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overview I direct the Molecular Oncology Laboratory in the Department of Orthopaedic Surgery and Rehabilitation Medicine. Our lab consists of a dynamic group of basic science investigators and physician scientists, who have diverse expertise and a broad range of research interests. Our shared long-term objective is to better understand the molecular pathogenesis of bone and musculoskeletal diseases and to translate basic discoveries into potential therapies and/or preventive measures in clinical settings. Specifically, we focus on the following areas: LINEAGE COMMITMENT AND TERMINAL DIFFERENTIATION OF MESENCHYMAL STEM CELLS (MSCS) Multipotency of MSCs MSCs are pluripotent and capable of differentiating into osteogenic, chondrogenic, myogenic or adipogenic lineage. Understanding the molecular mechanisms of bone formation is pivotal for studying the pathogenesis of bone diseases. We are interested in elucidating the molecular mechanisms through which regulate the proliferation and differentiation of osteoblasts, chondrocytes, and adipocytes. Both Wnt/beta-catenin and bone morphogenetic proteins (BMPs) have been considered as important regulators of osteogenic differentiation of mesenchymal stem cells. We are investigating the biological functions of BMPs and Wnt/beta-catenin signaling in regulating the osteoblast differentiation of MSCs. We have therefore conducted a comprehensive analysis of BMP and Wnt3A-induced osteoblast differentiation of MSCs. Our findings indicate that osteoblast differentiation is a well-regulated process in normal progenitor cells, while osteosarcoma cells are refractory to osteogenic differentiation signal. BMP-9 is one of the most potent regulators of osteogenic differentiation The bone-forming osteoblasts are derived from pluripotent bone marrow fibroblasts (a.k.a., MSCs). Although the molecular mechanisms underlying bone formation remain to be defined, BMPs seem to play an important role in osteoblast differentiation. At least 15 types of BMPs have been identified in mice and humans. However, the ability of BMPs to induce osteoblast differentiation of mesenchymal stem cells has not been comprehensively investigated, mostly due to the fact that recombinant proteins are either not biologically active or not available for all BMPs. Through a comprehensive analysis, we found that BMP2, BMP6, and BMP9 (to a much lesser extent, BMP4 and BMP7) exhibited the greatest ability to induce osteoblast differentiation, whereas BMP3 was shown to inhibit osteogenesis, both in vitro and in vivo. Our findings about BMP9 as one of the most potent inducers of osteoblast differentiation are novel and particularly intriguing because BMP9 is one of the least characterized BMPs and its functions are largely unknown. Thus, many questions regarding BMP9 signaling need to be answered: What are the type I and type II TGFbeta/BMP receptors involved in BMP9 binding? What Smads are required for BMP9 signaling? How are the downstream targets regulated by BMP9? More importantly, what are the roles of BMP9 during embryonic and/or skeletal development? We are interested in addressing these questions. Critical mediators of BMP-induced differentiation of MSCs We have identified several potentially important signaling mediators of BMP-induced osteogenic differentiation. These targets include the Inhibitors of DNA binding/Differentiation helix-loop-helix (a.k.a., Id proteins) and CTGF. Interestingly, both Ids and CTGF have been shown to overexpress in human tumors. Our findings suggest that Ids and CTGF may play an important role in promoting the proliferation of early osteoblast progenitor cells and that their expression must be down-regulated during the terminal differentiation of committed osteoblasts, suggesting that a balanced regulation of their expression may be critical to BMP-induced osteoblast lineage-specific differentiation of MSCs. We are currently dissecting the functional roles of the important downstream mediators in BMP-induced osteogenic signaling. We are also interested in identifying the molecular switches that control the lineage-specific differentiation of osteoblasts, chondrocytes, and adipocytes in MSCs. We are especially interested in understanding at what stage osteogenic BMPs (e.g., BMP2 or BMP9)-induced osteogenic and adipogenic differentiation diverges. What are the potential regulators that control this lineage divergence? It has been long postulated that a disrupted balance between osteogenesis and adipogenesis may cause musculoskeletal diseases, such as osteoporosis. Wnts regulate osteogenic differentiation of mesenchymal stem cells Our earlier