 Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
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| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
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| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
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Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1990 | 0 | 4 | 4 | | 1991 | 2 | 2 | 4 | | 1992 | 2 | 1 | 3 | | 1993 | 5 | 0 | 5 | | 1994 | 4 | 2 | 6 | | 1995 | 6 | 0 | 6 | | 1996 | 7 | 4 | 11 | | 1997 | 8 | 1 | 9 | | 1998 | 6 | 4 | 10 | | 1999 | 2 | 1 | 3 | | 2000 | 3 | 2 | 5 | | 2001 | 3 | 1 | 4 | | 2002 | 6 | 1 | 7 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 1 | 3 | | 2005 | 2 | 3 | 5 | | 2006 | 4 | 0 | 4 | | 2007 | 2 | 1 | 3 | | 2008 | 1 | 1 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 2 | 3 | 5 | | 2011 | 1 | 1 | 2 | | 2012 | 5 | 1 | 6 | | 2013 | 2 | 0 | 2 | | 2014 | 4 | 1 | 5 | | 2015 | 3 | 1 | 4 | | 2016 | 3 | 0 | 3 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.
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Sun R, He T, Pan Y, Katusic ZS. Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells. Aging (Albany NY). 2018 01 15; 10(1):100-114.
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Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9665-E9674.
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Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411.
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Andrew RJ, Kellett KA, Thinakaran G, Hooper NM. A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis. J Biol Chem. 2016 09 09; 291(37):19235-44.
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Deyts C, Clutter M, Herrera S, Jovanovic N, Goddi A, Parent AT. Loss of presenilin function is associated with a selective gain of APP function. Elife. 2016 05 19; 5.
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Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aß generation in Alzheimer's disease. Acta Neuropathol. 2016 08; 132(2):235-256.
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Deyts C, Thinakaran G, Parent AT. APP Receptor? To Be or Not To Be. Trends Pharmacol Sci. 2016 05; 37(5):390-411.
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Schwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler B. Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Nat Neurosci. 2016 Feb; 19(2):233-42.
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Tkatchenko AV, Tkatchenko TV, Guggenheim JA, Verhoeven VJ, Hysi PG, Wojciechowski R, Singh PK, Kumar A, Thinakaran G. APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans. PLoS Genet. 2015 Aug; 11(8):e1005432.
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Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, Seidah NG. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. J Biol Chem. 2015 Jul 24; 290(30):18609-20.
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