"Syk Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.
- Syk Kinase
- Kinase, Syk
- SYK Tyrosine Kinase
- Kinase, SYK Tyrosine
- Tyrosine Kinase, SYK
- Spleen Tyrosine Kinase
- Kinase, Spleen Tyrosine
- Tyrosine Kinase, Spleen
Below are MeSH descriptors whose meaning is more general than "Syk Kinase".
Below are MeSH descriptors whose meaning is more specific than "Syk Kinase".
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Below are the most recent publications written about "Syk Kinase" by people in Profiles.
Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies. Clin Cancer Res. 2019 02 15; 25(4):1174-1184.
Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 2014 Dec 01; 210(11):1844-54.
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol. 2007 Sep; 124(3):244-57.
Tyrosine kinase inhibition affects skate anion exchanger isoform I alterations after volume expansion. Am J Physiol Regul Integr Comp Physiol. 2005 Apr; 288(4):R885-90.
The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol. 2002 Apr; 22(8):2524-35.
Volume-activated trimethylamine oxide efflux in red blood cells of spiny dogfish (Squalus acanthias). Am J Physiol Regul Integr Comp Physiol. 2001 Sep; 281(3):R803-10.
Inhibition of volume-stimulated taurine efflux and tyrosine kinase activity in the skate red blood cell. Pflugers Arch. 2000 May; 440(1):132-9.
Volume expansion stimulates p72(syk) and p56(lyn) in skate erythrocytes. J Biol Chem. 1999 Mar 19; 274(12):7923-8.
BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. J Immunol. 1998 Dec 01; 161(11):5804-8.
syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes. EMBO J. 1998 Aug 17; 17(16):4606-16.