Loading...
The University of Chicago Header Logo
Keywords
Last Name
Institution

Marcus Ramsay Clark

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR. CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis. Nat Immunol. 2019 Oct; 20(10):1393-1403. PMID: 31477919.
      View in: PubMed
    2. Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Quantifying in situ adaptive immune cell cognate interactions in humans. Nat Immunol. 2019 04; 20(4):503-513. PMID: 30778242.
      View in: PubMed
    3. Karki S, Banerjee S, Mclean K, Dinner A, Clark MR. Transcription factories in Ig? allelic choice and diversity. Adv Immunol. 2019; 141:33-49. PMID: 30904132.
      View in: PubMed
    4. Mandal M, Maienschein-Cline M, Maffucci P, Veselits M, Kennedy DE, McLean KC, Okoreeh MK, Karki S, Cunningham-Rundles C, Clark MR. BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Nat Commun. 2018 09 24; 9(1):3888. PMID: 30250168.
      View in: PubMed
    5. Kennedy DE, Clark MR. PI3Kd: Too much of a good thing. Nat Immunol. 2018 09; 19(9):910-911. PMID: 30127436.
      View in: PubMed
    6. Karki S, Kennedy DE, Mclean K, Grzybowski AT, Maienschein-Cline M, Banerjee S, Xu H, Davis E, Mandal M, Labno C, Powers SE, Le Beau MM, Dinner AR, Singh H, Ruthenburg AJ, Clark MR. Regulated Capture of V? Gene Topologically Associating Domains by Transcription Factories. Cell Rep. 2018 08 28; 24(9):2443-2456. PMID: 30157436.
      View in: PubMed
    7. Kinloch AJ, Kaiser Y, Wolfgeher D, Ai J, Eklund A, Clark MR, Grunewald J. In Situ Humoral Immunity to Vimentin in HLA-DRB1*03+ Patients With Pulmonary Sarcoidosis. Front Immunol. 2018; 9:1516. PMID: 30038611.
      View in: PubMed
    8. Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill SK, Wilson P, Sciammas R, Clark MR. Igß ubiquitination activates PI3K signals required for endosomal sorting. J Exp Med. 2017 Dec 04; 214(12):3775-3790. PMID: 29141870.
      View in: PubMed
    9. Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL. EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. J Immunol. 2017 06 15; 198(12):4682-4691. PMID: 28490575.
      View in: PubMed
    10. Ko K, Wang J, Perper S, Jiang Y, Yanez D, Kaverina N, Ai J, Liarski VM, Chang A, Peng Y, Lan L, Westmoreland S, Olson L, Giger ML, Chun Wang L, Clark MR. Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation. Arthritis Rheumatol. 2016 11; 68(11):2740-2751. PMID: 27159593.
      View in: PubMed
    11. Trotter K, Clark MR, Liarski VM. Overview of pathophysiology and treatment of human lupus nephritis. Curr Opin Rheumatol. 2016 09; 28(5):460-7. PMID: 27341623.
      View in: PubMed
    12. Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA. Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Nat Immunol. 2016 Feb; 17(2):196-203. PMID: 26692173.
      View in: PubMed
    13. Clark MR, Trotter K, Chang A. The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus Nephritis. Semin Nephrol. 2015 Sep; 35(5):455-64. PMID: 26573548.
      View in: PubMed
    14. Mandal M, Hamel KM, Maienschein-Cline M, Tanaka A, Teng G, Tuteja JH, Bunker JJ, Bahroos N, Eppig JJ, Schatz DG, Clark MR. Histone reader BRWD1 targets and restricts recombination to the Igk locus. Nat Immunol. 2015 Oct; 16(10):1094-103. PMID: 26301565.
      View in: PubMed
    15. Teng G, Maman Y, Resch W, Kim M, Yamane A, Qian J, Kieffer-Kwon KR, Mandal M, Ji Y, Meffre E, Clark MR, Cowell LG, Casellas R, Schatz DG. RAG Represents a Widespread Threat to the Lymphocyte Genome. Cell. 2015 Aug 13; 162(4):751-65. PMID: 26234156.
      View in: PubMed
    16. Kinloch AJ, Chang A, Ko K, Henry Dunand CJ, Henderson S, Maienschein-Cline M, Kaverina N, Rovin BH, Salgado Ferrer M, Wolfgeher D, Liarski V, Haddon DJ, Utz PJ, Wilson PC, Clark MR. Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis. Arthritis Rheumatol. 2014 Dec; 66(12):3359-70. PMID: 25306868.
      View in: PubMed
    17. Shi C, Shenkar R, Kinloch A, Henderson SG, Shaaya M, Chong AS, Clark MR, Awad IA. Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations. J Neuroimmunol. 2014 Jul 15; 272(1-2):67-75. PMID: 24864012.
      View in: PubMed
    18. Chang A, Ko K, Clark MR. The emerging role of the inflammasome in kidney diseases. Curr Opin Nephrol Hypertens. 2014 May; 23(3):204-10. PMID: 24685591.
