Item Type | Name |
Concept
|
Androgen-Binding Protein
|
Concept
|
Bacterial Proteins
|
Concept
|
DNA-Binding Proteins
|
Concept
|
Microtubule-Associated Proteins
|
Concept
|
Glial Fibrillary Acidic Protein
|
Concept
|
Membrane Proteins
|
Concept
|
Microfilament Proteins
|
Concept
|
Nerve Tissue Proteins
|
Concept
|
Muscle Proteins
|
Concept
|
Protein Precursors
|
Concept
|
Protein-Tyrosine Kinases
|
Concept
|
Protein Binding
|
Concept
|
Protein Conformation
|
Concept
|
Protein Processing, Post-Translational
|
Concept
|
Proto-Oncogene Proteins
|
Concept
|
Protein Synthesis Inhibitors
|
Concept
|
Proteins
|
Concept
|
Repressor Proteins
|
Concept
|
Protein Kinases
|
Concept
|
Intermediate Filament Proteins
|
Concept
|
Protein Biosynthesis
|
Concept
|
Proto-Oncogene Proteins pp60(c-src)
|
Concept
|
Oncogene Proteins
|
Concept
|
Insect Proteins
|
Concept
|
Mitogen-Activated Protein Kinases
|
Concept
|
HMGA2 Protein
|
Concept
|
Protein-Lysine 6-Oxidase
|
Concept
|
Cysteine Proteinase Inhibitors
|
Concept
|
Proto-Oncogene Proteins c-fos
|
Concept
|
Cyclic AMP Response Element-Binding Protein
|
Concept
|
Protein Structure, Tertiary
|
Concept
|
RNA-Binding Proteins
|
Concept
|
Immediate-Early Proteins
|
Concept
|
Adenovirus E3 Proteins
|
Concept
|
Phosphatidylethanolamine Binding Protein
|
Concept
|
ras Proteins
|
Concept
|
ets-Domain Protein Elk-1
|
Concept
|
Apoptosis Regulatory Proteins
|
Concept
|
Wnt1 Protein
|
Concept
|
BRCA1 Protein
|
Concept
|
Fas Ligand Protein
|
Concept
|
Receptor Protein-Tyrosine Kinases
|
Concept
|
Protein Transport
|
Concept
|
Drosophila Proteins
|
Concept
|
Protein Tyrosine Phosphatases
|
Concept
|
Protein Structure, Secondary
|
Concept
|
Intercellular Signaling Peptides and Proteins
|
Concept
|
Receptors, G-Protein-Coupled
|
Concept
|
F-Box Proteins
|
Concept
|
Proto-Oncogene Proteins c-ets
|
Concept
|
bcl-2-Associated X Protein
|
Concept
|
Protein Kinase C-delta
|
Concept
|
Mitogen-Activated Protein Kinase 3
|
Concept
|
Mitogen-Activated Protein Kinase 7
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
Concept
|
Proto-Oncogene Proteins c-raf
|
Concept
|
Proto-Oncogene Proteins B-raf
|
Concept
|
Cell Cycle Proteins
|
Concept
|
rac GTP-Binding Proteins
|
Concept
|
rap1 GTP-Binding Proteins
|
Concept
|
Mitogen-Activated Protein Kinase Kinases
|
Concept
|
I-kappa B Proteins
|
Concept
|
BRCA2 Protein
|
Concept
|
bcl-X Protein
|
Concept
|
Oncogene Protein v-akt
|
Concept
|
WT1 Proteins
|
Concept
|
Saccharomyces cerevisiae Proteins
|
Concept
|
Early Growth Response Protein 1
|
Concept
|
Protein Kinase C
|
Concept
|
Recombinant Proteins
|
Concept
|
Protein Phosphatase 1
|
Concept
|
Ubiquitin-Protein Ligases
|
Concept
|
Shc Signaling Adaptor Proteins
|
Concept
|
Phospholipid Transfer Proteins
|
Concept
|
Adaptor Proteins, Signal Transducing
|
Concept
|
Inhibitor of Differentiation Protein 1
|
Concept
|
Viral Proteins
|
Concept
|
Retroviridae Proteins, Oncogenic
|
Concept
|
GTP-Binding Proteins
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
Concept
|
Calcium-Calmodulin-Dependent Protein Kinases
|
Concept
|
Homeodomain Proteins
|
Concept
|
JNK Mitogen-Activated Protein Kinases
|
Concept
|
Tumor Suppressor Proteins
|
Concept
|
CASP8 and FADD-Like Apoptosis Regulating Protein
|
Concept
|
Insulin Receptor Substrate Proteins
|
Concept
|
Ribosomal Protein S6
|
Concept
|
Ribosomal Protein S6 Kinases, 70-kDa
|
Concept
|
Protein Interaction Maps
|
Concept
|
Intracellular Signaling Peptides and Proteins
|
Concept
|
14-3-3 Proteins
|
Concept
|
bcl-Associated Death Protein
|
Concept
|
Protein Kinase C-alpha
|
Concept
|
Methyl-CpG-Binding Protein 2
|
Concept
|
Fanconi Anemia Complementation Group Proteins
|
Concept
|
Protein Phosphatase 2
|
Concept
|
Carrier Proteins
|
Concept
|
Neoplasm Proteins
|
Concept
|
Nuclear Proteins
|
Concept
|
Recombinant Fusion Proteins
|
Concept
|
Oncogene Protein pp60(v-src)
|
Concept
|
Tumor Suppressor Protein p53
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
Concept
|
Protein Isoforms
|
Concept
|
Oncogene Proteins v-raf
|
Concept
|
Vesicular Transport Proteins
|
Concept
|
Adaptor Proteins, Vesicular Transport
|
Concept
|
Telomere-Binding Proteins
|
Concept
|
Protein Kinase Inhibitors
|
Concept
|
Proto-Oncogene Proteins c-akt
|
Concept
|
G-Protein-Coupled Receptor Kinase 2
|
Academic Article
|
Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.
