eIF-2 Kinase
"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Descriptor ID |
D019892
|
MeSH Number(s) |
D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
|
Concept/Terms |
eIF-2 Kinase- eIF-2 Kinase
- Kinase, eIF-2
- eIF 2 Kinase
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- dsRNA-Activated Inhibitor
- Inhibitor, dsRNA-Activated
- dsRNA Activated Inhibitor
- DSRNA-Dep Protein Kinase
- DSRNA Dep Protein Kinase
- Kinase, DSRNA-Dep Protein
- Protein Kinase, DSRNA-Dep
- eIF-2alpha Kinase
- Kinase, eIF-2alpha
- eIF 2alpha Kinase
- eRF, eIF-2 Recycling Factor
- eRF, eIF 2 Recycling Factor
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme Controlled Repressor
- Controlled Repressor, Heme
- Repressor, Heme Controlled
- Heme-Controlled Inhibitor
- Heme Controlled Inhibitor
- Inhibitor, Heme-Controlled
- Heme-Controlled Translational Repressor
- Heme Controlled Translational Repressor
- Repressor, Heme-Controlled Translational
- Translational Repressor, Heme-Controlled
- Heme-Regulated eIF-2alpha Kinase
- Heme Regulated eIF 2alpha Kinase
- Kinase, Heme-Regulated eIF-2alpha
- eIF-2alpha Kinase, Heme-Regulated
- Hemin Controlled Repressor
- Controlled Repressor, Hemin
- Repressor, Hemin Controlled
- Hemin-Controlled Translational Repressor
- Hemin Controlled Translational Repressor
- Repressor, Hemin-Controlled Translational
- Translational Repressor, Hemin-Controlled
- p65 Kinase
- Kinase, p65
- p68 Kinase
- Kinase, p68
- P68 Protein Kinase
- Kinase, P68 Protein
- Protein Kinase, P68
- Protein Kinase PKR
- Kinase PKR, Protein
- PKR, Protein Kinase
- Protein Kinase, RNA Activated
- RNA-Dependent Protein Kinase
- Kinase, RNA-Dependent Protein
- Protein Kinase, RNA-Dependent
- RNA Dependent Protein Kinase
- Self-Phosphorylating Protein Kinase
- Kinase, Self-Phosphorylating Protein
- Protein Kinase, Self-Phosphorylating
- Self Phosphorylating Protein Kinase
- TIK Kinase
- Kinase, TIK
- DAI Protein Kinase
- Kinase, DAI Protein
- Protein Kinase, DAI
|
Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".
Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".
This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
---|
1992 | 0 | 2 | 2 | 1993 | 0 | 3 | 3 | 1994 | 0 | 2 | 2 | 1995 | 0 | 2 | 2 | 2002 | 1 | 0 | 1 | 2003 | 1 | 0 | 1 | 2004 | 0 | 2 | 2 | 2005 | 1 | 0 | 1 | 2006 | 1 | 0 | 1 | 2008 | 1 | 0 | 1 | 2009 | 1 | 1 | 2 | 2010 | 0 | 3 | 3 | 2011 | 1 | 3 | 4 | 2012 | 0 | 1 | 1 | 2013 | 1 | 0 | 1 | 2014 | 1 | 0 | 1 | 2015 | 1 | 0 | 1 | 2016 | 1 | 1 | 2 | 2019 | 2 | 1 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.
-
Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019 12 15; 79(24):6190-6203.
-
Minogue PJ, Beyer EC, Berthoud VM. CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice. Mol Vis. 2019; 25:535-545.
-
Jin HR, Du CH, Wang CZ, Yuan CS, Du W. Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK. Cell Death Dis. 2019 04 05; 10(4):311.
-
Dzhashiashvili Y, Monckton CP, Shah HS, Kunjamma RB, Popko B. The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS. Neurobiol Dis. 2019 07; 127:527-544.
-
Won B, Mambetsariev I, Salgia R. Post-crizotinib management of effective ceritinib therapy in a patient with ALK-positive non-small cell lung cancer. BMC Cancer. 2016 08 02; 16:568.
-
Berthoud VM, Minogue PJ, Lambert PA, Snabb JI, Beyer EC. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem. 2016 08 19; 291(34):17569-78.
-
Leisegang M, Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H. Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation. Clin Cancer Res. 2016 06 01; 22(11):2734-43.
-
Hussien Y, Cavener DR, Popko B. Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination. Glia. 2014 May; 62(5):680-91.
-
Lin W, Lin Y, Li J, Fenstermaker AG, Way SW, Clayton B, Jamison S, Harding HP, Ron D, Popko B. Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis. J Neurosci. 2013 Apr 03; 33(14):5980-91.
-
Sciortino MT, Parisi T, Siracusano G, Mastino A, Taddeo B, Roizman B. The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1. J Virol. 2013 Mar; 87(6):3271-6.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|