Loading...
The University of Chicago Header Logo
Keywords
Last Name
Institution

Eugene B. Chang

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Gastroenterology
AddressChicago IL 60637
Email
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome.

    For more information, visit my laboratory website: http://changlab.uchicago.edu/


    Collapse Biography 
    Collapse awards and honors
    2014Takeda Distinguished Scientist Award, Takeda, Inc.
    2013 - 2017National Diabetes and Digestive and Kidney Disease Advisory Council, National Institutes of Health
    2013AGA Outstanding Mentorship award, American Gastroenterological Association
    2013AGA Academy of Educators, American Gastroenterological Association
    2008 - 2018NIH Merit Award, National Institutes of Health

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Santa Mina D, Au D, Auger LE, Alibhai SMH, Matthew AG, Sabiston CM, Oh P, Ritvo PG, Chang EB, Jones JM. Development, implementation, and effects of a cancer center's exercise-oncology program. Cancer. 2019 Jun 17. PMID: 31206630.
      View in: PubMed
    2. Shan Y, Segre JA, Chang EB. Responsible stewardship for communicating microbiome research to the press and public. Nat Med. 2019 Jun; 25(6):872-874. PMID: 31133694.
      View in: PubMed
    3. Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 May 16; 25(Supplement_2):S5-S12. PMID: 31095706.
      View in: PubMed
    4. Pierre JF, Li Y, Gomes CK, Rao P, Chang EB, Yin DP. Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR). Obesity (Silver Spring). 2019 May; 27(5):803-812. PMID: 30933435.
      View in: PubMed
    5. Zhang YG, Zhu X, Lu R, Messer JS, Xia Y, Chang EB, Sun J. Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy. Autophagy. 2019 Mar 20; 1-19. PMID: 30894054.
      View in: PubMed
    6. Kim SY, Lee MS, Chang E, Jung S, Ko H, Lee E, Lee S, Kim CT, Kim IH, Kim Y. Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats. Nutrients. 2019 Mar 18; 11(3). PMID: 30889894.
      View in: PubMed
    7. Schwartz MH, Wang H, Pan JN, Clark WC, Cui S, Eckwahl MJ, Pan DW, Parisien M, Owens SM, Cheng BL, Martinez K, Xu J, Chang EB, Pan T, Eren AM. Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis. Nat Commun. 2018 12 17; 9(1):5353. PMID: 30559359.
      View in: PubMed
    8. Wun K, Theriault BR, Pierre JF, Chen EB, Leone VA, Harris KG, Xiong L, Jiang Q, Spedale M, Eskandari OM, Chang EB, Ho KJ. Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury. PLoS One. 2018; 13(12):e0208426. PMID: 30521585.
      View in: PubMed
    9. Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V. Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. Cell Rep. 2018 Nov 13; 25(7):1816-1828.e4. PMID: 30428350.
      View in: PubMed
    10. Harris KG, Chang EB. The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease. Clin Sci (Lond). 2018 Sep 28; 132(18):2013-2028. PMID: 30232239.
      View in: PubMed
    11. Mina DS, Langelier D, Adams SC, Alibhai SMH, Chasen M, Campbell KL, Oh P, Jones JM, Chang E. Exercise as part of routine cancer care. Lancet Oncol. 2018 09; 19(9):e433-e436. PMID: 30191843.
      View in: PubMed
    12. Chang EB, Martinez-Guryn K. Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption. Gut Microbes. 2019; 10(2):235-240. PMID: 30136893.
      View in: PubMed
    13. Klurfeld DM, Davis CD, Karp RW, Allen-Vercoe E, Chang EB, Chassaing B, Fahey GC, Hamaker BR, Holscher HD, Lampe JW, Marette A, Martens E, O'Keefe SJ, Rose DJ, Saarela M, Schneeman BO, Slavin JL, Sonnenburg JL, Swanson KS, Wu GD, Lynch CJ. Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome. Am J Physiol Endocrinol Metab. 2018 Dec 01; 315(6):E1087-E1097. PMID: 30130151.
      View in: PubMed
    14. Pierre JF, Hinterleitner R, Bouziat R, Hubert N, Leone V, Miyoshi J, Jabri B, Chang EB. Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts. Data Brief. 2018 Oct; 20:387-393. PMID: 30175203.
      View in: PubMed
    15. Miyoshi J, Leone V, Nobutani K, Musch MW, Martinez-Guryn K, Wang Y, Miyoshi S, Bobe AM, Eren AM, Chang EB. Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome. PeerJ. 2018; 6:e5166. PMID: 30013837.
      View in: PubMed
    16. Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584. PMID: 29769727.
      View in: PubMed
    17. Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB. Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids. Cell Host Microbe. 2018 04 11; 23(4):458-469.e5. PMID: 29649441.
      View in: PubMed
    18. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice. Clin Transl Oncol. 2018 03; 20(3):425. PMID: 29027650.
      View in: PubMed
    19. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H. Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther. 2018 05 02; 26(5):1375-1384. PMID: 29599080.
      View in: PubMed
    20. Miyoshi J, Nobutani K, Musch MW, Ringus DL, Hubert NA, Yamamoto M, Kase Y, Nishiyama M, Chang EB. Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100). Evid Based Complement Alternat Med. 2018; 2018:7415975. PMID: 29681983.
      View in: PubMed
    21. Cason CA, Dolan KT, Sharma G, Tao M, Kulkarni R, Helenowski IB, Doane BM, Avram MJ, McDermott MM, Chang EB, Ozaki CK, Ho KJ. Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes. J Vasc Surg. 2018 11; 68(5):1552-1562.e7. PMID: 29248242.
      View in: PubMed
    22. Pierre JF, Hinterleitner R, Bouziat R, Hubert NA, Leone V, Miyoshi J, Jabri B, Chang EB. Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility. J Nutr Biochem. 2018 04; 54:95-104. PMID: 29331497.
      View in: PubMed
    23. Rentea RM, Guo Y, Zhu X, Musch MW, Chang EB, Gourlay DM, Liedel JL. Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2. Pediatr Surg Int. 2018 Mar; 34(3):323-330. PMID: 29196880.
      View in: PubMed
    24. Maruvada P, Leone V, Kaplan LM, Chang EB. The Human Microbiome and Obesity: Moving beyond Associations. Cell Host Microbe. 2017 Nov 08; 22(5):589-599. PMID: 29120742.
      View in: PubMed
    25. Wang Y, Lin F, Zhu X, Leone VA, Dalal S, Tao Y, Messer JS, Chang EB. Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2018 02 01; 314(2):G164-G178. PMID: 29051186.
      View in: PubMed
    26. Guo Y, Chang E, Bozkurt M, Park M, Liu D, Fu JB. Factors affecting hospital length of stay following pelvic exenteration surgery. J Surg Oncol. 2018 Mar; 117(3):529-534. PMID: 29044540.
      View in: PubMed
    27. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 Nov 01; 8(11):7879. PMID: 30123473.
      View in: PubMed
    28. Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang EB. Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect. 2017 10; 5(5). PMID: 28971602.
      View in: PubMed
    29. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 Nov 01; 8(11):7588-7592. PMID: 29568422.
      View in: PubMed
    30. Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease. Sci Rep. 2017 09 05; 7(1):10411. PMID: 28874832.
      View in: PubMed
    31. Cho S, Tripathi A, Chlipala G, Green S, Lee H, Chang EB, Jeong H. Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice. PLoS One. 2017; 12(8):e0182977. PMID: 28832650.
      View in: PubMed
    32. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected]. Clin Transl Oncol. 2018 03; 20(3):302-312. PMID: 28808878.
      View in: PubMed
    33. Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS, Henderson W, Jose PA, Ketchum CJ, Lampe JW, Pepine CJ, Pluznick JL, Raj D, Seals DR, Gioscia-Ryan RA, Tang WHW, Oh YS. Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions. Hypertension. 2017 Jul 31. PMID: 28760940.
      View in: PubMed
    34. Miyoshi J, Bobe AM, Miyoshi S, Huang Y, Hubert N, Delmont TO, Eren AM, Leone V, Chang EB. Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring. Cell Rep. 2017 07 11; 20(2):491-504. PMID: 28700948.
      View in: PubMed
    35. Chang EB, Rao MC. A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade. Am J Physiol Gastrointest Liver Physiol. 2017 07 01; 313(1):G14-G15. PMID: 28546284.
      View in: PubMed
    36. Guo Y, Li P, Gao L, Zhang J, Yang Z, Bledsoe G, Chang E, Chao L, Chao J. Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 2017 08; 16(4):837-846. PMID: 28544111.
      View in: PubMed
    37. Chang E, Nayak L, Jain MK. Krüppel-like factors in endothelial cell biology. Curr Opin Hematol. 2017 May; 24(3):224-229. PMID: 28306664.
      View in: PubMed
    38. Martinez KB, Leone V, Chang EB. Microbial metabolites in health and disease: Navigating the unknown in search of function. J Biol Chem. 2017 05 26; 292(21):8553-8559. PMID: 28389566.
      View in: PubMed
    39. Chang E, Kim Y. Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats. Nutrients. 2017 Mar 29; 9(4). PMID: 28353634.
      View in: PubMed
    40. Touw K, Ringus DL, Hubert N, Wang Y, Leone VA, Nadimpalli A, Theriault BR, Huang YE, Tune JD, Herring PB, Farrugia G, Kashyap PC, Antonopoulos DA, Chang EB. Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models. Physiol Rep. 2017 Mar; 5(6). PMID: 28320888.
