"T-Box Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.
| Descriptor ID |
D020825
|
| MeSH Number(s) |
D12.776.260.725 D12.776.930.850
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "T-Box Domain Proteins".
Below are MeSH descriptors whose meaning is more specific than "T-Box Domain Proteins".
This graph shows the total number of publications written about "T-Box Domain Proteins" by people in this website by year, and whether "T-Box Domain Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 3 | 0 | 3 |
| 2002 | 1 | 0 | 1 |
| 2003 | 2 | 0 | 2 |
| 2004 | 2 | 3 | 5 |
| 2005 | 3 | 1 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 2 | 0 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 4 | 1 | 5 |
| 2011 | 4 | 0 | 4 |
| 2012 | 5 | 5 | 10 |
| 2013 | 4 | 3 | 7 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 1 | 3 |
| 2016 | 5 | 1 | 6 |
| 2017 | 1 | 2 | 3 |
| 2018 | 4 | 0 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 4 | 2 | 6 |
| 2021 | 1 | 4 | 5 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "T-Box Domain Proteins" by people in Profiles.
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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection. Science. 2025 Jan 02; 387(6735):eadn2337.
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Ancient developmental genes underlie evolutionary novelties in walking fish. Curr Biol. 2024 Oct 07; 34(19):4339-4348.e6.
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Eomes expression identifies the early bone marrow precursor to classical NK cells. Nat Immunol. 2024 Jul; 25(7):1172-1182.
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Regulation of stem cell identity by miR-200a during spinal cord regeneration. Development. 2022 02 01; 149(3).
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Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries. Circ Res. 2022 01 21; 130(2):166-180.
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Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10.
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Noncanonical Notch signals have opposing roles during cardiac development. Biochem Biophys Res Commun. 2021 11 05; 577:12-16.
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Randomized, Double-Blind, Placebo-Controlled Phase II Study of Yeast-Brachyury Vaccine (GI-6301) in Combination with Standard-of-Care Radiotherapy in Locally Advanced, Unresectable Chordoma. Oncologist. 2021 05; 26(5):e847-e858.
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Progenitor cell diversity in the developing mouse neocortex. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).
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Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1. Cardiovasc Res. 2020 07 01; 116(8):1473-1486.