 Binding Sites, Antibody
"Binding Sites, Antibody" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
| Descriptor ID |
D001666
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| MeSH Number(s) |
G02.111.570.060.425.079 G02.111.570.120.408 G12.125 G12.425.143.232
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| Concept/Terms |
Binding Sites, Antibody- Binding Sites, Antibody
- Antibody Binding Site
- Binding Site, Antibody
- Paratopes
- Paratope
- Antibody Binding Sites
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Below are MeSH descriptors whose meaning is more general than "Binding Sites, Antibody".
Below are MeSH descriptors whose meaning is more specific than "Binding Sites, Antibody".
This graph shows the total number of publications written about "Binding Sites, Antibody" by people in this website by year, and whether "Binding Sites, Antibody" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 0 | 1 | | 1981 | 5 | 0 | 5 | | 1982 | 2 | 0 | 2 | | 1983 | 0 | 4 | 4 | | 1984 | 0 | 3 | 3 | | 1985 | 0 | 1 | 1 | | 1986 | 0 | 1 | 1 | | 1988 | 0 | 2 | 2 | | 1991 | 0 | 1 | 1 | | 1992 | 1 | 3 | 4 | | 1993 | 2 | 0 | 2 | | 1994 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 |
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Below are the most recent publications written about "Binding Sites, Antibody" by people in Profiles.
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Schaefer ZP, Bailey LJ, Kossiakoff AA. A polar ring endows improved specificity to an antibody fragment. Protein Sci. 2016 07; 25(7):1290-8.
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Hattori T, Lai D, Dementieva IS, Montaño SP, Kurosawa K, Zheng Y, Akin LR, Swist-Rosowska KM, Grzybowski AT, Koide A, Krajewski K, Strahl BD, Kelleher NL, Ruthenburg AJ, Koide S. Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2092-7.
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Fanning SW, Walter R, Horn JR. Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site. Protein Eng Des Sel. 2014 Oct; 27(10):391-7.
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Hattori T, Taft JM, Swist KM, Luo H, Witt H, Slattery M, Koide A, Ruthenburg AJ, Krajewski K, Strahl BD, White KP, Farnham PJ, Zhao Y, Koide S. Recombinant antibodies to histone post-translational modifications. Nat Methods. 2013 Oct; 10(10):992-5.
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Kim HK, Emolo C, DeDent AC, Falugi F, Missiakas DM, Schneewind O. Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice. Infect Immun. 2012 Oct; 80(10):3460-70.
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Fanning SW, Murtaugh ML, Horn JR. A combinatorial approach to engineering a dual-specific metal switch antibody. Biochemistry. 2011 Jun 14; 50(23):5093-5.
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Koide A, Tereshko V, Uysal S, Margalef K, Kossiakoff AA, Koide S. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. J Mol Biol. 2007 Nov 02; 373(4):941-53.
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Sekiguchi DR, Yunk L, Gary D, Charan D, Srivastava B, Allman D, Weigert MG, Prak ET. Development and selection of edited B cells in B6.56R mice. J Immunol. 2006 Jun 01; 176(11):6879-87.
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Costagliola S, Bonomi M, Morgenthaler NG, Van Durme J, Panneels V, Refetoff S, Vassart G. Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity. Mol Endocrinol. 2004 Dec; 18(12):3020-34.
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Radic MZ, Weigert M. Intricacies of anti-DNA autoantibodies. J Immunol. 2004 Mar 15; 172(6):3367; author reply 3367-8.
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