      View in: PubMed
    41. Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB. Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 03; 23(3):366-378. PMID: 28221248.
      View in: PubMed
    42. Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB. Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 Feb 13. PMID: 28248733.
      View in: PubMed
    43. Rodriguez-Palacios A, Corridoni D, Di Stefano G, Di Martino L, Antonopoulos DA, Chang E, Pizarro TT, Cominelli F. O-014 Bacterial Sensor NOD2 Deletion Causes Th2-Inflammatory Bowel Disease Improvement Without Inducing Acute Metatranscriptomic Dysbiosis in Mice. Inflamm Bowel Dis. 2017 Feb; 23 Suppl 1:S5. PMID: 28125562.
      View in: PubMed
    44. Messer JS, Liechty ER, Vogel OA, Chang EB. Evolutionary and ecological forces that shape the bacterial communities of the human gut. Mucosal Immunol. 2017 05; 10(3):567-579. PMID: 28145439.
      View in: PubMed
    45. Martinez KB, Leone V, Chang EB. Western diets, gut dysbiosis, and metabolic diseases: Are they linked? Gut Microbes. 2017 03 04; 8(2):130-142. PMID: 28059614.
      View in: PubMed
    46. Martinez KB, Pierre JF, Chang EB. The Gut Microbiota: The Gateway to Improved Metabolism. Gastroenterol Clin North Am. 2016 12; 45(4):601-614. PMID: 27837775.
      View in: PubMed
    47. Corridoni D, Rodriguez-Palacios A, Di Stefano G, Di Martino L, Antonopoulos DA, Chang EB, Arseneau KO, Pizarro TT, Cominelli F. Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis. Mucosal Immunol. 2017 07; 10(4):971-982. PMID: 27848951.
      View in: PubMed
    48. Vineis JH, Ringus DL, Morrison HG, Delmont TO, Dalal S, Raffals LH, Antonopoulos DA, Rubin DT, Eren AM, Chang EB, Sogin ML. Patient-Specific Bacteroides Genome Variants in Pouchitis. MBio. 2016 11 15; 7(6). PMID: 27935837.
      View in: PubMed
    49. Poroyko VA, Carreras A, Khalyfa A, Khalyfa AA, Leone V, Peris E, Almendros I, Gileles-Hillel A, Qiao Z, Hubert N, Farré R, Chang EB, Gozal D. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice. Sci Rep. 2016 10 14; 6:35405. PMID: 27739530.
      View in: PubMed
    50. Wan JY, Wang CZ, Zhang QH, Liu Z, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota. Biomed Chromatogr. 2017 Apr; 31(4). PMID: 27606833.
      View in: PubMed
    51. Arvans D, Jung YC, Antonopoulos D, Koval J, Granja I, Bashir M, Karrar E, Roy-Chowdhury J, Musch M, Asplin J, Chang E, Hassan H. Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells. J Am Soc Nephrol. 2017 Mar; 28(3):876-887. PMID: 27738124.
      View in: PubMed
    52. Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer. Phytother Res. 2017 Jan; 31(1):90-99. PMID: 27730672.
      View in: PubMed
    53. Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Sci Rep. 2016 08 26; 6:32094. PMID: 27561676.
      View in: PubMed
    54. Dolan KT, Chang EB. Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases. Mol Nutr Food Res. 2017 01; 61(1). PMID: 27346644.
      View in: PubMed
    55. Inaba Y, Ueno N, Numata M, Zhu X, Messer JS, Boone DL, Fujiya M, Kohgo Y, Musch MW, Chang EB. Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G634-G647. PMID: 27514476.
      View in: PubMed
    56. Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep. 2016 07 21; 6:30028. PMID: 27443609.
      View in: PubMed
    57. Sato H, Zhang LS, Martinez K, Chang EB, Yang Q, Wang F, Howles PN, Hokari R, Miura S, Tso P. Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats. Gastroenterology. 2016 11; 151(5):923-932. PMID: 27436071.
      View in: PubMed
    58. Raffals LE, Chang EB. Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel. Gut Liver. 2016 Jul 15; 10(4):502-8. PMID: 27377740.
      View in: PubMed
    59. Pierre JF, Martinez KB, Ye H, Nadimpalli A, Morton TC, Yang J, Wang Q, Patno N, Chang EB, Yin DP. Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice. Am J Physiol Gastrointest Liver Physiol. 2016 08 01; 311(2):G286-304. PMID: 27340128.
      View in: PubMed
    60. Miyoshi J, Chang EB. The gut microbiota and inflammatory bowel diseases. Transl Res. 2017 01; 179:38-48. PMID: 27371886.
      View in: PubMed
    61. Tao Y, Messer JS, Goss KH, Hart J, Bissonnette M, Chang EB. Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model. Carcinogenesis. 2016 07; 37(7):731-739. PMID: 27207671.
      View in: PubMed
    62. Antonopoulos DA, Chang EB. Transplanting a Microbial Organ: the Good, the Bad, and the Unknown. MBio. 2016 05 03; 7(3). PMID: 27143392.
      View in: PubMed
    63. Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EB. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G973-88. PMID: 27079612.
      View in: PubMed
    64. Collins B, Hoffman J, Martinez K, Grace M, Lila MA, Cockrell C, Nadimpalli A, Chang E, Chuang CC, Zhong W, Mackert J, Shen W, Cooney P, Hopkins R, McIntosh M. A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice. J Nutr Biochem. 2016 05; 31:150-65. PMID: 27133434.
      View in: PubMed
    65. Park SE, Park CY, Choi JM, Chang E, Rhee EJ, Lee WY, Oh KW, Park SW, Kang ES, Lee HC, Cha BS. Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model. PLoS One. 2016; 11(2):e0148141. PMID: 26894429.
      View in: PubMed
    66. Hasebe T, Ueno N, Musch MW, Nadimpalli A, Kaneko A, Kaifuchi N, Watanabe J, Yamamoto M, Kono T, Inaba Y, Fujiya M, Kohgo Y, Chang EB. Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K. Pharmacol Res Perspect. 2016 02; 4(1):e00215. PMID: 26977303.
      View in: PubMed
    67. Wan JY, Wang CZ, Liu Z, Zhang QH, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:62-73. PMID: 26896573.
      View in: PubMed
    68. Chang E, Abe J. Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism. 2016 May; 65(5):623-33. PMID: 27085771.
      View in: PubMed
    69. Huang CK, Lee SO, Chang E, Pang H, Chang C. Androgen receptor (AR) in cardiovascular diseases. J Endocrinol. 2016 04; 229(1):R1-R16. PMID: 26769913.
      View in: PubMed
    70. Kamdar K, Khakpour S, Chen J, Leone V, Brulc J, Mangatu T, Antonopoulos DA, Chang EB, Kahn SA, Kirschner BS, Young G, DePaolo RW. Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease. Cell Host Microbe. 2016 Jan 13; 19(1):21-31. PMID: 26764594.
      View in: PubMed
    71. Chang E, Kim Y. Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes. Nutrition. 2016 Jun; 32(6):702-8. PMID: 26899162.
      View in: PubMed
    72. Willis AL, Calton JB, Carr TF, Chiu AG, Chang EH. Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome. Am J Rhinol Allergy. 2016 Mar-Apr; 30(2):94-8. PMID: 26715059.
      View in: PubMed
    73. Ho KJ, Xiong L, Hubert NA, Nadimpalli A, Wun K, Chang EB, Kibbe MR. Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury. Physiol Rep. 2015 12; 3(12). PMID: 26660548.
      View in: PubMed
    74. Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB, Gajewski TF. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 2015 Nov 27; 350(6264):1084-9. PMID: 26541606.
      View in: PubMed
    75. Howe A, Ringus DL, Williams RJ, Choo ZN, Greenwald SM, Owens SM, Coleman ML, Meyer F, Chang EB. Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice. ISME J. 2016 May; 10(5):1217-27. PMID: 26473721.
      View in: PubMed
    76. Hu S, Liu L, Chang EB, Wang JY, Raufman JP. Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. Mol Cancer. 2015 Oct 13; 14:180. PMID: 26463716.
      View in: PubMed
    77. Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, Chang C. Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression. Hypertension. 2015 Oct; 66(4):881-91. PMID: 26324502.
      View in: PubMed
    78. Seo S, Lee MS, Chang E, Shin Y, Oh S, Kim IH, Kim Y. Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats. Nutrients. 2015 Sep 22; 7(9):8152-69. PMID: 26402699.
      View in: PubMed
    79. Baldwin J, Collins B, Wolf PG, Martinez K, Shen W, Chuang CC, Zhong W, Cooney P, Cockrell C, Chang E, Gaskins HR, McIntosh MK. Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice. J Nutr Biochem. 2016 Jan; 27:123-35. PMID: 26423887.
      View in: PubMed
    80. Chang E, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 07; 21(25):7754-63. PMID: 26167075.
      View in: PubMed
    81. Chang EH, Zabner J. Precision Genomic Medicine in Cystic Fibrosis. Clin Transl Sci. 2015 Oct; 8(5):606-10. PMID: 26073768.
      View in: PubMed
    82. Devkota S, Chang EB. Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases. Dig Dis. 2015; 33(3):351-6. PMID: 26045269.
      View in: PubMed
    83. Chang E, Choi JM, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY. Adiponectin deletion impairs insulin signaling in insulin-sensitive but not insulin-resistant 3T3-L1 adipocytes. Life Sci. 2015 Jul 01; 132:93-100. PMID: 25956568.
