 Signal Transduction
"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 1 | 1 | 2 | | 1990 | 1 | 3 | 4 | | 1991 | 6 | 3 | 9 | | 1992 | 6 | 10 | 16 | | 1993 | 5 | 11 | 16 | | 1994 | 9 | 19 | 28 | | 1995 | 14 | 23 | 37 | | 1996 | 11 | 15 | 26 | | 1997 | 25 | 16 | 41 | | 1998 | 13 | 25 | 38 | | 1999 | 19 | 33 | 52 | | 2000 | 19 | 27 | 46 | | 2001 | 17 | 38 | 55 | | 2002 | 36 | 43 | 79 | | 2003 | 27 | 62 | 89 | | 2004 | 29 | 53 | 82 | | 2005 | 19 | 70 | 89 | | 2006 | 35 | 71 | 106 | | 2007 | 27 | 58 | 85 | | 2008 | 36 | 72 | 108 | | 2009 | 50 | 74 | 124 | | 2010 | 48 | 90 | 138 | | 2011 | 45 | 97 | 142 | | 2012 | 42 | 87 | 129 | | 2013 | 32 | 89 | 121 | | 2014 | 36 | 96 | 132 | | 2015 | 45 | 91 | 136 | | 2016 | 26 | 103 | 129 | | 2017 | 26 | 67 | 93 | | 2018 | 21 | 69 | 90 | | 2019 | 7 | 17 | 24 |
To return to the timeline, click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
-
Bianco AC, Dumitrescu A, Gereben B, Ribeiro MO, Fonseca TL, Fernandes GW, Bocco BMLC. Paradigms of Dynamic Control of Thyroid Hormone Signaling. Endocr Rev. 2019 08 01; 40(4):1000-1047.
-
Gutiontov SI, Weichselbaum RR. STING (or SRC) Like an ICB: Priming the Immune Response in Pancreatic Cancer. Cancer Res. 2019 Aug 01; 79(15):3815-3817.
-
Bao Y, Sun YW, Ji J, Gan L, Zhang CF, Wang CZ, Yuan CS. Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK/STAT and NF-?B signaling pathways. Phytomedicine. 2019 Oct; 63:153036.
-
Reed EB, Ard S, La J, Park CY, Culligan L, Fredberg JJ, Smolyaninova LV, Orlov SN, Chen B, Guzy R, Mutlu GM, Dulin NO. Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling. Respir Res. 2019 Jul 29; 20(1):168.
-
Flood BA, Higgs EF, Li S, Luke JJ, Gajewski TF. STING pathway agonism as a cancer therapeutic. Immunol Rev. 2019 07; 290(1):24-38.
-
Sural-Fehr T, Singh H, Cantuti-Catelvetri L, Zhu H, Marshall MS, Rebiai R, Jastrzebski MJ, Givogri MI, Rasenick MM, Bongarzone ER. Inhibition of the IGF-1-PI3K-Akt-mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis. Dis Model Mech. 2019 05 23; 12(5).
-
Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie L. Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS Genet. 2019 05; 15(5):e1007711.
-
Politano SF, Salemme RR, Ashley J, López-Rivera JA, Bakula TA, Puhalla KA, Quinn JP, Juszczak MJ, Phillip LK, Carrillo RA, Vanderzalm PJ. Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila. Dev Neurobiol. 2019 04; 79(4):335-349.
-
Reyes Ruiz LM, Fiebig A, Crosson S. Regulation of bacterial surface attachment by a network of sensory transduction proteins. PLoS Genet. 2019 05; 15(5):e1008022.
-
Beeler JA, Kisbye Dreyer J. Synchronicity: The Role of Midbrain Dopamine in Whole-Brain Coordination. eNeuro. 2019 Mar/Apr; 6(2).
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|