"Werner Syndrome Helicase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
|Werner Syndrome Helicase
- Werner Syndrome Helicase
- Helicase, Werner Syndrome
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome ATP Dependent Helicase
- RECQL2 Protein
- Werner Syndrome RecQ-Like Helicase
- Werner Syndrome RecQ Like Helicase
- RECQ3 Protein
Below are MeSH descriptors whose meaning is more general than "Werner Syndrome Helicase".
Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome Helicase".
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Below are the most recent publications written about "Werner Syndrome Helicase" by people in Profiles.
The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds. Cancer Chemother Pharmacol. 2009 Apr; 63(5):881-7.