| Item Type | Name |
|
Concept
|
Adenocarcinoma
|
|
Concept
|
Age Factors
|
|
Concept
|
Acetylation
|
|
Concept
|
Acquired Immunodeficiency Syndrome
|
|
Concept
|
Aldosterone
|
|
Concept
|
Androstenols
|
|
Concept
|
Acetaminophen
|
|
Concept
|
Adenoma
|
|
Concept
|
Transaminases
|
|
Concept
|
Analgesics, Opioid
|
|
Concept
|
Ambulatory Care
|
|
Concept
|
Adrenocorticotropic Hormone
|
|
Concept
|
Alcohol Dehydrogenase
|
|
Concept
|
Anticonvulsants
|
|
Concept
|
Busulfan
|
|
Concept
|
Carbazoles
|
|
Concept
|
Carcinoma, Squamous Cell
|
|
Concept
|
Analgesics
|
|
Concept
|
Anesthesiology
|
|
Concept
|
Anthraquinones
|
|
Concept
|
Antimetabolites, Antineoplastic
|
|
Concept
|
Carcinoma
|
|
Concept
|
Antihypertensive Agents
|
|
Concept
|
Anesthetics
|
|
Concept
|
Anthropometry
|
|
Concept
|
Antibodies, Monoclonal
|
|
Concept
|
Codeine
|
|
Concept
|
Asthma
|
|
Concept
|
Aryl Hydrocarbon Hydroxylases
|
|
Concept
|
B-Lymphocytes
|
|
Concept
|
Base Sequence
|
|
Concept
|
Benzamides
|
|
Concept
|
Aspartate Aminotransferases
|
|
Concept
|
Dipeptides
|
|
Concept
|
Body Height
|
|
Concept
|
Pan troglodytes
|
|
Concept
|
Carcinoma, Renal Cell
|
|
Concept
|
Astrocytoma
|
|
Concept
|
Bilirubin
|
|
Concept
|
Bleomycin
|
|
Concept
|
Body Weight
|
|
Concept
|
Cancer Care Facilities
|
|
Concept
|
Ethics, Medical
|
|
Concept
|
Complement System Proteins
|
|
Concept
|
Carbon Radioisotopes
|
|
Concept
|
Flavonoids
|
|
Concept
|
Floxuridine
|
|
Concept
|
Colonic Neoplasms
|
|
Concept
|
Uterine Cervical Neoplasms
|
|
Concept
|
Chicago
|
|
Concept
|
Burkitt Lymphoma
|
|
Concept
|
Leucovorin
|
|
Concept
|
Colonic Polyps
|
|
Concept
|
C-Reactive Protein
|
|
Concept
|
Career Choice
|
|
Concept
|
Crigler-Najjar Syndrome
|
|
Concept
|
Chromatography, Ion Exchange
|
|
Concept
|
Hemoglobins
|
|
Concept
|
Demography
|
|
Concept
|
Hockey
|
|
Concept
|
Cosyntropin
|
|
Concept
|
Hydroxylation
|
|
Concept
|
Hymecromone
|
|
Concept
|
Dexamethasone
|
|
Concept
|
Drug Synergism
|
|
Concept
|
Immunosuppressive Agents
|
|
Concept
|
Interleukin-2
|
|
Concept
|
Critical Care
|
|
Concept
|
Cytidine Deaminase
|
|
Concept
|
Cytochrome P-450 Enzyme System
|
|
Concept
|
Child, Preschool
|
|
Concept
|
DNA, Neoplasm
|
|
Concept
|
Cyclohexanecarboxylic Acids
|
|
Concept
|
Cyclophosphamide
|
|
Concept
|
Daunorubicin
|
|
Concept
|
Dehydroepiandrosterone
|
|
Concept
|
Tegafur
|
|
Concept
|
Patient Care
|
|
Concept
|
Glucocorticoids
|
|
Concept
|
Hemoglobin A
|
|
Concept
|
Kidney Neoplasms
|
|
Concept
|
Chromatography, High Pressure Liquid
|
|
Concept
|
Chromatography, Liquid
|
|
Concept
|
Erythropoietin
|
|
Concept
|
Etoposide
|
|
Concept
|
Coformycin
|
|
Concept
|
Cytarabine
|
|
Concept
|
DNA Topoisomerases, Type II
|
|
Concept
|
Double-Blind Method
|
|
Concept
|
Drug Utilization
|
|
Concept
|
Diphtheria Toxin
|
|
Concept