      View in: PubMed
    84. Huang EY, Inoue T, Leone VA, Dalal S, Touw K, Wang Y, Musch MW, Theriault B, Higuchi K, Donovan S, Gilbert J, Chang EB. Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases. Inflamm Bowel Dis. 2015 May; 21(5):963-72. PMID: 25738379.
      View in: PubMed
    85. Lu L, Yu Y, Guo Y, Wang Y, Chang EB, Claud EC. Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model. PLoS One. 2015; 10(4):e0124504. PMID: 25928420.
      View in: PubMed
    86. Messer J, Chang E. Intracellular HMGB1: defender of client proteins and cell fate. Oncotarget. 2015 Apr 20; 6(11):8432-3. PMID: 25909293.
      View in: PubMed
    87. Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Pierre JF, Heneghan AF, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner AR, Musch MW, Kudsk KA, Prendergast BJ, Gilbert JA, Chang EB. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe. 2015 May 13; 17(5):681-9. PMID: 25891358.
      View in: PubMed
    88. Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC. Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact. J Trauma Acute Care Surg. 2015 Apr; 78(4):823-9. PMID: 25807409.
      View in: PubMed
    89. Bellaguarda E, Chang EB. IBD and the gut microbiota--from bench to personalized medicine. Curr Gastroenterol Rep. 2015 Apr; 17(4):15. PMID: 25762474.
      View in: PubMed
    90. Cockrell RC, Christley S, Chang E, An G. Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC). PLoS One. 2015; 10(3):e0122192. PMID: 25806784.
      View in: PubMed
    91. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310. PMID: 25689261.
      View in: PubMed
    92. Chang E, Kim L, Choi JM, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park DI, Park CY. Ezetimibe stimulates intestinal glucagon-like peptide 1 secretion via the MEK/ERK pathway rather than dipeptidyl peptidase 4 inhibition. Metabolism. 2015 May; 64(5):633-41. PMID: 25704082.
      View in: PubMed
    93. Zhu X, Messer JS, Wang Y, Lin F, Cham CM, Chang J, Billiar TR, Lotze MT, Boone DL, Chang EB. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 02; 125(3):1098-110. PMID: 25642769.
      View in: PubMed
    94. Sun J, Chang EB. Exploring gut microbes in human health and disease: Pushing the envelope. Genes Dis. 2014 Dec; 1(2):132-139. PMID: 25642449.
      View in: PubMed
    95. Chang EH, Tang XX, Shah VS, Launspach JL, Ernst SE, Hilkin B, Karp PH, Abou Alaiwa MH, Graham SM, Hornick DB, Welsh MJ, Stoltz DA, Zabner J. Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. Int Forum Allergy Rhinol. 2015 Feb; 5(2):178-81. PMID: 25363320.
      View in: PubMed
    96. Chang EB, Guandalini S, Rao MC, Sellin JH, Semrad CE, Worman H. Michael Field, MD (1933-2014). Gastroenterology. 2014 Dec; 147(6):1191-2. PMID: 25449022.
      View in: PubMed
    97. Gao L, Li P, Zhang J, Hagiwara M, Shen B, Bledsoe G, Chang E, Chao L, Chao J. Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells. J Am Heart Assoc. 2014 Sep 18; 3(5):e001194. PMID: 25237049.
      View in: PubMed
    98. Leone VA, Cham CM, Chang EB. Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? Curr Opin Immunol. 2014 Dec; 31:16-23. PMID: 25214301.
      View in: PubMed
    99. Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu YX, Nagler CR. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13145-50. PMID: 25157157.
      View in: PubMed
    100. Yang SJ, Choi JM, Chang E, Park SW, Park CY. Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation. PLoS One. 2014; 9(8):e105456. PMID: 25133775.
      View in: PubMed
    101. Dalal SR, Chang EB. The microbial basis of inflammatory bowel diseases. J Clin Invest. 2014 Oct; 124(10):4190-6. PMID: 25083986.
      View in: PubMed
    102. Wu S, Zhang YG, Lu R, Xia Y, Zhou D, Petrof EO, Claud EC, Chen D, Chang EB, Carmeliet G, Sun J. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut. 2015 Jul; 64(7):1082-94. PMID: 25080448.
      View in: PubMed
    103. Ma L, Kim J, Hatzenpichler R, Karymov MA, Hubert N, Hanan IM, Chang EB, Ismagilov RF. Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9768-73. PMID: 24965364.
      View in: PubMed
    104. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1509-19. PMID: 24707934.
      View in: PubMed
    105. Chang E, Choi JM, Kim WJ, Rhee EJ, Oh KW, Lee WY, Park SE, Park SW, Park CY. Restoration of adiponectin expression via the ERK pathway in TNFa-treated 3T3-L1 adipocytes. Mol Med Rep. 2014 Aug; 10(2):905-10. PMID: 24890319.
      View in: PubMed
    106. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression. PLoS One. 2014; 9(5):e97456. PMID: 24857966.
      View in: PubMed
    107. Huang H, Nace GW, McDonald KA, Tai S, Klune JR, Rosborough BR, Ding Q, Loughran P, Zhu X, Beer-Stolz D, Chang EB, Billiar T, Tsung A. Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection. Hepatology. 2014 May; 59(5):1984-1997. PMID: 24375466.
      View in: PubMed
    108. Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO, Chang C. New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis. Hypertension. 2014 Jun; 63(6):1345-53. PMID: 24688120.
      View in: PubMed
    109. Evans CC, LePard KJ, Kwak JW, Stancukas MC, Laskowski S, Dougherty J, Moulton L, Glawe A, Wang Y, Leone V, Antonopoulos DA, Smith D, Chang EB, Ciancio MJ. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS One. 2014; 9(3):e92193. PMID: 24670791.
      View in: PubMed
    110. Elson CO, Chang EB, Lira SA. Lloyd F. Mayer, MD: a remembrance. Mucosal Immunol. 2014 Mar; 7(2):205-9. PMID: 24553067.
      View in: PubMed
    111. Huse SM, Young VB, Morrison HG, Antonopoulos DA, Kwon J, Dalal S, Arrieta R, Hubert NA, Shen L, Vineis JH, Koval JC, Sogin ML, Chang EB, Raffals LE. Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects. Microbiome. 2014 Feb 14; 2(1):5. PMID: 24529162.
      View in: PubMed
    112. Alverdy J, Gilbert J, DeFazio JR, Sadowsky MJ, Chang EB, Morowitz MJ, Teitelbaum DH. Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected]. JPEN J Parenter Enteral Nutr. 2014 Feb; 38(2):167-78. PMID: 24379111.
      View in: PubMed
    113. Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J, Bansal P, Billiar TR, Tsung A, Wang Q, Bartlett DL, Whitcomb DC, Chang EB, Zhu X, Wang H, Lu B, Tracey KJ, Cao L, Fan XG, Lotze MT, Zeh HJ, Tang D. Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. Gastroenterology. 2014 Apr; 146(4):1097-107. PMID: 24361123.
      View in: PubMed
    114. Chang EH. New insights into the pathogenesis of cystic fibrosis sinusitis. Int Forum Allergy Rhinol. 2014 Feb; 4(2):132-7. PMID: 24282147.
      View in: PubMed
    115. Devkota S, Chang EB. Nutrition, microbiomes, and intestinal inflammation. Curr Opin Gastroenterol. 2013 Nov; 29(6):603-7. PMID: 24100722.
      View in: PubMed
    116. Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K. Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res. 2013 Oct 01; 73(19):5905-13. PMID: 23955389.
      View in: PubMed
    117. Shogan BD, Smith DP, Packman AI, Kelley ST, Landon EM, Bhangar S, Vora GJ, Jones RM, Keegan K, Stephens B, Ramos T, Kirkup BC, Levin H, Rosenthal M, Foxman B, Chang EB, Siegel J, Cobey S, An G, Alverdy JC, Olsiewski PJ, Martin MO, Marrs R, Hernandez M, Christley S, Morowitz M, Weber S, Gilbert J. The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013. Stand Genomic Sci. 2013 Jul 30; 8(3):571-9. PMID: 24501640.
      View in: PubMed
    118. Huang EY, Devkota S, Moscoso D, Chang EB, Leone VA. The role of diet in triggering human inflammatory disorders in the modern age. Microbes Infect. 2013 Nov; 15(12):765-74. PMID: 23876436.
      View in: PubMed
    119. Claud EC, Keegan KP, Brulc JM, Lu L, Bartels D, Glass E, Chang EB, Meyer F, Antonopoulos DA. Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants. Microbiome. 2013 Jul 10; 1(1):20. PMID: 24450928.
      View in: PubMed
    120. Bhattacharyya S, Xue L, Devkota S, Chang E, Morris S, Tobacman JK. Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice. Mediators Inflamm. 2013; 2013:397642. PMID: 23766559.
      View in: PubMed
    121. Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA, Hoffman EA, Chang EH, Zabner J, McCray PB, Prather RS, Meyerholz DK, Welsh MJ. Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest. 2013 Jun; 123(6):2685-93. PMID: 23676501.
      View in: PubMed
    122. Huang EY, Leone VA, Devkota S, Wang Y, Brady MJ, Chang EB. Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue. JPEN J Parenter Enteral Nutr. 2013 Nov; 37(6):746-54. PMID: 23639897.
      View in: PubMed
    123. Potash AE, Wallen TJ, Karp PH, Ernst S, Moninger TO, Gansemer ND, Stoltz DA, Zabner J, Chang EH. Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model. Mol Ther. 2013 May; 21(5):947-53. PMID: 23511247.
