"Receptors, Notch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
| Descriptor ID |
D051880
|
| MeSH Number(s) |
D12.776.543.750.725 D12.776.930.770
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Notch".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Notch".
This graph shows the total number of publications written about "Receptors, Notch" by people in this website by year, and whether "Receptors, Notch" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 5 | 5 |
| 2006 | 2 | 2 | 4 |
| 2007 | 2 | 2 | 4 |
| 2008 | 5 | 2 | 7 |
| 2009 | 0 | 5 | 5 |
| 2010 | 3 | 1 | 4 |
| 2011 | 2 | 2 | 4 |
| 2012 | 3 | 3 | 6 |
| 2013 | 1 | 2 | 3 |
| 2014 | 3 | 5 | 8 |
| 2015 | 4 | 3 | 7 |
| 2016 | 2 | 5 | 7 |
| 2017 | 2 | 1 | 3 |
| 2018 | 5 | 1 | 6 |
| 2019 | 2 | 2 | 4 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Notch" by people in Profiles.
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The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling. J Cell Biol. 2025 Jun 02; 224(6).
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A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/ß-catenin signaling pathways. J Am Acad Dermatol. 2025 Apr; 92(4):761-772.
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Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa. HGG Adv. 2023 04 13; 4(2):100187.
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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis. 2022 08 05; 13(8):678.
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Noncanonical Notch signals have opposing roles during cardiac development. Biochem Biophys Res Commun. 2021 11 05; 577:12-16.
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IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Commun Biol. 2021 03 05; 4(1):290.
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Chamber-specific transcriptional responses in atrial fibrillation. JCI Insight. 2020 09 17; 5(18).
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lncRNA Rmst acts as an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by antagonizing Notch-targeting microRNAs. Aging (Albany NY). 2019 12 11; 11(24):12476-12496.
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Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma. J Clin Invest. 2019 10 01; 129(10):4276-4289.
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Notch signaling in breast cancer: From pathway analysis to therapy. Cancer Lett. 2019 10 01; 461:123-131.