|
Inactivation, Metabolic
|
|
Concept
|
Indicators and Reagents
|
|
Concept
|
Indoles
|
|
Concept
|
Interferons
|
|
Concept
|
Introns
|
|
Concept
|
Electrocardiography
|
|
Concept
|
Microtubule-Associated Proteins
|
|
Concept
|
Fluorouracil
|
|
Concept
|
Food Labeling
|
|
Concept
|
Decision Making
|
|
Concept
|
Glioma
|
|
Concept
|
Glioblastoma
|
|
Concept
|
Glomerular Filtration Rate
|
|
Concept
|
Fasting
|
|
Concept
|
Feasibility Studies
|
|
Concept
|
Terminology as Topic
|
|
Concept
|
Jaundice
|
|
Concept
|
Karyotyping
|
|
Concept
|
Kidney Diseases
|
|
Concept
|
Killer Cells, Natural
|
|
Concept
|
Forced Expiratory Volume
|
|
Concept
|
Formaldehyde
|
|
Concept
|
Government Agencies
|
|
Concept
|
Electroencephalography
|
|
Concept
|
DNA Topoisomerases, Type I
|
|
Concept
|
Drug Labeling
|
|
Concept
|
Hyperlipidemias
|
|
Concept
|
Life Expectancy
|
|
Concept
|
Liposomes
|
|
Concept
|
Immunotherapy
|
|
Concept
|
Efficiency
|
|
Concept
|
Hospitalization
|
|
Concept
|
Erythropoiesis
|
|
Concept
|
Hydrocortisone
|
|
Concept
|
Hypnotics and Sedatives
|
|
Concept
|
Feces
|
|
Concept
|
Intercalating Agents
|
|
Concept
|
Germ Cells
|
|
Concept
|
Glutathione
|
|
Concept
|
Leukocytes, Mononuclear
|
|
Concept
|
Gastrointestinal Hemorrhage
|
|
Concept
|
Maryland
|
|
Concept
|
Hepatitis C
|
|
Concept
|
Carcinoma, Hepatocellular
|
|
Concept
|
Maytansine
|
|
Concept
|
Medical Records
|
|
Concept
|
Metformin
|
|
Concept
|
Hydroxytestosterones
|
|
Concept
|
Pilot Projects
|
|
Concept
|
Liver Function Tests
|
|
Concept
|
Macaca mulatta
|
|
Concept
|
Nogalamycin
|
|
Concept
|
Medication Errors
|
|
Concept
|
Estrogen Antagonists
|
|
Concept
|
Professional Practice
|
|
Concept
|
Imides
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Indazoles
|
|
Concept
|
Molecular Sequence Data
|
|
Concept
|
Pain
|
|
Concept
|
Pancreatic Neoplasms
|
|
Concept
|
Meperidine
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Random Allocation
|
|
Concept
|
Mitoxantrone
|
|
Concept
|
Mycosis Fungoides
|
|
Concept
|
Health Policy
|
|
Concept
|
Patents as Topic
|
|
Concept
|
Patient Education as Topic
|
|
Concept
|
Rheumatology
|
|
Concept
|
Kidney Function Tests
|
|
Concept
|
Neutrophils
|
|
Concept
|
Ovarian Neoplasms
|
|
Concept
|
Ligands
|
|
Concept
|
Oxycodone
|
|
Concept
|
Melphalan
|
|
Concept
|
Patient Acceptance of Health Care
|
|
Concept
|
Phenylurea Compounds
|
|
Concept
|
Fear
|
|
Concept
|
Pharmacy and Therapeutics Committee
|
|
Concept
|
Drug Prescriptions
|
|
Concept
|
Prednisone
|
|
Concept
|
Epoprostenol
|
|
Concept
|
Prostatic Neoplasms
|
|
Concept
|
Hyponatremia
|
|
Concept
|
Idoxuridine
|
|
Concept
|
Imipramine
|
|
Concept
|
Immunoenzyme Techniques
|
|
Concept
|
Guanine
|
|
Concept
|
Research Support as Topic
|
|
Concept
|
Risk Factors
|
|
Concept
|
Verapamil
|
|
Concept
|
