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Prabhakar, Nanduri R.
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overview Nanduri R. Prabhakar, Ph.D., D.Sc. Harold Hines Jr. Professor of Medicine Director, Center for Systems Biology Director, Oxygen Sensing Department of Medicine The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.
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Academic Article Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells.
Academic Article Cell selective induction and transcriptional activation of immediate early genes by hypoxia.
Academic Article Carbon monoxide and carotid body chemoreception.
Academic Article Regulation of neuronal nitric oxide synthase gene expression by hypoxia. Role of nitric oxide in respiratory adaptation to low pO2.
Academic Article G proteins in carotid body chemoreception.
Academic Article Carotid body I1-imidazoline receptors: binding, visualization and modulatory function.
Academic Article Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons.
Academic Article Nitric oxide and ventilatory response to hypoxia.
Academic Article Norepinephrine inhibits a toxin resistant Ca2+ current in carotid body glomus cells: evidence for a direct G protein mechanism.
Academic Article Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia.
Academic Article Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels.
Academic Article Induction of immediate early response genes by hypoxia. Possible molecular bases for systems adaptation to low pO2.
Academic Article Dual influence of nitric oxide on gene regulation during hypoxia.
Academic Article Oxygen sensing by the carotid body chemoreceptors.
Academic Article Intracellular pathways linking hypoxia to activation of c-fos and AP-1.
Academic Article Release of dopamine and norepinephrine by hypoxia from PC-12 cells.
Academic Article HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body.
Academic Article Role of substance P in neutral endopeptidase modulation of hypoxic response of the carotid body.
Academic Article Selected Contribution: Improved anoxic tolerance in rat diaphragm following intermittent hypoxia.
Academic Article Neural drives and breathing stability.
Academic Article CO2/HCO3- modulates K+ and Ca2+ currents in glomus cells of the carotid body.
Academic Article Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen.
Academic Article Neurotransmitter release from the rabbit carotid body: differential effects of hypoxia on substance P and acetylcholine release.
Academic Article Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.
Academic Article Sleep apneas: an oxidative stress?
Academic Article Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3.
Academic Article The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.
Academic Article Ventilatory changes during intermittent hypoxia: importance of pattern and duration.
Academic Article Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels.
Academic Article Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway.
Academic Article Intermittent hypoxia: cell to system.
Academic Article Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms.
Academic Article Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing.
Academic Article Peripheral and central chemosensitivity: multiple mechanisms, multiple sites? A workshop summary.
Academic Article Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era.
Academic Article Gene regulation during intermittent hypoxia: evidence for the involvement of reactive oxygen species.
Academic Article Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia.
Academic Article Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels.
Academic Article Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction.
Academic Article Peripheral chemoreceptors in health and disease.
Academic Article Oxidative stress in the systemic and cellular responses to intermittent hypoxia.
Academic Article Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration.
Academic Article Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body.
Academic Article Functional role of substance P for respiratory control during development.
Academic Article CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells.
Academic Article Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups.
Academic Article Detection of oxygen sensing during intermittent hypoxia.
Academic Article Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors.
Academic Article Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B.
Academic Article Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia.
Academic Article Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling.
Academic Article Regulation of gene expression by HIF-1.
Academic Article Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.
Academic Article Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia.
Academic Article Regulation of breathing by tissue oxygen: evidence from mutant mice with Presbyterian hemoglobinopathy.
Academic Article Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia.
Academic Article 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase.
Academic Article Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas.
Academic Article Effect of adenosine on chemosensory activity of the cat aortic body.
Academic Article Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.
Academic Article ROS signaling in systemic and cellular responses to chronic intermittent hypoxia.
Academic Article Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.
Academic Article Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
Academic Article HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia.
Academic Article Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.
Academic Article Transcriptional responses to intermittent hypoxia.
Academic Article Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception.
Academic Article Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells.
Academic Article Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities.
Academic Article Role of substance P in hypercapnic excitation of carotid chemoreceptors.
Academic Article Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits.
Academic Article Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing.
Academic Article Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases.
Academic Article NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.
Academic Article Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS.
Academic Article Redox Pioneer: Professor Gregg L. Semenza.
