 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 1 | 1 | 2 | | 1990 | 1 | 3 | 4 | | 1991 | 6 | 3 | 9 | | 1992 | 6 | 10 | 16 | | 1993 | 5 | 11 | 16 | | 1994 | 9 | 18 | 27 | | 1995 | 14 | 23 | 37 | | 1996 | 10 | 14 | 24 | | 1997 | 25 | 15 | 40 | | 1998 | 12 | 25 | 37 | | 1999 | 19 | 33 | 52 | | 2000 | 19 | 28 | 47 | | 2001 | 17 | 38 | 55 | | 2002 | 35 | 44 | 79 | | 2003 | 26 | 61 | 87 | | 2004 | 30 | 53 | 83 | | 2005 | 19 | 68 | 87 | | 2006 | 32 | 71 | 103 | | 2007 | 27 | 62 | 89 | | 2008 | 36 | 75 | 111 | | 2009 | 51 | 74 | 125 | | 2010 | 52 | 97 | 149 | | 2011 | 45 | 97 | 142 | | 2012 | 43 | 95 | 138 | | 2013 | 37 | 89 | 126 | | 2014 | 39 | 99 | 138 | | 2015 | 48 | 97 | 145 | | 2016 | 27 | 104 | 131 | | 2017 | 28 | 70 | 98 | | 2018 | 23 | 77 | 100 | | 2019 | 22 | 61 | 83 | | 2020 | 24 | 48 | 72 | | 2021 | 14 | 41 | 55 | | 2022 | 0 | 6 | 6 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Lee J, Olivieri C, Ong C, Masterson LR, Gomes S, Lee BS, Schaefer F, Lorenz K, Veglia G, Rosner MR. Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop. Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25):e2121867119.
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Zhang L, Luo H, Ni HM, Liu S, Xing H, Zhang J, Sellin M, Breslin S J P, Wei W, Denning MF, Small W, Ding WX, Huang S, Zhang J. Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice. Stem Cell Reports. 2022 Jun 14; 17(6):1428-1441.
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Alhashem Z, Feldner-Busztin D, Revell C, Alvarez-Garcillan Portillo M, Camargo-Sosa K, Richardson J, Rocha M, Gauert A, Corbeaux T, Milanetto M, Argenton F, Tiso N, Kelsh RN, Prince VE, Bentley K, Linker C. Notch controls the cell cycle to define leader versus follower identities during collective cell migration. Elife. 2022 Apr 19; 11.
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Tatsumi Y, Kato A, Niimi N, Yako H, Himeno T, Kondo M, Tsunekawa S, Kato Y, Kamiya H, Nakamura J, Higai K, Sango K, Kato K. Docosahexaenoic Acid Suppresses Oxidative Stress-Induced Autophagy and Cell Death via the AMPK-Dependent Signaling Pathway in Immortalized Fischer Rat Schwann Cells 1. Int J Mol Sci. 2022 Apr 15; 23(8).
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Semina SE, Pal P, Kansara NS, Huggins RJ, Alarid ET, Greene GL, Frasor J. Selective pressure of endocrine therapy activates the integrated stress response through NF?B signaling in a subpopulation of ER positive breast cancer cells. Breast Cancer Res. 2022 Mar 09; 24(1):19.
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Morgan SM, Tanizawa H, Caruso LB, Hulse M, Kossenkov A, Madzo J, Keith K, Tan Y, Boyle S, Lieberman PM, Tempera I. The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity. Nat Commun. 2022 01 17; 13(1):187.
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Arora R, Van Theemsche KM, Van Remoortel S, Snyders DJ, Labro AJ, Timmermans JP. Constitutive, Basal, and ß-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-?B Signaling. Int J Mol Sci. 2021 Dec 09; 22(24).
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Bi J, Khan A, Tang J, Armando AM, Wu S, Zhang W, Gimple RC, Reed A, Jing H, Koga T, Wong IT, Gu Y, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Kornblum HI, Quehenberger O, Rzhetsky A, Cravatt BF, Mischel PS. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957.
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Wang J, Vaddadi N, Pak JS, Park Y, Quilez S, Roman CA, Dumontier E, Thornton JW, Cloutier JF, Özkan E. Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep. 2021 11 02; 37(5):109940.
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Wu J, Galvan KJ, Bogard RD, Peterson CE, Shergill A, Crowe DL. DNA Double-strand Break Signaling Is a Therapeutic Target in Head and Neck Cancer. Anticancer Res. 2021 Nov; 41(11):5393-5403.
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