      View in: PubMed
    124. Leone V, Chang EB, Devkota S. Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases. J Gastroenterol. 2013 Mar; 48(3):315-21. PMID: 23475322.
      View in: PubMed
    125. Young VB, Raffals LH, Huse SM, Vital M, Dai D, Schloss PD, Brulc JM, Antonopoulos DA, Arrieta RL, Kwon JH, Reddy KG, Hubert NA, Grim SL, Vineis JH, Dalal S, Morrison HG, Eren AM, Meyer F, Schmidt TM, Tiedje JM, Chang EB, Sogin ML. Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis. Microbiome. 2013 Mar 04; 1(1):9. PMID: 24451366.
      View in: PubMed
    126. Vital M, Penton CR, Wang Q, Young VB, Antonopoulos DA, Sogin ML, Morrison HG, Raffals L, Chang EB, Huffnagle GB, Schmidt TM, Cole JR, Tiedje JM. A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community. Microbiome. 2013 Mar 04; 1(1):8. PMID: 24451334.
      View in: PubMed
    127. Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res. 2013 Mar 15; 112(6):911-23. PMID: 23381569.
      View in: PubMed
    128. Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, He TC, Du W, Bissonnette M, Musch MW, Chang EB, Yuan CS. Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci. 2013 Jan 31; 14(2):2980-95. PMID: 23434653.
      View in: PubMed
    129. Musch MW, Wang Y, Claud EC, Chang EB. Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota. Dig Dis Sci. 2013 Mar; 58(3):668-77. PMID: 23329012.
      View in: PubMed
    130. Devkota S, Chang EB. Diet-induced expansion of pathobionts in experimental colitis: implications for tailored therapies. Gut Microbes. 2013 Mar-Apr; 4(2):172-4. PMID: 23333863.
      View in: PubMed
    131. Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99. PMID: 23243209.
      View in: PubMed
    132. Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J. Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9. PMID: 23202365.
      View in: PubMed
    133. Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H, Fu YX. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol. 2012 Oct; 13(10):947-53. PMID: 22922363.
      View in: PubMed
    134. Hansen JJ, Huang Y, Peterson DA, Goeser L, Fan TJ, Chang EB, Sartor RB. The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen. PLoS One. 2012; 7(8):e42645. PMID: 22880065.
      View in: PubMed
    135. Vieira Potter VJ, Strissel KJ, Xie C, Chang E, Bennett G, Defuria J, Obin MS, Greenberg AS. Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity. Endocrinology. 2012 Sep; 153(9):4266-77. PMID: 22778213.
      View in: PubMed
    136. Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, Antonopoulos DA, Jabri B, Chang EB. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature. 2012 Jul 05; 487(7405):104-8. PMID: 22722865.
      View in: PubMed
    137. Chang EY, Zhang J, Sullivan S, Newman R, Singh I. N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model. J Matern Fetal Neonatal Med. 2012 Nov; 25(11):2395-400. PMID: 22676250.
      View in: PubMed
    138. Chang EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR, Sieren JC, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB, Stoltz DA, Welsh MJ, Zabner J. Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. Laryngoscope. 2012 Sep; 122(9):1898-905. PMID: 22711071.
      View in: PubMed
    139. Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine ML. Requirements for ion and solute transport, and pH regulation during enamel maturation. J Cell Physiol. 2012 Apr; 227(4):1776-85. PMID: 21732355.
      View in: PubMed
    140. Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012 May 01; 188(9):4543-57. PMID: 22461698.
      View in: PubMed
    141. Wang CZ, Du GJ, Zhang Z, Wen XD, Calway T, Zhen Z, Musch MW, Bissonnette M, Chang EB, Yuan CS. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int J Oncol. 2012 Jun; 40(6):1970-6. PMID: 22426808.
      View in: PubMed
    142. Harrell L, Wang Y, Antonopoulos D, Young V, Lichtenstein L, Huang Y, Hanauer S, Chang E. Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon. PLoS One. 2012; 7(2):e32545. PMID: 22389708.
      View in: PubMed
    143. Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y. Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection. Int J Colorectal Dis. 2012 Aug; 27(8):1039-46. PMID: 22297864.
      View in: PubMed
    144. Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50. PMID: 22267842.
      View in: PubMed
    145. Meyer F, Trimble WL, Chang EB, Handley KM. Functional predictions from inference and observation in sequence-based inflammatory bowel disease research. Genome Biol. 2012; 13(9):169. PMID: 23013527.
      View in: PubMed
    146. Schneider JA, Vadivelu S, Liao C, Kandukuri SR, Trikamji BV, Chang E, Antonopoulos D, Prasad S, Lakshmi V. Increased Likelihood of Bacterial Pathogens in the Coronal Sulcus and Urethra of Uncircumcised Men in a Diverse Group of HIV Infected and Uninfected Patients in India. J Glob Infect Dis. 2012 Jan; 4(1):6-9. PMID: 22529620.
      View in: PubMed
    147. Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement Altern Med. 2011 Nov 09; 11:111. PMID: 22070864.
      View in: PubMed
    148. Young VB, Kahn SA, Schmidt TM, Chang EB. Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward. Front Microbiol. 2011; 2:144. PMID: 21772835.
      View in: PubMed
    149. Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol. 2011 May 30; 193(5):867-84. PMID: 21624955.
      View in: PubMed
    150. Pekow JR, Dougherty U, Mustafi R, Zhu H, Kocherginsky M, Rubin DT, Hanauer SB, Hart J, Chang EB, Fichera A, Joseph LJ, Bissonnette M. miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. Inflamm Bowel Dis. 2012 Jan; 18(1):94-100. PMID: 21557394.
      View in: PubMed
    151. Chang EH, Lacruz RS, Bromage TG, Bringas P, Welsh MJ, Zabner J, Paine ML. Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs. 2011; 194(2-4):249-54. PMID: 21525720.
      View in: PubMed
    152. Iwashita Y, Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EB. Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G181-7. PMID: 21512157.
      View in: PubMed
    153. Perfield JW, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 2011 Apr; 60(4):1168-76. PMID: 21346175.
      View in: PubMed
    154. Hu S, Dong TS, Dalal SR, Wu F, Bissonnette M, Kwon JH, Chang EB. The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer. PLoS One. 2011 Jan 20; 6(1):e16221. PMID: 21283757.
      View in: PubMed
    155. Wang CZ, Kim KE, Du GJ, Qi LW, Wen XD, Li P, Bauer BA, Bissonnette MB, Musch MW, Chang EB, Yuan CS. Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. Am J Chin Med. 2011; 39(6):1161-71. PMID: 22083988.
      View in: PubMed
    156. Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe J. MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood. 2011 Feb 24; 117(8):2527-37. PMID: 21131586.
      View in: PubMed
    157. Wang Y, Devkota S, Musch MW, Jabri B, Nagler C, Antonopoulos DA, Chervonsky A, Chang EB. Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS One. 2010 Oct 22; 5(10):e13607. PMID: 21042588.
      View in: PubMed
    158. Wang Y, Antonopoulos DA, Zhu X, Harrell L, Hanan I, Alverdy JC, Meyer F, Musch MW, Young VB, Chang EB. Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon. Appl Microbiol Biotechnol. 2010 Dec; 88(6):1333-42. PMID: 20931185.
      View in: PubMed
    159. Lee JW, Cho YK, Ryan M, Kim H, Lee SW, Chang E, Joo KJ, Kim JT, Kim BS, Sung KC. Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study. Gut Liver. 2010 Sep; 4(3):378-83. PMID: 20981217.
      View in: PubMed
    160. Hu S, Wang Y, Lichtenstein L, Tao Y, Musch MW, Jabri B, Antonopoulos D, Claud EC, Chang EB. Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1266-75. PMID: 20864653.
      View in: PubMed
    161. Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe J. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. FASEB J. 2010 Dec; 24(12):4917-28. PMID: 20724525.
      View in: PubMed
    162. Fujiya M, Inaba Y, Musch MW, Hu S, Kohgo Y, Chang EB. Cytokine regulation of OCTN2 expression and activity in small and large intestine. Inflamm Bowel Dis. 2011 Apr; 17(4):907-16. PMID: 20722056.
      View in: PubMed
    163. Yeruva S, Farkas K, Hubricht J, Rode K, Riederer B, Bachmann O, Cinar A, Rakonczay Z, Molnár T, Nagy F, Wedemeyer J, Manns M, Raddatz D, Musch MW, Chang EB, Hegyi P, Seidler U. Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis. Inflamm Bowel Dis. 2010 Jul; 16(7):1149-61. PMID: 20027604.
      View in: PubMed
    164. Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB, Zabner J, Welsh MJ. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med. 2010 Apr 28; 2(29):29ra31. PMID: 20427821.
      View in: PubMed
    165. Leung FW, Aljebreen AM, Brocchi E, Chang EB, Liao WC, Mizukami T, Schapiro M, Triantafyllou K. Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening. World J Gastrointest Endosc. 2010 Mar 16; 2(3):81-9. PMID: 21160707.
      View in: PubMed
    166. Chang EH, Lee JH, Zabner J. Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells. Am J Rhinol Allergy. 2010 Mar-Apr; 24(2):126-8. PMID: 20338110.
      View in: PubMed
    167. Hu S, Claud EC, Musch MW, Chang EB. Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 2010 Apr; 298(4):G481-92. PMID: 20110459.
      View in: PubMed
    168. Musch MW, Arvans DL, Wang Y, Nakagawa Y, Solomaha E, Chang EB. Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G203-11. PMID: 19926819.