Quality of Life
|
|
Concept
|
Interferon-gamma
|
|
Concept
|
Interinstitutional Relations
|
|
Concept
|
Intestinal Mucosa
|
|
Concept
|
Carcinoma, Merkel Cell
|
|
Concept
|
Cohort Studies
|
|
Concept
|
Leukemia, B-Cell
|
|
Concept
|
Interleukin-6
|
|
Concept
|
Shivering
|
|
Concept
|
Health Knowledge, Attitudes, Practice
|
|
Concept
|
Stomatitis
|
|
Concept
|
Sensitivity and Specificity
|
|
Concept
|
Humans
|
|
Concept
|
Complement C1q
|
|
Concept
|
Body Mass Index
|
|
Concept
|
Incidence
|
|
Concept
|
Linear Models
|
|
Concept
|
Bone Marrow Transplantation
|
|
Concept
|
Testicular Neoplasms
|
|
Concept
|
Informed Consent
|
|
Concept
|
Interferon Type I
|
|
Concept
|
Tetrahydrofolates
|
|
Concept
|
Lymphoma, T-Cell, Cutaneous
|
|
Concept
|
CHO Cells
|
|
Concept
|
Truth Disclosure
|
|
Concept
|
United States Food and Drug Administration
|
|
Concept
|
Program Development
|
|
Concept
|
Clinical Trials, Phase I as Topic
|
|
Concept
|
Hypertrophy, Right Ventricular
|
|
Concept
|
Warfarin
|
|
Concept
|
Tamoxifen
|
|
Concept
|
Vasodilator Agents
|
|
Concept
|
Drug Design
|
|
Concept
|
Multicenter Studies as Topic
|
|
Concept
|
Leukemia, Lymphocytic, Chronic, B-Cell
|
|
Concept
|
Isotretinoin
|
|
Concept
|
Mercaptopurine
|
|
Concept
|
Sulfotransferases
|
|
Concept
|
Lung
|
|
Concept
|
Lymphoma, Follicular
|
|
Concept
|
Thyroxine
|
|
Concept
|
Carcinoma, Neuroendocrine
|
|
Concept
|
Randomized Controlled Trials as Topic
|
|
Concept
|
Risk Assessment
|
|
Concept
|
Myeloablative Agonists
|
|
Concept
|
Receptors, Interleukin-6
|
|
Concept
|
Oligodeoxyribonucleotides, Antisense
|
|
Concept
|
Multifactorial Inheritance
|
|
Concept
|
Mitogen-Activated Protein Kinases
|
|
Concept
|
Vinca Alkaloids
|
|
Concept
|
Werner Syndrome
|
|
Concept
|
Treatment Refusal
|
|
Concept
|
Myosin Type II
|
|
Concept
|
Propofol
|
|
Concept
|
Global Health
|
|
Concept
|
Arylsulfotransferase
|
|
Concept
|
Bias
|
|
Concept
|
Prevalence
|
|
Concept
|
DNA, Antisense
|
|
Concept
|
Ethical Review
|
|
Concept
|
Medicine
|
|
Concept
|
Mephenytoin
|
|
Concept
|
Metabolic Clearance Rate
|
|
Concept
|
Immunocompromised Host
|
|
Concept
|
Receptors, Interleukin-2
|
|
Concept
|
Leukemia, Prolymphocytic
|
|
Concept
|
Observer Variation
|
|
Concept
|
Drug Costs
|
|
Concept
|
Morphine
|
|
Concept
|
Causality
|
|
Concept
|
Least-Squares Analysis
|
|
Concept
|
Lymphocytes, Tumor-Infiltrating
|
|
Concept
|
Paclitaxel
|
|
Concept
|
Comorbidity
|
|
Concept
|
Ethics, Research
|
|
Concept
|
Private Sector
|
|
Concept
|
Clinical Trials, Phase II as Topic
|
|
Concept
|
Case-Control Studies
|
|
Concept
|
Human Genome Project
|
|
Concept
|
Prostate-Specific Antigen
|
|
Concept
|
Medical Oncology
|
|
Concept
|
Melanoma
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
Microtubules
|
|
Concept
|
National Institutes of Health (U.S.)
