Apoptosis Inducing Factor
"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
| Descriptor ID |
D051033
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| MeSH Number(s) |
D08.811.682.608.047 D12.644.360.075.311 D12.776.157.687.063 D12.776.331.161 D12.776.476.075.311 D12.776.660.720.063
|
| Concept/Terms |
Apoptosis Inducing Factor- Apoptosis Inducing Factor
- Apoptosis-Inducing Factor
- Mitochondrial Apoptosis-Inducing Factor
- Apoptosis-Inducing Factor, Mitochondrial
- Mitochondrial Apoptosis Inducing Factor
- AIF Apoptosis Regulatory Protein
|
Below are MeSH descriptors whose meaning is more general than "Apoptosis Inducing Factor".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis Inducing Factor".
This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in this website by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
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Below are the most recent publications written about "Apoptosis Inducing Factor" by people in Profiles.
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Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo. Neuroscience. 2007 Feb 09; 144(3):991-1003.
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Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res. 2003 Dec 01; 63(23):8233-40.
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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 02; 22(43):6669-78.
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Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 2001 Sep; 3(9):839-43.
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Amphiphilic, tri-block copolymers provide potent membrane-targeted neuroprotection. FASEB J. 2001 Apr; 15(6):1107-9.
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Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts. J Virol. 2000 Oct; 74(19):9048-53.
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Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000 Sep; 2(9):645-52.