studies demonstrated that Wnt/beta-catenin signaling is de-regulated in over 70% of human osteosarcoma. Recent studies also suggest that Wnt signaling may play an important role in regulating bone density, and one of the Wnt signaling antagonists Dkk1 may be implicated in the development of osteolytic lesion in multiple myeloma patients. We demonstrated that Wnt3A can induce the early osteogenic marker alkaline phosphatase in MSCs. Upon analyzing the gene expression profile of MSCs that were stimulated with Wnt3A, we found that three members of the CCN family, CCN1/Cyr61, CCN2/CTGF, and CCN5/WISP2, were among the most significantly up-regulated genes. Further studies demonstrate that CTGF is a mutual target of Wnt and BMP-9, and plays an important role in regulating osteogenic differentiation. However, more questions remain to be answered. We are currently investigating how osteogenic differentiation of MSCs is regulated by canonical and non-canonical Wnt signaling. MOLECULAR BASES OF BONE AND SOFT TISSUE SARCOMAS Sarcomas represent a heterogeneous group of malignant mesenchymal tumors with numerous histologic subtypes and complex cytogenetic abnormalities. Unlike other common solid tumors, sarcomas are relatively uncommon and their molecular pathogenesis, in general, are poorly understood. We mainly focus on understanding the molecular biology of primary bone tumor (a.k.a., osteosarcoma, OS). Osteosarcoma is the most common primary malignancy of bone, and is among the most common non-hematological primary tumors of bone in both children and adults. The peak incidence occurs in the second decade. With preoperative chemotherapy, the five-year survival rate of patients with non-metastatic tumors has improved significantly to approximately 60-70%. However, cases with local recurrence and/or pulmonary metastasis are usually less sensitive, if not resistant, to conventional chemotherapies. Several cytogenetic studies suggest that certain chromosomal regions may be amplified, rearranged, or deleted in some, but not all, human osteosarcomas. Unfortunately, the low incidence of this disease and the absence of any familial predisposition have complicated efforts to identify osteosarcoma-associated genes. Thus, we are taking a comprehensive approach to elucidate the molecular mechanisms underlying the development of osteosarcoma. Wnt/beta-catenin signaling in the development of human osteosarcoma Aberrant activation of Wnt/beta-catenin signaling by inactivating APC tumor suppressor or oncogenic activation of beta-catenin plays an important role in colorectal tumorigenesis. Oncogenic activation of beta-catenin has also been reported in several types of human solid tumors. We found that beta-catenin signaling is de-regulated in about 70% of human osteosarcoma without beta-catenin mutations. As in many other types of non-colon cancer, little is known about how Wnt/beta-catenin signaling pathway is activated. Therefore, we are interested in elucidating the upstream regulatory mechanisms that may underline of the beta-catenin signaling pathway. We are also interested in investigating the possible pathogenic role of beta-catenin deregulation in bone and soft tissue tumors. Furthermore, we are investigating the potential roles of EF-hand calcium-binding S100 proteins in osteosarcoma progression and the development of pulmonary metastasis. Clinically relevant osteosarcoma animal model In order to investigate the pathogenesis of human osteosarcoma, there is a great need to develop a clinically relevant animal model. We have developed such an orthotopic animal model of osteosarcoma using several human osteosarcoma lines. This clinically relevant model of human osteosarcoma provides varying degrees of tumor growth at the primary site and of metastatic potential. Thus, this orthotopic model is being used as a valuable tool to investigate factors that promote or inhibit osteosarcoma growth and/or metastasis. For instance, we are now using this model to investigate the roles of genes that are known to promote cell proliferation and inhibit differentiation, and genes that potentially promote or inhibit cancer metastasis. This orthotopic model can also be used to test anti-tumor small molecules or other targeted therapies. Osteosarcoma is a differentiation disease We believe that understanding the molecular events behind normal osteoblast differentiation of MSCs may provide important clues to osteosarcoma development. Stem cell differentiation and tumorigenesis share some strikingly similar characteristics. Both normal stem cells and cancer stem cells have the ability to self-renew. Although stem cells are often the target of genetic events that