| Item Type | Name |
|
Concept
|
Acute Disease
|
|
Concept
|
Actins
|
|
Concept
|
Adenoviridae
|
|
Concept
|
Age Factors
|
|
Concept
|
Aorta, Thoracic
|
|
Concept
|
Aldosterone
|
|
Concept
|
Arteries
|
|
Concept
|
Atropine Derivatives
|
|
Concept
|
Arteriovenous Malformations
|
|
Concept
|
Acetylcholine
|
|
Concept
|
Adaptation, Physiological
|
|
Concept
|
Adenylyl Cyclases
|
|
Concept
|
Actinin
|
|
Concept
|
Calcimycin
|
|
Concept
|
Cyclic AMP
|
|
Concept
|
Blood Platelets
|
|
Concept
|
Blood Pressure
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Adenosine Triphosphate
|
|
Concept
|
Administration, Oral
|
|
Concept
|
Mineralocorticoid Receptor Antagonists
|
|
Concept
|
Boston
|
|
Concept
|
Hypoxia, Brain
|
|
Concept
|
Androstadienes
|
|
Concept
|
Animals, Newborn
|
|
Concept
|
Angina Pectoris
|
|
Concept
|
Aorta
|
|
Concept
|
Calmodulin
|
|
Concept
|
Antioxidants
|
|
Concept
|
Anions
|
|
Concept
|
Arginase
|
|
Concept
|
B-Lymphocytes
|
|
Concept
|
Base Sequence
|
|
Concept
|
Cell Nucleus
|
|
Concept
|
Cerebral Infarction
|
|
Concept
|
Diabetes Mellitus, Experimental
|
|
Concept
|
Blood Vessels
|
|
Concept
|
Atrial Fibrillation
|
|
Concept
|
Calcitriol
|
|
Concept
|
Basilar Artery
|
|
Concept
|
Bleomycin
|
|
Concept
|
Brachial Artery
|
|
Concept
|
Emergency Service, Hospital
|
|
Concept
|
Carotid Arteries
|
|
Concept
|
Cattle
|
|
Concept
|
Cell Membrane
|
|
Concept
|
Cell Division
|
|
Concept
|
Cell Separation
|
|
Concept
|
Ischemic Attack, Transient
|
|
Concept
|
Botulinum Toxins
|
|
Concept
|
Cholesterol, Dietary
|
|
Concept
|
Capillaries
|
|
Concept
|
Cardiomyopathy, Dilated
|
|
Concept
|
Cell Adhesion
|
|
Concept
|
Chicago
|
|
Concept
|
Blood Gas Analysis
|
|
Concept
|
Blood-Brain Barrier
|
|
Concept
|
Bradykinin
|
|
Concept
|
Cisplatin
|
|
Concept
|
Collateral Circulation
|
|
Concept
|
Cardiotonic Agents
|
|
Concept
|
Glutathione Transferase
|
|
Concept
|
Coronary Disease
|
|
Concept
|
Cholesterol
|
|
Concept
|
Citrulline
|
|
Concept
|
Collagen
|
|
Concept
|
Coronary Artery Disease
|
|
Concept
|
Cytosol
|
|
Concept
|
Demography
|
|
Concept
|
Diabetes Mellitus, Type 1
|
|
Concept
|
Huntington Disease
|
|
Concept
|
Densitometry
|
|
Concept
|
Coronary Thrombosis
|
|
Concept
|
Cytoplasm
|
|
Concept
|
Dexamethasone
|
|
Concept
|
Diabetic Angiopathies
|
|
Concept
|
Dendritic Cells
|
|
Concept
|
Diet
|
|
Concept
|
Insulin
|
|
Concept
|
Interleukins
|
|
Concept
|
Endothelium, Vascular
|
|
Concept
|
Ergosterol
|
|
Concept
|
Cost Control
|
|
Concept
|
Cytochrome P-450 Enzyme System
|
|
Concept
|
Cytoskeleton
|
|
Concept
|
Drug Implants
|
|
Concept
|
Cerebral Hemorrhage
|
|
Concept
|
Dogs
|
|
Concept
|
Echocardiography
|
|
Concept
|
Cytotoxins
|
|
Concept
|
Cardiomegaly
|
|
Concept
|
Estradiol
|
|
Concept
|
Chromones
|
|
Concept
|
Chronic Disease
|
|
Concept
|
Exons
|
|
Concept
|
Coronary Vasospasm
|
|
Concept
|
Corpus Striatum
|
|
Concept
|
Cross-Sectional Studies
|
|
Concept
|
Disease Susceptibility
|
|
Concept
|
Diterpenes
|
|
Concept
|
Eating
|
|
Concept
|
Introns
|
|
Concept
|
Electrocardiography
|
|
Concept
|
Microtubule-Associated Proteins
|
|
Concept
|
