 Receptor, Macrophage Colony-Stimulating Factor
"Receptor, Macrophage Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.
| Descriptor ID |
D016186
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.500 D12.776.543.750.060.492 D12.776.543.750.705.852.150.150 D12.776.543.750.750.400.200.200 D12.776.624.664.700.800 D23.050.301.264.035.597 D23.101.100.110.597
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| Concept/Terms |
Receptor, Macrophage Colony-Stimulating Factor- Receptor, Macrophage Colony-Stimulating Factor
- Receptor, Macrophage Colony Stimulating Factor
- c-fms Protein
- c fms Protein
- CD115 Antigen
- Antigen, CD115
- CD115 Antigens
- CSF-1 Receptor
- Receptors, Macrophage Colony-Stimulating Factor
- Receptors, Macrophage Colony Stimulating Factor
- M-CSF Receptors
- Macrophage Colony-Stimulating Factor Receptors
- Macrophage Colony Stimulating Factor Receptors
- Proto-Oncogene Protein fms
- Receptor, CSF-1
- Receptor, CSF 1
- Receptors, CSF-1
- CSF-1 Receptors
- Receptors, CSF 1
- Receptors, M-CSF
- Receptors, M CSF
- Antigens, CD115
- fms Proto-Oncogene Protein
- Proto-Oncogene Protein, fms
- fms Proto Oncogene Protein
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Below are MeSH descriptors whose meaning is more general than "Receptor, Macrophage Colony-Stimulating Factor".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.060]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.060.492]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, Colony-Stimulating Factor [D12.776.543.750.705.852.150]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.705.852.150.150]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.750.400.200.200]
- Neoplasm Proteins [D12.776.624]
- Oncogene Proteins [D12.776.624.664]
- Proto-Oncogene Proteins [D12.776.624.664.700]
- Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- Receptor, Macrophage Colony-Stimulating Factor [D23.050.301.264.035.597]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- Receptor, Macrophage Colony-Stimulating Factor [D23.101.100.110.597]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Macrophage Colony-Stimulating Factor".
This graph shows the total number of publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in this website by year, and whether "Receptor, Macrophage Colony-Stimulating Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Macrophage Colony-Stimulating Factor" by people in Profiles.
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Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, Joyce JA, Fagin JA. Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS One. 2013; 8(1):e54302.
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Hiroyasu S, Chinnasamy P, Hou R, Hotchkiss K, Casimiro I, Dai XM, Stanley ER, Sibinga NE. Donor and recipient cell surface colony stimulating factor-1 promote neointimal formation in transplant-associated arteriosclerosis. Arterioscler Thromb Vasc Biol. 2013 Jan; 33(1):87-95.
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Powers RW, Jeyabalan A, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, Lindheimer MD, Sibai B, Landon M, Miodovnik M. Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS One. 2010 Oct 11; 5(10):e13263.
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Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med. 2010 May; 16(5):580-5, 1p following 585.
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Zou GM, Wu W, Chen J, Rowley JD. Duplexes of 21-nucleotide RNAs mediate RNA interference in differentiated mouse ES cells. Biol Cell. 2003 Sep; 95(6):365-71.
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Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W. Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression. Mol Biol Cell. 2000 Nov; 11(11):3835-48.
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Kee BL, Murre C. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med. 1998 Aug 17; 188(4):699-713.
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Fears S, Gavin M, Zhang DE, Hetherington C, Ben-David Y, Rowley JD, Nucifora G. Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1949-54.
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Rhoades KL, Hetherington CJ, Rowley JD, Hiebert SW, Nucifora G, Tenen DG, Zhang DE. Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11895-900.
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Zent CS, Mathieu C, Claxton DF, Zhang DE, Tenen DG, Rowley JD, Nucifora G. The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1044-8.
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