E2F Transcription Factors
"E2F Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
| Descriptor ID |
D050684
|
| MeSH Number(s) |
D12.776.930.211
|
| Concept/Terms |
E2F Transcription Factors- E2F Transcription Factors
- Transcription Factors, E2F
- E2F Proteins
- Transcription Factor E2F
- E2F, Transcription Factor
|
Below are MeSH descriptors whose meaning is more general than "E2F Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "E2F Transcription Factors".
This graph shows the total number of publications written about "E2F Transcription Factors" by people in this website by year, and whether "E2F Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "E2F Transcription Factors" by people in Profiles.
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Rb family-independent activating E2F increases genome stability, promotes homologous recombination, and decreases non-homologous end joining. Mech Dev. 2020 06; 162:103607.
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An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64.
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RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo. Mol Biol Cell. 2011 Apr; 22(7):931-9.
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Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol. 2009 Feb 15; 326(2):347-56.
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BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007 Sep; 27(17):6229-42.
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Cell cycle regulation. Fly (Austin). 2007 Mar-Apr; 1(2):125-31.
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ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene. 2004 Oct 07; 23(46):7601-10.
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Endocycle and E2F-dependent transcriptional activation and repression. Cell Cycle. 2003 Nov-Dec; 2(6):515-6.
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Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 2003 Aug 01; 22(15):3865-75.
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DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol. 2001 Mar; 3(3):289-95.