Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Descriptor ID |
D013329
|
MeSH Number(s) |
G02.111.830 G07.690.773.997
|
Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1993 | 0 | 9 | 9 |
1994 | 0 | 9 | 9 |
1995 | 0 | 6 | 6 |
1996 | 0 | 8 | 8 |
1997 | 0 | 8 | 8 |
1998 | 0 | 7 | 7 |
1999 | 0 | 7 | 7 |
2000 | 0 | 7 | 7 |
2001 | 0 | 13 | 13 |
2002 | 0 | 7 | 7 |
2003 | 0 | 17 | 17 |
2004 | 0 | 16 | 16 |
2005 | 1 | 12 | 13 |
2006 | 0 | 11 | 11 |
2007 | 0 | 14 | 14 |
2008 | 0 | 10 | 10 |
2009 | 0 | 11 | 11 |
2010 | 0 | 10 | 10 |
2011 | 0 | 10 | 10 |
2012 | 1 | 10 | 11 |
2013 | 0 | 17 | 17 |
2014 | 0 | 11 | 11 |
2015 | 0 | 14 | 14 |
2016 | 0 | 13 | 13 |
2017 | 0 | 14 | 14 |
2018 | 0 | 9 | 9 |
2019 | 0 | 11 | 11 |
2020 | 0 | 5 | 5 |
2021 | 0 | 7 | 7 |
2023 | 0 | 2 | 2 |
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click here.
Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Nov 05; 259:115561.
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Asymmetric Total Synthesis of (+)-Phainanoid A and Biological Evaluation of the Natural Product and Its Synthetic Analogues. J Am Chem Soc. 2023 03 01; 145(8):4828-4852.
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Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep. 2021 11 02; 37(5):109940.
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Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations. Cancer Res. 2021 09 15; 81(18):4685-4695.
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1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure. ChemMedChem. 2021 09 16; 16(18):2882-2894.
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Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient. Cardiovasc Res. 2021 07 07; 117(8):1923-1934.
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Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC. Eur J Med Chem. 2021 Nov 15; 224:113672.
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Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance. Am J Hum Genet. 2021 03 04; 108(3):458-468.
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Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations. J Clin Immunol. 2021 05; 41(4):756-768.
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Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer. J Med Chem. 2021 01 14; 64(1):741-767.