      View in: PubMed
    19. Liarski VM, Kaverina N, Chang A, Brandt D, Yanez D, Talasnik L, Carlesso G, Herbst R, Utset TO, Labno C, Peng Y, Jiang Y, Giger ML, Clark MR. Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue. Sci Transl Med. 2014 Apr 02; 6(230):230ra46. PMID: 24695686.
      View in: PubMed
    20. Hamel KM, Mandal M, Karki S, Clark MR. Balancing Proliferation with Ig? Recombination during B-lymphopoiesis. Front Immunol. 2014; 5:139. PMID: 24765092.
      View in: PubMed
    21. Veselits M, Tanaka A, Lipkowitz S, O'Neill S, Sciammas R, Finnegan A, Zhang J, Clark MR. Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes. PLoS One. 2014; 9(3):e89792. PMID: 24651487.
      View in: PubMed
    22. Clark MR, Mandal M, Ochiai K, Singh H. Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling. Nat Rev Immunol. 2014 Feb; 14(2):69-80. PMID: 24378843.
      View in: PubMed
    23. Powers SE, Mandal M, Matsuda S, Miletic AV, Cato MH, Tanaka A, Rickert RC, Koyasu S, Clark MR. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J Exp Med. 2012 Nov 19; 209(12):2199-213. PMID: 23109711.
      View in: PubMed
    24. Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M, Soulier J, Chen-Kiang S, Aifantis I. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Cancer Cell. 2012 Oct 16; 22(4):452-65. PMID: 23079656.
      View in: PubMed
    25. Hamel KM, Liarski VM, Clark MR. Germinal center B-cells. Autoimmunity. 2012 Aug; 45(5):333-47. PMID: 22390182.
      View in: PubMed
    26. Ochiai K, Maienschein-Cline M, Mandal M, Triggs JR, Bertolino E, Sciammas R, Dinner AR, Clark MR, Singh H. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol. 2012 Jan 22; 13(3):300-7. PMID: 22267219.
      View in: PubMed
    27. Mandal M, Powers SE, Maienschein-Cline M, Bartom ET, Hamel KM, Kee BL, Dinner AR, Clark MR. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat Immunol. 2011 Oct 30; 12(12):1212-20. PMID: 22037603.
      View in: PubMed
    28. Hsieh C, Chang A, Brandt D, Guttikonda R, Utset TO, Clark MR. Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring. Arthritis Care Res (Hoboken). 2011 Jun; 63(6):865-74. PMID: 21309006.
      View in: PubMed
    29. Clark MR. Flippin' lipids. Nat Immunol. 2011 May; 12(5):373-5. PMID: 21502987.
      View in: PubMed
    30. Chang A, Henderson SG, Brandt D, Liu N, Guttikonda R, Hsieh C, Kaverina N, Utset TO, Meehan SM, Quigg RJ, Meffre E, Clark MR. In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis. J Immunol. 2011 Feb 01; 186(3):1849-60. PMID: 21187439.
      View in: PubMed
    31. Clark MR, Tanaka A, Powers SE, Veselits M. Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy. Mol Immunol. 2011 Jun; 48(11):1281-6. PMID: 21144589.
      View in: PubMed
    32. Ma S, Pathak S, Mandal M, Trinh L, Clark MR, Lu R. Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression. Mol Cell Biol. 2010 Sep; 30(17):4149-58. PMID: 20566697.
      View in: PubMed
    33. Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nat Immunol. 2009 Oct; 10(10):1110-7. PMID: 19734904.
      View in: PubMed
    34. O'Neill SK, Veselits ML, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre ML, Cambier JC, Clark MR. Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6262-7. PMID: 19332776.
      View in: PubMed
    35. Mandal M, Crusio KM, Meng F, Liu S, Kinsella M, Clark MR, Takeuchi O, Aifantis I. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20840-5. PMID: 19088189.
      View in: PubMed
    36. Zhang M, Veselits M, O'Neill S, Hou P, Reddi AL, Berlin I, Ikeda M, Nash PD, Longnecker R, Band H, Clark MR. Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. J Immunol. 2007 Oct 01; 179(7):4435-43. PMID: 17878339.
      View in: PubMed
    37. Hou P, Araujo E, Zhao T, Zhang M, Massenburg D, Veselits M, Doyle C, Dinner AR, Clark MR. B cell antigen receptor signaling and internalization are mutually exclusive events. PLoS Biol. 2006 Jul; 4(7):e200. PMID: 16719564.
      View in: PubMed
    38. Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK. HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity. 2006 Jun; 24(6):741-52. PMID: 16782030.
      View in: PubMed
    39. Cooper AB, Sawai CM, Sicinska E, Powers SE, Sicinski P, Clark MR, Aifantis I. A unique function for cyclin D3 in early B cell development. Nat Immunol. 2006 May; 7(5):489-97. PMID: 16582912.
