"Bcl-2-Like Protein 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A BCL-2-like protein that has a C-terminal BCL-2 homology (BH3) domain and forms heterodimers with other BCL-2 FAMILY PROTEINS. It is a strong inducer of APOPTOSIS and ANOIKIS; several isoforms are expressed (BimEL, Bim L, Bim-alpha, Bim-s; and Bim-gamma) that have different potencies for inducing apoptosis.
| Descriptor ID |
D000072224
|
| MeSH Number(s) |
D12.644.360.075.323 D12.776.476.075.323 D12.776.543.116 D12.776.624.664.700.025
|
| Concept/Terms |
Bcl-2-Like Protein 11- Bcl-2-Like Protein 11
- 11, Bcl-2-Like Protein
- Bcl 2 Like Protein 11
- Protein 11, Bcl-2-Like
- Bcl-2-Interacting Mediator of Cell Death
- Bcl 2 Interacting Mediator of Cell Death
- Bcl-2-Binding Protein, BIM
- BIM Bcl-2-Binding Protein
- Bcl 2 Binding Protein, BIM
- Protein, BIM Bcl-2-Binding
- BCL2L11 Protein
- Protein, BCL2L11
- BIM Protein
- Protein, BIM
|
Below are MeSH descriptors whose meaning is more general than "Bcl-2-Like Protein 11".
Below are MeSH descriptors whose meaning is more specific than "Bcl-2-Like Protein 11".
This graph shows the total number of publications written about "Bcl-2-Like Protein 11" by people in this website by year, and whether "Bcl-2-Like Protein 11" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Bcl-2-Like Protein 11" by people in Profiles.
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BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways. Cell Oncol (Dordr). 2020 Dec; 43(6):1049-1066.
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Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization. Apoptosis. 2020 04; 25(3-4):247-260.
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Bim suppresses the development of SLE by limiting myeloid inflammatory responses. J Exp Med. 2017 Dec 04; 214(12):3753-3773.
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Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation. Arthritis Rheumatol. 2016 11; 68(11):2740-2751.
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An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nat Cell Biol. 2015 Oct; 17(10):1270-81.
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Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion. J Biol Chem. 2015 Mar 13; 290(11):6868-77.
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Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa. Cell Death Dis. 2014 Apr 24; 5:e1190.
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BH3-only molecule Bim mediates ß-cell death in IRS2 deficiency. Diabetes. 2014 Oct; 63(10):3378-87.
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Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency. Diabetes. 2014 Aug; 63(8):2744-50.
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Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2014 Sep; 28(9):1819-27.