 Calcineurin
"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
| Descriptor ID |
D019703
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| MeSH Number(s) |
D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
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| Concept/Terms |
Calcineurin- Calcineurin
- Protein Phosphatase-2B
- Protein Phosphatase 2B
- Protein Phosphatase 3
- Phosphatase 3, Protein
Calcineurin B- Calcineurin B
- Protein Phosphatase 3 Regulatory Subunit
Calcineurin A- Calcineurin A
- Protein Phosphatase 3 Catalytic Subunit
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Below are MeSH descriptors whose meaning is more general than "Calcineurin".
Below are MeSH descriptors whose meaning is more specific than "Calcineurin".
This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calcineurin" by people in Profiles.
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Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 04 08; 27(4):614-628.e6.
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Muir A, Ramachandran S, Roelants FM, Timmons G, Thorner J. TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids. Elife. 2014 Oct 03; 3.
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Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, Ashcroft FM, In't Veld P, Saada A, Magnuson MA, Glaser B, Dor Y. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ? cells. Cell Metab. 2014 Jan 07; 19(1):109-21.
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Hanauer SB, Kirsner JB. Comparing guidelines for the treatment of inflammatory bowel disease. Dig Dis. 2013; 31(3-4):360-2.
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Malinge S, Bliss-Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, Crispino JD. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012 Mar; 122(3):948-62.
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Demozay D, Tsunekawa S, Briaud I, Shah R, Rhodes CJ. Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ?-cells. Diabetes. 2011 Nov; 60(11):2892-902.
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Depreux FF, Scheffler JM, Grant AL, Bidwell CA, Gerrard DE. Molecular cloning and characterization of porcine calcineurin-alpha subunit expression in skeletal muscle. J Anim Sci. 2010 Feb; 88(2):562-71.
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van Woerden GM, Hoebeek FE, Gao Z, Nagaraja RY, Hoogenraad CC, Kushner SA, Hansel C, De Zeeuw CI, Elgersma Y. betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses. Nat Neurosci. 2009 Jul; 12(7):823-5.
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Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, Sweeney HL, Molkentin JD. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. J Biol Chem. 2007 Mar 30; 282(13):10068-10078.
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Belmeguenai A, Hansel C. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. J Neurosci. 2005 Nov 16; 25(46):10768-72.
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