"Centromere Protein A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
| Descriptor ID |
D000076247
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| MeSH Number(s) |
D12.776.157.687.173 D12.776.260.123 D12.776.660.235.100 D12.776.660.720.173 D12.776.664.235.100 D23.050.422.031
|
| Concept/Terms |
Centromere Protein A- Centromere Protein A
- CENPA Protein
- Centromere Protein 17K
- CENP-A Protein
- CENP A Protein
- Centromere Autoantigens 17K
- Autoantigens 17K, Centromere
|
Below are MeSH descriptors whose meaning is more general than "Centromere Protein A".
Below are MeSH descriptors whose meaning is more specific than "Centromere Protein A".
This graph shows the total number of publications written about "Centromere Protein A" by people in this website by year, and whether "Centromere Protein A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Centromere Protein A" by people in Profiles.
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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6.
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Sequences associated with centromere competency in the human genome. Mol Cell Biol. 2013 Feb; 33(4):763-72.
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An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature. 2012 Apr 08; 484(7395):534-7.
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Organization and molecular evolution of CENP-A--associated satellite DNA families in a basal primate genome. Genome Biol Evol. 2011; 3:1136-49.
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HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell. 2009 May 01; 137(3):485-97.
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Centromeres of human chromosomes. Environ Mol Mutagen. 1996; 28(3):182-91.