|
|
Concept
|
Neoplasms, Experimental
|
|
Concept
|
Oligodeoxyribonucleotides
|
|
Concept
|
Interferon-alpha
|
|
Concept
|
Health Care Costs
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Receptors, Growth Factor
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Cell Proliferation
|
|
Concept
|
Patient-Centered Care
|
|
Concept
|
Neoplasms, Squamous Cell
|
|
Concept
|
Sample Size
|
|
Concept
|
Evolution, Molecular
|
|
Concept
|
ras Proteins
|
|
Concept
|
Hepatocyte Nuclear Factor 1-alpha
|
|
Concept
|
Sepsis
|
|
Concept
|
Rats, Inbred Dahl
|
|
Concept
|
Angiogenesis Inhibitors
|
|
Concept
|
Cytochrome P-450 CYP2D6
|
|
Concept
|
Kv1.3 Potassium Channel
|
|
Concept
|
Cyclohexenes
|
|
Concept
|
Receptor Protein-Tyrosine Kinases
|
|
Concept
|
Hepatocytes
|
|
Concept
|
Multidrug Resistance-Associated Proteins
|
|
Concept
|
Cross-Over Studies
|
|
Concept
|
Analgesics, Non-Narcotic
|
|
Concept
|
Osteolysis
|
|
Concept
|
Disclosure
|
|
Concept
|
Myosin Heavy Chains
|
|
Concept
|
Public Sector
|
|
Concept
|
Parkinson Disease
|
|
Concept
|
In Situ Hybridization, Fluorescence
|
|
Concept
|
Comprehension
|
|
Concept
|
Federal Government
|
|
Concept
|
Therapeutic Human Experimentation
|
|
Concept
|
Vascular Endothelial Growth Factor Receptor-2
|
|
Concept
|
Endostatins
|
|
Concept
|
Nontherapeutic Human Experimentation
|
|
Concept
|
Trust
|
|
Concept
|
History, 21st Century
|
|
Concept
|
Renal Insufficiency, Chronic
|
|
Concept
|
Hepatocyte Nuclear Factor 1
|
|
Concept
|
Tumor Burden
|
|
Concept
|
Carcinoma, Small Cell
|
|
Concept
|
Megestrol Acetate
|
|
Concept
|
Proto-Oncogene Proteins c-raf
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Proto-Oncogene Proteins B-raf
|
|
Concept
|
Cultural Diversity
|
|
Concept
|
Patient Participation
|
|
Concept
|
3' Untranslated Regions
|
|
Concept
|
RecQ Helicases
|
|
Concept
|
Evidence-Based Medicine
|
|
Concept
|
Personal Autonomy
|
|
Concept
|
Perioperative Care
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
|
Concept
|
Proto-Oncogene Proteins c-ret
|
|
Concept
|
Pharmacists
|
|
Concept
|
Physicians
|
|
Concept
|
Podophyllotoxin
|
|
Concept
|
Polyethylene Glycols
|
|
Concept
|
Organic Anion Transporters, Sodium-Independent
|
|
Concept
|
Mucositis
|
|
Concept
|
Prostate
|
|
Concept
|
National Cancer Institute (U.S.)
