 NF-kappa B
"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
| Descriptor ID |
D016328
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| MeSH Number(s) |
D12.776.260.600 D12.776.660.600 D12.776.930.600
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| Concept/Terms |
NF-kappa B- NF-kappa B
- kappa B Enhancer Binding Protein
- NF-kappaB
- NF kappaB
- Transcription Factor NF-kB
- Factor NF-kB, Transcription
- NF-kB, Transcription Factor
- Transcription Factor NF kB
- NF-kB
- NF kB
- Immunoglobulin Enhancer-Binding Protein
- Enhancer-Binding Protein, Immunoglobulin
- Immunoglobulin Enhancer Binding Protein
- Nuclear Factor kappa B
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Below are MeSH descriptors whose meaning is more general than "NF-kappa B".
Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".
This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1990 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 2 | 1 | 3 | | 1993 | 5 | 0 | 5 | | 1994 | 4 | 1 | 5 | | 1995 | 4 | 1 | 5 | | 1996 | 5 | 0 | 5 | | 1997 | 7 | 2 | 9 | | 1998 | 1 | 3 | 4 | | 1999 | 2 | 3 | 5 | | 2000 | 8 | 5 | 13 | | 2001 | 8 | 4 | 12 | | 2002 | 12 | 7 | 19 | | 2003 | 13 | 6 | 19 | | 2004 | 11 | 8 | 19 | | 2005 | 7 | 3 | 10 | | 2006 | 11 | 8 | 19 | | 2007 | 11 | 8 | 19 | | 2008 | 6 | 4 | 10 | | 2009 | 9 | 13 | 22 | | 2010 | 2 | 10 | 12 | | 2011 | 6 | 4 | 10 | | 2012 | 6 | 14 | 20 | | 2013 | 7 | 11 | 18 | | 2014 | 3 | 2 | 5 | | 2015 | 4 | 9 | 13 | | 2016 | 1 | 10 | 11 | | 2017 | 3 | 3 | 6 | | 2018 | 3 | 3 | 6 | | 2019 | 2 | 4 | 6 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "NF-kappa B" by people in Profiles.
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Candas-Green D, Xie B, Huang J, Fan M, Wang A, Menaa C, Zhang Y, Zhang L, Jing D, Azghadi S, Zhou W, Liu L, Jiang N, Li T, Gao T, Sweeney C, Shen R, Lin TY, Pan CX, Ozpiskin OM, Woloschak G, Grdina DJ, Vaughan AT, Wang JM, Xia S, Monjazeb AM, Murphy WJ, Sun LQ, Chen HW, Lam KS, Weichselbaum RR, Li JJ. Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. Nat Commun. 2020 09 14; 11(1):4591.
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Szymura SJ, Bernal GM, Wu L, Zhang Z, Crawley CD, Voce DJ, Campbell PA, Ranoa DE, Weichselbaum RR, Yamini B. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy. BMC Biol. 2020 03 24; 18(1):32.
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Sanz J, Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J, Barreiro LB. Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23317-23322.
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Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J. Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal. 2019 08 05; 17(1):90.
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Bao Y, Sun YW, Ji J, Gan L, Zhang CF, Wang CZ, Yuan CS. Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK/STAT and NF-?B signaling pathways. Phytomedicine. 2019 Oct; 63:153036.
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Egaña-Gorroño L, Chinnasamy P, Casimiro I, Almonte VM, Parikh D, Oliveira-Paula GH, Jayakumar S, Law C, Riascos-Bernal DF, Sibinga NES. Allograft inflammatory factor-1 supports macrophage survival and efferocytosis and limits necrosis in atherosclerotic plaques. Atherosclerosis. 2019 10; 289:184-194.
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Voce DJ, Bernal GM, Wu L, Crawley CD, Zhang W, Mansour NM, Cahill KE, Szymura SJ, Uppal A, Raleigh DR, Spretz R, Nunez L, Larsen G, Khodarev NN, Weichselbaum RR, Yamini B. Temozolomide Treatment Induces lncRNA MALAT1 in an NF-?B and p53 Codependent Manner in Glioblastoma. Cancer Res. 2019 05 15; 79(10):2536-2548.
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Godfrey J, Tumuluru S, Bao R, Leukam M, Venkataraman G, Phillip J, Fitzpatrick C, McElherne J, MacNabb BW, Orlowski R, Smith SM, Kline J. PD-L1 gene alterations identify a subset of diffuse large B-cell lymphoma harboring a T-cell-inflamed phenotype. Blood. 2019 05 23; 133(21):2279-2290.
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Ming M, Wu W, Xie B, Sukhanova M, Wang W, Kadri S, Sharma S, Lee J, Shacham S, Landesman Y, Maltsev N, Lu P, Wang YL. XPO1 Inhibitor Selinexor Overcomes Intrinsic Ibrutinib Resistance in Mantle Cell Lymphoma via Nuclear Retention of I?B. . 2018 12; 17(12):2564-2574.
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Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Clinical proof of concept for a safe and effective NF-?B-targeting strategy in multiple myeloma. Br J Haematol. 2019 05; 185(3):588-592.
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