Ergonovine
|
|
Concept
|
Genes, MHC Class II
|
|
Concept
|
Nifedipine
|
|
Concept
|
KB Cells
|
|
Concept
|
Dicarboxylic Acids
|
|
Concept
|
Cyclic GMP
|
|
Concept
|
Heart Diseases
|
|
Concept
|
Heart Failure
|
|
Concept
|
Embryo, Mammalian
|
|
Concept
|
Hydrogen Peroxide
|
|
Concept
|
Hydroxyeicosatetraenoic Acids
|
|
Concept
|
Enzyme Induction
|
|
Concept
|
Eosinophils
|
|
Concept
|
Heptanoic Acids
|
|
Concept
|
Feedback
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Interleukin-1
|
|
Concept
|
Mesenteric Arteries
|
|
Concept
|
Metalloendopeptidases
|
|
Concept
|
Leukocytes
|
|
Concept
|
Microfilament Proteins
|
|
Concept
|
Phenylephrine
|
|
Concept
|
Myocardial Infarction
|
|
Concept
|
Platelet-Derived Growth Factor
|
|
Concept
|
Potassium Chloride
|
|
Concept
|
Estrogens
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Molecular Sequence Data
|
|
Concept
|
Muscle, Smooth, Vascular
|
|
Concept
|
Glycolysis
|
|
Concept
|
Mevalonic Acid
|
|
Concept
|
Radiation Chimera
|
|
Concept
|
Radioligand Assay
|
|
Concept
|
Cricetinae
|
|
Concept
|
Patient Education as Topic
|
|
Concept
|
Retinal Vessels
|
|
Concept
|
Nerve Growth Factors
|
|
Concept
|
Nutritional Physiological Phenomena
|
|
Concept
|
Ovalbumin
|
|
Concept
|
Oxidation-Reduction
|
|
Concept
|
Cholesterol, HDL
|
|
Concept
|
Lymphokines
|
|
Concept
|
Salicylates
|
|
Concept
|
Saphenous Vein
|
|
Concept
|
Patient Discharge
|
|
Concept
|
Sodium Salicylate
|
|
Concept
|
Muscle Proteins
|
|
Concept
|
Nitrites
|
|
Concept
|
Nitroprusside
|
|
Concept
|
Oxygen
|
|
Concept
|
Tissue Plasminogen Activator
|
|
Concept
|
Pre-Eclampsia
|
|
Concept
|
Recurrence
|
|
Concept
|
Heart Septal Defects, Ventricular
|
|
Concept
|
Repressor Proteins
|
|
Concept
|
Risk Factors
|
|
Concept
|
Interferon-gamma
|
|
Concept
|
Cohort Studies
|
|
Concept
|
Receptors, Adrenergic, alpha
|
|
Concept
|
Cadherins
|
|
Concept
|
Interleukin-6
|
|
Concept
|
Japan
|
|
Concept
|
RNA Polymerase II
|
|
Concept
|
Thrombin
|
|
Concept
|
Sialoglycoproteins
|
|
Concept
|
Body Mass Index
|
|
Concept
|
Incidence
|
|
Concept
|
Endothelial Growth Factors
|
|
Concept
|
Transcription, Genetic
|
|
Concept
|
Protein Biosynthesis
|
|
Concept
|
Superoxides
|
|
Concept
|
Umbilical Veins
|
|
Concept
|
Tumor Necrosis Factor-alpha
|
|
Concept
|
Drug Design
|
|
Concept
|
Ultraviolet Rays
|
|
Concept
|
Cholesterol, LDL
|
|
Concept
|
Randomized Controlled Trials as Topic
|
|
Concept
|
Macrophage Colony-Stimulating Factor
|
|
Concept
|
Caspases
|
|
Concept
|
Peptide Elongation Factor 1
|
|
Concept
|
rho GTP-Binding Proteins
|
|
Concept
|
rhoB GTP-Binding Protein
|
|
Concept
|
Tumor Cells, Cultured
|
|
Concept
|
rac1 GTP-Binding Protein
|
|
Concept
|
Veratrine
|
|
Concept
|
Transforming Growth Factor beta
|
|
Concept
|
NF-kappa B
|
|
Concept
|
Cell Adhesion Molecules
|
|
Concept
|
Carotid Stenosis
|
|
Concept
|
Mitochondria
|
|
Concept
|
Mitochondria, Muscle
|
|
Concept
|
CD4-Positive T-Lymphocytes
|
|
Concept
|
Chi-Square Distribution
|
|
Concept
|
Interleukin-8
|
|
Concept
|
Proto-Oncogene Proteins c-fos
|
|
Concept
|
Cytochalasin D
|
|
Concept
|
Eicosanoids
|
|
