"DNA Repair" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
| Descriptor ID |
D004260
|
| MeSH Number(s) |
G02.111.222 G05.219
|
| Concept/Terms |
Base Excision Repair- Base Excision Repair
- Base Excision Repairs
- Excision Repair, Base
- Repair, Base Excision
- Repairs, Base Excision
|
Below are MeSH descriptors whose meaning is more general than "DNA Repair".
Below are MeSH descriptors whose meaning is more specific than "DNA Repair".
This graph shows the total number of publications written about "DNA Repair" by people in this website by year, and whether "DNA Repair" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 1 | 3 |
| 1994 | 1 | 0 | 1 |
| 1995 | 2 | 2 | 4 |
| 1996 | 1 | 1 | 2 |
| 1997 | 7 | 3 | 10 |
| 1998 | 3 | 6 | 9 |
| 1999 | 6 | 7 | 13 |
| 2000 | 4 | 2 | 6 |
| 2001 | 0 | 3 | 3 |
| 2002 | 3 | 6 | 9 |
| 2003 | 1 | 5 | 6 |
| 2004 | 4 | 5 | 9 |
| 2005 | 5 | 5 | 10 |
| 2006 | 3 | 3 | 6 |
| 2007 | 3 | 5 | 8 |
| 2008 | 1 | 5 | 6 |
| 2009 | 3 | 3 | 6 |
| 2010 | 3 | 5 | 8 |
| 2011 | 3 | 5 | 8 |
| 2012 | 3 | 4 | 7 |
| 2013 | 1 | 6 | 7 |
| 2014 | 7 | 4 | 11 |
| 2015 | 8 | 5 | 13 |
| 2016 | 3 | 3 | 6 |
| 2017 | 2 | 3 | 5 |
| 2018 | 4 | 2 | 6 |
| 2019 | 6 | 6 | 12 |
| 2020 | 1 | 3 | 4 |
| 2021 | 5 | 3 | 8 |
| 2022 | 1 | 3 | 4 |
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Below are the most recent publications written about "DNA Repair" by people in Profiles.
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High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders. Cell Death Dis. 2022 11 26; 13(11):999.
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Wilms tumor reveals DNA repair gene hyperexpression is linked to lack of tumor immune infiltration. J Immunother Cancer. 2022 06; 10(6).
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Loss of MEN1 function impairs DNA repair capability of pancreatic neuroendocrine tumors. Endocr Relat Cancer. 2022 03 21; 29(4):225-239.
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TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks. Methods Mol Biol. 2022; 2394:299-317.
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Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res. 2021 12 16; 49(22):13135-13149.
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Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial. Nat Med. 2021 11; 27(11):1910-1920.
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Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms. Blood. 2021 09 02; 138(9):790-805.
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METTL14 facilitates global genome repair and suppresses skin tumorigenesis. Proc Natl Acad Sci U S A. 2021 08 31; 118(35).
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The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms. Cancer Res. 2021 10 15; 81(20):5131-5140.
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TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Cancer Res. 2021 10 01; 81(19):5089-5101.