Signaling Lymphocytic Activation Molecule Family
"Signaling Lymphocytic Activation Molecule Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
| Descriptor ID |
D000071176
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| MeSH Number(s) |
D12.776.395.550.736 D12.776.543.550.746 D12.776.543.750.705.970
|
| Concept/Terms |
Signaling Lymphocytic Activation Molecule Family- Signaling Lymphocytic Activation Molecule Family
- Signaling Lymphocytic Activation Molecule Receptors
- SLAMF Receptors
- Signaling Lymphocytic Activation Molecule Family Receptors
- Signaling Lymphocytic Activation Molecules
- SLAM Family Receptors
|
Below are MeSH descriptors whose meaning is more general than "Signaling Lymphocytic Activation Molecule Family".
Below are MeSH descriptors whose meaning is more specific than "Signaling Lymphocytic Activation Molecule Family".
This graph shows the total number of publications written about "Signaling Lymphocytic Activation Molecule Family" by people in this website by year, and whether "Signaling Lymphocytic Activation Molecule Family" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 4 | 4 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Signaling Lymphocytic Activation Molecule Family" by people in Profiles.
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First-in-Human Phase I Study of ABBV-838, an Antibody-Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma. Clin Cancer Res. 2020 05 15; 26(10):2308-2317.
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CD84 is markedly up-regulated in Kawasaki disease arteriopathy. Clin Exp Immunol. 2014 Jul; 177(1):203-11.
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Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet. 2013 Mar; 9(3):e1003394.
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Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo. Autoimmunity. 2011 Dec; 44(8):599-606.
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Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nat Genet. 2008 Oct; 40(10):1224-9.
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Molecular basis of the dual functions of 2B4 (CD244). J Immunol. 2008 Jun 15; 180(12):8159-67.
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Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity. 2007 Nov; 27(5):751-62.
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2B4 inhibits NK-cell fratricide. Blood. 2007 Sep 15; 110(6):2020-3.
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Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. 2006 Apr 15; 107(8):3181-8.
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2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood. 2005 Aug 15; 106(4):1337-40.