|
Academic Article
|
Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.
|
Academic Article
|
Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.
|
Academic Article
|
Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
|
Academic Article
|
Cloning and characterization of MST4, a novel Ste20-like kinase.
|
Academic Article
|
Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.
|
Academic Article
|
Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.
|
Academic Article
|
A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.
|
Academic Article
|
ERK7 is an autoactivated member of the MAPK family.
|
Academic Article
|
ERK8, a new member of the mitogen-activated protein kinase family.
|
Academic Article
|
Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway.
|
Academic Article
|
ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway.
|
Academic Article
|
Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.
|
Academic Article
|
The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.
|
Academic Article
|
Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
|
Academic Article
|
NMR assignment of rat Raf kinase inhibitor protein.
|
Academic Article
|
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
|
Academic Article
|
Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.
|
Academic Article
|
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
|
Academic Article
|
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
|
Academic Article
|
Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
|
Academic Article
|
Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target.
|
Academic Article
|
Identification of novel metastasis suppressor signaling pathways for breast cancer.
|
Academic Article
|
Anthrax edema factor potency depends on mode of cell entry.
|
Academic Article
|
Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
|
Academic Article
|
Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
|
Academic Article
|
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
|
Academic Article
|
Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
|
Academic Article
|
Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease.
|
Academic Article
|
Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.
|
Academic Article
|
Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.
|
Academic Article
|
Anti-tumor effects of an engineered "killer" transfer RNA.
|
Academic Article
|
Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
|
Academic Article
|
The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
|
Academic Article
|
Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
|
Academic Article
|
A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
|
Academic Article
|
Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
|
Academic Article
|
Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.
|
Academic Article
|
Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
|
Academic Article
|
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity.
|
Academic Article
|
Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
|
Academic Article
|
Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites.
|
Academic Article
|
An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity.
|
Academic Article
|
Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.
|
Academic Article
|
Characterization of murine-specific leukemia virus receptor from L cells.
|
Academic Article
|
Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway.
|
Academic Article
|
Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin.
|
Academic Article
|
Growth factors modify the epidermal growth factor receptor through multiple pathways.
|
Academic Article
|
Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe.
|
Academic Article
|
Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
|
Academic Article
|
Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors.
|
Academic Article
|
Characterization of protein kinase C from normal and transformed cultured murine fibroblasts.
|
Academic Article
|
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
|
Academic Article
|
Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
|
Academic Article
|
Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
|
Academic Article
|
Relationship of GIX antigen expression to the glycosylation of murine leukemia virus glycoprotein.
|
Academic Article
|
WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.
|
Academic Article
|
Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines.
|
Academic Article
|
Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.
|
Academic Article
|
Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.
|
Academic Article
|
Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.
|
Academic Article
|
Selective cleavage by endo-beta-N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoproteins.
|
Academic Article
|
Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins.
|
Academic Article
|
Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells.
|
Academic Article
|
Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase.
|
Academic Article
|
Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
|
Academic Article
|
Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.
|
Academic Article
|
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
|
Academic Article
|
Functional human insulin-degrading enzyme can be expressed in bacteria.
|
Academic Article
|
Different protein kinase C isoforms determine growth factor specificity in neuronal cells.
|
Academic Article
|
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
|
Academic Article
|
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
|
Academic Article
|
Identification of an epidermal growth factor receptor transcriptional repressor.