|
|
Concept
|
Sarcoma
|
|
Concept
|
Severity of Illness Index
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Schools, Medical
|
|
Concept
|
Stomach Neoplasms
|
|
Concept
|
Taiwan
|
|
Concept
|
Testosterone
|
|
Concept
|
Receptors, Vascular Endothelial Growth Factor
|
|
Concept
|
Taxoids
|
|
Concept
|
Class I Phosphatidylinositol 3-Kinases
|
|
Concept
|
TOR Serine-Threonine Kinases
|
|
Concept
|
Adenosine A2 Receptor Antagonists
|
|
Concept
|
Antibodies, Monoclonal, Humanized
|
|
Concept
|
Human Umbilical Vein Endothelial Cells
|
|
Concept
|
Sex Factors
|
|
Concept
|
Stereoisomerism
|
|
Concept
|
Valproic Acid
|
|
Concept
|
Vincristine
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Suramin
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Colorectal Neoplasms
|
|
Concept
|
Epirubicin
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p15
|
|
Concept
|
Selection Bias
|
|
Concept
|
Life Tables
|
|
Concept
|
Logistic Models
|
|
Concept
|
Thyroid Neoplasms
|
|
Concept
|
Lymphoma, B-Cell
|
|
Concept
|
Vinblastine
|
|
Concept
|
Reproducibility of Results
|
|
Concept
|
Patient Satisfaction
|
|
Concept
|
Genetic Therapy
|
|
Concept
|
Molecular Structure
|
|
Concept
|
Clinical Medicine
|
|
Concept
|
Survival Rate
|
|
Concept
|
Lymphocyte Subsets
|
|
Concept
|
Granulocyte Colony-Stimulating Factor
|
|
Concept
|
Conflict of Interest
|
|
Concept
|
Receptor, ErbB-2
|
|
Concept
|
Lymphoma, Large B-Cell, Diffuse
|
|
Concept
|
Cyclin-Dependent Kinases
|
|
Concept
|
Intellectual Property
|
|
Concept
|
Menogaril
|
|
Concept
|
HIV Protease Inhibitors
|
|
Concept
|
Clinical Trials, Phase III as Topic
|
|
Concept
|
Naphthalimides
|
|
Concept
|
Karnofsky Performance Status
|
|
Concept
|
Metabolic Networks and Pathways
|
|
Concept
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
|
Concept
|
Dietary Supplements
|
|
Concept
|
Proto-Oncogene Proteins c-met
|
|
Concept
|
Interleukin-17
|
|
Concept
|
Gadolinium DTPA
|
|
Concept
|
Withholding Treatment
|
|
Concept
|
Receptor, trkA
|
|
Concept
|
MAP Kinase Signaling System
|
|
Concept
|
Hearing Loss
|
|
Concept
|
Receptor, EphA5
|
|
Concept
|
History, 20th Century
|
|
Concept
|
Organic Anion Transporters
|
|
Concept
|
Medical Order Entry Systems
|
|
Concept
|
Comparative Effectiveness Research
|
|
Concept
|
Ethics Committees, Research
|
|
Concept
|
Janus Kinase 2
|
|
Concept
|
Genome-Wide Association Study
|
|
Concept
|
Hep G2 Cells
|
|
Concept
|
Pathology, Molecular
|
|
Concept
|
Precision Medicine
|
|
Concept
|
Antibodies, Monoclonal, Murine-Derived
|
|
Concept
|
Ribosomal Protein S6 Kinases, 70-kDa
|
|
Concept
|
Vascular Endothelial Growth Factor A
|
|
Concept
|
Renal Insufficiency
|
|
Concept
|
Cytochrome P-450 CYP3A
|
|
Concept
|
Drug Discovery
|
|
Concept
|
Anemia, Sickle Cell
|
|
Concept
|
Anthracenes
|
|
Concept
|
Immunotoxins
|
|
Concept
|
Benzenesulfonates
|
|
Concept
|
Body Surface Area
|
|
Concept
|
Carbolines
|
|
Concept
|
Cardiovascular Agents
|
|
Concept
|
Catechin
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Concept
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Chlorambucil
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Concept
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Clinical Trials as Topic
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Concept
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Cytosine
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Concept
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Drug Eruptions
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Concept
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Doxorubicin
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Concept
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Follow-Up Studies
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Concept
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Genetic Testing
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Concept
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Government
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Concept
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Hyperglycemia
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Concept
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Indenes
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Concept
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Insurance, Health, Reimbursement
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Concept
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Leukemia, Hairy Cell
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Concept
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Leukemia, Monocytic, Acute
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Concept
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Longitudinal Studies
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Concept
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Lymphocytes
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Concept
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Lymphoma, Non-Hodgkin
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Concept
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Monocytes
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Concept
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Morphine Derivatives
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Concept
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Nitrophenols
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Concept
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Oligonucleotides
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Concept
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Patient Compliance
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Concept
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Physician-Patient Relations
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Concept
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Predictive Value of Tests
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Concept
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Professional Staff Committees
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Concept
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Prospective Studies
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Concept
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Retrospective Studies
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Concept
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Social Perception
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Concept
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T-Lymphocytes
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Concept
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Tramadol
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Concept
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Glucuronosyltransferase
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Concept
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Granulocyte-Macrophage Colony-Stimulating Factor
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Concept
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Databases, Factual
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Concept
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Oligonucleotides, Antisense
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Concept
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Hospital Mortality
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Concept
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Pharmacoepidemiology
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Concept
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DNA Primers
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Concept
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Neuroendocrine Tumors
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Concept
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Point-of-Care Systems
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Concept
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Organic Cation Transporter 1
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Concept
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Genetic Privacy
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Concept
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Consent Forms
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Concept
