos M, Gruijters T, Donaldson P, Bullivant S, Beyer E, Kistler J. Differential expression of two gap junction proteins in corneal epithelium. Eur J Cell Biol. 1994 Jun; 64(1):95-100. PMID: 7957318.
      Citations: 12     Fields:    Translation:AnimalsCells
    156. Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 1994 Jun; 74(6):1065-70. PMID: 8187276.
      Citations: 61     Fields:    Translation:AnimalsCells
    157. Veenstra RD, Wang HZ, Beyer EC, Ramanan SV, Brink PR. Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities. Biophys J. 1994 Jun; 66(6):1915-28. PMID: 7521227; PMCID: PMC1275917.
      Citations: 49     Fields:    Translation:AnimalsCells
    158. Laing JG, Westphale EM, Engelmann GL, Beyer EC. Characterization of the gap junction protein, connexin45. J Membr Biol. 1994 Apr; 139(1):31-40. PMID: 8071985.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    159. Dealy CN, Beyer EC, Kosher RA. Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature. Dev Dyn. 1994 Feb; 199(2):156-67. PMID: 8204908.
      Citations: 7     Fields:    Translation:AnimalsCells
    160. Meda P, Pepper MS, Traub O, Willecke K, Gros D, Beyer E, Nicholson B, Paul D, Orci L. Differential expression of gap junction connexins in endocrine and exocrine glands. Endocrinology. 1993 Nov; 133(5):2371-8. PMID: 8404689.
      Citations: 45     Fields:    Translation:Animals
    161. Kanter HL, Laing JG, Beyer EC, Green KG, Saffitz JE. Multiple connexins colocalize in canine ventricular myocyte gap junctions. Circ Res. 1993 Aug; 73(2):344-50. PMID: 8392450.
      Citations: 20     Fields:    Translation:AnimalsCells
    162. Minkoff R, Rundus VR, Parker SB, Beyer EC, Hertzberg EL. Connexin expression in the developing avian cardiovascular system. Circ Res. 1993 Jul; 73(1):71-8. PMID: 8389677.
      Citations: 8     Fields:    Translation:Animals
    163. Civitelli R, Beyer EC, Warlow PM, Robertson AJ, Geist ST, Steinberg TH. Connexin43 mediates direct intercellular communication in human osteoblastic cell networks. J Clin Invest. 1993 May; 91(5):1888-96. PMID: 8387535; PMCID: PMC288182.
      Citations: 61     Fields:    Translation:HumansCells
    164. Kanter HL, Laing JG, Beau SL, Beyer EC, Saffitz JE. Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle. Circ Res. 1993 May; 72(5):1124-31. PMID: 8386597.
      Citations: 18     Fields:    Translation:Animals
    165. Oh SY, Dupont E, Madhukar BV, Briand JP, Chang CC, Beyer E, Trosko JE. Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line. Eur J Cell Biol. 1993 Apr; 60(2):250-5. PMID: 7687215.
      Citations: 13     Fields:    Translation:AnimalsCells
    166. Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC. Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest. 1993 Mar; 91(3):997-1004. PMID: 7680674; PMCID: PMC288052.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    167. Rup DM, Veenstra RD, Wang HZ, Brink PR, Beyer EC. Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression. J Biol Chem. 1993 Jan 05; 268(1):706-12. PMID: 7678009.
      Citations: 27     Fields:    Translation:AnimalsCells
    168. Beyer EC. Gap junctions. Int Rev Cytol. 1993; 137C:1-37. PMID: 8387468.
      Citations: 46     Fields:    Translation:AnimalsCells
    169. Dolber PC, Beyer EC, Junker JL, Spach MS. Distribution of gap junctions in dog and rat ventricle studied with a double-label technique. J Mol Cell Cardiol. 1992 Dec; 24(12):1443-57. PMID: 1338112.
      Citations: 20     Fields:    Translation:AnimalsCells
    170. Veenstra RD, Wang HZ, Westphale EM, Beyer EC. Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart. Circ Res. 1992 Nov; 71(5):1277-83. PMID: 1382884.
      Citations: 48     Fields:    Translation:AnimalsCells
    171. Larson DM, Gilbert RJ, Beyer EC. Two-dimensional coupling by gap junctions in cultured gastric smooth muscle monolayers. Am J Physiol. 1992 Aug; 263(2 Pt 1):G261-8. PMID: 1514638.
