T-Cell Acute Lymphocytic Leukemia Protein 1
"T-Cell Acute Lymphocytic Leukemia Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix transcription factor that plays a critical role in HEMATOPOIESIS and as a positive regulator in the differentiation of ERYTHROID CELLS. Chromosome translocations involving the TAL-1 gene are associated with T-CELL ACUTE LYMPHOCYTIC LEUKEMIA.
| Descriptor ID |
D000073942
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| MeSH Number(s) |
D12.776.260.103.829 D12.776.624.664.700.960 D12.776.930.125.829
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "T-Cell Acute Lymphocytic Leukemia Protein 1".
Below are MeSH descriptors whose meaning is more specific than "T-Cell Acute Lymphocytic Leukemia Protein 1".
This graph shows the total number of publications written about "T-Cell Acute Lymphocytic Leukemia Protein 1" by people in this website by year, and whether "T-Cell Acute Lymphocytic Leukemia Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "T-Cell Acute Lymphocytic Leukemia Protein 1" by people in Profiles.
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S1P-S1PR3-RAS promotes the progression of S1PR3hi TAL1+ T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist. Leukemia. 2023 10; 37(10):1982-1993.
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Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1. J Immunol. 2019 05 15; 202(10):2837-2842.
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Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Blood. 2013 Dec 19; 122(26):4199-209.
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Interaction of retinoic acid and scl controls primitive blood development. Blood. 2010 Jul 15; 116(2):201-9.