 Proprotein Convertase 1
"Proprotein Convertase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
| Descriptor ID |
D045664
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| MeSH Number(s) |
D08.811.277.656.300.760.640 D08.811.277.656.837.500 D08.811.277.656.959.350.640
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| Concept/Terms |
Proprotein Convertase 1- Proprotein Convertase 1
- Convertase 1, Proprotein
- PC1 Prohormone Convertase
- PC3 Endoprotease
- Endoprotease, PC3
- PC3 Prohormone Convertase
- Convertase, PC3 Prohormone
- Prohormone Convertase, PC3
- Neuroendocrine Convertase PC1
- Convertase PC1, Neuroendocrine
- Proprotein Convertase SPC3
- Convertase SPC3, Proprotein
- Proinsulin Convertase 1
- Prohormone Convertase 3
- Prohormone Convertase, PC1
- Convertase, PC1 Prohormone
- PC1 Endoprotease
- Endoprotease, PC1
- Prohormone Convertase 1
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Below are MeSH descriptors whose meaning is more general than "Proprotein Convertase 1".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertase 1".
This graph shows the total number of publications written about "Proprotein Convertase 1" by people in this website by year, and whether "Proprotein Convertase 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 2 | 0 | 2 | | 2003 | 2 | 0 | 2 | | 2004 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proprotein Convertase 1" by people in Profiles.
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Wasserfall C, Nick HS, Campbell-Thompson M, Beachy D, Haataja L, Kusmartseva I, Posgai A, Beery M, Rhodes C, Bonifacio E, Arvan P, Atkinson M. Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata. Cell Metab. 2017 Sep 05; 26(3):568-575.e3.
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Raghuraman G, Kalari A, Dhingra R, Prabhakar NR, Kumar GK. Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing. Antioxid Redox Signal. 2011 Apr 01; 14(7):1179-90.
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Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ß-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55.
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Uchizono Y, Alarcón C, Wicksteed BL, Marsh BJ, Rhodes CJ. The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead? Diabetes Obes Metab. 2007 Nov; 9 Suppl 2:56-66.
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Zhu X, Cao Y, Voogd K, Voodg K, Steiner DF. On the processing of proghrelin to ghrelin. J Biol Chem. 2006 Dec 15; 281(50):38867-70.
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Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB. Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Diabetes. 2004 Jan; 53(1):141-8.
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Dey A, Norrbom C, Zhu X, Stein J, Zhang C, Ueda K, Steiner DF. Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Endocrinology. 2004 Apr; 145(4):1961-71.
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Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ, Holst JJ, Brubaker PL, Corvol P, Polonsky KS, Ostrega D, Becker KL, Bertagna X, Hutton JC, White A, Dattani MT, Hussain K, Middleton SJ, Nicole TM, Milla PJ, Lindley KJ, O'Rahilly S. Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest. 2003 Nov; 112(10):1550-60.
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Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10293-8.
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Zhu X, Orci L, Carroll R, Norrbom C, Ravazzola M, Steiner DF. Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10299-304.
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