"p21-Activated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
| Descriptor ID |
D054462
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.596 D12.644.360.552 D12.776.476.548
|
| Concept/Terms |
p21-Activated Kinases- p21-Activated Kinases
- Kinases, p21-Activated
- p21 Activated Kinases
- PAK Kinases
- Kinases, PAK
p21-Activated Kinase 2- p21-Activated Kinase 2
- p21 Activated Kinase 2
- p65(PAK)
- p65PAK Protein
- PAK-2 Kinase
- PAK 2 Kinase
- PAK2 Kinase
- PAK65
- gamma-PAK
- gamma PAK
p21-Activated Kinase 1- p21-Activated Kinase 1
- p21 Activated Kinase 1
- Serine-Threonine-Protein Kinase PAK 1
- Serine Threonine Protein Kinase PAK 1
- alpha p21-Activated Kinase
- alpha p21 Activated Kinase
- alpha-PAK
- PAK1 Kinase
- PAK-1 Kinase
- PAK 1 Kinase
p21-Activated Kinase 3- p21-Activated Kinase 3
- p21 Activated Kinase 3
- Oligophrenin-3
- Oligophrenin 3
- Serine-Threonine-Protein Kinase PAK 3
- Serine Threonine Protein Kinase PAK 3
- PAK3 Kinase
- beta p21-Activated Kinase
- beta p21 Activated Kinase
- p21-Activated Kinase, beta
- beta-PAK
|
Below are MeSH descriptors whose meaning is more general than "p21-Activated Kinases".
Below are MeSH descriptors whose meaning is more specific than "p21-Activated Kinases".
This graph shows the total number of publications written about "p21-Activated Kinases" by people in this website by year, and whether "p21-Activated Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "p21-Activated Kinases" by people in Profiles.
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Acetylation of METTL3: A negative regulator of m6A deposition on chromatin-associated regulatory RNAs. Mol Cell. 2025 Apr 03; 85(7):1251-1252.
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PAK4 as a cancer immune-evasion target. Nat Cancer. 2020 01; 1(1):18-19.
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The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development. PLoS Genet. 2019 05; 15(5):e1008083.
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A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence. BMC Genomics. 2019 Apr 15; 20(1):290.
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Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity. Heart Rhythm. 2018 08; 15(8):1233-1241.
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Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. 2016 Sep 20; 7(38):61229-61245.
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S1P1 deletion in oligodendroglial lineage cells: Effect on differentiation and myelination. Glia. 2016 Apr; 64(4):570-82.
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Pak1 is required to maintain ventricular Ca²? homeostasis and electrophysiological stability through SERCA2a regulation in mice. Circ Arrhythm Electrophysiol. 2014 Oct; 7(5):938-48.
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Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement. Cell Signal. 2014 Nov; 26(11):2306-16.
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Microtubule-dependent transport of vimentin filament precursors is regulated by actin and by the concerted action of Rho- and p21-activated kinases. FASEB J. 2014 Jul; 28(7):2879-90.