 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
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| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
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| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
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Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1988 | 1 | 1 | 2 | | 1990 | 1 | 3 | 4 | | 1991 | 6 | 3 | 9 | | 1992 | 6 | 10 | 16 | | 1993 | 5 | 11 | 16 | | 1994 | 9 | 19 | 28 | | 1995 | 14 | 23 | 37 | | 1996 | 11 | 15 | 26 | | 1997 | 25 | 16 | 41 | | 1998 | 13 | 25 | 38 | | 1999 | 19 | 33 | 52 | | 2000 | 19 | 27 | 46 | | 2001 | 17 | 39 | 56 | | 2002 | 36 | 43 | 79 | | 2003 | 28 | 61 | 89 | | 2004 | 30 | 53 | 83 | | 2005 | 19 | 70 | 89 | | 2006 | 35 | 71 | 106 | | 2007 | 26 | 58 | 84 | | 2008 | 35 | 72 | 107 | | 2009 | 50 | 77 | 127 | | 2010 | 48 | 90 | 138 | | 2011 | 46 | 98 | 144 | | 2012 | 42 | 89 | 131 | | 2013 | 33 | 88 | 121 | | 2014 | 36 | 97 | 133 | | 2015 | 45 | 91 | 136 | | 2016 | 27 | 101 | 128 | | 2017 | 27 | 68 | 95 | | 2018 | 20 | 66 | 86 | | 2019 | 2 | 8 | 10 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Gutiontov SI, Weichselbaum RR. STING (or SRC) Like an ICB: Priming the Immune Response in Pancreatic Cancer. Cancer Res. 2019 Aug 01; 79(15):3815-3817.
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Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie L. Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS Genet. 2019 05; 15(5):e1007711.
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Reyes Ruiz LM, Fiebig A, Crosson S. Regulation of bacterial surface attachment by a network of sensory transduction proteins. PLoS Genet. 2019 05; 15(5):e1008022.
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Samant SA, Pillai VB, Gupta MP. Cellular mechanisms promoting cachexia and how they are opposed by sirtuins 1. Can J Physiol Pharmacol. 2019 Apr; 97(4):235-245.
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Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X, Chu WM. GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2. Gastroenterology. 2019 06; 156(8):2297-2312.
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Waise TMZ, Rasti M, Duca FA, Zhang SY, Bauer PV, Rhodes CJ, Lam TKT. Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production. Nat Commun. 2019 02 12; 10(1):714.
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Ebenezer DL, Berdyshev EV, Bronova IA, Liu Y, Tiruppathi C, Komarova Y, Benevolenskaya EV, Suryadevara V, Ha AW, Harijith A, Tuder RM, Natarajan V, Fu P. Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury. Thorax. 2019 06; 74(6):579-591.
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Park DM, Overton KW, Jiao Y. The UzcRS two-component system in Caulobacter crescentus integrates regulatory input from diverse auxiliary regulators. Mol Microbiol. 2019 03; 111(3):678-699.
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Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol. 2019 02; 20(2):195-205.
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Xu J, Su T, Tokamov SA, Fehon RG. Live Imaging of Hippo Pathway Components in Drosophila Imaginal Discs. Methods Mol Biol. 2019; 1893:53-59.
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