are necessary or sufficient for malignant transformation, in some cases restricted progenitors or even differentiated cells may become transformed. Thus, cancer stem cells may be derived from tissue-specific stem cells or progenitors, such as MSCs. Although cancer stem cells for osteosarcoma remain to be identified, OS cells indeed exhibit the characteristics of undifferentiated osteoblasts, and we have shown that differentiation-promoting agents can inhibit OS proliferation. Accordingly, we found that human osteosarcoma cells are in general refractory to osteogenic BMPs and exhibit no signs of terminal differentiation upon osteogenic BMP stimulation. Thus, we hypothesize that osteosarcoma development is caused by molecular/genetic disruptions of the osteogenic differentiation pathway. We are investigating and identifying the possible defects in osteogenic pathway, including the possible roles of the early target genes of BMP-induced osteoblast lineage-specific differentiation of MSCs. MOLECULAR BIOLOGY OF CANCER METASTASIS Cancer metastasis is an often overlooked and least understood problem. Metastasis is defined as the progressive growth of tumor cells at a site that is discontinuous from the primary tumor. Although not an efficient process, colonization at distant tissues by tumor cells represents the most dangerous attribute of cancer, because metastases, rather than primary tumors, are responsible for most cancer deaths. Metastatic cells are a subset of primary tumor cells that have acquired the ability to complete a multi-step metastatic cascade, including migration, dissemination, extravasation, and eventual proliferation at a discontinuous secondary site. Understanding the molecular biology of cancer metastasis may provide novel intervention strategies to control/contain metastatic lesions, and/or to improve the quality of life for the patients with these advanced diseases. Pulmonary metastasis of primary bone tumors Lung metastasis is the leading cause of OS mortality. Our orthotopic tumor model of human OS provides a unique opportunity for us to investigate the molecular events underlying osteosarcoma pulmonary metastasis. Using this model, we have conducted serial selections of highly metastatic human OS sublines, which were otherwise non-metastatic. Using microarray analysis, we have compared the gene expression profiles between these sublines and the parental lines in search for gene(s) that may cause or be associated with osteosarcoma metastasis. In an alternative approach, we are conducting functional selection assays, in which an RNAi library has been introduced into the non-metastatic or less metastatic human osteosarcoma cells to recover lung metastases and to identify potential metastasis suppressors of human osteosarcoma. Metastatic bone tumors Bone is one of the most frequently targeted organs for cancer metastasis, and bone is the most common site for distant relapse of most cancers. The bone microenvironment is unique among metastatic target tissues because it is subjected to continuous remodeling under the influence circulating hormones and local bone-derived factors. Interactions between the bone microenvironment and the cancer cells can give rise to osteolytic (bone resorbing) or osteoblastic (bone forming) metastasis. Osteolytic bone metastasis are characteristic for most malignancies, such as breast cancer and lung cancer, while osteoblastic metastasis is mostly associated with prostate cancer. We are investigating the molecular mechanisms through which the interactions between metastatic (breast and prostate) cancer cells and bone microenvironment are regulated. NOVEL THERAPEUTIC AND/OR PREVENTIVE STRATEGIES FOR BONE AND MUSCULOSKELETAL DISEASES The ultimate goal of biomedical research is to develop innovative diagnostic, therapeutic, and/or preventive strategies for human diseases. We are interested in developing innovative approaches for local or systemic delivery of therapeutic genes as effective treatment for bone and musculoskeletal diseases. We are investigating the use of osteogenic BMPs for bone regeneration, enhancing fracture healing, repairing segmental defects, promoting spinal fusion, and preventing implant wear particle-induced osteolysis. We have recently demonstrated the potential use of some of the BMPs in promoting biomechanical features of healing tendons/ligaments. We also demonstrated that Sox9, a master regulator of chondrogenesis, may be used in gene therapy to treat intervertebral disc degeneration and articular cartilage injuries. These lines of investigation reflect our commitment to the true spirit of translational research in bone and musculoskeletal disorders.

