 Orphan Nuclear Receptors
"Orphan Nuclear Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
| Descriptor ID |
D057093
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| MeSH Number(s) |
D12.776.260.698.209 D12.776.826.209 D12.776.930.669.209
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Orphan Nuclear Receptors".
Below are MeSH descriptors whose meaning is more specific than "Orphan Nuclear Receptors".
- Orphan Nuclear Receptors
- COUP Transcription Factors
- Nuclear Receptor Subfamily 1, Group D, Member 1
- Nuclear Receptor Subfamily 1, Group F, Member 1
- Nuclear Receptor Subfamily 1, Group F, Member 2
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Nuclear Receptor Subfamily 2, Group C, Member 1
- Nuclear Receptor Subfamily 2, Group C, Member 2
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nuclear Receptor Subfamily 4, Group A, Member 3
- Nuclear Receptor Subfamily 6, Group A, Member 1
- Receptors, Aryl Hydrocarbon
This graph shows the total number of publications written about "Orphan Nuclear Receptors" by people in this website by year, and whether "Orphan Nuclear Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 2 | 1 | 3 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Orphan Nuclear Receptors" by people in Profiles.
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Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK. Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation. 2012 Oct 30; 126(18):2236-47.
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Obsen T, Faergeman NJ, Chung S, Martinez K, Gobern S, Loreau O, Wabitsch M, Mandrup S, McIntosh M. Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes. J Nutr Biochem. 2012 Jun; 23(6):580-90.
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Peng D, Hiipakka RA, Xie JT, Dai Q, Kokontis JM, Reardon CA, Getz GS, Liao S. A novel potent synthetic steroidal liver X receptor agonist lowers plasma cholesterol and triglycerides and reduces atherosclerosis in LDLR(-/-) mice. Br J Pharmacol. 2011 Apr; 162(8):1792-804.
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Christoffolete MA, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco AC, Gereben B. Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. J Endocrinol. 2010 May; 205(2):179-86.
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Ogihara T, Chuang JC, Vestermark GL, Garmey JC, Ketchum RJ, Huang X, Brayman KL, Thorner MO, Repa JJ, Mirmira RG, Evans-Molina C. Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem. 2010 Feb 19; 285(8):5392-404.
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Peng D, Hiipakka RA, Xie JT, Reardon CA, Getz GS, Liao S. Differential effects of activation of liver X receptor on plasma lipid homeostasis in wild-type and lipoprotein clearance-deficient mice. Atherosclerosis. 2010 Jan; 208(1):126-33.
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Davidson MH. Pharmacological approaches to modifying HDL: more basic science to understand HDL metabolism is necessary. Editorial to: "NO-1886 up-regulates Niemann-Pick C1 protein (NPC1) expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells" by Xin Ma et al. Cardiovasc Drugs Ther. 2009 Jun; 23(3):187-8.
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Yue L, Mazzone T. Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway. J Biol Chem. 2009 Apr 17; 284(16):10453-61.
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Johnson LE, Elias MS, Bolick DT, Skaflen MD, Green RM, Hedrick CC. The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice. Hepatology. 2008 Oct; 48(4):1138-48.
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Kumar RA, McGhee KA, Leach S, Bonaguro R, Maclean A, Aguirre-Hernandez R, Abrahams BS, Coccaro EF, Hodgins S, Turecki G, Condon A, Muir WJ, Brooks-Wilson AR, Blackwood DH, Simpson EM. Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 05; 147B(6):880-9.
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