"Mad2 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
- Mad2 Proteins
- Mad2 Mitotic Arrest Deficient-like 1 Proteins
Below are MeSH descriptors whose meaning is more general than "Mad2 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Mad2 Proteins".
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Below are the most recent publications written about "Mad2 Proteins" by people in Profiles.
Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):11252-7.
The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint. J Cell Biol. 2008 Oct 20; 183(2):267-77.