One or more keywords matched the following items that are connected to He, Tong-Chuan

Item TypeName
Concept DNA-Binding Proteins
Concept Eye Proteins
Concept Microtubule-Associated Proteins
Concept High Mobility Group Proteins
Concept Membrane Proteins
Concept Nerve Tissue Proteins
Concept Heat-Shock Proteins
Concept Muscle Proteins
Concept Protein Precursors
Concept Protein-Tyrosine Kinases
Concept Protein Binding
Concept Protein Processing, Post-Translational
Concept Proto-Oncogene Proteins
Concept Proteins
Concept Repressor Proteins
Concept Viral Core Proteins
Concept Intermediate Filament Proteins
Concept Adenovirus E1A Proteins
Concept Protein Engineering
Concept rho GTP-Binding Proteins
Concept Mitogen-Activated Protein Kinases
Concept Extracellular Matrix Proteins
Concept Zebrafish Proteins
Concept Cysteine Proteinase Inhibitors
Concept Proto-Oncogene Proteins c-fos
Concept Cyclic AMP Response Element-Binding Protein
Concept Proto-Oncogene Proteins c-myc
Concept Protein Structure, Tertiary
Concept S100 Proteins
Concept Amyloid beta-Protein Precursor
Concept Immediate-Early Proteins
Concept ets-Domain Protein Elk-1
Concept Apoptosis Regulatory Proteins
Concept Inhibitor of Apoptosis Proteins
Concept Wnt1 Protein
Concept Insulin-Like Growth Factor Binding Protein 5
Concept Von Hippel-Lindau Tumor Suppressor Protein
Concept Insulin-Like Growth Factor Binding Protein 3
Concept Intercellular Signaling Peptides and Proteins
Concept Wnt3 Protein
Concept Green Fluorescent Proteins
Concept Smad4 Protein
Concept Mitogen-Activated Protein Kinase 3
Concept Proto-Oncogene Proteins c-bcl-2
Concept Cell Cycle Proteins
Concept Insulin-Like Growth Factor Binding Protein 4
Concept Proto-Oncogene Proteins c-kit
Concept Bone Morphogenetic Proteins
Concept I-kappa B Proteins
Concept Oncogene Protein v-akt
Concept Wnt Proteins
Concept Adenomatous Polyposis Coli Protein
Concept Recombinant Proteins
Concept Hedgehog Proteins
Concept Ribosomal Proteins
Concept Bone Morphogenetic Protein 4
Concept CCN Intercellular Signaling Proteins
Concept Phospholipid Transfer Proteins
Concept Low Density Lipoprotein Receptor-Related Protein-5
Concept Adaptor Proteins, Signal Transducing
Concept Protein Interaction Domains and Motifs
Concept Bone Morphogenetic Protein 7
Concept Viral Proteins
Concept Retinoblastoma Protein
Concept GTP-Binding Proteins
Concept Nucleocapsid Proteins
Concept Cysteine-Rich Protein 61
Concept Homeodomain Proteins
Concept JNK Mitogen-Activated Protein Kinases
Concept Tumor Suppressor Proteins
Concept Tumor Suppressor Protein p14ARF
Concept Transcription Factor 7-Like 2 Protein
Concept Escherichia coli Proteins
Concept Bone Morphogenetic Protein 6
Concept Wnt3A Protein
Concept Intracellular Signaling Peptides and Proteins
Concept 14-3-3 Proteins
Concept bcl-Associated Death Protein
Concept Amyloid Precursor Protein Secretases
Concept Bone Morphogenetic Protein 2
Concept Bone Morphogenetic Protein 3
Concept Protein Stability
Concept Calcium-Binding Proteins
Concept Carrier Proteins
Concept Cytoskeletal Proteins
Concept Luminescent Proteins
Concept Neoplasm Proteins
Concept Nuclear Proteins
Concept Pregnancy Proteins
Concept Recombinant Fusion Proteins
Concept Tumor Suppressor Protein p53
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Isoforms
Concept Protein Array Analysis
Concept Protein Kinase Inhibitors
Concept p38 Mitogen-Activated Protein Kinases
Concept Proto-Oncogene Proteins c-akt
Concept Smad Proteins
Academic Article Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity.
Academic Article Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma.
Academic Article [The expression of Recombinant adenovirus IkappaBalphaM in human hepatocarcinoma HepG2 and it's inhibitive effect to the activity of NF-kappaB].
Academic Article Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
Academic Article Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells.
Academic Article Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling.
Academic Article Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells.
Academic Article Potential use of Sox9 gene therapy for intervertebral degenerative disc disease.
Academic Article Characterization of adenovirus-mediated gene transfer in rabbit flexor tendons.
Academic Article Transduced bovine articular chondrocytes affect the metabolism of cocultured nucleus pulposus cells in vitro: implications for chondrocyte transplantation into the intervertebral disc.
Academic Article Is cytomegalovirus associated with human colorectal tumorigenesis?
Academic Article Gene therapy for spinal fusion.
Academic Article Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases.
Academic Article Wnt signaling and human diseases: what are the therapeutic implications?
Academic Article S100A6 expression and function in human osteosarcoma.
Academic Article Tyrosine kinase inhibitor STI-571: the new wonder drug of cancer therapy.
Academic Article BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling.
