"Paxillin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.
| Descriptor ID |
D051419
|
| MeSH Number(s) |
D12.644.360.024.316 D12.776.157.057.092 D12.776.476.024.397 D12.776.512.374 D12.776.744.665
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Paxillin".
Below are MeSH descriptors whose meaning is more specific than "Paxillin".
This graph shows the total number of publications written about "Paxillin" by people in this website by year, and whether "Paxillin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 2 | 1 | 3 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Paxillin" by people in Profiles.
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Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss. Sci Rep. 2021 09 02; 11(1):17546.
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Novel insights into how autophagy regulates tumor cell motility. Autophagy. 2016 09; 12(9):1679-80.
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FAK and paxillin, two potential targets in pancreatic cancer. Oncotarget. 2016 May 24; 7(21):31586-601.
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Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3. Cell Rep. 2016 05 24; 15(8):1660-72.
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Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin. J Mol Biol. 2015 Jul 31; 427(15):2532-2547.
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c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1025-38.
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Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB J. 2014 Jul; 28(7):3249-60.
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Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer. Cancer Biol Ther. 2013 Jul; 14(7):679-91.
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Identification of paxillin domains interacting with ß-catenin. FEBS Lett. 2012 Jul 30; 586(16):2294-9.
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Spatiotemporal constraints on the force-dependent growth of focal adhesions. Biophys J. 2011 Jun 22; 100(12):2883-93.