"POU Domain Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors characterized by the presence of a bipartite DNA-binding domain known as the POU domain. The POU domain contains two subdomains, a POU-specific domain and a POU-homeodomain. The POU domain was originally identified as a region of approximately 150 amino acids shared between the Pit-1, Oct-1, Oct-2, and Unc-86 transcription factors.
| Descriptor ID |
D050809
|
| MeSH Number(s) |
D12.776.260.655 D12.776.930.710
|
| Concept/Terms |
POU Domain Factors- POU Domain Factors
- Pit-Oct-Unc Proteins
- Pit Oct Unc Proteins
- POU Proteins
- Transcription Factor POU
- POU, Transcription Factor
|
Below are MeSH descriptors whose meaning is more general than "POU Domain Factors".
Below are MeSH descriptors whose meaning is more specific than "POU Domain Factors".
This graph shows the total number of publications written about "POU Domain Factors" by people in this website by year, and whether "POU Domain Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "POU Domain Factors" by people in Profiles.
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Progenitor cell diversity in the developing mouse neocortex. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).
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Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships. Elife. 2020 05 11; 9.
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MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun. 2020 01 17; 11(1):338.
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The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders. Sci Transl Med. 2018 12 19; 10(472).
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Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013 Feb 06; 77(3):472-84.
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Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis. Mol Syst Biol. 2007; 3:72.
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POU/TBP cooperativity: a mechanism for enhancer action from a distance. Mol Cell. 2002 Aug; 10(2):397-407.
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spiel ohne grenzen/pou2 is required for zebrafish hindbrain segmentation. Development. 2002 Apr; 129(7):1645-55.
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Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors. Mol Endocrinol. 2002 Mar; 16(3):435-49.