"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
|
MeSH Number(s) |
G02.111.820 G04.835
|
Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1993 | 4 | 11 | 15 |
1994 | 9 | 18 | 27 |
1995 | 14 | 20 | 34 |
1996 | 10 | 12 | 22 |
1997 | 24 | 15 | 39 |
1998 | 12 | 23 | 35 |
1999 | 18 | 29 | 47 |
2000 | 17 | 27 | 44 |
2001 | 16 | 38 | 54 |
2002 | 34 | 43 | 77 |
2003 | 25 | 58 | 83 |
2004 | 30 | 50 | 80 |
2005 | 17 | 63 | 80 |
2006 | 31 | 64 | 95 |
2007 | 25 | 58 | 83 |
2008 | 37 | 70 | 107 |
2009 | 49 | 73 | 122 |
2010 | 49 | 95 | 144 |
2011 | 45 | 91 | 136 |
2012 | 42 | 91 | 133 |
2013 | 36 | 86 | 122 |
2014 | 37 | 94 | 131 |
2015 | 44 | 90 | 134 |
2016 | 25 | 98 | 123 |
2017 | 26 | 75 | 101 |
2018 | 22 | 75 | 97 |
2019 | 19 | 59 | 78 |
2020 | 25 | 46 | 71 |
2021 | 14 | 39 | 53 |
2022 | 3 | 15 | 18 |
2023 | 1 | 15 | 16 |
To return to the timeline,
click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
-
Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 12; 55(1):954-964.
-
Purinergic signaling mediates neuroglial interactions to modulate sighs. Nat Commun. 2023 08 31; 14(1):5300.
-
Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia. Clin Cancer Res. 2023 08 15; 29(16):3151-3161.
-
6mA-METL-9 axis regulates innate immunity in C. elegans. Cell Res. 2023 08; 33(8):581-582.
-
YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs. EMBO J. 2023 08 01; 42(15):e113126.
-
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. Cancer Cell. 2023 07 10; 41(7):1294-1308.e8.
-
STAT3 signaling in B cells controls germinal center zone organization and recycling. Cell Rep. 2023 05 30; 42(5):112512.
-
SOX2 expression in prostate cancer drives resistance to nuclear hormone receptor signaling inhibition through the WEE1/CDK1 signaling axis. Cancer Lett. 2023 07 01; 565:216209.
-
The Functional Role and Regulatory Mechanism of FTO m6A RNA Demethylase in Human Uterine Leiomyosarcoma. Int J Mol Sci. 2023 Apr 27; 24(9).
-
Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer. Endocrinology. 2023 04 17; 164(6).