Concept
|
Gene Expression
|
|
Concept
|
Case-Control Studies
|
|
Concept
|
Sp1 Transcription Factor
|
|
Concept
|
RNA Interference
|
|
Concept
|
In Situ Hybridization
|
|
Concept
|
Tunica Media
|
|
Concept
|
Fractals
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
Cardiomyopathies
|
|
Concept
|
Myosins
|
|
Concept
|
Angiopoietin-2
|
|
Concept
|
Receptor, Bradykinin B1
|
|
Concept
|
Neurites
|
|
Concept
|
Hypertrophy, Left Ventricular
|
|
Concept
|
Arachidonic Acid
|
|
Concept
|
Gelatinases
|
|
Concept
|
Amlodipine
|
|
Concept
|
Receptors, Bradykinin
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Receptors, AMPA
|
|
Concept
|
Cell Proliferation
|
|
Concept
|
GTP-Binding Protein alpha Subunits, Gs
|
|
Concept
|
ras Proteins
|
|
Concept
|
Interferon-Stimulated Gene Factor 3
|
|
Concept
|
Th2 Cells
|
|
Concept
|
Infarction, Middle Cerebral Artery
|
|
Concept
|
GTP-Binding Protein alpha Subunits, Gi-Go
|
|
Concept
|
Caspase 3
|
|
Concept
|
P-Selectin
|
|
Concept
|
Fluorescent Antibody Technique, Indirect
|
|
Concept
|
GTP Phosphohydrolases
|
|
Concept
|
Intracranial Embolism
|
|
Concept
|
Matrix Metalloproteinase 2
|
|
Concept
|
Orphan Nuclear Receptors
|
|
Concept
|
Rifabutin
|
|
Concept
|
Cyclic GMP-Dependent Protein Kinases
|
|
Concept
|
Myofibroblasts
|
|
Concept
|
Vascular Endothelial Growth Factor Receptor-2
|
|
Concept
|
Myosin-Light-Chain Phosphatase
|
|
Concept
|
Receptor, Bradykinin B2
|
|
Concept
|
PPAR gamma
|
|
Concept
|
Green Fluorescent Proteins
|
|
Concept
|
Vascular Endothelial Growth Factors
|
|
Concept
|
Catenins
|
|
Concept
|
Sterol Regulatory Element Binding Protein 2
|
|
Concept
|
Endothelin-1
|
|
Concept
|
Area Under Curve
|
|
Concept
|
COS Cells
|
|
Concept
|
Transcription Factor AP-1
|
|
Concept
|
3' Untranslated Regions
|
|
Concept
|
Hydroxymethylglutaryl-CoA Reductase Inhibitors
|
|
Concept
|
Matrix Metalloproteinase 3
|
|
Concept
|
rhoA GTP-Binding Protein
|
|
Concept
|
rac GTP-Binding Proteins
|
|
Concept
|
Embryo Loss
|
|
Concept
|
Platelet Endothelial Cell Adhesion Molecule-1
|
|
Concept
|
Cationic Amino Acid Transporter 1
|
|
Concept
|
I-kappa B Proteins
|
|
Concept
|
Hemangioma, Cavernous, Central Nervous System
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
|
Concept
|
Phosphoric Monoester Hydrolases
|
|
Concept
|
Popliteal Artery
|
|
Concept
|
Precipitin Tests
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Early Growth Response Protein 1
|
|
Concept
|
Pulmonary Artery
|
|
Concept
|
Acute Coronary Syndrome
|
|
Concept
|
Renin
|
|
Concept
|
Spironolactone
|
|
Concept
|
Farnesyl-Diphosphate Farnesyltransferase
|
|
Concept
|
Taiwan
|
|
Concept
|
Interferon Regulatory Factors
|
|
Concept
|
GATA4 Transcription Factor
|
|
Concept
|
Human Umbilical Vein Endothelial Cells
|
|
Concept
|
Osteopontin
|
|
Concept
|
Vitamin D
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Chemokine CXCL10
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Cyclins
|
|
Concept
|
Tibial Arteries
|
|
Concept
|
Transcription Factor RelA
|
|
Concept
|
Tubulin
|
|
Concept
|
8,11,14-Eicosatrienoic Acid
|
|
Concept
|
Myocardial Ischemia
|
|
