Proto-Oncogene Proteins c-bcr
"Proto-Oncogene Proteins c-bcr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
| Descriptor ID |
D051562
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| MeSH Number(s) |
D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.624.664.700.171
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| Concept/Terms |
Proto-Oncogene Proteins c-bcr- Proto-Oncogene Proteins c-bcr
- Proto Oncogene Proteins c bcr
- c-bcr, Proto-Oncogene Proteins
- Proto-Oncogene Protein c-bcr
- Proto Oncogene Protein c bcr
- c-bcr, Proto-Oncogene Protein
- Breakpoint Cluster Region Protein
- c-bcr Proteins
- c bcr Proteins
- c-bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, c-bcr
- c bcr Proto Oncogene Proteins
- bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, bcr
- bcr Proto Oncogene Proteins
- Proto-Oncogene Protein bcr
- Proto Oncogene Protein bcr
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-bcr".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-bcr".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-bcr" by people in this website by year, and whether "Proto-Oncogene Proteins c-bcr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-bcr" by people in Profiles.
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BCR-ABL1-like B-Lymphoblastic Leukemia/Lymphoma with FOXP1-ABL1 Rearrangement: Comprehensive Laboratory Identification Allowing Tyrosine Kinase Inhibitor Use. Lab Med. 2019 Oct 10; 50(4):401-405.
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Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy. Clin Cancer Res. 2015 Oct 01; 21(19):4337-46.
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Cytogenetic, fluorescence in situ hybridization, and genomic array characterization of chronic myeloid leukemia with cryptic BCR-ABL1 fusions. Cancer Genet. 2015 Jul-Aug; 208(7-8):396-403.
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Selection of individual VH genes occurs at the pro-B to pre-B cell transition. J Immunol. 2011 Aug 15; 187(4):1835-44.
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BimL upregulation induced by BCR cross-linking in BL41 Burkitt's lymphoma results from a splicing mechanism of the BimEL mRNA. Biochem Biophys Res Commun. 2009 May 22; 383(1):32-6.
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Thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced chronic myelogenous leukemia. Bone Marrow Transplant. 1999 May; 23(10):977-81.
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Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. Oncogene. 1998 May 07; 16(18):2333-43.
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Value of molecular monitoring during the treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol. 1997 Jan; 15(1):26-36.
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CGG-repeat polymorphism of the BCR gene rules out predisposing alleles leading to the Philadelphia chromosome. Genes Chromosomes Cancer. 1994 Feb; 9(2):141-4.