      View in: PubMed
    169. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1041-52. PMID: 19833862.
      View in: PubMed
    170. Petrof EO, Claud EC, Sun J, Abramova T, Guo Y, Waypa TS, He SM, Nakagawa Y, Chang EB. Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function. Inflamm Bowel Dis. 2009 Oct; 15(10):1537-47. PMID: 19373789.
      View in: PubMed
    171. Jenkins DD, Chang E, Singh I. Neuroprotective interventions: is it too late? J Child Neurol. 2009 Sep; 24(9):1212-9. PMID: 19745093.
      View in: PubMed
    172. Musch MW, Arvans DL, Paris H, Chang EB. Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3. J Pharmacol Exp Ther. 2009 Sep; 330(3):818-25. PMID: 19556451.
      View in: PubMed
    173. Wang Y, Hoenig JD, Malin KJ, Qamar S, Petrof EO, Sun J, Antonopoulos DA, Chang EB, Claud EC. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. ISME J. 2009 Aug; 3(8):944-54. PMID: 19369970.
      View in: PubMed
    174. Chang E, Donkin SS, Teegarden D. Parathyroid hormone suppresses insulin signaling in adipocytes. Mol Cell Endocrinol. 2009 Aug 13; 307(1-2):77-82. PMID: 19524129.
      View in: PubMed
    175. Musch MW, Li YC, Chang EB. Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells. BMC Physiol. 2009 Apr 01; 9:5. PMID: 19338654.
      View in: PubMed
    176. Bourdeau RW, Malito E, Chenal A, Bishop BL, Musch MW, Villereal ML, Chang EB, Mosser EM, Rest RF, Tang WJ. Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis. J Biol Chem. 2009 May 22; 284(21):14645-56. PMID: 19307185.
      View in: PubMed
    177. Hu S, Zhu X, Triggs JR, Tao Y, Wang Y, Lichtenstein L, Bissonnette M, Musch MW, Chang EB. Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296(5):G1003-11. PMID: 19299581.
      View in: PubMed
    178. Musch MW, Arvans DL, Wu GD, Chang EB. Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G202-10. PMID: 19056765.
      View in: PubMed
    179. Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EB. Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology. 2009 Mar; 136(3):924-32. PMID: 19121316.
      View in: PubMed
    180. Tao Y, Hart J, Lichtenstein L, Joseph LJ, Ciancio MJ, Hu S, Chang EB, Bissonnette M. Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. Carcinogenesis. 2009 Jan; 30(1):175-82. PMID: 19005184.
      View in: PubMed
    181. Siddiqui SM, Chang E, Li J, Burlage C, Zou M, Buhman KK, Koser S, Donkin SS, Teegarden D. Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats. Nutr Res. 2008 Nov; 28(11):783-90. PMID: 19083488.
      View in: PubMed
    182. Ciancio MJ, Chang EB. Do heat shock proteins play any role in gut inflammation? Inflamm Bowel Dis. 2008 Oct; 14 Suppl 2:S102-3. PMID: 18816666.
      View in: PubMed
    183. Musch MW, Lucioni A, Chang EB. Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G909-19. PMID: 18801914.
      View in: PubMed
    184. Li J, Byrne ME, Chang E, Jiang Y, Donkin SS, Buhman KK, Burgess JR, Teegarden D. 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol. 2008 Nov; 112(1-3):122-6. PMID: 18840526.
      View in: PubMed
    185. Sellin JH, Chang EB. Therapy Insight: gastrointestinal complications of diabetes--pathophysiology and management. Nat Clin Pract Gastroenterol Hepatol. 2008 Mar; 5(3):162-71. PMID: 18268523.
      View in: PubMed
    186. Petrof EO, Musch MW, Ciancio M, Sun J, Hobert ME, Claud EC, Gewirtz A, Chang EB. Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G808-18. PMID: 18202113.
      View in: PubMed
    187. Ko R, Mazur JE, Pastis NJ, Chang E, Sahn SA, Boylan AM. Common problems in critically ill obstetric patients, with an emphasis on pharmacotherapy. Am J Med Sci. 2008 Jan; 335(1):65-70. PMID: 18195587.
      View in: PubMed
    188. Alverdy JC, Chang EB. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away. J Leukoc Biol. 2008 Mar; 83(3):461-6. PMID: 18160538.
      View in: PubMed
    189. Hu S, Ciancio MJ, Lahav M, Fujiya M, Lichtenstein L, Anant S, Musch MW, Chang EB. Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation. Gastroenterology. 2007 Dec; 133(6):1893-904. PMID: 18054561.
      View in: PubMed
    190. Chang EY, Morris CD, Seltman AK, O'Rourke RW, Chan BK, Hunter JG, Jobe BA. The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review. Ann Surg. 2007 Jul; 246(1):11-21. PMID: 17592284.
      View in: PubMed
    191. Fujiya M, Musch MW, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007 Jun 14; 1(4):299-308. PMID: 18005709.
      View in: PubMed
    192. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35. PMID: 17367209.
      View in: PubMed
    193. Musch MW, Arvans DL, Walsh-Reitz MM, Uchiyama K, Fukuda M, Chang EB. Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1549-58. PMID: 17307723.
      View in: PubMed
    194. Chang E, Ni J, Yin Y, Lin CC, Chang P, James NS, Chemler SR, Yeh S. Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells. Asian J Androl. 2007 Jan; 9(1):31-9. PMID: 17187157.
      View in: PubMed
    195. Cash BD, Chang E, Talley NJ, Wald A. Fresh perspectives in chronic constipation and other functional bowel disorders. Rev Gastroenterol Disord. 2007; 7(3):116-33. PMID: 17928791.
      View in: PubMed
    196. Carlson RM, Vavricka SR, Eloranta JJ, Musch MW, Arvans DL, Kles KA, Walsh-Reitz MM, Kullak-Ublick GA, Chang EB. fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 292(4):G1070-8. PMID: 17185631.
      View in: PubMed
    197. O'Rourke RW, Seltman AK, Chang EY, Reavis KM, Diggs BS, Hunter JG, Jobe BA. A model for gastric banding in the treatment of morbid obesity: the effect of chronic partial gastric outlet obstruction on esophageal physiology. Ann Surg. 2006 Nov; 244(5):723-33. PMID: 17060765.
      View in: PubMed
    198. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42. PMID: 16901993.
      View in: PubMed
    199. Phanvijhitsiri K, Musch MW, Ropeleski MJ, Chang EB. Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 Aug; 291(2):C290-9. PMID: 16554407.
      View in: PubMed
    200. Wu L, Kohler JE, Zaborina O, Akash G, Musch MW, Chang EB, Alverdy JC. Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa. Curr Issues Intest Microbiol. 2006 Mar; 7(1):19-28. PMID: 16570696.
      View in: PubMed
    201. Kles KA, Chang EB. Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure. Gastroenterology. 2006 Feb; 130(2 Suppl 1):S100-5. PMID: 16473056.
      View in: PubMed
    202. Gopal DV, Chang EY, Kim CY, Sandone C, Pfau PR, Frick TJ, Hunter JG, Kahrilas PJ, Jobe BA. EUS characteristics of Nissen fundoplication: normal appearance and mechanisms of failure. Gastrointest Endosc. 2006 Jan; 63(1):35-44. PMID: 16377313.
      View in: PubMed
    203. Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1018-30. PMID: 16306130.
      View in: PubMed
    204. Vavricka SR, Musch MW, Fujiya M, Kles K, Chang L, Eloranta JJ, Kullak-Ublick GA, Drabik K, Merlin D, Chang EB. Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. Pflugers Arch. 2006 Apr; 452(1):71-80. PMID: 16328452.
      View in: PubMed
    205. Musch MW, Walsh-Reitz MM, Chang EB. Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G222-31. PMID: 16239402.
      View in: PubMed
    206. Harrell L, Chang EB. This month in gastroenterology. Gastroenterology. 2005 Oct; 129(4):1143-5. PMID: 16230063.
      View in: PubMed
    207. Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa. Science. 2005 Jul 29; 309(5735):774-7. PMID: 16051797.
      View in: PubMed
    208. Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G163-71. PMID: 15961882.
      View in: PubMed
    209. Ropeleski MJ, Riehm J, Baer KA, Musch MW, Chang EB. Anti-apoptotic effects of L-glutamine-mediated transcriptional modulation of the heat shock protein 72 during heat shock. Gastroenterology. 2005 Jul; 129(1):170-84. PMID: 16012946.
      View in: PubMed
    210. Reavis KM, Chang EY, Hunter JG, Jobe BA. Utilization of the delay phenomenon improves blood flow and reduces collagen deposition in esophagogastric anastomoses. Ann Surg. 2005 May; 241(5):736-45; discussion 745-7. PMID: 15849509.
      View in: PubMed
    211. Chang E, Chalikonda S, Friedl J, Xu H, Phan GQ, Marincola FM, Alexander HR, Bartlett DL. Targeting vaccinia to solid tumors with local hyperthermia. Hum Gene Ther. 2005 Apr; 16(4):435-44. PMID: 15871675.
      View in: PubMed
    212. Sun J, Hobert ME, Duan Y, Rao AS, He TC, Chang EB, Madara JL. Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G129-37. PMID: 15790758.
      View in: PubMed
    213. Kles KA, Vavricka SR, Turner JR, Musch MW, Hanauer SB, Chang EB. Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum. Inflamm Bowel Dis. 2005 Mar; 11(3):253-7. PMID: 15735431.