Academic Article O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?
Academic Article Long-term regulation of carotid body function: acclimatization and adaptation--invited article.
Academic Article Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells.
Academic Article Respiratory effects of N-methyl-D-aspartate on the ventrolateral medullary surface.
Academic Article H2S mediates O2 sensing in the carotid body.
Academic Article Sensing hypoxia: carotid body mechanisms and reflexes in health and disease.
Academic Article NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats.
Academic Article NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells.
Academic Article Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS.
Academic Article Cellular mechanisms associated with intermittent hypoxia.
Academic Article Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance.
Academic Article Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation.
Academic Article Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.
Academic Article Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus.
Academic Article Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol.
Academic Article Sympatho-adrenal activation by chronic intermittent hypoxia.
Academic Article The role of hypoxia-inducible factors in oxygen sensing by the carotid body.
Academic Article Institute for integrative physiology: resurrection of physiology at the University of Chicago.
Academic Article Hydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia.
Academic Article Somatostatin in the control of respiration.
Academic Article Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface.
Academic Article Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein.
Academic Article Post-translational modification of proteins during intermittent hypoxia.
Academic Article Oxygen sensing in the body.
Academic Article Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia.
Academic Article Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats.
Academic Article Refinement of telemetry for measuring blood pressure in conscious rats.
Academic Article Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells.
Academic Article Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2.
Academic Article Substance P and mitochondrial oxygen consumption: evidence for a direct intracellular role for the peptide.
Academic Article Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.
Academic Article Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing.
Academic Article Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Academic Article Role of adenosine in hypoxic ventilatory depression.
Academic Article Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.
Academic Article Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress.
Academic Article Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: II. Responses of respiratory muscles and their motor nerves.
Academic Article Respiratory and vasomotor responses to focal cooling of the ventral medullary surface (VMS) of the rat.
Academic Article Naloxone enhances the response to hypercapnia of spinal and cranial respiratory nerves.
Academic Article Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia.
Academic Article Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Academic Article Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: I. Ventilatory responses.
Academic Article Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase.
Academic Article Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia.
Academic Article NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells.
Academic Article Gas biology: small molecular medicine.
Academic Article Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat.
Academic Article Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat.
Academic Article Novel role for reactive oxygen species as amplifiers of intermittent hypoxia. Focus on "Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia".
Academic Article Nitric oxide in the sensory function of the carotid body.
Academic Article Effect of focal cooling of central chemosensitive areas on cerebral ischemic response.
Academic Article Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.
Academic Article Low PO2 dependency of neutral endopeptidase and acetylcholinesterase activities of the rat carotid body.
Academic Article Effect of distension of urinary bladder on blood pressure and respiration.
Academic Article Role of substance P in rat carotid body responses to hypoxia and capsaicin.
Academic Article Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345.
Academic Article Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345.
Academic Article Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2.
Academic Article Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.
Academic Article Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body.
Academic Article Endogenous H2S is required for hypoxic sensing by carotid body glomus cells.
Academic Article Ventral medullary surface inputs to cervical sympathetic respiratory oscillations.
Academic Article Altered breathing pattern elicited by stimulation of abdominal visceral afferents.
Academic Article Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase.
Academic Article Cardiorespiratory changes induced by vertebral artery injection of sodium cyanide in cats.
Academic Article L-type Ca(2+) channel activation regulates induction of c-fos transcription by hypoxia.
Academic Article Chemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells.
Academic Article Peripheral chemosensitivity in mutant mice deficient in nitric oxide synthase.
Academic Article Augmentation of calcium current by hypoxia in carotid body glomus cells.
Academic Article Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia.
Academic Article Role of nitric oxide in short-term potentiation and long-term facilitation: involvement of NO in breathing stability.
Academic Article Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation.
Academic Article Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas.
Academic Article Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species.
Academic Article Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity.
Academic Article Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide.
Academic Article Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia.
Academic Article Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor.
Academic Article Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration.
Academic Article Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes.
Academic Article Reactive oxygen species facilitate oxygen sensing.
Academic Article Effect of adenosine on isolated and superfused cat carotid body activity.
