"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
| Descriptor ID |
D056926
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.049 D12.644.128.100 D12.776.189.200 D12.776.260.103.562 D12.776.930.125.562
|
| Concept/Terms |
CLOCK Proteins- CLOCK Proteins
- Circadian Locomotor Output Cycles Kaput Proteins
- CLOCK Protein
|
Below are MeSH descriptors whose meaning is more general than "CLOCK Proteins".
Below are MeSH descriptors whose meaning is more specific than "CLOCK Proteins".
This graph shows the total number of publications written about "CLOCK Proteins" by people in this website by year, and whether "CLOCK Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "CLOCK Proteins" by people in Profiles.
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Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex. Nat Commun. 2023 09 22; 14(1):5907.
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Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022 06 03; 10(6):770-784.
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Circadian regulation of apolipoprotein gene expression affects testosterone production in mouse testis. Theriogenology. 2021 Oct 15; 174:9-19.
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A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. Genes Dev. 2020 08 01; 34(15-16):1089-1105.
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An evolutionary hotspot defines functional differences between CRYPTOCHROMES. Nat Commun. 2018 03 19; 9(1):1138.
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Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EBioMedicine. 2016 Nov; 13:262-273.
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Peripheral circadian misalignment: contributor to systemic insulin resistance and potential intervention to improve bariatric surgical outcomes. Am J Physiol Regul Integr Comp Physiol. 2016 09 01; 311(3):R558-63.
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Pancreatic ß cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science. 2015 Nov 06; 350(6261):aac4250.
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Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem. 2014 Feb 21; 289(8):5013-24.
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The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22. J Virol. 2011 Sep; 85(18):9472-7.