Promyelocytic Leukemia Protein
"Promyelocytic Leukemia Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.
| Descriptor ID |
D000071156
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| MeSH Number(s) |
D12.776.624.776.654 D12.776.660.745 D12.776.930.713 D12.776.934.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Promyelocytic Leukemia Protein".
Below are MeSH descriptors whose meaning is more specific than "Promyelocytic Leukemia Protein".
This graph shows the total number of publications written about "Promyelocytic Leukemia Protein" by people in this website by year, and whether "Promyelocytic Leukemia Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Promyelocytic Leukemia Protein" by people in Profiles.
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The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):E3823-E3829.
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PML plays both inimical and beneficial roles in HSV-1 replication. Proc Natl Acad Sci U S A. 2016 May 24; 113(21):E3022-8.
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Puromycin-based vectors promote a ROS-dependent recruitment of PML to nuclear inclusions enriched with HSP70 and Proteasomes. BMC Cell Biol. 2009 May 01; 10:32.
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The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem. J Virol. 2009 Jan; 83(1):181-7.
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EVI1 abrogates interferon-alpha response by selectively blocking PML induction. J Biol Chem. 2005 Jan 07; 280(1):428-36.
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The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8963-8.
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Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. J Virol. 2003 Jun; 77(12):7101-5.
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Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins. J Virol. 2002 Sep; 76(18):9355-67.