 CD40 Ligand
"CD40 Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
| Descriptor ID |
D023201
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| MeSH Number(s) |
D12.644.276.374.750.124 D12.644.276.972.124 D12.776.395.550.185 D12.776.467.374.750.124 D12.776.467.972.124 D12.776.543.550.198 D23.050.301.264.035.278 D23.101.100.110.278 D23.529.374.750.124 D23.529.972.124
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| Concept/Terms |
CD40 Ligand- CD40 Ligand
- Antigens, CD154
- CD154 Antigen
- Tumor Necrosis Factor Ligand Superfamily Member 5
- CD40L
- gp39 Antigen, T-Cell
- T-Cell gp39 Antigen
- gp39 Antigen, T Cell
- T-B Cell Activating Molecule
- TNF Superfamily, Member 5
- Antigen, CD154
- CD154 Antigens
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Below are MeSH descriptors whose meaning is more general than "CD40 Ligand".
Below are MeSH descriptors whose meaning is more specific than "CD40 Ligand".
This graph shows the total number of publications written about "CD40 Ligand" by people in this website by year, and whether "CD40 Ligand" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 4 | 4 | | 2000 | 1 | 0 | 1 | | 2001 | 2 | 3 | 5 | | 2002 | 4 | 1 | 5 | | 2003 | 2 | 3 | 5 | | 2004 | 1 | 1 | 2 | | 2006 | 1 | 3 | 4 | | 2007 | 0 | 3 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 2 | 1 | 3 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 2 | 1 | 3 | | 2017 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "CD40 Ligand" by people in Profiles.
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Pototskiy E, Vinokuroff K, Ojeda A, Major CK, Sharma D, Anderson T, Howard K, Borenstein R, Musto AE. Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. Sci Rep. 2021 08 26; 11(1):17262.
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Zuniga MC, Raghuraman G, Hitchner E, Weyand C, Robinson W, Zhou W. PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages. Atherosclerosis. 2017 04; 259:51-59.
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Tsuji T, Sabbatini P, Jungbluth AA, Ritter E, Pan L, Ritter G, Ferran L, Spriggs D, Salazar AM, Gnjatic S. Effect of Montanide and poly-ICLC adjuvant on human self/tumor antigen-specific CD4+ T cells in phase I overlapping long peptide vaccine trial. Cancer Immunol Res. 2013 Nov; 1(5):340-50.
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Chen J, Yin H, Xu J, Wang Q, Edelblum KL, Sciammas R, Chong AS. Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig. Am J Transplant. 2013 Sep; 13(9):2280-92.
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Krill KT, Csencsits-Smith K, Wood SC, Faust S, Lu G, Bishop DK. Glucocorticoid-induced TNFR-related protein stimulation reverses cardiac allograft acceptance induced by CD40-CD40L blockade. Clin Dev Immunol. 2013; 2013:986859.
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Kishi Y, Higuchi T, Phoon S, Sakamaki Y, Kamiya K, Riemekasten G, Akiyoshi K, Weigert MG, Tsubata T. Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7811-6.
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Ahmed EB, Wang T, Daniels M, Alegre ML, Chong AS. IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice. Am J Transplant. 2011 May; 11(5):936-46.
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Burns AM, Chong AS. Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming. J Immunol. 2011 Jan 01; 186(1):214-21.
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Wang L, Xiang Z, Ma LL, Chen Z, Gao X, Sun Z, Williams P, Chari RS, Yin DP. Deficiency of protein kinase C-theta facilitates tolerance induction. Transplantation. 2009 Feb 27; 87(4):507-16.
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Burns AM, Ma L, Li Y, Yin D, Shen J, Xu J, Chong AS. Memory alloreactive B cells and alloantibodies prevent anti-CD154-mediated allograft acceptance. J Immunol. 2009 Feb 01; 182(3):1314-24.
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