Academic Article Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects.
Academic Article Gene therapy for bone regeneration.
Academic Article Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.
Academic Article Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells.
Academic Article Neurogenesis-related genes expression profiling of mouse fibroblastic stem cells induced by Wnt signaling.
Academic Article Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype.
Academic Article Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.
Academic Article Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells.
Academic Article Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation.
Academic Article Pre-activation of retinoid signaling facilitates neuronal differentiation of mesenchymal stem cells.
Academic Article Low serum concentration facilitates the differentiation of hepatic progenitor cells.
Academic Article The therapeutic potential of the Wnt signaling pathway in bone disorders.
Academic Article Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing.
Academic Article Tetrandrine inhibits Wnt/ß-catenin signaling and suppresses tumor growth of human colorectal cancer.
Academic Article Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair.
Academic Article Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling.
Academic Article Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells.
Academic Article The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.
Academic Article Potent and specific inhibition of SARS-CoV antigen expression by RNA interference.
Academic Article TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells.
Academic Article CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells.
Academic Article All-trans retinoic acid inhibits tumor growth of human osteosarcoma by activating Smad signaling-induced osteogenic differentiation.
Academic Article Enhancement of canonical Wnt/ß-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells.
Academic Article Biphasic effects of TGFß1 on BMP9-induced osteogenic differentiation of mesenchymal stem cells.
Academic Article The first identification of lysine malonylation substrates and its regulatory enzyme.
Academic Article A protocol for rapid generation of recombinant adenoviruses using the AdEasy system.
Academic Article Osteosarcoma development and stem cell differentiation.
Academic Article A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells.
Academic Article Oncolytic adenoviral vectors which employ the survivin promoter induce glioma oncolysis via a process of beclin-dependent autophagy.
Academic Article Differentiation of osteoprogenitor cells is induced by high-frequency pulsed electromagnetic fields.
Academic Article Conditional immortalization establishes a repertoire of mouse melanocyte progenitors with distinct melanogenic differentiation potential.
Academic Article Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).
Academic Article Dual regulation of gene expression mediated by tetracycline and Cre recombinase.
Academic Article Wnt/beta-catenin signaling pathway as a novel cancer drug target.
Academic Article Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.
Academic Article Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells.
Academic Article Osteosarcoma and osteoblastic differentiation: a new perspective on oncogenesis.
Academic Article BMP-14 gene therapy increases tendon tensile strength in a rat model of Achilles tendon injury.
Academic Article Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model.
Academic Article Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
Academic Article Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential.
Academic Article Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway.
Academic Article Bone morphogenetic proteins in craniofacial surgery: current techniques, clinical experiences, and the future of personalized stem cell therapy.
Academic Article Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways.
Academic Article Distinct osteogenic activity of BMPs and their orthopaedic applications.
Academic Article Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells.
Academic Article IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma.
Academic Article [Effect of BMP-2 and -3 overexpression on osteogenic and chondrogenic differentiation of prenatal mouse intervertebral disc cells in vitro].
Academic Article Regulation of cell proliferation and migration by p62 through stabilization of Twist1.
Academic Article Crosstalk between Wnt/ß-catenin and estrogen receptor signaling synergistically promotes osteogenic differentiation of mesenchymal progenitor cells.
Academic Article Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.
Academic Article Noggin resistance contributes to the potent osteogenic capability of BMP9 in mesenchymal stem cells.
Academic Article BMP9 regulates cross-talk between breast cancer cells and bone marrow-derived mesenchymal stem cells.
Academic Article A simplified and versatile system for the simultaneous expression of multiple siRNAs in mammalian cells using Gibson DNA Assembly.
Academic Article S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/ß-catenin pathway.
Academic Article Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs).
Academic Article Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/ß-catenin signaling.
Academic Article Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells.
Academic Article The E-F hand calcium-binding protein S100A4 regulates the proliferation, survival and differentiation potential of human osteosarcoma cells.
Academic Article Destabilization of heterologous proteins mediated by the GSK3ß phosphorylation domain of the ß-catenin protein.
Academic Article Modulation of ß-catenin signaling by the inhibitors of MAP kinase, tyrosine kinase, and PI3-kinase pathways.
Academic Article BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways.
Academic Article Overexpression of Ad5 precursor terminal protein accelerates recombinant adenovirus packaging and amplification in HEK-293 packaging cells.
Academic Article Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla.