|
Academic Article
|
Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
|
Academic Article
|
Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.
|
Academic Article
|
Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
|
Academic Article
|
Proteins interacting with the tuberous sclerosis gene products.
|
Academic Article
|
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
|
Academic Article
|
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
|
Academic Article
|
CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.
|
Academic Article
|
A proline- and glutamine-rich protein promotes apoptosis in neuronal cells.
|
Academic Article
|
Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation.
|
Academic Article
|
Cytoplasmic/nuclear localization of tuberin in different cell lines.
|
Academic Article
|
Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.
|
Academic Article
|
Tuberous sclerosis gene products in proliferation control.
|
Academic Article
|
Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes.
|
Academic Article
|
Role of cyclins in neuronal differentiation of immortalized hippocampal cells.
|
Academic Article
|
mTOR phosphorylated at S2448 binds to raptor and rictor.
|
Academic Article
|
Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.
|
Academic Article
|
Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244.
|
Academic Article
|
FGF induces a switch in death receptor pathways in neuronal cells.
|
Academic Article
|
Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression.
|
Academic Article
|
Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.
|
Academic Article
|
Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
|
Academic Article
|
Tuberin negatively affects BCL-2's cell survival function.
|
Academic Article
|
Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR.
|
Academic Article
|
Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
|
Academic Article
|
Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
|
Academic Article
|
Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
|
Academic Article
|
Tuberin, p27 and mTOR in different cells.
|
Academic Article
|
The TSC1 gene product, hamartin, negatively regulates cell proliferation.
|
Academic Article
|
Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation.
|
Academic Article
|
Ras mediates cell survival by regulating tuberin.
|
Academic Article
|
MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
|
Academic Article
|
Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
|
Academic Article
|
p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.
|
Academic Article
|
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
|
Academic Article
|
14-3-3 proteins are involved in the regulation of mammalian cell proliferation.
|
Academic Article
|
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
|
Academic Article
|
Akt regulates nuclear/cytoplasmic localization of tuberin.
|
Academic Article
|
HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
|
Academic Article
|
Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
|
Academic Article
|
Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
|
Academic Article
|
CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?
|
Academic Article
|
Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
|
Academic Article
|
MAP kinase regulation of the mitotic spindle checkpoint.
|
Academic Article
|
RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.
|
Academic Article
|
Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells.
|
Academic Article
|
RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
|
Academic Article
|
An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
|
Academic Article
|
Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
|
Academic Article
|
Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.
|
Academic Article
|
Cyclin D1 is required for S phase traversal in bovine tracheal myocytes.
|
Academic Article
|
Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.
|
Academic Article
|
Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
|
Academic Article
|
Tuberin activates the proapoptotic molecule BAD.
|
Academic Article
|
Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
|
Academic Article
|
An integrated view of cyclin E function and regulation.
|
Academic Article
|
A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
|
Academic Article
|
RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
|
Academic Article
|
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
|
Academic Article
|
RKIP structure drives its function: a three-state model for regulation of RKIP.
|
Academic Article
|
Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
|
Academic Article
|
Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
|
Academic Article
|
Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
|
Academic Article
|
Raf kinase inhibitor protein: lessons of a better way for ß-adrenergic receptor activation in the heart.
|
Academic Article
|
Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.
|
Academic Article
|
Targeting Raf Kinase Inhibitory Protein Regulation and Function.
|
Academic Article
|
Limited inhibition of multiple nodes in a driver network blocks metastasis.
|
Academic Article
|
New strategies for targeting kinase networks in cancer.
|
Academic Article
|
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
|
Academic Article
|
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.
|
Concept
|
X-Box Binding Protein 1
|
Concept
|
Src Homology 2 Domain-Containing, Transforming Protein 1
|
Concept
|
F-Box-WD Repeat-Containing Protein 7
|
Concept
|
Protein Kinase C-theta
|
Concept
|
Regulatory-Associated Protein of mTOR
|
Concept
|
Rapamycin-Insensitive Companion of mTOR Protein
|
Concept
|
3-Phosphoinositide-Dependent Protein Kinases
|
Grant
|
Regulation of RKIP Function
|
Grant
|
Tumor-stromal interactions as targets of tumor metastasis suppressors
|
Grant
|
REGULATION OF PROTEIN KINASE C
|
Grant
|
Signaling Pathways in Neuronal Cells
|
Grant
|
CHARACTERIZATION OF A NOVEL MAP/ERK KINASE
|
Grant
|
Modulation of Head and Neck Cancer by Protein Kinase C
|
Grant
|
Role of Raf Kinase Inhibitory Protein in Prostate Cancer
|
Grant
|
Signaling Pathways in Neuronal Cells
|