"Wnt-5a Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Wnt protein and ligand for FRIZZLED RECEPTORS that may function as an inhibitor or activator of the WNT SIGNALING PATHWAY. For example, it activates signaling in the presence of Frizzled-4 but is inhibitory when coupled with ROR2 TYROSINE KINASE. It is required for axis formation during EMBRYOGENESIS and inhibits the proliferation, migration, and invasiveness of cancer cells.
| Descriptor ID |
D000071818
|
| MeSH Number(s) |
D12.776.467.984.050 D12.776.624.664.700.962 D23.529.984.050
|
| Concept/Terms |
Wnt-5a Protein- Wnt-5a Protein
- Wnt 5a Protein
- Wingless-Type MMTV Integration Site Family, Member 5A
- Wingless Type MMTV Integration Site Family, Member 5A
- Wnt5a Protein
|
Below are MeSH descriptors whose meaning is more general than "Wnt-5a Protein".
Below are MeSH descriptors whose meaning is more specific than "Wnt-5a Protein".
This graph shows the total number of publications written about "Wnt-5a Protein" by people in this website by year, and whether "Wnt-5a Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Wnt-5a Protein" by people in Profiles.
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Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries. Circ Res. 2022 01 21; 130(2):166-180.
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NOTCH maintains developmental cardiac gene network through WNT5A. J Mol Cell Cardiol. 2018 12; 125:98-105.
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Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior. Elife. 2018 04 12; 7.
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Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Sci Rep. 2016 08 26; 6:32094.
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Effects of Wnt5a Haploinsufficiency on Bone Repair. J Orthop Trauma. 2014 Aug; 28(8):e191-7.
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Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer. Cancer Cell. 2014 Feb 10; 25(2):210-25.
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WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action. Pigment Cell Res. 2005 Jun; 18(3):167-80.
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The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development. 1998 Jun; 125(12):2315-25.