DNA Topoisomerases, Type I
"DNA Topoisomerases, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
| Descriptor ID |
D004264
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| MeSH Number(s) |
D08.811.399.403.483 D12.776.157.687.375 D12.776.660.720.375
|
| Concept/Terms |
DNA Topoisomerases, Type I- DNA Topoisomerases, Type I
- DNA Nicking-Closing Proteins
- DNA Relaxing Enzyme
- DNA Relaxing Enzymes
- DNA Relaxing Protein
- DNA Topoisomerase
- DNA Topoisomerase I
- DNA Type 1 Topoisomerase
- DNA Untwisting Enzyme
- DNA Untwisting Enzymes
- DNA Untwisting Protein
- DNA Untwisting Proteins
- Topoisomerase I
- Type I DNA Topoisomerase
- DNA Nicking-Closing Protein
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type I".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type I".
This graph shows the total number of publications written about "DNA Topoisomerases, Type I" by people in this website by year, and whether "DNA Topoisomerases, Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 2 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 3 | 0 | 3 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Topoisomerases, Type I" by people in Profiles.
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RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 Sep 05; 84(17):3192-3208.e11.
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Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons. Cell Chem Biol. 2021 06 17; 28(6):776-787.e8.
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Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors. Clin Colorectal Cancer. 2021 06; 20(2):e129-e138.
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Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites. Nat Commun. 2020 08 07; 11(1):3940.
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qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing. Nat Commun. 2019 05 24; 10(1):2313.
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Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751.
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Synthesizing topological structures containing RNA. Nat Commun. 2017 03 31; 8:14936.
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Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS). Ann Rheum Dis. 2017 Jul; 76(7):1207-1218.
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Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity. Arthritis Rheumatol. 2016 10; 68(10):2492-502.
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Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIa catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. Eur J Med Chem. 2017 Jan 05; 125:49-67.