"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 14 | 20 | 34 |
| 1996 | 10 | 12 | 22 |
| 1997 | 24 | 15 | 39 |
| 1998 | 12 | 23 | 35 |
| 1999 | 18 | 29 | 47 |
| 2000 | 17 | 26 | 43 |
| 2001 | 16 | 38 | 54 |
| 2002 | 35 | 45 | 80 |
| 2003 | 26 | 58 | 84 |
| 2004 | 31 | 52 | 83 |
| 2005 | 18 | 66 | 84 |
| 2006 | 31 | 66 | 97 |
| 2007 | 25 | 61 | 86 |
| 2008 | 37 | 73 | 110 |
| 2009 | 51 | 79 | 130 |
| 2010 | 50 | 96 | 146 |
| 2011 | 47 | 96 | 143 |
| 2012 | 46 | 94 | 140 |
| 2013 | 37 | 93 | 130 |
| 2014 | 38 | 98 | 136 |
| 2015 | 47 | 94 | 141 |
| 2016 | 29 | 102 | 131 |
| 2017 | 32 | 81 | 113 |
| 2018 | 26 | 84 | 110 |
| 2019 | 22 | 68 | 90 |
| 2020 | 28 | 49 | 77 |
| 2021 | 16 | 49 | 65 |
| 2022 | 4 | 20 | 24 |
| 2023 | 4 | 28 | 32 |
| 2024 | 18 | 39 | 57 |
| 2025 | 6 | 6 | 12 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Variability in radiotherapy outcomes across cancer types: a comparative study of glioblastoma multiforme and low-grade gliomas. Aging (Albany NY). 2025 Feb 27; 17(2):550-562.
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Dynamic PRDX S-acylation modulates ROS stress and signaling. Cell Chem Biol. 2025 Mar 20; 32(3):511-519.e5.
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Signal Transduction Pathway Mediating Carotid Body Dependent Sympathetic Activation and Hypertension by Chronic Intermittent Hypoxia. Function (Oxf). 2025 Feb 12; 6(1).
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Macrophage memory emerges from coordinated transcription factor and chromatin dynamics. Cell Syst. 2025 Feb 19; 16(2):101171.
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Adapted Exosomes for Addressing Chemotherapy-induced Premature Ovarian Insufficiency. Stem Cell Rev Rep. 2025 Apr; 21(3):779-796.
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Variable transduction of thyroid hormone signaling in structures of the mouse brain. Proc Natl Acad Sci U S A. 2025 Feb 11; 122(6):e2415970122.
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Aberrantly Expressed Mitochondrial Lipid Kinase, AGK, Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy. Clin Cancer Res. 2025 Feb 03; 31(3):588-602.
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Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice. J Clin Invest. 2025 Feb 03; 135(3).
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Hepatic conditioning results in better lung endothelial cell preservation under hypoxic environment in vitro. Int J Artif Organs. 2025 Feb; 48(2):84-91.
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Sustained hypoxia but not intermittent hypoxia induces HIF-1a transcriptional response in human aortic endothelial cells. Mol Omics. 2025 Jan 13; 21(1):19-31.