 MAP Kinase Kinase Kinases
"MAP Kinase Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
| Descriptor ID |
D020930
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| MeSH Number(s) |
D08.811.913.696.620.682.700.559 D12.644.360.400 D12.776.476.400
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| Concept/Terms |
MAP Kinase Kinase Kinases- MAP Kinase Kinase Kinases
- MAP Kinase Kinase Kinase
- MAPKKKs
- Mitogen-Activated Protein Kinase Kinase Kinases
- Mitogen Activated Protein Kinase Kinase Kinases
- Kinases, MAP Kinase Kinase
- MAP3 Kinases
- Kinases, MAP3
MAPK-ERK Kinase Kinases- MAPK-ERK Kinase Kinases
- Kinase Kinases, MAPK-ERK
- Kinases, MAPK-ERK Kinase
- MAPK ERK Kinase Kinases
- MEKKs
- MEK Kinases
- Kinases, MEK
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Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinases".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinases".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinases" by people in this website by year, and whether "MAP Kinase Kinase Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 1 | 2 | | 2004 | 2 | 0 | 2 | | 2006 | 0 | 2 | 2 | | 2007 | 1 | 3 | 4 | | 2009 | 1 | 2 | 3 | | 2010 | 1 | 2 | 3 | | 2011 | 2 | 2 | 4 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 4 | 5 | | 2014 | 0 | 1 | 1 | | 2015 | 2 | 1 | 3 | | 2018 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinases" by people in Profiles.
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Liu W, Zhuang J, Jiang Y, Sun J, Prinz RA, Sun J, Jiao X, Xu X. Toll-like receptor signalling cross-activates the autophagic pathway to restrict Salmonella Typhimurium growth in macrophages. Cell Microbiol. 2019 12; 21(12):e13095.
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Liu W, Jiang Y, Sun J, Geng S, Pan Z, Prinz RA, Wang C, Sun J, Jiao X, Xu X. Activation of TGF-ß-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy. Cell Death Dis. 2018 05 01; 9(5):570.
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Sun J, Mu Y, Jiang Y, Song R, Yi J, Zhou J, Sun J, Jiao X, Prinz RA, Li Y, Xu X. Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates. Cell Death Dis. 2018 03 14; 9(3):407.
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Zimmerman EI, Gibson AA, Hu S, Vasilyeva A, Orwick SJ, Du G, Mascara GP, Ong SS, Chen T, Vogel P, Inaba H, Maitland ML, Sparreboom A, Baker SD. Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death. Cancer Res. 2016 Jan 01; 76(1):117-26.
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Teicher BA, Polley E, Kunkel M, Evans D, Silvers T, Delosh R, Laudeman J, Ogle C, Reinhart R, Selby M, Connelly J, Harris E, Monks A, Morris J. Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression. . 2015 Nov; 14(11):2452-62.
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Hu-Lieskovan S, Mok S, Homet Moreno B, Tsoi J, Robert L, Goedert L, Pinheiro EM, Koya RC, Graeber TG, Comin-Anduix B, Ribas A. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma. Sci Transl Med. 2015 Mar 18; 7(279):279ra41.
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Takahashi H, Jin C, Rajabi H, Pitroda S, Alam M, Ahmad R, Raina D, Hasegawa M, Suzuki Y, Tagde A, Bronson RT, Weichselbaum R, Kufe D. MUC1-C activates the TAK1 inflammatory pathway in colon cancer. Oncogene. 2015 Oct 01; 34(40):5187-97.
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Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Microtubules regulate focal adhesion dynamics through MAP4K4. Dev Cell. 2014 Dec 08; 31(5):572-85.
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Luke JJ, Ott PA. Kinase inhibitors and immune check-point blockade for the treatment of metastatic melanoma and advanced cancer: synergistic or antagonistic? Expert Opin Pharmacother. 2013 Dec; 14(18):2457-62.
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Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov. 2013 Sep; 3(9):993-1001.
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