 Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
| Descriptor ID |
D019860
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| MeSH Number(s) |
D08.811.913.696.620.682.725.800.315 D12.776.624.664.700.128
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| Concept/Terms |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- p56 lck
- Proto-Oncogene Protein c-lck
- Protein c-lck, Proto-Oncogene
- Proto Oncogene Protein c lck
- c-lck, Proto-Oncogene Protein
- Proto-Oncogene Protein lck
- Protein lck, Proto-Oncogene
- Proto Oncogene Protein lck
- lck, Proto-Oncogene Protein
- lck Kinase
- Kinase, lck
- Protein Tyrosine Kinase p56(lck)
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
This graph shows the total number of publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in this website by year, and whether "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1990 | 0 | 1 | 1 | | 1991 | 0 | 3 | 3 | | 1993 | 0 | 3 | 3 | | 1994 | 0 | 4 | 4 | | 1995 | 0 | 2 | 2 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 2 | 3 | | 2003 | 1 | 2 | 3 | | 2004 | 3 | 0 | 3 | | 2006 | 0 | 1 | 1 | | 2010 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Profiles.
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Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife. 2016 10 04; 5.
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Sinha RK, Bojjireddy N, Kanojia D, Subrahmanyam G. Type II PtdIns 4-kinase ß associates with CD4-p56lck complex and is involved in CD4 receptor signaling. Mol Cell Biochem. 2014 Oct; 395(1-2):231-9.
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Kemp KL, Levin SD, Stein PL. Lck regulates IL-10 expression in memory-like Th1 cells. Eur J Immunol. 2010 Nov; 40(11):3210-9.
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Kemp KL, Levin SD, Bryce PJ, Stein PL. Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol. 2010 Apr 15; 184(8):4178-84.
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Heck E, Friedrich U, Gack MU, Lengenfelder D, Schmidt M, Müller-Fleckenstein I, Fleckenstein B, Ensser A, Biesinger B. Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs. J Virol. 2006 Oct; 80(20):9934-42.
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Zimmer MI, Colmone A, Felio K, Xu H, Ma A, Wang CR. A cell-type specific CD1d expression program modulates invariant NKT cell development and function. J Immunol. 2006 Feb 01; 176(3):1421-30.
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Fuertes MB, Molinero LL, Toscano MA, Ilarregui JM, Rubinstein N, Fainboim L, Zwirner NW, Rabinovich GA. Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase. Mol Cell Biochem. 2004 Dec; 267(1-2):177-85.
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Li QJ, Dinner AR, Qi S, Irvine DJ, Huppa JB, Davis MM, Chakraborty AK. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol. 2004 Aug; 5(8):791-9.
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Yu XZ, Levin SD, Madrenas J, Anasetti C. Lck is required for activation-induced T cell death after TCR ligation with partial agonists. J Immunol. 2004 Feb 01; 172(3):1437-43.
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Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003 Dec; 4(6):451-61.
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