"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
- CCCTC-Binding Factor
- CCCTC Binding Factor
- DNA-Binding Protein CTCF
- CTCF, DNA-Binding Protein
- DNA Binding Protein CTCF
- CTCF Protein
Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".
Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".
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Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.
The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity. Nat Commun. 2022 01 17; 13(1):187.
Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution. Nat Biotechnol. 2021 02; 39(2):225-235.
Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf. Cell Rep. 2019 10 29; 29(5):1203-1220.e7.
PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type. J Virol. 2018 09 15; 92(18).
Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7542-7.
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association. PLoS Genet. 2014 Nov; 10(11):e1004798.
Epigenetic dysregulation by nickel through repressive chromatin domain disruption. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14631-6.
Functional and topological characteristics of mammalian regulatory domains. Genome Res. 2014 Mar; 24(3):390-400.
Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes. Genome Biol. 2013 Dec 31; 14(12):R148.
Extensive variation in chromatin states across humans. Science. 2013 Nov 08; 342(6159):750-2.