"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
|
MeSH Number(s) |
G02.111.820 G04.835
|
Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 9 | 18 | 27 |
1995 | 14 | 20 | 34 |
1996 | 10 | 12 | 22 |
1997 | 24 | 15 | 39 |
1998 | 12 | 23 | 35 |
1999 | 18 | 29 | 47 |
2000 | 17 | 27 | 44 |
2001 | 16 | 38 | 54 |
2002 | 35 | 44 | 79 |
2003 | 26 | 58 | 84 |
2004 | 30 | 51 | 81 |
2005 | 17 | 66 | 83 |
2006 | 31 | 65 | 96 |
2007 | 25 | 61 | 86 |
2008 | 37 | 72 | 109 |
2009 | 50 | 76 | 126 |
2010 | 50 | 95 | 145 |
2011 | 47 | 97 | 144 |
2012 | 46 | 94 | 140 |
2013 | 36 | 91 | 127 |
2014 | 37 | 98 | 135 |
2015 | 47 | 95 | 142 |
2016 | 29 | 102 | 131 |
2017 | 30 | 79 | 109 |
2018 | 23 | 79 | 102 |
2019 | 21 | 65 | 86 |
2020 | 26 | 48 | 74 |
2021 | 14 | 45 | 59 |
2022 | 4 | 19 | 23 |
2023 | 4 | 26 | 30 |
2024 | 6 | 19 | 25 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science. 2024 Jun 21; 384(6702):eadh5548.
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Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice. Cell Rep. 2024 Jun 25; 43(6):114284.
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Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness. Cell Death Dis. 2024 May 28; 15(5):370.
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The CD8+ TÂ cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects. Immunity. 2024 Jun 11; 57(6):1324-1344.e8.
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Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024 May 16; 15(1):4177.
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Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling. Free Radic Biol Med. 2024 Aug 20; 221:125-135.
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MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer. Int J Mol Sci. 2024 May 08; 25(10).
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RFX6 regulates human intestinal patterning and function upstream of PDX1. Development. 2024 May 01; 151(9).
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Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers. Clin Transl Sci. 2024 May; 17(5):e13816.
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Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling. Arterioscler Thromb Vasc Biol. 2024 Jun; 44(6):1246-1264.