Concept
|
Tunica Intima
|
|
Concept
|
Cell Hypoxia
|
|
Concept
|
Survival Rate
|
|
Concept
|
Retinoblastoma Protein
|
|
Concept
|
ATP-Binding Cassette Transporters
|
|
Concept
|
Intercellular Adhesion Molecule-1
|
|
Concept
|
Coronary Angiography
|
|
Concept
|
Cyclin-Dependent Kinases
|
|
Concept
|
GTP-Binding Proteins
|
|
Concept
|
Matrix Metalloproteinases, Membrane-Associated
|
|
Concept
|
Myeloid Differentiation Factor 88
|
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
|
Concept
|
Troponin T
|
|
Concept
|
Intracranial Hemorrhages
|
|
Concept
|
Interleukin-17
|
|
Concept
|
Stroke
|
|
Concept
|
cdc42 GTP-Binding Protein
|
|
Concept
|
Xenograft Model Antitumor Assays
|
|
Concept
|
Homeodomain Proteins
|
|
Concept
|
Interleukin-13
|
|
Concept
|
HSP90 Heat-Shock Proteins
|
|
Concept
|
Vascular Cell Adhesion Molecule-1
|
|
Concept
|
Carotid Artery Injuries
|
|
Concept
|
Monomeric GTP-Binding Proteins
|
|
Concept
|
Two-Hybrid System Techniques
|
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
|
Concept
|
S-Nitrosoglutathione
|
|
Concept
|
gamma Catenin
|
|
Concept
|
Basic Helix-Loop-Helix Transcription Factors
|
|
Concept
|
Keratin-14
|
|
Concept
|
Escherichia coli Proteins
|
|
Concept
|
Haploinsufficiency
|
|
Concept
|
Vascular Endothelial Growth Factor A
|
|
Concept
|
LIM-Homeodomain Proteins
|
|
Concept
|
GTP-Binding Protein alpha Subunits, Gq-G11
|
|
Concept
|
Cell Line, Tumor
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p27
|
|
Concept
|
Plakophilins
|
|
Concept
|
Amyloid Precursor Protein Secretases
|
|
Concept
|
Microvessels
|
|
Concept
|
Gene Knock-In Techniques
|
|
Concept
|
Nuclear Receptor Coactivator 3
|
|
Concept
|
Diet, High-Fat
|
|
Concept
|
Anticholesteremic Agents
|
|
Concept
|
Brain Neoplasms
|
|
Concept
|
Calcium
|
|
Concept
|
Calcium Channel Blockers
|
|
Concept
|
Cell Line
|
|
Concept
|
Cells, Cultured
|
|
Concept
|
Cerebral Arteries
|
|
Concept
|
Brain Ischemia
|
|
Concept
|
Clinical Trials as Topic
|
|
Concept
|
Coronary Vessels
|
|
Concept
|
Desmosomes
|
|
Concept
|
Diabetes Mellitus
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
Drugs, Chinese Herbal
|
|
Concept
|
Endothelium
|
|
Concept
|
Epidermis
|
|
Concept
|
Femoral Artery
|
|
Concept
|
Follow-Up Studies
|
|
Concept
|
Genetic Testing
|
|
Concept
|
Longitudinal Studies
|
|
Concept
|
Monocytes
|
|
Concept
|
Proadifen
|
|
Concept
|
Prospective Studies
|
|
Concept
|
Retrospective Studies
|
|
Concept
|
T-Lymphocytes
|
|
Concept
|
Violence
|
|
Concept
|
Neuroimmunomodulation
|
|
Concept
|
Interleukin-5
|
|
Concept
|
Tumor Suppressor Protein p53
|
|
Concept
|
Cytokines
|
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
|
Concept
|
DNA Primers
|
|
Concept
|
E-Selectin
|
|
Concept
|
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
|
|
Concept
|
Chemokines, CXC
|
|
Concept
|
Genetic Predisposition to Disease
|
|
Concept
|
Proto-Oncogene Proteins c-sis
|
|
Concept
|
Adherens Junctions
|
|
Concept
|
GATA2 Transcription Factor
|
|
Concept
|
Smad Proteins
|
|
Concept
|
HLA-DR alpha-Chains
|
|
Academic Article
|
Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.
|
|
Academic Article
|
Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene.
|
|
Academic Article
|
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
|
|
Academic Article
|
Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
|
|
Academic Article
|
Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
|
|
Academic Article
|
Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
|
|
Academic Article
|
Increased Rho kinase activity in a Taiwanese population with metabolic syndrome.
|
|
Academic Article
|
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
|
|
Academic Article
|
Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.
|
|
Academic Article
|
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
|
|
Academic Article
|
A method for measuring Rho kinase activity in tissues and cells.
|
|
Academic Article
|
Essential role of endothelial Notch1 in angiogenesis.
|
|
Academic Article
|
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
|
|
Academic Article
|
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
|
|
Academic Article
|
Pleiotropic effects of statins. - Basic research and clinical perspectives -.
|
|
Academic Article
|
Smooth muscle Notch1 mediates neointimal formation after vascular injury.
|
|
Academic Article
|
Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers.
|
|
Academic Article
|
Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction.
|
|
Academic Article
|
Calcium channel blocker and Rho-associated kinase activity in patients with hypertension.
|
|
Academic Article
|
Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins?
|
|
Academic Article
|
ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery.
|
|
Academic Article
|
Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina.
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Academic Article
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Increased Rho kinase activity in congestive heart failure.
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Academic Article
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Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
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Academic Article
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Statins inhibit Rho kinase activity in patients with atherosclerosis.
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Academic Article
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Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy.
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Academic Article
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Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.
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Academic Article
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Role of Rho kinase isoforms in murine allergic airway responses.
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Academic Article
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Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.
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Academic Article
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Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
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Academic Article
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Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
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Academic Article
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Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
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Academic Article
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Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.
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Academic Article
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Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.
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Academic Article
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Rho kinase: an important mediator of atherosclerosis and vascular disease.
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Academic Article
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Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice.
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Academic Article
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Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.
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Academic Article
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Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB.
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Academic Article
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Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(Kip1).
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Academic Article
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Rapid effects of statins: from prophylaxis to therapy for ischemic stroke.
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Academic Article
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Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular disease.
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Academic Article
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Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase.
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Academic Article
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Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol.
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Academic Article
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Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
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Academic Article
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A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
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Academic Article
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Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
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Academic Article
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Endothelium-dependent effects of statins.
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Academic Article
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Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.
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Academic Article
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Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
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Academic Article
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Nonnuclear actions of estrogen.
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Academic Article
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Isoprenoid metabolism and the pleiotropic effects of statins.
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Academic Article
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Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.
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Academic Article
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Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.
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Academic Article
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Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.
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Academic Article
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Does it matter whether or not a lipid-lowering agent inhibits Rho kinase?
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Academic Article
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Mitohormesis: another pleiotropic effect of statins?
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Academic Article
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A mouse model of diet-induced obesity and insulin resistance.
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Academic Article
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Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension.
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Academic Article
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gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice.
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Academic Article
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ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.
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Academic Article
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Pleiotropic effects of statins.
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Academic Article
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Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease.
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Academic Article
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FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1.
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Academic Article
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Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction.
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Academic Article
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Translational therapeutics of dipyridamole.
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Academic Article
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Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.
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Academic Article
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Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
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Academic Article
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Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.
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Academic Article
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Linking endothelial dysfunction with endothelial cell activation.
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Academic Article
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The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
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Academic Article
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Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel.
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Academic Article
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The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.
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Academic Article
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Rac1 is a critical mediator of endothelium-derived neurotrophic activity.
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Academic Article
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Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
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Academic Article
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Isoprenoids as mediators of the biological effects of statins.
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Academic Article
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Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.
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Academic Article
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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
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Academic Article
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Safety and efficacy of statins in Asians.
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Academic Article
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Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants.
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Academic Article
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Statins and ischemic stroke.
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Academic Article
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Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency.
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Academic Article
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Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
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Academic Article
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Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors.
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Academic Article
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Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
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Academic Article
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1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase.
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Academic Article
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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
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Academic Article
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Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase.
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Academic Article
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A functional role of I kappa B-epsilon in endothelial cell activation.
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Academic Article
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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
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Academic Article
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Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.
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Academic Article
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Statins: potent vascular anti-inflammatory agents.
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Academic Article
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Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
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Academic Article
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Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinase.
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Academic Article
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Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.
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Academic Article
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ROCKs as therapeutic targets in cardiovascular diseases.
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Academic Article
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Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.
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Academic Article
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NF-?B and innate immunity in ischemic stroke.
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Academic Article
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Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.
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Academic Article
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Nontranscriptional actions of the glucocorticoid receptor.
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Academic Article
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Rho GTPases, statins, and nitric oxide.
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Academic Article
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Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.
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Academic Article
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Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis.
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Academic Article
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Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
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Academic Article
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Clinical implications for statin pleiotropy.
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Academic Article
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ROCKs as immunomodulators of stroke.
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Academic Article
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Pleiotropic effects of statin therapy: molecular mechanisms and clinical results.
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Academic Article
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Physiological role of ROCKs in the cardiovascular system.
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Academic Article
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Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.
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Academic Article
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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
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Academic Article
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A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome.
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Academic Article
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Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
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Academic Article
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Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2.
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Academic Article
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Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.
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Academic Article
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Requirement of Rac1 in the development of cardiac hypertrophy.
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Academic Article
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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
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Academic Article
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Potential serum biomarkers in the pathophysiological processes of stroke.
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Academic Article
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Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
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Academic Article
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Linking Notch signaling to ischemic stroke.
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Academic Article
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Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide.
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Academic Article
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Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection.
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Academic Article
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Simvastatin decreases IL-6 and IL-8 production in epithelial cells.
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Academic Article
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Statin therapy: having the good without the bad.
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Academic Article
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Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.
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Academic Article
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Statins and myocardial hypertrophy.
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Academic Article
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Salicylates and vascular smooth muscle cell proliferation: molecular mechanisms for cell cycle arrest.
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Academic Article
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Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
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Academic Article
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Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.
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Academic Article
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Novel aspects of the roles of Rac1 GTPase in the cardiovascular system.
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Academic Article
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RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis.
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Academic Article
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Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
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Academic Article
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Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1.
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Academic Article
|
FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
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Academic Article
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Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
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Academic Article
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Rapid nongenomic actions of thyroid hormone.
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Academic Article
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Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism.
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Academic Article
|
Rho kinase (ROCK) inhibitors.
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Academic Article
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NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy.
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Academic Article
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Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection.
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Academic Article
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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
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Academic Article
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Fine-tuning the angiogenic response to vascular endothelial growth factor.
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Academic Article
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Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
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Academic Article
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Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
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Academic Article
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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.
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Academic Article
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Rho-associated kinase activity is a predictor of cardiovascular outcomes.
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Academic Article
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Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein.
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Academic Article
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Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial.
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Academic Article
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MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1.
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Academic Article
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Effect of torcetrapib in patients at high risk for coronary events.
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Academic Article
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Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome.
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Academic Article
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ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.
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Academic Article
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Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts.
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Academic Article
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Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study.
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Academic Article
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Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
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Academic Article
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Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis.
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Academic Article
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Distribution of sphingosine kinase activity and mRNA in rodent brain.
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Academic Article
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HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events.
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Academic Article
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Increased leukocyte ROCK activity in patients after acute ischemic stroke.
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Academic Article
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Drug Insight: statins and stroke.
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Academic Article
|
Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.
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Academic Article
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Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients.
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Academic Article
|
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.
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Academic Article
|
Relative Lack of Culprit and Obstructive Coronary Lesions in Patients With Acute Ischemic Stroke and Elevated Cardiac Troponin.
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Academic Article
|
Role of statin pleiotropism in acute coronary syndromes and stroke.
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Academic Article
|
Genetically elevated C-reactive protein and ischemic vascular disease.
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Academic Article
|
Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.
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Academic Article
|
Interventional Transcatheter Closure Ameliorates the Leukocyte Rho Kinase Activities among Patients with Patent Ductus Arteriosus.
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Academic Article
|
Rho Kinases and Cardiac Remodeling.
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Academic Article
|
Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression.
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Academic Article
|
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
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Academic Article
|
Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding.
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Academic Article
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MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation.
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Academic Article
|
Fingolimod provides long-term protection in rodent models of cerebral ischemia.
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Academic Article
|
RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
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Academic Article
|
Role of ROCK2 in CD4+ cells in allergic airways responses in mice.
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Academic Article
|
Activation of guanine nucleotide-binding proteins and induction of endothelial tissue-type plasminogen activator gene transcription by alcohol.
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Academic Article
|
Targeting Rho in cardiovascular disease.
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Academic Article
|
Lipid management with statins. The lower the better?
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Academic Article
|
Targeting eNOS for stroke protection.
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Academic Article
|
Nuclear run-on assay to study gene transcription in vascular cells.
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Academic Article
|
Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor.
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Academic Article
|
[Regulation of endothelial NO production by Rho GTPase].
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Academic Article
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Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1.
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Academic Article
|
Direct vascular effects of HMG-CoA reductase inhibitors.
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Academic Article
|
Pleiotropic Effects of Statins on the Cardiovascular System.
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Academic Article
|
Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms.
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Academic Article
|
Preservation of NO production by statins in the treatment of heart failure.
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Academic Article
|
Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor.
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Academic Article
|
Notch signaling as an important mediator of cardiac repair and regeneration after myocardial infarction.
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Academic Article
|
Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.
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Academic Article
|
Beyond lipid lowering: the role of statins in vascular protection.
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Academic Article
|
Statin therapy for cardiac hypertrophy and heart failure.
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Academic Article
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Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure.
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Academic Article
|
Tumor necrosis factor-a levels and non-surgical bleeding in continuous-flow left ventricular assist devices.
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Academic Article
|
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
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Academic Article
|
Inhibition of MHC II gene transcription by nitric oxide and antioxidants.
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Academic Article
|
Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase.
|
|
Academic Article
|
Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
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|
Academic Article
|
Impaired Cognitive Performance in Endothelial Nitric Oxide Synthase Knockout Mice After Ischemic Stroke: A Pilot Study.
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Academic Article
|
ROCK as a therapeutic target for ischemic stroke.
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Academic Article
|
Simvastatin preserves cardiac function in genetically determined cardiomyopathy.
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Academic Article
|
The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
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Academic Article
|
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
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Academic Article
|
Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study.
|
|
Academic Article
|
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
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Academic Article
|
Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
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Academic Article
|
Is statin discontinuation an option in patients who have had a stroke?
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Academic Article
|
The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
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Academic Article
|
Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies.
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Academic Article
|
Dynamic regulation of endothelial NOS mediated by competitive interaction with alpha-actinin-4 and calmodulin.
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Academic Article
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Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
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Academic Article
|
Association of Rising Violent Crime With Blood Pressure and Cardiovascular Risk: Longitudinal Evidence From Chicago, 2014-2016.
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Academic Article
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A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
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Academic Article
|
Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening.
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Academic Article
|
Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure.
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Academic Article
|
Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.
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Academic Article
|
Long-term statin use and psychological well-being.
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Academic Article
|
Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
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Academic Article
|
SALAD-BAAR: A numerical risk score for hospital admission or emergency department presentation in ambulatory patients with cardiovascular disease.
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Academic Article
|
Emerging views of statin pleiotropy and cholesterol lowering.
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Academic Article
|
Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway.
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Academic Article
|
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury.
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Academic Article
|
Challenging Statin Pleiotropy: Preeclampsia.
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Academic Article
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Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.
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Academic Article
|
Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity.
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Academic Article
|
Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-a Signaling Abrogates Estrogen Protection Against Vascular Injury.
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Concept
|
Forkhead Box Protein O1
|
|
Concept
|
Liver X Receptors
|
|
Concept
|
NF-KappaB Inhibitor alpha
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|
Concept
|
KRIT1 Protein
|
|
Concept
|
Tertiary Care Centers
|
|
Concept
|
ATP Binding Cassette Transporter 1
|
|
Concept
|
Social Determinants of Health
|
|
Grant
|
Cellular Determinants of Adipocyte Phenotype and Function
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|
Grant
|
ROCK and Obesity
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|
Grant
|
Mechanisms Underlying Vascular Aging
|
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Academic Article
|
Understanding the molecular mechanisms of statin pleiotropic effects.
|
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Academic Article
|
A Novel HIF-2a/ARNT Signaling Pathway Protects Against Microvascular Dysfunction and heart failure After Myocardial Infarction.
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Academic Article
|
Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations.
|