Academic Article Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells.
Academic Article S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
Academic Article 5-azacytidine promotes terminal differentiation of hepatic progenitor cells.
Academic Article Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.
Academic Article TqPCR: A Touchdown qPCR Assay with Significantly Improved Detection Sensitivity and Amplification Efficiency of SYBR Green qPCR.
Academic Article Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells.
Academic Article Activation of PKA/CREB Signaling is Involved in BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells.
Academic Article Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells.
Academic Article The Calcium-Binding Protein S100A6 Accelerates Human Osteosarcoma Growth by Promoting Cell Proliferation and Inhibiting Osteogenic Differentiation.
Academic Article The Prodomain-Containing BMP9 Produced from a Stable Line Effectively Regulates the Differentiation of Mesenchymal Stem Cells.
Academic Article The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Academic Article Immortalized Mouse Achilles Tenocytes Demonstrate Long-Term Proliferative Capacity While Retaining Tenogenic Properties.
Academic Article Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
Academic Article A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities.
Academic Article Bone morphogenetic protein 9 (BMP9) induces effective bone formation from reversibly immortalized multipotent adipose-derived (iMAD) mesenchymal stem cells.
Academic Article A method for whole protein isolation from human cranial bone.
Academic Article Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid's anti-metastatic effect in 4T1 tumor bearing mice.
Academic Article Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.
Academic Article NEL-Like Molecule-1 (Nell1) Is Regulated by Bone Morphogenetic Protein 9 (BMP9) and Potentiates BMP9-Induced Osteogenic Differentiation at the Expense of Adipogenesis in Mesenchymal Stem Cells.
Academic Article Characterization of retroviral infectivity and superinfection resistance during retrovirus-mediated transduction of mammalian cells.
Academic Article Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors.
Academic Article Engineering the Rapid Adenovirus Production and Amplification (RAPA) Cell Line to Expedite the Generation of Recombinant Adenoviruses.
Academic Article Epimedin C Promotes Vascularization during BMP2-Induced Osteogenesis and Tumor-Associated Angiogenesis.
Academic Article In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/ß-catenin signaling pathway in osteosarcoma.
Academic Article The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells.
Academic Article Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.
Academic Article CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.
Academic Article The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.
Academic Article 14-3-3sigma is a p53-regulated inhibitor of G2/M progression.
Academic Article Genetic determinants of p53-induced apoptosis and growth arrest.
Academic Article Converting cancer genes into killer genes.
Academic Article Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2.
Academic Article Dominant negative effects of a carboxy-truncated Jak2 mutant on Epo-induced proliferation and Jak2 activation.
Academic Article Neural EGF-like protein 1 (NELL-1): Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine.
Academic Article Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway.
Academic Article A simplified system for generating recombinant adenoviruses.
Academic Article The box1 domain of the erythropoietin receptor specifies Janus kinase 2 activation and functions mitogenically within an interleukin 2 beta-receptor chimera.
Academic Article Identification of c-MYC as a target of the APC pathway.
Academic Article PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.
Academic Article The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation.
Academic Article Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells.
Academic Article Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference.
Academic Article Inhibitor of ß-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/ß-catenin complex.
Academic Article Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.
Academic Article Whole-Proteome Analysis of Human Craniosynostotic Tissue Suggests a Link between Inflammatory Signaling and Osteoclast Activation in Human Cranial Suture Patency.
Academic Article Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells.
Academic Article The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs.
Academic Article Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway.
Academic Article Bone Morphogenetic Protein-9-Stimulated Adipocyte-Derived Mesenchymal Progenitors Entrapped in a Thermoresponsive Nanocomposite Scaffold Facilitate Cranial Defect Repair.
Academic Article Dentinogenesis and Tooth-Alveolar Bone Complex Defects in BMP9/GDF2 Knockout Mice.
Academic Article Developing a Versatile Shotgun Cloning Strategy for Single-Vector-Based Multiplex Expression of Short Interfering RNAs (siRNAs) in Mammalian Cells.
Academic Article ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia.
Academic Article Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes.
Academic Article Correction for: Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes.
Academic Article Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs).
Academic Article Differential Responsiveness to BMP9 between Patent and Fused Suture Progenitor Cells from Craniosynostosis Patients.
Academic Article Role of Special AT-Rich Sequence-Binding Protein 2 in the Osteogenesis of Human Dental Mesenchymal Stem Cells.

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