      Citations: 3     Fields:    Translation:AnimalsCells
    172. Beyer EC, Reed KE, Westphale EM, Kanter HL, Larson DM. Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle. J Membr Biol. 1992 Apr; 127(1):69-76. PMID: 1328644.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    173. Saffitz JE, Hoyt RH, Luke RA, Lee Kanter H, Beyer EC. Cardiac myocyte interconnections at gap junctions Role in normal and abnormal electrical conduction. Trends Cardiovasc Med. 1992 Mar-Apr; 2(2):56-60. PMID: 21239275.
      Citations: 4     Fields:    
    174. Kanter HL, Saffitz JE, Beyer EC. Cardiac myocytes express multiple gap junction proteins. Circ Res. 1992 Feb; 70(2):438-44. PMID: 1310450.
      Citations: 53     Fields:    Translation:AnimalsCells
    175. Valdimarsson G, De Sousa PA, Beyer EC, Paul DL, Kidder GM. Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development. Mol Reprod Dev. 1991 Sep; 30(1):18-26. PMID: 1664214.
      Citations: 10     Fields:    Translation:AnimalsCells
    176. Stutenkemper R, Traub O, Beyer E, Willecke K, Winterhager E. Expression of different connexin genes in rat uterus during decidualization and at term. Eur J Cell Biol. 1991 Jun; 55(1):133-42. PMID: 1655436.
      Citations: 11     Fields:    Translation:Animals
    177. Beyer EC, Steinberg TH. Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. J Biol Chem. 1991 May 05; 266(13):7971-4. PMID: 1708769.
      Citations: 56     Fields:    Translation:AnimalsCells
    178. Lang LM, Beyer EC, Schwartz AL, Gitlin JD. Molecular cloning of a rat uterine gap junction protein and analysis of gene expression during gestation. Am J Physiol. 1991 May; 260(5 Pt 1):E787-93. PMID: 1852114.
      Citations: 4     Fields:    Translation:AnimalsCells
    179. Moore LK, Beyer EC, Burt JM. Characterization of gap junction channels in A7r5 vascular smooth muscle cells. Am J Physiol. 1991 May; 260(5 Pt 1):C975-81. PMID: 1709787.
      Citations: 19     Fields:    Translation:AnimalsCells
    180. Meda P, Chanson M, Pepper M, Giordano E, Bosco D, Traub O, Willecke K, el Aoumari A, Gros D, Beyer EC, et al. In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells. Exp Cell Res. 1991 Feb; 192(2):469-80. PMID: 1846336.
      Citations: 22     Fields:    Translation:AnimalsCells
    181. Filson AJ, Azarnia R, Beyer EC, Loewenstein WR, Brugge JS. Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication. Cell Growth Differ. 1990 Dec; 1(12):661-8. PMID: 1963075.
      Citations: 37     Fields:    Translation:AnimalsCells
    182. Beyer EC. Molecular cloning and developmental expression of two chick embryo gap junction proteins. J Biol Chem. 1990 Aug 25; 265(24):14439-43. PMID: 2167316.
      Citations: 31     Fields:    Translation:AnimalsCells
    183. Beyer EC, Paul DL, Goodenough DA. Connexin family of gap junction proteins. J Membr Biol. 1990 Jul; 116(3):187-94. PMID: 2167375.
      Citations: 117     Fields:    Translation:AnimalsCells
    184. Musil LS, Beyer EC, Goodenough DA. Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation. J Membr Biol. 1990 Jun; 116(2):163-75. PMID: 2166164.
      Citations: 96     Fields:    Translation:AnimalsCells
    185. Beyer E, Schono N, Kozlova I, Wiederschain G. Relationship of the multiple forms of human alpha-D-galactosidase and alpha-D-fucosidase in the normal and in Fabry's disease. Biochim Biophys Acta. 1990 May 08; 1038(3):386-9. PMID: 2160280.
      Citations: 1     Fields:    Translation:Humans
    186. Larson DM, Haudenschild CC, Beyer EC. Gap junction messenger RNA expression by vascular wall cells. Circ Res. 1990 Apr; 66(4):1074-80. PMID: 1690612.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    187. Crow DS, Beyer EC, Paul DL, Kobe SS, Lau AF. Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts. Mol Cell Biol. 1990 Apr; 10(4):1754-63. PMID: 1690850; PMCID: PMC362281.
      Citations: 101     Fields:    Translation:AnimalsCells
    188. Traub O, Hwang TK, Beyer E, Bennett MV, Spray DC, Willecke K, Dermietzel R. Differential expression of three gap junction proteins in developing and mature brain tissues. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):10148-52. PMID: 2557621; PMCID: PMC298664.
