 NF-kappa B
"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
| Descriptor ID |
D016328
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| MeSH Number(s) |
D12.776.260.600 D12.776.660.600 D12.776.930.600
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| Concept/Terms |
NF-kappa B- NF-kappa B
- kappa B Enhancer Binding Protein
- NF-kappaB
- NF kappaB
- Transcription Factor NF-kB
- Factor NF-kB, Transcription
- NF-kB, Transcription Factor
- Transcription Factor NF kB
- NF-kB
- NF kB
- Immunoglobulin Enhancer-Binding Protein
- Enhancer-Binding Protein, Immunoglobulin
- Immunoglobulin Enhancer Binding Protein
- Nuclear Factor kappa B
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Below are MeSH descriptors whose meaning is more general than "NF-kappa B".
Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".
This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1990 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 2 | 1 | 3 | | 1993 | 5 | 0 | 5 | | 1994 | 4 | 1 | 5 | | 1995 | 4 | 1 | 5 | | 1996 | 5 | 0 | 5 | | 1997 | 7 | 2 | 9 | | 1998 | 1 | 3 | 4 | | 1999 | 2 | 3 | 5 | | 2000 | 8 | 5 | 13 | | 2001 | 8 | 4 | 12 | | 2002 | 12 | 7 | 19 | | 2003 | 13 | 6 | 19 | | 2004 | 11 | 8 | 19 | | 2005 | 7 | 3 | 10 | | 2006 | 11 | 8 | 19 | | 2007 | 11 | 10 | 21 | | 2008 | 6 | 4 | 10 | | 2009 | 9 | 13 | 22 | | 2010 | 3 | 11 | 14 | | 2011 | 6 | 4 | 10 | | 2012 | 6 | 14 | 20 | | 2013 | 7 | 11 | 18 | | 2014 | 3 | 2 | 5 | | 2015 | 4 | 10 | 14 | | 2016 | 1 | 10 | 11 | | 2017 | 3 | 4 | 7 | | 2018 | 3 | 3 | 6 | | 2019 | 3 | 4 | 7 | | 2020 | 5 | 2 | 7 | | 2021 | 3 | 5 | 8 |
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Below are the most recent publications written about "NF-kappa B" by people in Profiles.
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Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY. Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183.
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Voce DJ, Bernal GM, Cahill KE, Wu L, Mansour N, Crawley CD, Campbell PS, Arina A, Weichselbaum RR, Yamini B. CDK1 is up-regulated by temozolomide in an NF-?B dependent manner in glioblastoma. Sci Rep. 2021 03 11; 11(1):5665.
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Kimani FW, Ajit J, Galluppi A, Manna S, Howitz WJ, Tang S, Esser-Kahn AP. Receptor-Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands. ACS Chem Biol. 2021 02 19; 16(2):380-388.
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Son M, Wang AG, Tu HL, Metzig MO, Patel P, Husain K, Lin J, Murugan A, Hoffmann A, Tay S. NF-?B responds to absolute differences in cytokine concentrations. Sci Signal. 2021 01 19; 14(666).
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Vecchiotti D, Verzella D, Capece D, Nolfi MDV, Di Francesco B, Cornice J, Franzoso G, Alesse E, Zazzeroni F. Biochemical Methods to Analyze the Subcellular Localization of NF-?B Proteins Using Cell Fractionation. Methods Mol Biol. 2021; 2366:19-25.
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Vecchiotti D, Verzella D, Capece D, Cornice J, Nolfi MDV, Di Francesco B, Franzoso G, Alesse E, Zazzeroni F. Immunohistochemical Analysis of Expression, Phosphorylation, and Nuclear Translocation of NF-?B Proteins in Human Tissues. Methods Mol Biol. 2021; 2366:27-42.
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Capece D, Verzella D, Begalli F, Bennett J, D'Andrea D, Vecchiotti D, Zazzeroni F, Franzoso G. Extracellular Flux Analysis to Investigate the Impact of NF-?B on Mitochondrial Respiration in Colorectal Carcinoma (CRC). Methods Mol Biol. 2021; 2366:293-303.
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Tornatore L, Capece D, Sandomenico A, Verzella D, Vecchiotti D, Zazzeroni F, Ruvo M, Franzoso G. The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-?B Pathway. Methods Mol Biol. 2021; 2366:343-356.
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Antonangeli F, Natalini A, Garassino MC, Sica A, Santoni A, Di Rosa F. Regulation of PD-L1 Expression by NF-?B in Cancer. Front Immunol. 2020; 11:584626.
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Karunakaran D, Nguyen MA, Geoffrion M, Vreeken D, Lister Z, Cheng HS, Otte N, Essebier P, Wyatt H, Kandiah JW, Jung R, Alenghat FJ, Mompeon A, Lee R, Pan C, Gordon E, Rasheed A, Lusis AJ, Liu P, Matic LP, Hedin U, Fish JE, Guo L, Kolodgie F, Virmani R, van Gils JM, Rayner KJ. RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-?B Activation and Atherogenesis in Mice. Circulation. 2021 01 12; 143(2):163-177.
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