"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
| Descriptor ID |
D000076246
|
| MeSH Number(s) |
D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563
|
| Concept/Terms |
CCCTC-Binding Factor- CCCTC-Binding Factor
- CCCTC Binding Factor
- DNA-Binding Protein CTCF
- CTCF, DNA-Binding Protein
- DNA Binding Protein CTCF
- CTCF Protein
|
Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".
Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".
This graph shows the total number of publications written about "CCCTC-Binding Factor" by people in this website by year, and whether "CCCTC-Binding Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.
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The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity. Nat Commun. 2022 01 17; 13(1):187.
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Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution. Nat Biotechnol. 2021 02; 39(2):225-235.
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Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf. Cell Rep. 2019 10 29; 29(5):1203-1220.e7.
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PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type. J Virol. 2018 09 15; 92(18).
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Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7542-7.
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Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association. PLoS Genet. 2014 Nov; 10(11):e1004798.
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Epigenetic dysregulation by nickel through repressive chromatin domain disruption. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14631-6.
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Functional and topological characteristics of mammalian regulatory domains. Genome Res. 2014 Mar; 24(3):390-400.
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Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes. Genome Biol. 2013 Dec 31; 14(12):R148.
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Extensive variation in chromatin states across humans. Science. 2013 Nov 08; 342(6159):750-2.