      Citations: 132     Fields:    Translation:Animals
    189. Luke RA, Beyer EC, Hoyt RH, Saffitz JE. Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43. Circ Res. 1989 Nov; 65(5):1450-7. PMID: 2478314.
      Citations: 11     Fields:    Translation:AnimalsCells
    190. Swenson KI, Jordan JR, Beyer EC, Paul DL. Formation of gap junctions by expression of connexins in Xenopus oocyte pairs. Cell. 1989 Apr 07; 57(1):145-55. PMID: 2467743.
      Citations: 96     Fields:    Translation:AnimalsCells
    191. Ebihara L, Beyer EC, Swenson KI, Paul DL, Goodenough DA. Cloning and expression of a Xenopus embryonic gap junction protein. Science. 1989 Mar 03; 243(4895):1194-5. PMID: 2466337.
      Citations: 54     Fields:    Translation:AnimalsCells
    192. Beyer EC, Kistler J, Paul DL, Goodenough DA. Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol. 1989 Feb; 108(2):595-605. PMID: 2537319; PMCID: PMC2115444.
      Citations: 117     Fields:    Translation:AnimalsCells
    193. Beyer EC, Paul DL, Goodenough DA. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987 Dec; 105(6 Pt 1):2621-9. PMID: 2826492; PMCID: PMC2114703.
      Citations: 279     Fields:    Translation:AnimalsCells
    194. Key LL, Hoch S, Cairns L, Carnes D, Beyer E, Anast CS. Monocyte bone degradation: in vitro analysis of monocyte activity in patients with juvenile rheumatoid arthritis. J Pediatr. 1986 Mar; 108(3):405-9. PMID: 3081699.
      Citations: 1     Fields:    Translation:HumansCells
    195. Deuticke B, Beyer E, Forst B. Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties. Biochim Biophys Acta. 1982 Jan 04; 684(1):96-110. PMID: 7055558.
      Citations: 34     Fields:    Translation:HumansCells
    196. Beyer EC, Barondes SH. Quantitation of two endogenous lactose-inhibitable lectins in embryonic and adult chicken tissues. J Cell Biol. 1982 Jan; 92(1):23-7. PMID: 7056800; PMCID: PMC2111994.
      Citations: 18     Fields:    Translation:AnimalsCells
    197. Lipsick JS, Beyer EC, Barondes SH, Kaplan NO. Lectins from chicken tissues are mitogenic for Thy-1 negative murine spleen cells. Biochem Biophys Res Commun. 1980 Nov 17; 97(1):56-61. PMID: 7458941.
      Citations: 8     Fields:    Translation:AnimalsCells
    198. Beyer EC, Zweig SE, Barondes SH. Two lactose binding lectins from chicken tissues. Purified lectin from intestine is different from those in liver and muscle. J Biol Chem. 1980 May 10; 255(9):4236-9. PMID: 6768752.
      Citations: 33     Fields:    Translation:AnimalsCells
    199. Beyer EC, Barondes SH. Chicken tissue binding sites for a purified chicken lectin. J Supramol Struct. 1980; 13(2):219-27. PMID: 7017279.
      Citations: 8     Fields:    Translation:AnimalsCells
    200. Deuticke B, von Bentheim M, Beyer E, Kamp D. Reversible inhibition of anion exchange in human erythrocytes by an inorganic disulfonate, tetrathionate. J Membr Biol. 1978 Dec 15; 44(2):135-58. PMID: 731685.
      Citations: 8     Fields:    Translation:HumansCells
    201. Friedlander M, Beyer EC, Fischman DA. Muscle development in vitro following X irradiation. Dev Biol. 1978 Oct; 66(2):457-69. PMID: 568088.
      Citations: 4     Fields:    Translation:AnimalsCells
    202. Kobiler D, Beyer EC, Barondes SH. Developmentally regulated lectins from chick muscle, brain, and liver have similar chemical and immunological properties. Dev Biol. 1978 Jun; 64(2):265-72. PMID: 680346.
      Citations: 17     Fields:    Translation:AnimalsCells
    203. Deuticke B, Rickert I, Beyer E, Deuticke B, Rickert I, Beyer E. Stereoselective, SH-dependent transfer of lactate in mammalian erythrocytes. Biochim Biophys Acta. 1978 Feb 02; 507(1):137-55. PMID: 23829.
      Citations: 39     Fields:    Translation:Cells
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