      View in: PubMed
    214. Wu LR, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Turner JR, Alverdy JC. Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa. Surg Infect (Larchmt). 2005; 6(2):185-95. PMID: 16128625.
      View in: PubMed
    215. Arvans DL, Vavricka SR, Ren H, Musch MW, Kang L, Rocha FG, Lucioni A, Turner JR, Alverdy J, Chang EB. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G696-704. PMID: 15528251.
      View in: PubMed
    216. Shiue H, Musch MW, Wang Y, Chang EB, Turner JR. Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem. 2005 Jan 14; 280(2):1688-95. PMID: 15531580.
      View in: PubMed
    217. Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O, Chang EB. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology. 2004 Nov; 127(5):1401-9. PMID: 15521010.
      View in: PubMed
    218. Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, Chang EB. Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology. 2004 Nov; 127(5):1474-87. PMID: 15521016.
      View in: PubMed
    219. Zhao H, Shiue H, Palkon S, Wang Y, Cullinan P, Burkhardt JK, Musch MW, Chang EB, Turner JR. Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9485-90. PMID: 15197272.
      View in: PubMed
    220. Musch MW, Petrof EO, Kojima K, Ren H, McKay DM, Chang EB. Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity. Infect Immun. 2004 Jun; 72(6):3187-94. PMID: 15155620.
      View in: PubMed
    221. Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F. SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8090-5. PMID: 15141091.
      View in: PubMed
    222. Wu L, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Shapiro J, Turner JR, Wu G, Lee KY, Alverdy JC. High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa. Gastroenterology. 2004 Feb; 126(2):488-98. PMID: 14762786.
      View in: PubMed
    223. Musch MW, Kapil A, Chang EB. Heat shock protein 72 binds and protects dihydrofolate reductase against oxidative injury. Biochem Biophys Res Commun. 2004 Jan 02; 313(1):185-92. PMID: 14672716.
      View in: PubMed
    224. Petrof EO, Ciancio MJ, Chang EB. Role and regulation of intestinal epithelial heat shock proteins in health and disease. Chin J Dig Dis. 2004; 5(2):45-50. PMID: 15612656.
      View in: PubMed
    225. Kojima K, Musch MW, Ropeleski MJ, Boone DL, Ma A, Chang EB. Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation. Am J Physiol Gastrointest Liver Physiol. 2004 Apr; 286(4):G645-52. PMID: 14630641.
      View in: PubMed
    226. Ohtsu H, Itokawa H, Xiao Z, Su CY, Shih CC, Chiang T, Chang E, Lee Y, Chiu SY, Chang C, Lee KH. Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids. Bioorg Med Chem. 2003 Nov 17; 11(23):5083-90. PMID: 14604672.
      View in: PubMed
    227. Wu L, Holbrook C, Zaborina O, Ploplys E, Rocha F, Pelham D, Chang E, Musch M, Alverdy J. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System. Ann Surg. 2003 Nov; 238(5):754-64. PMID: 14578740.
      View in: PubMed
    228. Toback FG, Walsh-Reitz MM, Musch MW, Chang EB, Del Valle J, Ren H, Huang E, Martin TE. Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic. Am J Physiol Gastrointest Liver Physiol. 2003 Aug; 285(2):G344-53. PMID: 12851219.
      View in: PubMed
    229. Ropeleski MJ, Tang J, Walsh-Reitz MM, Musch MW, Chang EB. Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress. Gastroenterology. 2003 May; 124(5):1358-68. PMID: 12730876.
      View in: PubMed
    230. Kojima K, Musch MW, Ren H, Boone DL, Hendrickson BA, Ma A, Chang EB. Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells. Gastroenterology. 2003 May; 124(5):1395-407. PMID: 12730879.
      View in: PubMed
    231. Inui S, Lee YF, Chang E, Shyr CR, Chang C. Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. J Dermatol Sci. 2003 Feb; 31(1):65-71. PMID: 12615366.
      View in: PubMed
    232. Wischmeyer PE, Riehm J, Singleton KD, Ren H, Musch MW, Kahana M, Chang EB. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition. 2003 Jan; 19(1):1-6. PMID: 12507630.
      View in: PubMed
    233. Liu TS, Musch MW, Sugi K, Walsh-Reitz MM, Ropeleski MJ, Hendrickson BA, Pothoulakis C, Lamont JT, Chang EB. Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C1073-82. PMID: 12490434.
      View in: PubMed
    234. Musch MW, Clarke LL, Mamah D, Gawenis LR, Zhang Z, Ellsworth W, Shalowitz D, Mittal N, Efthimiou P, Alnadjim Z, Hurst SD, Chang EB, Barrett TA. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest. 2002 Dec; 110(11):1739-47. PMID: 12464679.
      View in: PubMed
    235. Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee Y, Tsai MY, Chang C, Lee KH. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J Med Chem. 2002 Nov 07; 45(23):5037-42. PMID: 12408714.
      View in: PubMed
    236. Lahav M, Chang E. Immunologic basis for diarrhea. Curr Opin Gastroenterol. 2002 Nov; 18(6):691-5. PMID: 17033350.
      View in: PubMed
    237. Musch MW, Bookstein C, Rocha F, Lucioni A, Ren H, Daniel J, Xie Y, McSwine RL, Rao MC, Alverdy J, Chang EB. Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G975-85. PMID: 12223358.
      View in: PubMed
    238. Lucioni A, Womack C, Musch MW, Rocha FL, Bookstein C, Chang EB. Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G51-6. PMID: 12065291.
      View in: PubMed
    239. Zhang Y, Ni J, Messing EM, Chang E, Yang CR, Yeh S. Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7408-13. PMID: 12032296.
      View in: PubMed
    240. Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM, Chang EB. Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. Shock. 2001 Nov; 16(5):398-402. PMID: 11699081.
      View in: PubMed
    241. Ren H, Musch MW, Kojima K, Boone D, Ma A, Chang EB. Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells. Gastroenterology. 2001 Sep; 121(3):631-9. PMID: 11522747.
      View in: PubMed
    242. Musch MW, Kaplan B, Chang EB. Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells. Cell Growth Differ. 2001 Aug; 12(8):419-26. PMID: 11504707.
      View in: PubMed
    243. Rocha F, Laughlin R, Musch MW, Hendrickson BA, Chang EB, Alverdy J. Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation. Surgery. 2001 Jul; 130(1):65-73. PMID: 11436014.
      View in: PubMed
    244. Wischmeyer PE, Kahana M, Wolfson R, Ren H, Musch MM, Chang EB. Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J Appl Physiol (1985). 2001 Jun; 90(6):2403-10. PMID: 11356807.
      View in: PubMed
    245. Rocha F, Musch MW, Lishanskiy L, Bookstein C, Sugi K, Xie Y, Chang EB. IFN-gamma downregulates expression of Na(+)/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells. Am J Physiol Cell Physiol. 2001 May; 280(5):C1224-32. PMID: 11287336.
      View in: PubMed
    246. Sugi K, Musch MW, Field M, Chang EB. Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function. Gastroenterology. 2001 May; 120(6):1393-403. PMID: 11313309.
      View in: PubMed
    247. Musch MW, Bookstein C, Xie Y, Sellin JH, Chang EB. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. Am J Physiol Gastrointest Liver Physiol. 2001 Apr; 280(4):G687-93. PMID: 11254495.
      View in: PubMed
    248. Sugi K, Musch MW, Di A, Nelson DJ, Chang EB. Oxidants potentiate Ca(2+)- and cAMP-stimulated Cl(-) secretion in intestinal epithelial T84 cells. Gastroenterology. 2001 Jan; 120(1):89-98. PMID: 11208717.
      View in: PubMed
    249. Alverdy J, Holbrook C, Rocha F, Seiden L, Wu RL, Musch M, Chang E, Ohman D, Suh S. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg. 2000 Oct; 232(4):480-9. PMID: 10998646.
      View in: PubMed
    250. Laughlin RS, Musch MW, Hollbrook CJ, Rocha FM, Chang EB, Alverdy JC. The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis. Ann Surg. 2000 Jul; 232(1):133-42. PMID: 10862206.
      View in: PubMed
    251. Bookstein C, Musch MW, Xie Y, Rao MC, Chang EB. Regulation of intestinal epithelial brush border Na(+)/H(+) exchanger isoforms, NHE2 and NHE3, in C2bbe cells. J Membr Biol. 1999 Sep 01; 171(1):87-95. PMID: 10485997.
      View in: PubMed
    252. Musch MW, Sugi K, Straus D, Chang EB. Heat-shock protein 72 protects against oxidant-induced injury of barrier function of human colonic epithelial Caco2/bbe cells. Gastroenterology. 1999 Jul; 117(1):115-22. PMID: 10381917.
      View in: PubMed
    253. Bhartur SG, Ballarin LJ, Musch MW, Bookstein C, Chang EB, Rao MC. A unique Na+/H+ exchanger, analogous to NHE1, in the chicken embryonic fibroblast. Am J Physiol. 1999 03; 276(3):R838-46. PMID: 10070146.
      View in: PubMed
    254. Park K, Olschowka JA, Richardson LA, Bookstein C, Chang EB, Melvin JE. Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells. Am J Physiol. 1999 02; 276(2):G470-8. PMID: 9950821.
      View in: PubMed
    255. Urayama S, Musch MW, Retsky J, Madonna MB, Straus D, Chang EB. Dexamethasone protection of rat intestinal epithelial cells against oxidant injury is mediated by induction of heat shock protein 72. J Clin Invest. 1998 Nov 15; 102(10):1860-5. PMID: 9819372.