      View in: PubMed
    40. Garrett-Sinha LA, Hou P, Wang D, Grabiner B, Araujo E, Rao S, Yun TJ, Clark EA, Simon MC, Clark MR. Spi-1 and Spi-B control the expression of the Grap2 gene in B cells. Gene. 2005 Jun 20; 353(1):134-46. PMID: 15936902.
      View in: PubMed
    41. Clark MR, Cooper AB, Wang LD, Aifantis I. The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms. Curr Top Microbiol Immunol. 2005; 290:87-103. PMID: 16480040.
      View in: PubMed
    42. Kabak S, Clark MR. Membrane-targeted peptides derived from Igalpha attenuate B-cell antigen receptor function. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1249-55. PMID: 15504349.
      View in: PubMed
    43. Clark MR, Massenburg D, Siemasko K, Hou P, Zhang M. B-cell antigen receptor signaling requirements for targeting antigen to the MHC class II presentation pathway. Curr Opin Immunol. 2004 Jun; 16(3):382-7. PMID: 15134789.
      View in: PubMed
    44. Wang LD, Lopes J, Cooper AB, Dang-Lawson M, Matsuuchi L, Clark MR. Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):1027-32. PMID: 14722356.
      View in: PubMed
    45. Wang LD, Clark MR. B-cell antigen-receptor signalling in lymphocyte development. Immunology. 2003 Dec; 110(4):411-20. PMID: 14632637.
      View in: PubMed
    46. Clark MR, Massenburg D, Zhang M, Siemasko K. Molecular mechanisms of B cell antigen receptor trafficking. Ann N Y Acad Sci. 2003 Apr; 987:26-37. PMID: 12727621.
      View in: PubMed
    47. Li C, Siemasko K, Clark MR, Song W. Cooperative interaction of Ig(alpha) and Ig(beta) of the BCR regulates the kinetics and specificity of antigen targeting. Int Immunol. 2002 Oct; 14(10):1179-91. PMID: 12356683.
      View in: PubMed
    48. Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. J Rheumatol. 2002 Sep; 29(9):1907-13. PMID: 12233885.
      View in: PubMed
    49. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, Foster MS, Siemasko K, Chan AC, Aebersold R, Clark MR. The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol. 2002 Apr; 22(8):2524-35. PMID: 11909947.
      View in: PubMed
    50. Siemasko K, Skaggs BJ, Kabak S, Williamson E, Brown BK, Song W, Clark MR. Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. J Immunol. 2002 Mar 01; 168(5):2127-38. PMID: 11859098.
      View in: PubMed
    51. Sun T, Clark MR, Storb U. A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity. 2002 Feb; 16(2):245-55. PMID: 11869685.
      View in: PubMed
    52. Siemasko K, Clark MR. The control and facilitation of MHC class II antigen processing by the BCR. Curr Opin Immunol. 2001 Feb; 13(1):32-6. PMID: 11154914.
      View in: PubMed
    53. Wang LD, Clark MR. Igalpha: B all that you can B. J Clin Invest. 1999 Oct; 104(8):1011-2. PMID: 10525036.
      View in: PubMed
    54. Siemasko K, Eisfelder BJ, Stebbins C, Kabak S, Sant AJ, Song W, Clark MR. Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation. J Immunol. 1999 Jun 01; 162(11):6518-25. PMID: 10352267.
      View in: PubMed
    55. Garrett-Sinha LA, Su GH, Rao S, Kabak S, Hao Z, Clark MR, Simon MC. PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity. 1999 Apr; 10(4):399-408. PMID: 10229183.
      View in: PubMed
    56. Siemasko K, Eisfelder BJ, Williamson E, Kabak S, Clark MR. Cutting edge: signals from the B lymphocyte antigen receptor regulate MHC class II containing late endosomes. J Immunol. 1998 Jun 01; 160(11):5203-8. PMID: 9605114.
      View in: PubMed
    57. Tseng J, Eisfelder BJ, Clark MR. B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta. Blood. 1997 Mar 01; 89(5):1513-20. PMID: 9057631.
      View in: PubMed
    58. Alegre ML, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, Thompson CB. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol. 1996 Dec 01; 157(11):4762-70. PMID: 8943377.
      View in: PubMed
    59. Lee YJ, Luisiri P, Clark MR. A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation. J Immunol. 1996 Nov 01; 157(9):3828-37. PMID: 8892612.
      View in: PubMed
    60. Luisiri P, Lee YJ, Eisfelder BJ, Clark MR. Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex. J Biol Chem. 1996 Mar 01; 271(9):5158-63. PMID: 8617796.
      View in: PubMed
    61. Tseng J, Lee YJ, Eisfelder BJ, Clark MR. The B cell antigen receptor complex: mechanisms and implications of tyrosine kinase activation. Immunol Res. 1994; 13(4):299-310. PMID: 7542303.
      View in: PubMed
    Clark's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _