Tumor Suppressor p53-Binding Protein 1
"Tumor Suppressor p53-Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.
| Descriptor ID |
D000071857
|
| MeSH Number(s) |
D12.776.260.805 D12.776.660.235.850 D12.776.664.235.950
|
| Concept/Terms |
Tumor Suppressor p53-Binding Protein 1- Tumor Suppressor p53-Binding Protein 1
- Tumor Suppressor p53 Binding Protein 1
- TP53BP1 Protein
- p202 Protein
- Tumor Protein p53-Binding Protein, 1
- Tumor Protein p53 Binding Protein, 1
- 53BP1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor p53-Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor p53-Binding Protein 1".
This graph shows the total number of publications written about "Tumor Suppressor p53-Binding Protein 1" by people in this website by year, and whether "Tumor Suppressor p53-Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tumor Suppressor p53-Binding Protein 1" by people in Profiles.
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Chromatin compartmentalization regulates the response to DNA damage. Nature. 2023 Nov; 623(7985):183-192.
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DNA Double-strand Break Signaling Is a Therapeutic Target in Head and Neck Cancer. Anticancer Res. 2021 Nov; 41(11):5393-5403.
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The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic Acids Res. 2019 04 08; 47(6):2703-2715.
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ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response. Nucleic Acids Res. 2019 01 25; 47(2):824-842.
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Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell. 2018 10 18; 72(2):250-262.e6.
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Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10028-10033.
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53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination. J Immunol. 2017 03 15; 198(6):2434-2444.
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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 2013 Jul 04; 499(7456):50-4.
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Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res. 2010 Aug 01; 70(15):6277-82.
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53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis. Genes Cells. 2006 Aug; 11(8):935-48.