"Ectodysplasins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
| Descriptor ID |
D053331
|
| MeSH Number(s) |
D12.644.276.374.750.186 D12.776.395.550.275 D12.776.467.374.750.186 D12.776.543.550.275 D23.529.374.750.186
|
| Concept/Terms |
Ectodysplasins- Ectodysplasins
- Ectodysplasin-A
- Ectodysplasin A
- Ectodysplasin
|
Below are MeSH descriptors whose meaning is more general than "Ectodysplasins".
Below are MeSH descriptors whose meaning is more specific than "Ectodysplasins".
This graph shows the total number of publications written about "Ectodysplasins" by people in this website by year, and whether "Ectodysplasins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ectodysplasins" by people in Profiles.
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Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway. Mol Cancer Res. 2010 Jun; 8(6):855-63.
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Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha. J Neurosci. 2008 Nov 19; 28(47):12199-211.
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Repair process of fetal brain after 5-azacytidine-induced damage. Eur J Neurosci. 2006 Nov; 24(10):2758-68.