      View in: PubMed
    256. McSwine RL, Musch MW, Bookstein C, Xie Y, Rao M, Chang EB. Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe. Am J Physiol. 1998 09; 275(3):C693-701. PMID: 9730953.
      View in: PubMed
    257. Musch MW, Hayden D, Sugi K, Straus D, Chang EB. Cell-specific induction of hsp72-mediated protection by glutamine against oxidant injury in IEC18 cells. Proc Assoc Am Physicians. 1998 Mar-Apr; 110(2):136-9. PMID: 9542769.
      View in: PubMed
    258. Cho JH, Musch MW, Bookstein CM, McSwine RL, Rabenau K, Chang EB. Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon. Am J Physiol. 1998 03; 274(3):C586-94. PMID: 9530089.
      View in: PubMed
    259. Bookstein C, Musch MW, Dudeja PK, McSwine RL, Xie Y, Brasitus TA, Rao MC, Chang EB. Inverse relationship between membrane lipid fluidity and activity of Na+/H+ exchangers, NHE1 and NHE3, in transfected fibroblasts. J Membr Biol. 1997 Dec 01; 160(3):183-92. PMID: 9425602.
      View in: PubMed
    260. Burress GC, Musch MW, Jurivich DA, Welk J, Chang EB. Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells. Gastroenterology. 1997 Nov; 113(5):1474-9. PMID: 9352849.
      View in: PubMed
    261. Bookstein C, Xie Y, Rabenau K, Musch MW, McSwine RL, Rao MC, Chang EB. Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney. Am J Physiol. 1997 11; 273(5):C1496-505. PMID: 9374634.
      View in: PubMed
    262. Bhartur SG, Bookstein C, Musch MW, Boxer R, Chang EB, Rao MC. An avian sodium-hydrogen exchanger. Comp Biochem Physiol A Physiol. 1997 Nov; 118(3):883-9. PMID: 9406452.
      View in: PubMed
    263. Wischmeyer PE, Musch MW, Madonna MB, Thisted R, Chang EB. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol. 1997 Apr; 272(4 Pt 1):G879-84. PMID: 9142921.
      View in: PubMed
    264. Urayama S, Chang EB. Mechanisms and treatment of diarrhea in inflammatory bowel diseases. Inflamm Bowel Dis. 1997; 3(2):114-31. PMID: 23282752.
      View in: PubMed
    265. Bookstein C, Musch MW, DePaoli A, Xie Y, Rabenau K, Villereal M, Rao MC, Chang EB. Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1629-38. PMID: 8944646.
      View in: PubMed
    266. Coupaye-Gerard B, Bookstein C, Duncan P, Chen XY, Smith PR, Musch M, Ernst SA, Chang EB, Kleyman TR. Biosynthesis and cell surface delivery of the NHE1 isoform of Na+/H+ exchanger in A6 cells. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1639-45. PMID: 8944647.
      View in: PubMed
    267. Chang EB. Intestinal water and electrolyte absorption and secretion. Transplant Proc. 1996 Oct; 28(5):2679-82. PMID: 8908010.
      View in: PubMed
    268. Bizal GL, Howard RL, Bookstein C, Rao MC, Chang EB, Soleimani M. Glycosylation of the Na+/H+ exchanger isoform NHE-3 is species specific. J Lab Clin Med. 1996 Sep; 128(3):304-12. PMID: 8783638.
      View in: PubMed
    269. Soleimani M, Singh G, Bookstein C, Rao MC, Chang EB, Dominguez JH. Inhibition of glycosylation decreases Na+/H+ exchange activity, blocks NHE-3 transport to the membrane, and increases NHE-3 mRNA expression in LLC-PK1 cells. J Lab Clin Med. 1996 Jun; 127(6):565-73. PMID: 8648261.
      View in: PubMed
    270. LaRusso NF, Phillips SF, Bloomer JR, Boland CR, Chang EB, DiMagno EP, Giannella RA, Gores GJ, Malagelada JR, Miller LJ, Rakela J, Szurszewski JH, Binder HJ, Clain JE, LaMont JT, Link AM. Passing the torch: a look back at our editorship. Gastroenterology. 1996 May; 110(5):1336-8. PMID: 8613036.
      View in: PubMed
    271. Wilson KT, Vaandrager AB, De Vente J, Musch MW, De Jonge HR, Chang EB. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Am J Physiol. 1996 Mar; 270(3 Pt 1):C832-40. PMID: 8638664.
      View in: PubMed
    272. Musch MW, Ciancio MJ, Sarge K, Chang EB. Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury. Am J Physiol. 1996 Feb; 270(2 Pt 1):C429-36. PMID: 8779904.
      View in: PubMed
    273. Shallat S, Schmidt L, Reaka A, Rao D, Chang EB, Rao MC, Ramaswamy K, Layden TJ. NHE-1 isoform of the Na+/H+ antiport is expressed in the rat and rabbit esophagus. Gastroenterology. 1995 Nov; 109(5):1421-8. PMID: 7557121.
      View in: PubMed
    274. Soleimani M, Bookstein C, Singh G, Rao MC, Chang EB, Bastani B. Differential regulation of Na+/H+ exchange and H(+)-ATPase by pH and HCO3- in kidney proximal tubules. J Membr Biol. 1995 Apr; 144(3):209-16. PMID: 7658458.
      View in: PubMed
    275. Bookstein C, Musch MW, DePaoli A, Xie Y, Villereal M, Rao MC, Chang EB. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity. J Biol Chem. 1994 Nov 25; 269(47):29704-9. PMID: 7961960.
      View in: PubMed
    276. McSwine RL, Babnigg G, Musch MW, Chang EB, Villereal ML. Expression and phosphorylation of NHE1 in wild-type and transformed human and rodent fibroblasts. J Cell Physiol. 1994 Nov; 161(2):351-7. PMID: 7962119.
      View in: PubMed
    277. Soleimani M, Bookstein C, Bizal GL, Musch MW, Hattabaugh YJ, Rao MC, Chang EB. Localization of the Na+/H+ exchanger isoform NHE-3 in rabbit and canine kidney. Biochim Biophys Acta. 1994 Oct 12; 1195(1):89-95. PMID: 7918570.
      View in: PubMed
    278. Cho JH, Musch MW, DePaoli AM, Bookstein CM, Xie Y, Burant CF, Rao MC, Chang EB. Glucocorticoids regulate Na+/H+ exchange expression and activity in region- and tissue-specific manner. Am J Physiol. 1994 Sep; 267(3 Pt 1):C796-803. PMID: 7943208.
      View in: PubMed
    279. Soleimani M, Bookstein C, McAteer JA, Hattabaugh YJ, Bizal GL, Musch MW, Villereal M, Rao MC, Howard RL, Chang EB. Effect of high osmolality on Na+/H+ exchange in renal proximal tubule cells. J Biol Chem. 1994 Jun 03; 269(22):15613-8. PMID: 8195209.
      View in: PubMed
    280. Toskulkao C, Bhartur S, Musch MW, Chang EB, Rao MC. Phorbol dibutyrate-specific protein phosphorylation in brush border membranes of chicken enterocytes. J Cell Physiol. 1994 May; 159(2):347-55. PMID: 8163573.
      View in: PubMed
    281. Burant CF, Flink S, DePaoli AM, Chen J, Lee WS, Hediger MA, Buse JB, Chang EB. Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes. J Clin Invest. 1994 Feb; 93(2):578-85. PMID: 8113395.
      View in: PubMed
    282. Bookstein C, DePaoli AM, Xie Y, Niu P, Musch MW, Rao MC, Chang EB. Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization. J Clin Invest. 1994 Jan; 93(1):106-13. PMID: 8282777.
      View in: PubMed
    283. Wilson KT, Xie Y, Musch MW, Chang EB. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J Pharmacol Exp Ther. 1993 Jul; 266(1):224-30. PMID: 8331560.
      View in: PubMed
    284. Tamai H, Kachur JF, Grisham MB, Musch MW, Chang EB, Gaginella TS. Effect of the thiol-oxidizing agent diamide on NH2Cl-induced rat colonic electrolyte secretion. Am J Physiol. 1993 Jul; 265(1 Pt 1):C166-70. PMID: 8338125.
      View in: PubMed
    285. Pamukcu R, Spiegel AM, Chang EB. Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte. J Lab Clin Med. 1993 May; 121(5):689-96. PMID: 8478596.
      View in: PubMed
    286. Musch MW, Bookstein C, Arvans DL, Cragoe EJ, Rao MC, Chang EB. Characterization of chicken intestinal brush border membrane Na/H exchange. Comp Biochem Physiol Comp Physiol. 1992 Nov; 103(3):439-44. PMID: 1358503.
      View in: PubMed
    287. Ciancio MJ, Vitiritti L, Dhar A, Chang EB. Endotoxin-induced alterations in rat colonic water and electrolyte transport. Gastroenterology. 1992 Nov; 103(5):1437-43. PMID: 1358740.
      View in: PubMed
    288. Barrett TA, Gajewski TF, Danielpour D, Chang EB, Beagley KW, Bluestone JA. Differential function of intestinal intraepithelial lymphocyte subsets. J Immunol. 1992 Aug 15; 149(4):1124-30. PMID: 1380032.
      View in: PubMed
    289. Musch MW, Drabik-Arvans D, Rao MC, Chang EB. Bethanechol inhibition of chicken intestinal brush border Na/H exchange: role of protein kinase C and other calcium-dependent processes. J Cell Physiol. 1992 Aug; 152(2):362-71. PMID: 1353500.