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MicroRNAs
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Concept
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Transforming Growth Factor beta3
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Concept
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Medication Adherence
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Concept
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Drug Recalls
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Academic Article
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Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents.
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Academic Article
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Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital.
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Academic Article
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Individualizing dosing of cancer chemotherapy.
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Academic Article
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Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck.
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Academic Article
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Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071).
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Academic Article
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Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2.
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Academic Article
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Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients.
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Academic Article
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Clinical pharmacology of camptothecins.
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Academic Article
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Limited sampling model for area under the concentration time curve of total topotecan.
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Academic Article
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Pharmacogenetics and cancer chemotherapy.
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Academic Article
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A phase I study of oral uracil/ftorafur (UFT) plus leucovorin and bis-acetato-ammine-dichloro-cyclohexylamine-platinum IV (JM-216) each given over 14 days every 28 days.
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Academic Article
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Pharmacogenetics in cancer etiology and chemotherapy.
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Academic Article
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5-fluorouracil pharmacokinetics: causes for variability and strategies for modulation in cancer chemotherapy.
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Academic Article
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Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil.
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Academic Article
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Update on pharmacogenetics in cancer chemotherapy.
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Academic Article
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UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity.
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Academic Article
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Development of a schedule-dependent population pharmacodynamic model for rhizoxin without quantitation of plasma concentrations.
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Academic Article
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Anticancer drug discovery and development throughout the world.
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Academic Article
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Pharmacogenetics in cancer treatment.
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Academic Article
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Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide.
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Academic Article
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Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice.
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Academic Article
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Pharmacogenomics: road to anticancer therapeutics nirvana?
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Academic Article
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Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer.
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Academic Article
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Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors.
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Academic Article
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"Irinogenetics" and UGT1A: from genotypes to haplotypes.
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Academic Article
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A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer.
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Academic Article
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A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors.
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Academic Article
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Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies.
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Academic Article
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Randomized discontinuation design: application to cytostatic antineoplastic agents.
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Academic Article
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Modulation of irinotecan with cyclosporine: a phase II trial in advanced colorectal cancer.
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Academic Article
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Pharmacokinetic variability of anticancer agents.
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Academic Article
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A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871.
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Academic Article
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Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity.
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Academic Article
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Effects of green tea compounds on irinotecan metabolism.
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Academic Article
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The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity.
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Academic Article
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The pharmacogenetics research network: from SNP discovery to clinical drug response.
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Academic Article
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Interpreting P values in pharmacogenetic studies: a call for process and perspective.
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Academic Article
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CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
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Academic Article
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Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity.
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Academic Article
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Phase II studies of modern drugs directed against new targets: if you are fazed, too, then resist RECIST.
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Academic Article
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Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans.
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Academic Article
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Exploring the relationship between polymorphic (TG/CA)n repeats in intron 1 regions and gene expression.
