HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease.

HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease. Mol Cell. 2021 12 16; 81(24):5052-5065.e6.

View in: PubMed

subject areas

Adenine
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency
Animals
Apoptosis
Disease Models, Animal
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Endoplasmic Reticulum-Associated Degradation
HEK293 Cells
Hep G2 Cells
Humans
Liver
Liver Diseases
Methyltransferases
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
NIH 3T3 Cells
Proteolysis
Transcription Factor CHOP
Ubiquitination
Ubiquitin-Protein Ligases

authors with profiles

Chuan He