"Huntingtin Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.
| Descriptor ID |
D000071058
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| MeSH Number(s) |
D12.776.441
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Huntingtin Protein".
Below are MeSH descriptors whose meaning is more specific than "Huntingtin Protein".
This graph shows the total number of publications written about "Huntingtin Protein" by people in this website by year, and whether "Huntingtin Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Huntingtin Protein" by people in Profiles.
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Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease. Biochim Biophys Acta Mol Basis Dis. 2024 01; 1870(1):166928.
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Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity. Proc Natl Acad Sci U S A. 2019 09 17; 116(38):19165-19175.
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Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity. Cell Rep. 2019 04 02; 27(1):59-70.e4.
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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun. 2016 08 26; 7:12646.
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Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015; 11(2):e1004987.
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Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin. Hum Mol Genet. 2014 Jun 15; 23(12):3166-79.
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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis. Hum Mol Genet. 2011 Jun 15; 20(12):2344-55.
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Protein folding: sticky N17 speeds huntingtin pile-up. Nat Chem Biol. 2010 Jan; 6(1):7-8.
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Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect. Biophys J. 2009 Oct 21; 97(8):2295-305.
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Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death. FASEB J. 2008 Apr; 22(4):1083-93.