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Academic Article
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The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds.
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Academic Article
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Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma.
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Academic Article
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A survey of the population genetic variation in the human kinome.
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Academic Article
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R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.
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Academic Article
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Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
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Academic Article
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Hairy cell leukemia. Current management.
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Academic Article
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A pharmacogenetic study of vorinostat glucuronidation.
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Academic Article
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Other paradigms: better treatments are identified by better trials: the value of randomized phase II studies.
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Academic Article
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In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole.
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Academic Article
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A phase I study of sirolimus and bevacizumab in patients with advanced malignancies.
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Academic Article
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A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.
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Academic Article
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Recommended changes to oncology clinical trial design: revolution or evolution?
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Academic Article
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A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
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Academic Article
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Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.
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Academic Article
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Adaptive control of etoposide administration: impact of interpatient pharmacodynamic variability.
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Academic Article
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Pharmacokinetics and pharmacodynamics of long-term continuous-infusion doxorubicin.
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Academic Article
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Optimising the design of phase II oncology trials: the importance of randomisation.
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Academic Article
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Phase I and pharmacological study of vinblastine by prolonged continuous infusion.
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Academic Article
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The UGT1A1*28 polymorphism correlates with erlotinib's effect on SN-38 glucuronidation.
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Academic Article
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The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics.
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Academic Article
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Inconsistent labeling of food effect for oral agents across therapeutic areas: differences between oncology and non-oncology products.
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Academic Article
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TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
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Academic Article
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Human pharmacokinetics, excretion, and metabolism of the anthracycline antibiotic menogaril (7-OMEN, NSC 269148) and their correlation with clinical toxicities.
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Academic Article
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Phase I clinical and pharmacological study of thymidine (NSC 21548) and cis-diamminedichloroplatinum(II) in patients with advanced cancer.
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Academic Article
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A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours.
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Academic Article
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Pharmacogenetics and pharmacogenomics of anticancer agents.
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Academic Article
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Dose-escalation models for combination phase I trials in oncology.
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Academic Article
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Might cigarettes be a "smoking gun" to reduce taxane myelotoxicity?
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Academic Article
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Limited sampling models for amonafide (NSC 308847) pharmacokinetics.
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Academic Article
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Interpatient and intrapatient variability in vinblastine pharmacokinetics.
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Academic Article
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A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital.
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Academic Article
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Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies.
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Academic Article
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Modulation of vinblastine resistance with cyclosporine: a phase I study.
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Academic Article
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Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.
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Academic Article
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Measuring response in a post-RECIST world: from black and white to shades of grey.
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Academic Article
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The role of pharmacogenetics in cancer therapeutics.
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Academic Article
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Pharmacogenetic pathway analysis of irinotecan.
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Academic Article
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Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a Phase II randomized discontinuation trial.
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Academic Article
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Plasma pharmacokinetics of high-dose oral melphalan in patients treated with trialkylator chemotherapy and autologous bone marrow reinfusion.
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Academic Article
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A limited sampling strategy for cyclophosphamide pharmacokinetics.
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Academic Article
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Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients.
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Academic Article
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Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
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Academic Article
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Unsupported off-label chemotherapy in metastatic colon cancer.
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Academic Article
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CYP2D6 genotype and tamoxifen activity: understanding interstudy variability in methodological quality.
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Academic Article
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Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee.
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Academic Article
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Meaningful use of pharmacogenetics.
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Academic Article
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Evaluation of utility of pharmacokinetic studies in phase I trials of two oncology drugs.
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Academic Article
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Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
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Academic Article
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Are drug labels static or dynamic?
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Academic Article
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Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression.
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Academic Article
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
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Academic Article
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Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.
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Academic Article
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Re: Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.
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Academic Article
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Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10.
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Academic Article
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In vitro glucuronidation of aprepitant: a moderate inhibitor of UGT2B7.
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Academic Article
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The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone.
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Academic Article
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Comparative Effects of CT Imaging Measurement on RECIST End Points and Tumor Growth Kinetics Modeling.
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Academic Article
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Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia.