Academic Article Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.
Academic Article Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia.
Academic Article Gaseous messengers in oxygen sensing.
Academic Article Influence of adrenaline and hypoxia on rat muscle receptors in vitro.
Academic Article Influence of central chemoreceptor afferent inputs on respiratory muscle activity.
Academic Article Integration of cardiorespiratory responses in the ventrolateral medulla.
Academic Article Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms.
Academic Article Significance of pulmonary vagal afferents for respiratory muscle activity in the cat.
Academic Article Sensing hypoxia: physiology, genetics and epigenetics.
Academic Article Peripheral chemoreceptors: function and plasticity of the carotid body.
Academic Article Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis.
Academic Article Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats.
Academic Article Is insulin the new intermittent hypoxia?
Academic Article Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.
Academic Article Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.
Academic Article TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
Academic Article Hypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression.
Academic Article Central and peripheral factors contributing to obstructive sleep apneas.
Academic Article Impairment of pancreatic ß-cell function by chronic intermittent hypoxia.
Academic Article CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body.
Academic Article Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.
Academic Article Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia.
Academic Article Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia.
Academic Article Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome.
Academic Article Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla.
Academic Article Peripheral chemoreception and arterial pressure responses to intermittent hypoxia.
Academic Article Protein kinase G-regulated production of H2S governs oxygen sensing.
Academic Article HIF-1a activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase.
Academic Article The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.
Academic Article Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications.
Academic Article Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla.
Academic Article Oxygen Sensing and Homeostasis.
Academic Article This volume of Advances in Experimental Medicine and Biology holds the proceedings of the XVIIIth meeting. Introduction.
Academic Article Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.
Academic Article Regulation of carotid body oxygen sensing by hypoxia-inducible factors.
Academic Article CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.
Academic Article Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia.
Academic Article Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex.
Academic Article Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea.
Academic Article H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.
Academic Article Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.
Academic Article Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia.
Academic Article Complementary roles of gasotransmitters CO and H2S in sleep apnea.
Academic Article Systems biology of oxygen homeostasis.
Academic Article HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.
Academic Article Oxygen Sensing by the Carotid Body: Past and Present.
Academic Article Measurement of Sensory Nerve Activity from the Carotid Body.
Academic Article Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia.
Academic Article H2S mediates carotid body response to hypoxia but not anoxia.
Academic Article The role of hypoxia-inducible factors in carotid body (patho) physiology.
Academic Article Immunohistochemistry of the Carotid Body.
Academic Article Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model.
Academic Article DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.
Academic Article Epigenetic changes by DNA methylation in chronic and intermittent hypoxia.
Academic Article Recent advances in understanding the physiology of hypoxic sensing by the carotid body.
Academic Article Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.
Academic Article Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia.
Academic Article Neural Activation of Molecular Circuitry in Intermittent Hypoxia.
Academic Article Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.
Academic Article 2019 Nobel Prize in Physiology or Medicine.
Academic Article Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia.
Academic Article Hypoxia-inducible factors and obstructive sleep apnea.
Academic Article Hypoxia-inducible factor-1 mediates pancreatic ß-cell dysfunction by intermittent hypoxia.
Academic Article Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.
Academic Article Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells.
Academic Article Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia.
Academic Article Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure.
Academic Article Lysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia.
Academic Article Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.
Academic Article Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia.
Academic Article Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats.
Academic Article Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia.
Academic Article Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.
Academic Article A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans.
Academic Article Gasotransmitter modulation of hypoglossal motoneuron activity.
Concept ERG1 Potassium Channel
Concept Transcriptional Regulator ERG
Concept Endothelin-Converting Enzymes
Concept Essential Hypertension
Concept NAV1.5 Voltage-Gated Sodium Channel
Concept Gasotransmitters
Concept Neurokinin-1 Receptor Antagonists
Concept In Vitro Techniques
Academic Article Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea.
Academic Article Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78.
Academic Article Editorial: Vascular pathophysiology in hypoxia.
Academic Article P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
Academic Article Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.
Academic Article Transcriptomic Analysis of Postnatal Rat Carotid Body Development.
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