"RNA-Binding Protein FUS" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
| Descriptor ID |
D034702
|
| MeSH Number(s) |
D12.776.157.725.813.750.905 D12.776.624.664.700.915 D12.776.664.962.813.750.902
|
| Concept/Terms |
RNA-Binding Protein FUS- RNA-Binding Protein FUS
- RNA Binding Protein FUS
- TLS Protein
- POMp75 Protein
- Translocated in Liposarcoma Protein
- FUS RNA-Binding Protein
- FUS RNA Binding Protein
- RNA-Binding Protein, FUS
- Fusion Protein in Myxoid Liposarcoma
- FUS Protein
- hnRNP P2
|
Below are MeSH descriptors whose meaning is more general than "RNA-Binding Protein FUS".
Below are MeSH descriptors whose meaning is more specific than "RNA-Binding Protein FUS".
This graph shows the total number of publications written about "RNA-Binding Protein FUS" by people in this website by year, and whether "RNA-Binding Protein FUS" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA-Binding Protein FUS" by people in Profiles.
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Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN. Neurobiol Dis. 2021 07; 155:105364.
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Tuning shape and internal structure of protein droplets via biopolymer filaments. Soft Matter. 2020 Jun 24; 16(24):5659-5668.
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RNA-binding protein altered expression and mislocalization in MS. Neurol Neuroimmunol Neuroinflamm. 2020 05; 7(3).
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Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat Struct Mol Biol. 2018 04; 25(4):341-346.
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Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility. Cell Rep. 2018 02 06; 22(6):1473-1483.
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TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017 Aug 16; 95(4):808-816.e9.
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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. Cell. 2015 Aug 27; 162(5):1066-77.
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Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat Genet. 1993 Jun; 4(2):175-80.