      View in: PubMed
    290. Hoffman LR, Yen S, Chang EB. Regional alterations in intestinal sucrase expression in streptozocin-treated chronically diabetic rats. Dig Dis Sci. 1992 Jul; 37(7):1078-83. PMID: 1618056.
      View in: PubMed
    291. Hoffman LR, Chang EB. Altered regulation of regional sucrase-isomaltase expression in diabetic rat intestine. Am J Physiol. 1992 Jun; 262(6 Pt 1):G983-9. PMID: 1616047.
      View in: PubMed
    292. Ciancio MJ, Chang EB. Epithelial secretory response to inflammation. Ann N Y Acad Sci. 1992; 664:210-21. PMID: 1456652.
      View in: PubMed
    293. Tamai H, Gaginella TS, Kachur JF, Musch MW, Chang EB. Ca-mediated stimulation of Cl secretion by reactive oxygen metabolites in human colonic T84 cells. J Clin Invest. 1992 Jan; 89(1):301-7. PMID: 1729277.
      View in: PubMed
    294. Hoffman LR, Chang EB. Determinants of regional sucrase-isomaltase expression in adult rat small intestine. J Biol Chem. 1991 Nov 15; 266(32):21815-20. PMID: 1939205.
      View in: PubMed
    295. Chang EB, Bookstein C, Vaandrager A, DeJonge HR, Buse J, Musch MW. Cystic fibrosis transmembrane regulator mRNA expression relative to ion-nutrient transport in spontaneously differentiating human intestinal CaCo-2 epithelial cells. J Lab Clin Med. 1991 Oct; 118(4):377-81. PMID: 1719108.
      View in: PubMed
    296. Chang EB, Musch MW, Drabik-Arvans D, Rao MC. Phorbol ester inhibition of chicken intestinal brush-border sodium-proton exchange. Am J Physiol. 1991 Jun; 260(6 Pt 1):C1264-72. PMID: 1647664.
      View in: PubMed
    297. Barrett TA, Musch MW, Chang EB. Chemotactic peptide effects on intestinal electrolyte transport. Am J Physiol. 1990 Dec; 259(6 Pt 1):G947-54. PMID: 1701975.
      View in: PubMed
    298. Barrett TA, Chang EB. What's all the FLAP about? A new 5-lipoxygenase-binding protein identified! Gastroenterology. 1990 Oct; 99(4):1185-6. PMID: 2394341.
      View in: PubMed
    299. Musch MW, Nahkla AM, Chang EB. Phorbol ester-stimulated secretion in chicken ileum: role of arachidonic acid metabolism. Gastroenterology. 1990 Aug; 99(2):393-400. PMID: 2163937.
      View in: PubMed
    300. Semrad CE, Cragoe EJ, Chang EB. Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor. J Clin Invest. 1990 Aug; 86(2):585-91. PMID: 2166756.
      View in: PubMed
    301. Chang EB. Posttranslational processing of ras proteins. Gastroenterology. 1990 Jul; 99(1):276-7. PMID: 2188873.
      View in: PubMed
    302. Chang EB, Musch MW, Mayer L. Interleukins 1 and 3 stimulate anion secretion in chicken intestine. Gastroenterology. 1990 Jun; 98(6):1518-24. PMID: 1692549.
      View in: PubMed
    303. Chang EB. Protein kinase C unleashed. Gastroenterology. 1990 Apr; 98(4):1091-2. PMID: 2311866.
      View in: PubMed
    304. Chang EB. Acid secretion by parietal cells: relative roles for [Ca2+]i and protein kinase C. Gastroenterology. 1990 Jan; 98(1):244-5. PMID: 2293588.
      View in: PubMed
    305. Chang EB, Musch MW. Calcium mediated neurohumoral inhibition of chicken enterocyte Na influx: role of phosphatidylinositol metabolites. Life Sci. 1990; 46(26):1913-21. PMID: 1694550.
      View in: PubMed
    306. Chang EB. Transforming growth factors and intestinal epithelia: more questions than answers. Gastroenterology. 1989 Dec; 97(6):1587-8. PMID: 2583421.
      View in: PubMed
    307. Chang EB. Salmonella bacterial adherence and penetration of mucosal cells: inducing role of the epithelium. Gastroenterology. 1989 Oct; 97(4):1055-6. PMID: 2777029.
      View in: PubMed
    308. Field M, Rao MC, Chang EB. Intestinal electrolyte transport and diarrheal disease (2) N Engl J Med. 1989 Sep 28; 321(13):879-83. PMID: 2671741.
      View in: PubMed
    309. Field M, Rao MC, Chang EB. Intestinal electrolyte transport and diarrheal disease (1). N Engl J Med. 1989 Sep 21; 321(12):800-6. PMID: 2671736.
      View in: PubMed
    310. Fedorak RN, Kotake A, Douglas F, Chang EB. Inhibition of cholera-toxin-stimulated intestinal secretion by CGS 9343B in rats: a specific calmodulin inhibitor. J Pediatr Gastroenterol Nutr. 1989 Feb; 8(2):252-8. PMID: 2540305.
      View in: PubMed
    311. Pamukcu R, Hanauer SB, Chang EB. Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid. Gastroenterology. 1988 Oct; 95(4):975-81. PMID: 2842215.
      View in: PubMed
    312. Carroll KM, Wood RJ, Chang EB, Rosenberg IH. Glucose enhancement of transcellular calcium transport in the intestine. Am J Physiol. 1988 Sep; 255(3 Pt 1):G339-45. PMID: 3138919.
      View in: PubMed
    313. Hirose R, Chang EB. Effects of serotonin on Na+-H+ exchange and intracellular calcium in isolated chicken enterocytes. Am J Physiol. 1988 Jun; 254(6 Pt 1):G891-7. PMID: 3377086.
      View in: PubMed
    314. Roberts WG, Fedorak RN, Chang EB. In vitro effects of the long-acting somatostatin analogue SMS 201-995 on electrolyte transport by the rabbit ileum. Gastroenterology. 1988 Jun; 94(6):1343-50. PMID: 2896138.
      View in: PubMed
    315. Carroll KM, Wong TT, Drabik DL, Chang EB. Differentiation of rat small intestinal epithelial cells by extracellular matrix. Am J Physiol. 1988 Mar; 254(3 Pt 1):G355-60. PMID: 3348402.
      View in: PubMed
    316. Wood RJ, Carroll KM, Chang EB, Rosenberg IH. Effect of glucose on calcium transport in rat duodenum. Prog Clin Biol Res. 1988; 252:347-51. PMID: 3347625.
      View in: PubMed
    317. Fedorak RN, Chang EB, Madara JL, Field M. Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats. J Clin Invest. 1987 Jun; 79(6):1571-8. PMID: 2953760.
      View in: PubMed
    318. Semrad CE, Chang EB. Calcium-mediated cyclic AMP inhibition of Na-H exchange in small intestine. Am J Physiol. 1987 Mar; 252(3 Pt 1):C315-22. PMID: 3030130.
      View in: PubMed
    319. Chang EB, Fedorak RN, Field M. Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine. Gastroenterology. 1986 Sep; 91(3):564-9. PMID: 2874098.
      View in: PubMed
    320. Chang EB, Brown DR, Wang NS, Field M. Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide. J Clin Invest. 1986 Jul; 78(1):281-7. PMID: 2424933.
      View in: PubMed
    321. Ahn J, Chang EB, Field M. Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol. 1985 Nov; 249(5 Pt 1):C527-30. PMID: 3864381.
      View in: PubMed
    322. Chang EB, Wang NS, Rao MC. Phorbol ester stimulation of active anion secretion in intestine. Am J Physiol. 1985 Sep; 249(3 Pt 1):C356-61. PMID: 3862350.
      View in: PubMed
    323. Chang EB, Bergenstal RM, Field M. Diarrhea in streptozocin-treated rats. Loss of adrenergic regulation of intestinal fluid and electrolyte transport. J Clin Invest. 1985 May; 75(5):1666-70. PMID: 2987308.
      View in: PubMed
    324. Fedorak RN, Field M, Chang EB. Treatment of diabetic diarrhea with clonidine. Ann Intern Med. 1985 Feb; 102(2):197-9. PMID: 3966758.
      View in: PubMed
    325. Miller RJ, Brown DR, Chang EB, Friel DD. The pharmacological modification of secretory responses. Ciba Found Symp. 1985; 112:155-74. PMID: 2408831.
      View in: PubMed
    326. Chang EB, Brown DR, Field M, Miller RJ. An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats. J Pharmacol Exp Ther. 1984 Feb; 228(2):364-9. PMID: 6607339.
      View in: PubMed
    327. Field M, Chang EB. Pancreatic cholera: is the diarrhea due to VIP? N Engl J Med. 1983 Dec 15; 309(24):1513-5. PMID: 6316137.
      View in: PubMed
    328. Chang EB, Field M, Miller RJ. Enterocyte alpha 2-adrenergic receptors: yohimbine and p-aminoclonidine binding relative to ion transport. Am J Physiol. 1983 Jan; 244(1):G76-82. PMID: 6295186.
      View in: PubMed
    329. Chang EB, Field M, Miller RJ. alpha 2-Adrenergic receptor regulation of ion transport in rabbit ileum. Am J Physiol. 1982 Mar; 242(3):G237-42. PMID: 6278952.
      View in: PubMed
    Chang's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _