DNA-Activated Protein Kinase
"DNA-Activated Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.
| Descriptor ID |
D051747
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.250 D12.776.157.687.438 D12.776.660.720.438
|
| Concept/Terms |
DNA-Activated Protein Kinase- DNA-Activated Protein Kinase
- DNA Activated Protein Kinase
- Kinase, DNA-Activated Protein
- Protein Kinase, DNA-Activated
- DNA-Dependent Protein Serine-Threonine Kinase
- DNA Dependent Protein Serine Threonine Kinase
- DNA-Dependent Protein Kinase
- DNA Dependent Protein Kinase
- Kinase, DNA-Dependent Protein
- Protein Kinase, DNA-Dependent
|
Below are MeSH descriptors whose meaning is more general than "DNA-Activated Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Activated Protein Kinase".
This graph shows the total number of publications written about "DNA-Activated Protein Kinase" by people in this website by year, and whether "DNA-Activated Protein Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA-Activated Protein Kinase" by people in Profiles.
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Chromatin compartmentalization regulates the response to DNA damage. Nature. 2023 Nov; 623(7985):183-192.
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Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC. Int J Oncol. 2020 10; 57(4):939-955.
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Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence. J Cell Sci. 2019 07 01; 132(13).
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A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1. Cell Rep. 2016 06 07; 15(10):2097-2108.
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Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK. Mol Endocrinol. 2016 Feb; 30(2):158-72.
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PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest. 2013 Jul; 123(7):2969-80.
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Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J Exp Med. 2012 May 07; 209(5):955-63.
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Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway. J Radiat Res. 2009 Mar; 50(2):97-108.
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[Mechanisms of chromosomal DNA strand break repair in human cells]. Tanpakushitsu Kakusan Koso. 2009 Mar; 54(4 Suppl):472-8.
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KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation. Cell Signal. 2008 Nov; 20(11):1978-85.