3',5'-Cyclic-AMP Phosphodiesterases

"3',5'-Cyclic-AMP Phosphodiesterases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.

Descriptor ID	D015105
MeSH Number(s)	D08.811.277.352.640.150 D12.644.360.008 D12.776.476.008
Concept/Terms	3',5'-Cyclic-AMP Phosphodiesterases 3',5'-Cyclic-AMP Phosphodiesterases 3',5' Cyclic AMP Phosphodiesterases Phosphodiesterases, 3',5'-Cyclic-AMP 3',5'-Cyclic AMP 5'-Nucleotidohydrolase 3',5' Cyclic AMP 5' Nucleotidohydrolase 5'-Nucleotidohydrolase, 3',5'-Cyclic AMP AMP 5'-Nucleotidohydrolase, 3',5'-Cyclic 3',5' Cyclic AMP Phosphodiesterase 3',5'-Cyclic AMP Phosphodiesterase AMP Phosphodiesterase, 3',5'-Cyclic Phosphodiesterase, 3',5'-Cyclic AMP 3,5-Cyclic AMP Phosphodiesterase 3,5 Cyclic AMP Phosphodiesterase AMP Phosphodiesterase, 3,5-Cyclic Phosphodiesterase, 3,5-Cyclic AMP 3',5'-Cyclic Nucleotide Phosphodiesterase 3',5' Cyclic Nucleotide Phosphodiesterase Nucleotide Phosphodiesterase, 3',5'-Cyclic Phosphodiesterase, 3',5'-Cyclic Nucleotide 3',5'-Cyclic-Nucleotide Phosphodiesterase Phosphodiesterase, 3',5'-Cyclic-Nucleotide 3',5'-Nucleotide Phosphodiesterase 3',5' Nucleotide Phosphodiesterase Phosphodiesterase, 3',5'-Nucleotide CAMP Phosphodiesterase Phosphodiesterase, CAMP 3,5-Cyclic AMP 5-Nucleotidohydrolase 3,5 Cyclic AMP 5 Nucleotidohydrolase 5-Nucleotidohydrolase, 3,5-Cyclic AMP AMP 5-Nucleotidohydrolase, 3,5-Cyclic 3',5'-Cyclic-AMP Phosphodiesterase Phosphodiesterase, 3',5'-Cyclic-AMP

Below are MeSH descriptors whose meaning is more general than "3',5'-Cyclic-AMP Phosphodiesterases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Diester Hydrolases [D08.811.277.352.640]
3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]

Below are MeSH descriptors whose meaning is related to "3',5'-Cyclic-AMP Phosphodiesterases".

Below are MeSH descriptors whose meaning is more specific than "3',5'-Cyclic-AMP Phosphodiesterases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "3',5'-Cyclic-AMP Phosphodiesterases" by people in this website by year, and whether "3',5'-Cyclic-AMP Phosphodiesterases" was a major or minor topic of these publications.

Bar chart showing 8 publications over 5 distinct years, with a maximum of 4 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	1	0	1
2004	1	0	1
2006	2	2	4
2007	1	0	1

Below are the most recent publications written about "3',5'-Cyclic-AMP Phosphodiesterases" by people in Profiles.

Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures. Brain Res. 2007 May 29; 1149:58-68.

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A randomized, placebo-controlled, phase II study of tetomilast in active ulcerative colitis. Gastroenterology. 2007 Jan; 132(1):76-86.

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Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils. Eur Respir J. 2006 Nov; 28(5):920-8.

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Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline. Exp Anim. 2006 Apr; 55(2):143-6.

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Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4. Chest. 2006 Jan; 129(1):56-66.

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Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res. 2005 Feb 15; 303(2):388-99.

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Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils. Pulm Pharmacol Ther. 2004; 17(2):73-9.

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Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. J Allergy Clin Immunol. 2003 Aug; 112(2):404-10.

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Molecular markers that identify human astrocytomas and oligodendrogliomas. J Neuropathol Exp Neurol. 2002 Apr; 61(4):329-38.

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[The effect of milrinone administrated before weaning from cardiopulmonary bypass in adult cardiac surgery]. Kyobu Geka. 2000 Nov; 53(12):1019-23.

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