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Academic Article
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Low Dose Interferon Alfa-2B for the Induction of Remission of Hairy Cell Leukemia: A Multi-institutional Study of 49 Patients.
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Academic Article
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Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
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Academic Article
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Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST).
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Academic Article
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New feature: pathways and important genes from PharmGKB.
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Academic Article
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Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
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Academic Article
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ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia.
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Academic Article
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Phase I study of lurbinectedin, a synthetic tetrahydroisoquinoline that inhibits activated transcription, induces DNA single- and double-strand breaks, on a weekly × 2 every-3-week schedule.
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Academic Article
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Providing Balance in ASCO Clinical Practice Guidelines: CYP2D6 Genotyping and Tamoxifen Efficacy.
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Academic Article
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Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC).
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Academic Article
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Kinetic-Pharmacodynamic Model of Chemotherapy-Induced Peripheral Neuropathy in Patients with Metastatic Breast Cancer Treated with Paclitaxel, Nab-Paclitaxel, or Ixabepilone: CALGB 40502 (Alliance).
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Academic Article
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Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance).
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Academic Article
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Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.
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Academic Article
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A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).
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Academic Article
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
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Academic Article
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Genomic Heterogeneity Within Individual Prostate Cancer Foci Impacts Predictive Biomarkers of Targeted Therapy.
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Academic Article
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Immunotherapy and the A2A Adenosine Receptor: A Confounding Brew.
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Academic Article
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Prolonged Pharmacokinetic Interaction Between Capecitabine and a CYP2C9 Substrate, Celecoxib.
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Academic Article
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Personalized Management of Chemotherapy-Induced Peripheral Neuropathy Based on a Patient Reported Outcome: CALGB 40502 (Alliance).
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Academic Article
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Interventional Pharmacoeconomics: A Novel Mechanism for Unlocking Value.
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Academic Article
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Applied Clinical Pharmacology in a Crisis: Interleukin-6 Axis Blockade and COVID-19.
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Academic Article
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Influence of N-acetyltransferase 2 gene polymorphisms on the in vitro metabolism of the epidermal growth factor receptor inhibitor rociletinib.
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Academic Article
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The Right Dose: From Phase I to Clinical Practice.
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Academic Article
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Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
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Academic Article
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Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.
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Academic Article
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Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.
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Academic Article
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Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study.
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Academic Article
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An Expanded Role for IRBs in the Oversight of Research Biopsies.
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Academic Article
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Oncology phase I trial design and conduct: time for a change - MDICT Guidelines 2022.
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Academic Article
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US Government Payer-Funded Trials to Address Oncology's Drug-Dosing Conundrum: A Congressional Call to Action?
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Concept
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Bevacizumab
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Concept
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Imatinib Mesylate
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Concept
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Trastuzumab
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Concept
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Cetuximab
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Concept
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Rituximab
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Concept
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Capecitabine
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Concept
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Atazanavir Sulfate
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Concept
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Filgrastim
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Concept
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Patient Reported Outcome Measures
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Concept
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Pharmacogenomic Variants
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Concept
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Pharmacogenomic Testing
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Concept
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Werner Syndrome Helicase
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Concept
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Equivalence Trials as Topic
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Concept
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Solute Carrier Organic Anion Transporter Family Member 1B3
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Concept
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Tertiary Care Centers
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Concept
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Prostatic Neoplasms, Castration-Resistant
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Concept
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Cytochrome P-450 CYP2C19
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Concept
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Cytochrome P-450 Enzyme Inhibitors
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Concept
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Familial Primary Pulmonary Hypertension
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Concept
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Cytochrome P-450 CYP2D6 Inhibitors
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Concept
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Cytochrome P-450 CYP3A Inhibitors
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Concept
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Cytochrome P-450 CYP2B6
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Concept
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Cytochrome P-450 CYP2C8
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Concept
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Cytochrome P-450 CYP2C9
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Concept
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In Vitro Techniques
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Concept
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ErbB Receptors
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Academic Article
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Do patent applications and Cooperative Research and Development Agreements between the National Cancer Institute and industry serve the public interest?
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